大鼠植入式纤维肉瘤的生长与血浆前列腺素- e2和凝血素- b2的高水平有关

W.J. Kort , I.M. Weijma , A.M. Bijma , W.P. van Schalkwijk , F.J. Zijlstra , D.L. Westbroek
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引用次数: 11

摘要

恶性纤维肉瘤BN175的生长与高血浆TXB2和PGE2水平相关。这种统计学上显著的增加是在肿瘤接种后17天首次检测到的,此时肿瘤直径为20毫米。肿瘤大小的进一步增加与更高的PGE2和TXB2值相关。同时,通过adp诱导的血小板聚集,观察到血小板功能的进行性改变。在整个实验过程中,6-酮- pgf1 α水平保持正常。结论是肿瘤生长与PG合成和血小板功能的变化有关,尽管尚不清楚这些变化是由宿主对肿瘤的某些免疫反应引起的,还是主要是肿瘤PG合成的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Growth of an implanted fibrosarcoma in rats is associated with high levels of plasma prostaglandin-E2 and thromboxane-B2

Growth of BN175, a malignant fibrosarcoma, was correlated with high plasma TXB2 and PGE2 levels. This statistically significant increase was first detected 17 days after inoculation of the tumor, at which time the tumors were 20 mms in diameter. A further increase in tumor size was associated with still higher PGE2 and TXB2 values. At the same time, progressive alterations in platelet function, as measured by ADP-induced platelet aggregation, were observed.6-keto-PGF levels remained normal throughout the whole experiment.

It was concluded that tumor growth was associated with changes in PG synthesis and platelet function, although it remains unclear whether these changes were caused by some host immunological response towards the tumor or were predominantly the result of tumor PG-synthesis.

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