n-3和n-6多不饱和脂肪酸膳食补充剂与吲哚美辛对大鼠心脏力学性能和心律失常易感性的长期影响比较

Peter L. McLennan, Mahinda Y. Abeywardena, John S. Charnock
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引用次数: 35

摘要

在喂食低脂肪(4%,w/w)标准实验室饲料或添加额外(12%,w/w)饱和动物脂肪酸(羊肾周脂肪;分别从葵花籽油(SSO)或金枪鱼鱼油(FO)中提取n-6或n-3多不饱和脂肪酸(PUFA’s)。与成熟的REF或SF喂养组相比,SSO和FO喂养动物的肌肉对Ca++的正性肌力反应和异丙肾上腺素负荷下自发性心动过速的发生率显著降低。吲哚美辛降低了REF组和SF组对Ca++的反应,但对SSO组和FO组的肌肉没有影响。此外,该药还能显著降低REF和SF喂养动物的异丙肾上腺碱引起的肌肉心律失常,但对SSO和FO组的肌肉没有影响,因为SSO和FO组的肌肉对心律失常的易感程度已经低于前两组。这些结果表明,“长期”喂食n-3或n-6 PUFA可以通过可能涉及类二十烷代谢的机制显着减少该物种体外心律失常的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comparison of the long-term effects of n-3 and n-6 polyunsaturated fatty acid dietary supplements and the action of indomethacin upon the mechanical performance and susceptibility of the rat heart to dysrhythmia

The effect of different dietary lipid supplements on the contractility and susceptibility to isoprenaline-induced dysrhythmia in rat papillary muscles was examined after one year's prefeeding of either a low fat (4%, w/w) standard laboratory diet or those supplemented with additional (12%, w/w) saturated animal fatty acids (sheep perirenal fat; SF) or n-6 or n-3 polyunsaturated fatty acids (PUFA's) from sunflower seed oil (SSO) or tuna fish oil (FO) respectively.

The positive inotropic response to Ca++ and the incidence of spontaneous tachyarrhythmias under isoprenaline load were significantly less in the muscles from SSO and FO fed animals compared to either mature REF or SF fed groups. Indomethacin reduced the response to Ca++ in both the REF and SF groups, but was without effect upon the muscles from SSO and FO groups. In addition this drug also significantly reduced isoprenaline-induced dysrhythmia in the muscles from REF and SF fed animals, but had no effect upon those from SSO and FO groups which were already less suceptible to dysrhythmia than the muscles from animals in the former two groups.

These results indicate that “long-term” feeding of either n-3 or n-6 PUFA's can significantly reduce arrhythmogenesis in this species in vitro by mechanisms that may involve eicosanoid metabolism.

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