Progress in lipid research最新文献

Navigating the complexity of lipid oxidation and antioxidation: A review of evaluation methods and emerging approaches.

IF 14 1区医学

Progress in lipid research Pub Date : 2024-12-16 DOI: 10.1016/j.plipres.2024.101317

Erwann Durand, Mickael Laguerre, Claire Bourlieu-Lacanal, Jérôme Lecomte, Pierre Villeneuve

{"title":"Navigating the complexity of lipid oxidation and antioxidation: A review of evaluation methods and emerging approaches.","authors":"Erwann Durand, Mickael Laguerre, Claire Bourlieu-Lacanal, Jérôme Lecomte, Pierre Villeneuve","doi":"10.1016/j.plipres.2024.101317","DOIUrl":"https://doi.org/10.1016/j.plipres.2024.101317","url":null,"abstract":"<p><p>Lipid oxidative degradation contributes to the deterioration of food quality and poses potential health risks. A promising approach to counteract this is the use of plant-based antioxidants. However, accurately evaluating the antioxidant capacity and effectiveness of these compounds remains a challenge. While many rapid in vitro tests are available, they must be categorized according to their specific responses to avoid overinterpreting results. This review opens with an overview of current knowledge on lipid autoxidation and recent findings that highlight the challenges in measuring antioxidant capacity. We then examine various methods, addressing their limitations in accurately anticipating outcomes in complex compartmentalized lipid systems. The aim is to clarify the gap between predictions and real-world efficacy in final products. Additionally, the review compares the strengths and weaknesses of methods used to evaluate antioxidant capacity and assess oxidation degrees in complex environments, such as those found in food and cosmetics. Finally, new analytical techniques for multiproduct detection are introduced, paving the way for a more 'omic' and spatiotemporally defined approach.</p>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":" ","pages":"101317"},"PeriodicalIF":14.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis 活性胆固醇如何协调细胞胆固醇平衡：假设检验

IF 14 1区医学

Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101304

Yvonne Lange , Theodore L. Steck

{"title":"How active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis","authors":"Yvonne Lange , Theodore L. Steck","doi":"10.1016/j.plipres.2024.101304","DOIUrl":"10.1016/j.plipres.2024.101304","url":null,"abstract":"<div><div>How do cells coordinate the diverse elements that regulate their cholesterol homeostasis? Our model postulates that membrane cholesterol forms simple complexes with bilayer phospholipids. The phospholipids in the plasma membrane are of high affinity; consequently, they are fully complexed with the sterol. This sets the resting level of plasma membrane cholesterol. Cholesterol in excess of the stoichiometric equivalence point of these complexes has high chemical activity; we refer to it as <em>active cholesterol</em>. It equilibrates with the low affinity phospholipids in the intracellular membranes where it serves as a negative feedback signal to a manifold of regulatory proteins that rein in ongoing cholesterol accretion. We tested the model with a review of the literature regarding fourteen homeostatic proteins in enterocytes. It provided strong albeit indirect support for the following hypothesis. Active cholesterol inhibits cholesterol uptake and biosynthesis by suppressing both the expression and the activity of the gene products activated by SREBP-2; namely, HMGCR, LDLR and NPC1L1. It also reduces free cell cholesterol by serving as the substrate for its esterification by ACAT and for the synthesis of side-chain oxysterols, 27-hydroxycholesterol in particular. The oxysterols drive cholesterol depletion by promoting the destruction of HMGCR and stimulating sterol esterification as well as the activation of LXR. The latter fosters the expression of multiple homeostatic proteins, including four transporters for which active cholesterol is the likely substrate. By nulling active cholesterol, the manifold maintains the cellular sterol at its physiologic set point.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101304"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting PPARα 的脂质感应：在控制肝细胞基因调控网络和禁食代谢反应中的作用

IF 14 1区医学

Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101303

Anne Fougerat , Justine Bruse , Arnaud Polizzi , Alexandra Montagner , Hervé Guillou , Walter Wahli

{"title":"Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting","authors":"Anne Fougerat , Justine Bruse , Arnaud Polizzi , Alexandra Montagner , Hervé Guillou , Walter Wahli","doi":"10.1016/j.plipres.2024.101303","DOIUrl":"10.1016/j.plipres.2024.101303","url":null,"abstract":"<div><div>Peroxisome proliferator-activated receptors (PPARs) constitute a small family of three nuclear receptors that act as lipid sensors, and thereby regulate the transcription of genes having key roles in hepatic and whole-body energy homeostasis, and in other processes (e.g., inflammation), which have far-reaching health consequences. Peroxisome proliferator-activated receptor isotype α (PPARα) is expressed in oxidative tissues, particularly in the liver, carrying out critical functions during the adaptive fasting response. Advanced omics technologies have provided insight into the vast complexity of the regulation of PPAR expression and activity, as well as their downstream effects on the physiology of the liver and its associated metabolic organs. Here, we provide an overview of the gene regulatory networks controlled by PPARα in the liver in response to fasting. We discuss impacts on liver metabolism, the systemic repercussions and benefits of PPARα-regulated ketogenesis and production of fibroblast growth factor 21 (FGF21), a fasting- and stress-inducible metabolic hormone. We also highlight current challenges in using novel methods to further improve our knowledge of PPARα in health and disease.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101303"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing oil content in Brassica oilseed species 提高甘蓝类油菜籽的含油量。

IF 14 1区医学

Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101306

Randall J. Weselake , David A. Fell , Xiaoyu Wang , Simon Scofield , Guanqun Chen , John L. Harwood

{"title":"Increasing oil content in Brassica oilseed species","authors":"Randall J. Weselake , David A. Fell , Xiaoyu Wang , Simon Scofield , Guanqun Chen , John L. Harwood","doi":"10.1016/j.plipres.2024.101306","DOIUrl":"10.1016/j.plipres.2024.101306","url":null,"abstract":"<div><div>Brassica oilseed species are the third most important in the world, providing approximately 15 % of the total vegetable oils. Three species (<em>Brassica rapa, B. juncea, B. napus</em>) dominate with <em>B. napus</em> being the most common in Canada, China and Europe. Originally, <em>B. napus</em> was a crop producing seed with high erucic acid content, which still persists today, to some extent, and is used for industrial purposes. In contrast, cultivars which produce seed used for food and feed are low erucic acid cultivars which also have reduced glucosinolate content. Because of the limit to agricultural land, recent efforts have been made to increase productivity of oil crops, including Brassica oilseed species. In this article, we have detailed research in this regard. We have covered modern genetic, genomic and metabolic control analysis approaches to identifying potential targets for the manipulation of seed oil content. Details of work on the use of quantitative trait loci, genome-wide association and comparative functional genomics to highlight factors influencing seed oil accumulation are given and functional proteins which can affect this process are discussed. In summary, a wide variety of inputs are proving useful for the improvement of Brassica oilseed species, as major sources of global vegetable oil.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101306"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long chain polyunsaturated fatty acid (LC-PUFA) composition of fish sperm: nexus of dietary, evolutionary, and biomechanical drivers 鱼类精子的长链多不饱和脂肪酸（LC-PUFA）组成：膳食、进化和生物力学驱动因素的联系。

IF 14 1区医学

Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101305

Deepali Rahi Roy , Koushik Roy , Stephane Panserat , Vlastimil Stejskal , Jan Mraz , Giovanni M. Turchini

{"title":"Long chain polyunsaturated fatty acid (LC-PUFA) composition of fish sperm: nexus of dietary, evolutionary, and biomechanical drivers","authors":"Deepali Rahi Roy , Koushik Roy , Stephane Panserat , Vlastimil Stejskal , Jan Mraz , Giovanni M. Turchini","doi":"10.1016/j.plipres.2024.101305","DOIUrl":"10.1016/j.plipres.2024.101305","url":null,"abstract":"<div><div>Long-chain polyunsaturated fatty acids (LC-PUFA) like arachidonic acid (ARA, 20:4n-6), eicosapentaenoic acid (EPA, 20:5n-3), and docosahexaenoic acid (DHA, 22:6n-3) constitute one-third to half of fish sperm lipids. Fish sperm is rich in phospholipid (PL)—primarily phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin. DHA is generally the most abundant LC-PUFA in each PL class, followed by competition between ARA and EPA. While the total n-6: n-3 PUFA ratio does not correlate significantly with sperm biomechanics, LC-PUFA do. DHA positively influences sperm biomechanics, while ARA and EPA may be negatively associated. Fish sperm maintains lower (≤1) total n-6 PUFA per unit of n-3 PUFA but keep a higher (>1) ARA per unit EPA. A weak dietary influence on sperm EPA and DHA exists but not on ARA. The DHA: EPA ratio in fish sperm is often >1, though values <1 occur. Certain species cannot fortify DHA sufficiently during spermatogenesis, diverging through whole genome duplications. Fish sperm can show ARA: EPA ratios greater or less than 1, due to shifts in prostaglandin pathways in different evolutionary eras. DHA-rich PL bilayers provide unique packing and fusogenic properties, with ARA/EPA-derived eicosanoids guiding sperm rheotaxis/chemotaxis, modulated by DHA-derived resolvins. Docosapentaenoic acid (DPA, 22:5n-3) sometimes substitutes for DHA in fish sperm.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101305"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery 以细菌磷脂及其合成途径为目标，发现抗生素。

IF 14 1区医学

Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101307

Meirong Song , Shang Chen , Wenhan Lin , Kui Zhu

引用次数: 0

From fallopian tube epithelium to high-grade serous ovarian cancer: A single-cell resolution review of sex steroid hormone signaling 从输卵管上皮到高级别浆液性卵巢癌：性类固醇激素信号传导的单细胞分辨率回顾

IF 14 1区医学

Progress in lipid research Pub Date : 2024-10-11 DOI: 10.1016/j.plipres.2024.101302

Marija Gjorgoska, Tea Lanišnik Rižner

{"title":"From fallopian tube epithelium to high-grade serous ovarian cancer: A single-cell resolution review of sex steroid hormone signaling","authors":"Marija Gjorgoska, Tea Lanišnik Rižner","doi":"10.1016/j.plipres.2024.101302","DOIUrl":"10.1016/j.plipres.2024.101302","url":null,"abstract":"<div><div>High-grade serous ovarian cancer (HGSOC) represents the most lethal subtype of ovarian cancer, largely due to being commonly diagnosed at advanced stages. The early molecular mechanisms underlying ovarian carcinogenesis remain poorly defined, posing challenges to the development of prevention and early detection strategies. Here we dissect the molecular mechanisms of sex steroid hormone signaling throughout the decades-long evolution of HGSOC precursor lesions, which predominantly originate from secretory epithelial cells of fallopian tubes (FT). We also discuss the prognostic significance of sex steroid receptor isoforms and steroid metabolizing enzymes in HGSOCs. Finally, we provide a comprehensive gene expression atlases of sex steroid receptors, steroidogenic, and steroid-metabolizing enzymes across different cell populations in pre- and postmenopausal FTs, and HGSOCs, using published single-cell RNA sequencing datasets. These atlases reveal that secretory epithelial cells and stromal populations in FTs express sex steroid receptors and enzymes responsible for the formation and inactivation of genotoxic estrogen metabolites. In HGSOC, epithelial cells express various <em>HSD17B</em> isoforms and steroid conjugating enzymes, suggesting an enhanced ability to finely regulate the levels of bioactive sex steroids.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101302"},"PeriodicalIF":14.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update of isoprostanoid nomenclature 更新异甾烷类命名法

IF 14 1区医学

Progress in lipid research Pub Date : 2024-09-14 DOI: 10.1016/j.plipres.2024.101301

Camille Oger , Tereza Pavlíčková , Valérie Bultel-Poncé , Alexandre Guy , Jean-Marie Galano , Ullrich Jahn , Thierry Durand

引用次数: 0

Unraveling brain palmitic acid: Origin, levels and metabolic fate 揭开脑棕榈酸的神秘面纱：起源、含量和代谢命运

IF 14 1区医学

Progress in lipid research Pub Date : 2024-08-31 DOI: 10.1016/j.plipres.2024.101300

Mackenzie E. Smith, Richard P. Bazinet

{"title":"Unraveling brain palmitic acid: Origin, levels and metabolic fate","authors":"Mackenzie E. Smith, Richard P. Bazinet","doi":"10.1016/j.plipres.2024.101300","DOIUrl":"10.1016/j.plipres.2024.101300","url":null,"abstract":"<div><div>In the human brain, palmitic acid (16:0; PAM) comprises nearly half of total brain saturates and has been identified as the third most abundant fatty acid overall. Brain PAM supports the structure of membrane phospholipids, provides energy, and regulates protein stability. Sources underlying the origin of brain PAM are both diet and endogenous synthesis via de novo lipogenesis (DNL), primarily from glucose. However, studies investigating the origin of brain PAM are limited to tracer studies utilizing labelled (<sup>14</sup>C/<sup>11</sup>C/<sup>3</sup>H/<sup>2</sup>H) PAM, and results vary based on the model and tracer used. Nevertheless, there is evidence PAM is synthesized locally in the brain, in addition to obtained directly from the diet. Herein, we provide an overview of brain PAM origin, entry to the brain, metabolic fate, and factors influencing brain PAM kinetics and levels, the latter in the context of age, as well as neurological diseases and psychiatric disorders. Additionally, we briefly summarize the role of PAM in signaling at the level of the brain. We add to the literature a rudimentary summary on brain PAM metabolism.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101300"},"PeriodicalIF":14.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant and algal lipidomes: Analysis, composition, and their societal significance 植物和藻类脂质体：分析、组成及其社会意义。

IF 14 1区医学

Progress in lipid research Pub Date : 2024-07-31 DOI: 10.1016/j.plipres.2024.101290

Juliette Jouhet , Eliana Alves , Yohann Boutté , Sylvain Darnet , Frédéric Domergue , Thierry Durand , Pauline Fischer , Laetitia Fouillen , Mara Grube , Jérôme Joubès , Uldis Kalnenieks , Joanna M. Kargul , Inna Khozin-Goldberg , Catherine Leblanc , Sophia Letsiou , Josselin Lupette , Gabriel V. Markov , Isabel Medina , Tânia Melo , Peter Mojzeš , Rosário Domingues

{"title":"Plant and algal lipidomes: Analysis, composition, and their societal significance","authors":"Juliette Jouhet , Eliana Alves , Yohann Boutté , Sylvain Darnet , Frédéric Domergue , Thierry Durand , Pauline Fischer , Laetitia Fouillen , Mara Grube , Jérôme Joubès , Uldis Kalnenieks , Joanna M. Kargul , Inna Khozin-Goldberg , Catherine Leblanc , Sophia Letsiou , Josselin Lupette , Gabriel V. Markov , Isabel Medina , Tânia Melo , Peter Mojzeš , Rosário Domingues","doi":"10.1016/j.plipres.2024.101290","DOIUrl":"10.1016/j.plipres.2024.101290","url":null,"abstract":"<div><p>Plants and algae play a crucial role in the earth's ecosystems. Through photosynthesis they convert light energy into chemical energy, capture CO2 and produce oxygen and energy-rich organic compounds. Photosynthetic organisms are primary producers and synthesize the essential omega 3 and omega 6 fatty acids. They have also unique and highly diverse complex lipids, such as glycolipids, phospholipids, triglycerides, sphingolipids and phytosterols, with nutritional and health benefits. Plant and algal lipids are useful in food, feed, nutraceutical, cosmeceutical and pharmaceutical industries but also for green chemistry and bioenergy. The analysis of plant and algal lipidomes represents a significant challenge due to the intricate and diverse nature of their composition, as well as their plasticity under changing environmental conditions. Optimization of analytical tools is crucial for an in-depth exploration of the lipidome of plants and algae. This review highlights how lipidomics analytical tools can be used to establish a complete mapping of plant and algal lipidomes. Acquiring this knowledge will pave the way for the use of plants and algae as sources of tailored lipids for both industrial and environmental applications. This aligns with the main challenges for society, upholding the natural resources of our planet and respecting their limits.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101290"},"PeriodicalIF":14.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000237/pdfft?md5=8afa52fc297f9eab2e95f26117ac0614&pid=1-s2.0-S0163782724000237-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0