苯巴比妥对大鼠血栓素A2合成的抑制作用

Thomas I. Pynadath, Ali Z. Haghighi
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引用次数: 2

摘要

研究了苯巴比妥对大鼠血清脂蛋白及血小板中血栓素A2合成的影响。苯巴比妥使血清LDL水平降低33%,使HDL水平升高15%以上。发现苯巴比妥治疗的动物血小板中血栓素A2的合成减少了43%。对照动物血小板中血栓素A2的合成受到HDL的抑制,LDL的刺激。因此,苯巴比妥治疗大鼠血小板中血栓素A2合成的减少似乎至少部分是由于血清中高密度脂蛋白的增加和低密度脂蛋白的降低。苯巴比妥治疗也导致血清高密度脂蛋白胆固醇升高15%,尽管对总胆固醇没有显著影响。血清胆固醇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhibition of thromboxane A2 synthesis in rats treated with phenobarbital

The effect of phenobarbital administration on serum lipoproteins and thromboxane A2 synthesis in platelets was studied in rats. Phenobarbital decreased the serum LDL level by 33% and increased the HDL level by more than 15%. The synthesis of thromboxane A2 in the platelets of the phenobarbital treated animals was found to be reduced by 43%. Thromboxane A2 synthesis in the platelets of the control animals was inhibited by HDL and stimulated by LDL. Hence it appears that the decreased thromboxane A2 synthesis in the platelets of Phenobarbital treated rats was at least partly due to the increased HDL and decreased LDL in the serum. Phenobarbital treatment also caused a 15% increase in the serum HDL-cholesterol although it did not have any significant effect on the total. serum cholesterol.

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