多发性创伤患者粒细胞花生四烯酸代谢的改变

W. Schönfeld , J. Knöller , J. Brom , M. Raulf , M. Köller , T. Joka , W. König
{"title":"多发性创伤患者粒细胞花生四烯酸代谢的改变","authors":"W. Schönfeld ,&nbsp;J. Knöller ,&nbsp;J. Brom ,&nbsp;M. Raulf ,&nbsp;M. Köller ,&nbsp;T. Joka ,&nbsp;W. König","doi":"10.1016/0262-1746(87)90073-4","DOIUrl":null,"url":null,"abstract":"<div><p>The generation and metabolism of leukotrienes (LTs) from polymorphonuclear granulocytes of four polytraumatic patients on stimulation with the Ca-Ionophore A 23187 were studied by high performance liquid chromatography. In contrast to healthy donors the concentration of LTB<sub>4</sub> within the supernatant of the stimulated granulocytes from these patients is reduced. The ratio of LTB<sub>4</sub> versus the combined amounts of the biologically inactive 6-trans and 12-epi-6-trans-isomers is significantly decreased. In one patient who suffered from an Adult Respiratory Distress Syndrome (ARDS) a pronounced enhancement of LTC<sub>4</sub> synthesis was observed.</p></div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90073-4","citationCount":"6","resultStr":"{\"title\":\"Altered arachidonic acid metabolism in granulocytes of polytraumatized patients\",\"authors\":\"W. Schönfeld ,&nbsp;J. Knöller ,&nbsp;J. Brom ,&nbsp;M. Raulf ,&nbsp;M. Köller ,&nbsp;T. Joka ,&nbsp;W. König\",\"doi\":\"10.1016/0262-1746(87)90073-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The generation and metabolism of leukotrienes (LTs) from polymorphonuclear granulocytes of four polytraumatic patients on stimulation with the Ca-Ionophore A 23187 were studied by high performance liquid chromatography. In contrast to healthy donors the concentration of LTB<sub>4</sub> within the supernatant of the stimulated granulocytes from these patients is reduced. The ratio of LTB<sub>4</sub> versus the combined amounts of the biologically inactive 6-trans and 12-epi-6-trans-isomers is significantly decreased. In one patient who suffered from an Adult Respiratory Distress Syndrome (ARDS) a pronounced enhancement of LTC<sub>4</sub> synthesis was observed.</p></div>\",\"PeriodicalId\":20720,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0262-1746(87)90073-4\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0262174687900734\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0262174687900734","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6

摘要

用高效液相色谱法研究了4例外伤患者在钙离子载体a23187刺激下多形核粒细胞白三烯(LTs)的生成和代谢。与健康供者相比,这些患者受刺激的粒细胞上清液中LTB4的浓度降低。LTB4与无生物活性的6-反式和12-epi-6-反式异构体的总数量之比显著降低。在一名患有成人呼吸窘迫综合征(ARDS)的患者中,观察到LTC4合成明显增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altered arachidonic acid metabolism in granulocytes of polytraumatized patients

The generation and metabolism of leukotrienes (LTs) from polymorphonuclear granulocytes of four polytraumatic patients on stimulation with the Ca-Ionophore A 23187 were studied by high performance liquid chromatography. In contrast to healthy donors the concentration of LTB4 within the supernatant of the stimulated granulocytes from these patients is reduced. The ratio of LTB4 versus the combined amounts of the biologically inactive 6-trans and 12-epi-6-trans-isomers is significantly decreased. In one patient who suffered from an Adult Respiratory Distress Syndrome (ARDS) a pronounced enhancement of LTC4 synthesis was observed.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信