Progress in lipid research最新文献

筛选
英文 中文
Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions 水生动物参与长链多不饱和脂肪酸生物合成的去饱和酶和延长酶:从基因到功能
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-04-01 DOI: 10.1016/j.plipres.2022.101157
Ó. Monroig , A.C. Shu-Chien , N. Kabeya , D.R. Tocher , L.F.C. Castro
{"title":"Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions","authors":"Ó. Monroig ,&nbsp;A.C. Shu-Chien ,&nbsp;N. Kabeya ,&nbsp;D.R. Tocher ,&nbsp;L.F.C. Castro","doi":"10.1016/j.plipres.2022.101157","DOIUrl":"10.1016/j.plipres.2022.101157","url":null,"abstract":"<div><p>Marine ecosystems are rich in “omega-3” long-chain (C<sub>20-24</sub>) polyunsaturated fatty acids (LC-PUFA). Their production has been historically accepted to derive mostly from marine microbes. This long-standing dogma has been challenged recently by the discovery that numerous invertebrates, mostly with an aquatic life-style, have the enzyme machinery necessary for the de novo biosynthesis of polyunsaturated fatty acids (PUFA) and, from them, LC-PUFA. The key breakthrough was the detection in these animals of enzymes called “methyl-end desaturases” enabling PUFA de novo biosynthesis. Moreover, other enzymes with pivotal roles in LC-PUFA biosynthesis, including front-end desaturases and elongation of very long- chain fatty acids proteins, have been characterised in several non-vertebrate animal phyla. This review provides a comprehensive overview of the complement and functions of these gene/protein families in aquatic animals, particularly invertebrates and fish. Therefore, we expand and re-define our previous revision of the LC-PUFA biosynthetic enzymes present in chordates to animals as a whole, discussing how key genomic events have determined the diversity and distribution of desaturase and elongase genes in different taxa. We conclude that both invertebrates and fish display active, but markedly different, LC-PUFA biosynthetic gene networks that result from a complex evolutionary path combined with functional diversification and plasticity.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"86 ","pages":"Article 101157"},"PeriodicalIF":13.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782722000121/pdfft?md5=82fbfb7104670ef251d3349771139be2&pid=1-s2.0-S0163782722000121-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39740633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Plant monounsaturated fatty acids: Diversity, biosynthesis, functions and uses 植物单不饱和脂肪酸:多样性、生物合成、功能和用途
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101138
Sami Kazaz , Romane Miray , Loïc Lepiniec, Sébastien Baud
{"title":"Plant monounsaturated fatty acids: Diversity, biosynthesis, functions and uses","authors":"Sami Kazaz ,&nbsp;Romane Miray ,&nbsp;Loïc Lepiniec,&nbsp;Sébastien Baud","doi":"10.1016/j.plipres.2021.101138","DOIUrl":"10.1016/j.plipres.2021.101138","url":null,"abstract":"<div><p><span>Monounsaturated fatty acids are straight-chain aliphatic monocarboxylic acids comprising a unique carbon‑carbon double bond, also termed unsaturation. More than 50 distinct molecular structures have been described in the plant kingdom, and more remain to be discovered. The evolution of land plants has apparently resulted in the </span>convergent evolution<span><span> of non-homologous enzymes catalyzing the </span>dehydrogenation<span><span> of saturated acyl chain substrates in a chemo-, regio- and stereoselective manner. Contrasted enzymatic characteristics and different subcellular localizations of these desaturases account for the diversity of existing fatty acid structures. Interestingly, the location and geometrical configuration of the unsaturation confer specific characteristics to these molecules found in a variety of membrane, storage, and surface lipids. An ongoing research effort aimed at exploring the links existing between fatty acid structures and their biological functions has already unraveled the importance of several monounsaturated fatty acids in various physiological and developmental contexts. What is more, the monounsaturated acyl chains found in the oils of seeds and fruits are widely and increasingly used in the </span>food and chemical industries due to the physicochemical properties inherent in their structures. Breeders and plant biotechnologists therefore develop new crops with high monounsaturated contents for various agro-industrial purposes.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101138"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39874757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Dietary lipids from body to brain 膳食脂质从身体到大脑
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101144
Custers, E.M. Emma, Kiliaan, J. Amanda
{"title":"Dietary lipids from body to brain","authors":"Custers,&nbsp;E.M. Emma,&nbsp;Kiliaan,&nbsp;J. Amanda","doi":"10.1016/j.plipres.2021.101144","DOIUrl":"10.1016/j.plipres.2021.101144","url":null,"abstract":"<div><p>Dietary habits have drastically changed over the last decades in Western societies. The Western diet, rich in saturated fatty acids (SFA), trans fatty acids (TFA), omega-6 polyunsaturated fatty acids (n-6 PUFA) and cholesterol, is accepted as an important factor in the development of metabolic disorders, such as obesity and diabetes type 2. Alongside these diseases, nutrition is associated with the prevalence of brain disorders. Although clinical and epidemiological studies revealed that metabolic diseases and brain disorders might be related, the underlying pathology is multifactorial, making it hard to determine causal links. Neuroinflammation can be a result of unhealthy diets that may cause alterations in peripheral metabolism. Especially, dietary fatty acids are of interest, as they act as signalling molecules responsible for inflammatory processes. Diets rich in n-6 PUFA, SFA and TFA increase neuroinflammation, whereas diets rich in monounsaturated fatty acids (MUFA), omega-3 (n-3) PUFA and sphingolipids (SL) can diminish neuroinflammation. Moreover, these pro- and anti-inflammatory diets might indirectly influence neuroinflammation via the adipose tissue, microbiome, intestine and vasculature. Here, we review the impact of nutrition on brain health. In particular, we will discuss the role of dietary lipids in signalling pathways directly applicable to inflammation and neuronal function.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101144"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782721000606/pdfft?md5=50f371f180d9672ee8a22c8cff3bc286&pid=1-s2.0-S0163782721000606-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39843662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications 另一边的你好:脂滴与其他细胞器的膜接触及其后续功能影响
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101141
Rebekah Rakotonirina-Ricquebourg , Vítor Costa , Vitor Teixeira
{"title":"Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications","authors":"Rebekah Rakotonirina-Ricquebourg ,&nbsp;Vítor Costa ,&nbsp;Vitor Teixeira","doi":"10.1016/j.plipres.2021.101141","DOIUrl":"10.1016/j.plipres.2021.101141","url":null,"abstract":"<div><p><span>Lipid droplets (LDs) are ubiquitous organelles that play crucial roles in response to physiological and environmental cues. The identification of several </span>neutral lipid<span><span><span> synthesizing and regulatory protein complexes have propelled significant advance on the mechanisms of LD biogenesis in the endoplasmic reticulum (ER). Increasing evidence suggests that distinct proteins and regulatory factors, which localize to membrane contact sites (MCS), are involved not only in interorganellar </span>lipid<span> exchange and transport, but also function in other important cellular processes, including autophagy, mitochondrial dynamics<span> and inheritance, ion signaling and inter-regulation of these MCS. More and more tethers and molecular determinants are associated to MCS and to a diversity of cellular and pathophysiological processes, demonstrating the dynamics and importance of these junctions in health and disease. The conjugation of lipids with proteins in supramolecular complexes is known to be paramount for many biological processes, namely membrane </span></span></span>biosynthesis<span>, cell homeostasis, regulation of organelle division and biogenesis, and cell growth. Ultimately, this physical organization allows the contact sites to function as crucial metabolic hubs that control the occurrence of chemical reactions. This leads to biochemical and metabolite compartmentalization for the purposes of energetic efficiency and cellular homeostasis. In this review, we will focus on the structural and functional aspects of LD-organelle interactions and how they ensure signaling exchange and metabolites transfer between organelles.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101141"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39745863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Too complex to fail? Targeting fatty acid metabolism for cancer therapy 太复杂而不能失败?针对脂肪酸代谢的癌症治疗
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101143
Rimsha Munir , Jan Lisec , Johannes V. Swinnen , Nousheen Zaidi
{"title":"Too complex to fail? Targeting fatty acid metabolism for cancer therapy","authors":"Rimsha Munir ,&nbsp;Jan Lisec ,&nbsp;Johannes V. Swinnen ,&nbsp;Nousheen Zaidi","doi":"10.1016/j.plipres.2021.101143","DOIUrl":"10.1016/j.plipres.2021.101143","url":null,"abstract":"<div><p>Given the central role of fatty acids in cancer pathophysiology, the exploitation of fatty acid metabolism as a potential antineoplastic therapy has gained much attention. Several natural and synthetic compounds targeting fatty acid metabolism were hitherto identified, and their effectiveness against cancer cell proliferation<span><span> and survival was determined. This review will discuss the most clinically viable inhibitors or drugs targeting various proteins or </span>enzymes mapped on nine interconnected fatty acid metabolism-related processes. We will discuss the general significance of each of these processes and the effects of their inhibition on cancer cell progression. Moreover, their mechanisms of action, limitations, and future perspectives will be assessed.</span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101143"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39953409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Mapping the myristoylome through a complete understanding of protein myristoylation biochemistry 通过对蛋白质肉豆蔻酰化生物化学的全面了解来绘制肉豆蔻酰化的图谱
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101139
Carmela Giglione, Thierry Meinnel
{"title":"Mapping the myristoylome through a complete understanding of protein myristoylation biochemistry","authors":"Carmela Giglione,&nbsp;Thierry Meinnel","doi":"10.1016/j.plipres.2021.101139","DOIUrl":"10.1016/j.plipres.2021.101139","url":null,"abstract":"<div><p><span>Protein myristoylation is a C14 fatty acid modification found in all living organisms. Myristoylation tags either the N-terminal alpha groups of cysteine or glycine residues through amide bonds or lysine and cysteine side chains directly or indirectly </span><em>via</em><span><span> glycerol thioester and ester linkages. Before transfer to proteins, myristate must be activated into myristoyl </span>coenzyme A<span> in eukaryotes or, in bacteria, to derivatives like phosphatidylethanolamine. Myristate originates through </span></span><em>de novo</em><span> biosynthesis (</span><em>e.g.</em>, plants), from external uptake (<em>e.g.</em>, human tissues), or from mixed origins (<em>e.g.</em>, unicellular organisms). Myristate usually serves as a molecular anchor, allowing tagged proteins to be targeted to membranes and travel across endomembrane networks in eukaryotes. In this review, we describe and discuss the metabolic origins of protein-bound myristate. We review strategies for <em>in vivo</em><span> protein labeling that take advantage of click-chemistry with reactive analogs, and we discuss new approaches to the proteome-wide discovery of myristate-containing proteins. The machineries of myristoylation are described, along with how protein targets can be generated directly from translating precursors or from processed proteins. Few myristoylation catalysts are currently described, with only N-myristoyltransferase described to date in eukaryotes. Finally, we describe how viruses and bacteria hijack and exploit myristoylation for their pathogenicity.</span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101139"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39745864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Biophysical insights into modulating lipid digestion in food emulsions 调节食品乳剂中脂质消化的生物物理见解
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101129
Alejandra Acevedo-Fani, Harjinder Singh
{"title":"Biophysical insights into modulating lipid digestion in food emulsions","authors":"Alejandra Acevedo-Fani,&nbsp;Harjinder Singh","doi":"10.1016/j.plipres.2021.101129","DOIUrl":"10.1016/j.plipres.2021.101129","url":null,"abstract":"<div><p>During the last decade, major scientific advances on understanding the mechanisms of lipid digestion and metabolism have been made, with a view to addressing health issues (such as obesity) associated with overconsumption of lipid-rich and sucrose-rich foods. As lipids in common foods exist in the form of emulsions, the structuring of emulsions has been one the main strategies for controlling the rate of lipid digestion and absorption, at least from a colloid science viewpoint. Modulating the kinetics of lipid digestion and absorption offers interesting possibilities for developing foods that can provide control of postprandial lipaemia and control the release of lipophilic compounds. Food emulsions can be designed to achieve considerable differences in the kinetics of lipid digestion but most research has been applied to relatively simple model systems and in in vitro digestion models. Further research to translate this knowledge into more complex food systems and to validate the results in human studies is required. One promising approach to delay/control lipid digestion is to alter the stomach emptying rate of lipids, which is largely affected by interactions of emulsion droplets with the food matrices. Food matrices with different responses to the gastric environment and with different interactions between oil droplets and the food matrix can be designed to influence lipid digestion. This review focuses on key scientific advances made during the last decade on understanding the physicochemical and structural modifications of emulsified lipids, mainly from a biophysical science perspective. The review specifically explores different approaches by which the structure and stability of emulsions may be altered to achieve specific lipid digestion kinetics.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101129"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S016378272100045X/pdfft?md5=de7c86d2420fbf4c2a73176a7653abf4&pid=1-s2.0-S016378272100045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39674078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Lipid nutrition: “In silico” studies and undeveloped experiments 脂质营养学:“计算机”研究和未开发的实验
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101142
Bill Lands
{"title":"Lipid nutrition: “In silico” studies and undeveloped experiments","authors":"Bill Lands","doi":"10.1016/j.plipres.2021.101142","DOIUrl":"10.1016/j.plipres.2021.101142","url":null,"abstract":"<div><p>This review examines lipids and lipid-binding sites on proteins in relation to cardiovascular disease. Lipid nutrition involves food energy from ingested fatty acids plus fatty acids formed from excess ingested carbohydrate and protein. Non-esterified fatty acids (NEFA) and lipoproteins have many detailed attributes not evident in their names. Recognizing attributes of lipid-protein interactions decreases unexpected outcomes. Details of double bond position and configuration interacting with protein binding sites have unexpected consequences in acyltransferase and cell replication events. Highly unsaturated fatty acids (HUFA) have n-3 and n-6 motifs with documented differences in intensity of destabilizing positive feedback loops amplifying pathophysiology. However, actions of NEFA have been neglected relative to cholesterol, which is co-produced from excess food. Native low-density lipoproteins (LDL) bind to a high-affinity cell surface receptor which poorly recognizes biologically modified LDLs. NEFA increase negative charge of LDL and decrease its processing by “normal” receptors while increasing processing by “scavenger” receptors. A positive feedback loop in the recruitment of monocytes and macrophages amplifies chronic inflammatory pathophysiology. Computer tools combine multiple components in lipid nutrition and predict balance of energy and n-3:n-6 HUFA. The tools help design and execute precise clinical nutrition monitoring that either supports or disproves expectations.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101142"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782721000588/pdfft?md5=7c86f735dd452dc28d2b964e9d8458d6&pid=1-s2.0-S0163782721000588-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39655557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues 更新的ANGPTL3-4-8模型作为甘油三酯在脂肪和氧化组织之间分配的机制
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101140
Ren Zhang, Kezhong Zhang
{"title":"An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues","authors":"Ren Zhang,&nbsp;Kezhong Zhang","doi":"10.1016/j.plipres.2021.101140","DOIUrl":"10.1016/j.plipres.2021.101140","url":null,"abstract":"<div><p>In mammals, triglyceride<span><span> (TG), the main form of lipids for storing and providing energy, is stored in white adipose tissue (WAT) after food intake, while during fasting it is routed to oxidative tissues (heart and skeletal muscle) for energy production, a process referred to as TG partitioning. </span>Lipoprotein lipase<span><span> (LPL), a rate-limiting enzyme in this fundamental </span>physiological process<span><span>, hydrolyzes circulating TG to generate </span>free fatty acids that are taken up by peripheral tissues. The postprandial activity of LPL declines in oxidative tissues but rises in WAT, directing TG to WAT; the reverse is true during fasting. However, the molecular mechanism in regulating tissue-specific LPL activity during the fed-fast cycle has not been completely understood. Research on angiopoietin-like (ANGPTL) proteins (A3, A4, and A8) has resulted in an ANGPTL3-4-8 model to explain the TG partitioning between WAT and oxidative tissues. Food intake induces A8 expression in the liver and WAT. Liver A8 activates A3 by forming the A3-8 complex, which is then secreted into the circulation. The A3-8 complex acts in an endocrine manner to inhibit LPL in oxidative tissues. WAT A8 forms the A4-8 complex, which acts locally to block A4's LPL-inhibiting activity. Therefore, the postprandial activity of LPL is low in oxidative tissues but high in WAT, directing circulating TG to WAT. Conversely, during fasting, reduced A8 expression in the liver and WAT disables A3 from inhibiting oxidative-tissue LPL and restores WAT A4's LPL-inhibiting activity, respectively. Thus, the fasting LPL activity is high in oxidative tissues but low in WAT, directing TG to the former. According to the model, we hypothesize that A8 antagonism has the potential to simultaneously reduce TG and increase HDL-cholesterol plasma levels. Future research on A3, A4, and A8 can hopefully provide more insights into human health, disease, and therapeutics.</span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101140"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9699507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
A comprehensive review on the lipid and pleiotropic effects of pitavastatin 匹伐他汀对血脂和多效性的综合研究综述
IF 13.6 1区 医学
Progress in lipid research Pub Date : 2021-11-01 DOI: 10.1016/j.plipres.2021.101127
Amirhossein Sahebkar , Nasim Kiaie , Armita Mahdavi Gorabi , Massimo R. Mannarino , Vanessa Bianconi , Tannaz Jamialahmadi , Matteo Pirro , Maciej Banach
{"title":"A comprehensive review on the lipid and pleiotropic effects of pitavastatin","authors":"Amirhossein Sahebkar ,&nbsp;Nasim Kiaie ,&nbsp;Armita Mahdavi Gorabi ,&nbsp;Massimo R. Mannarino ,&nbsp;Vanessa Bianconi ,&nbsp;Tannaz Jamialahmadi ,&nbsp;Matteo Pirro ,&nbsp;Maciej Banach","doi":"10.1016/j.plipres.2021.101127","DOIUrl":"10.1016/j.plipres.2021.101127","url":null,"abstract":"<div><p><span><span>The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase<span> inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. </span></span>Pitavastatin<span> is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and </span></span>triacylglycerol<span>. It has been reported to have pleiotropic effects<span><span><span> such as decreasing inflammation and oxidative stress, regulating </span>angiogenesis<span> and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique </span></span>lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"84 ","pages":"Article 101127"},"PeriodicalIF":13.6,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39406233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信