内源性脂蛋白是否调节动物对致心律失常药物的敏感性?

J. Beitz, S. Schneider, A. Riedel, H.-J. Mest
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引用次数: 2

摘要

目前的研究表明,高密度脂蛋白水平的降低与对致心律失常刺激的易感性增强有关,仅在饮食中缺乏多不饱和脂肪酸(PUFA)的大鼠中,而在富含PUFA或颗粒饮食后则无关。内源性总胆固醇水平不影响乌头碱诱发的大鼠心律失常和瓦阿因诱发的豚鼠心律失常的心室扑动或心室颤动阈值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Do endogenous lipoproteins modulate the sensibility of animals against arrhythmogenic drugs?

The present study suggests that a diminished level of HDL is connected with an enhanced susceptibility to arrhythmogenic stimuli only in rats pretreated with a diet deficient in polyunsaturated fatty acids (PUFA), but not after a PUFA-rich or pellet diet. The endogenous level of total cholesterol did not influence the thresholds for ventricular flutter or ventricular fibrillation in aconitine-induced arrhythmia in rats or in ouabain-induced arrhythmia in guinea pigs.

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