Progress in lipid research最新文献

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Corrigendum to "An update of isoprostanoid nomenclature" [Progress in Lipid Research 96 (2024) 101301-101310]. 对 "更新异前列素命名法 "的更正[《脂质研究进展》96 (2024) 101301-101310]。
IF 14 1区 医学
Progress in lipid research Pub Date : 2025-02-04 DOI: 10.1016/j.plipres.2025.101321
Camille Oger, Tereza Pavlíčková, Valérie Bultel-Poncé, Alexandre Guy, Jean-Marie Galano, Ullrich Jahn, Thierry Durand
{"title":"Corrigendum to \"An update of isoprostanoid nomenclature\" [Progress in Lipid Research 96 (2024) 101301-101310].","authors":"Camille Oger, Tereza Pavlíčková, Valérie Bultel-Poncé, Alexandre Guy, Jean-Marie Galano, Ullrich Jahn, Thierry Durand","doi":"10.1016/j.plipres.2025.101321","DOIUrl":"https://doi.org/10.1016/j.plipres.2025.101321","url":null,"abstract":"","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":" ","pages":"101321"},"PeriodicalIF":14.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the complexity of lipid oxidation and antioxidation: A review of evaluation methods and emerging approaches 导航脂质氧化和抗氧化的复杂性:评价方法和新兴方法的回顾。
IF 14 1区 医学
Progress in lipid research Pub Date : 2025-01-01 DOI: 10.1016/j.plipres.2024.101317
Erwann Durand , Mickael Laguerre , Claire Bourlieu-Lacanal , Jérôme Lecomte , Pierre Villeneuve
{"title":"Navigating the complexity of lipid oxidation and antioxidation: A review of evaluation methods and emerging approaches","authors":"Erwann Durand ,&nbsp;Mickael Laguerre ,&nbsp;Claire Bourlieu-Lacanal ,&nbsp;Jérôme Lecomte ,&nbsp;Pierre Villeneuve","doi":"10.1016/j.plipres.2024.101317","DOIUrl":"10.1016/j.plipres.2024.101317","url":null,"abstract":"<div><div>Lipid oxidative degradation contributes to the deterioration of food quality and poses potential health risks. A promising approach to counteract this is the use of plant-based antioxidants. However, accurately evaluating the antioxidant capacity and effectiveness of these compounds remains a challenge. While many rapid <em>in vitro</em> tests are available, they must be categorized according to their specific responses to avoid overinterpreting results. This review opens with an overview of current knowledge on lipid autoxidation and recent findings that highlight the challenges in measuring antioxidant capacity. We then examine various methods, addressing their limitations in accurately anticipating outcomes in complex compartmentalized lipid systems. The aim is to clarify the gap between predictions and real-world efficacy in final products. Additionally, the review compares the strengths and weaknesses of methods used to evaluate antioxidant capacity and assess oxidation degrees in complex environments, such as those found in food and cosmetics. Finally, new analytical techniques for multiproduct detection are introduced, paving the way for a more ‘omic’ and spatiotemporally defined approach.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101317"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To image or not to image: Use of imaging mass spectrometry in biomedical lipidomics 成像或不成像:成像质谱法在生物医学脂组学中的应用。
IF 14 1区 医学
Progress in lipid research Pub Date : 2025-01-01 DOI: 10.1016/j.plipres.2025.101319
Albert Maimó-Barceló , Karim Pérez-Romero , Ramón M. Rodríguez , Cristina Huergo , Ibai Calvo , José A. Fernández , Gwendolyn Barceló-Coblijn
{"title":"To image or not to image: Use of imaging mass spectrometry in biomedical lipidomics","authors":"Albert Maimó-Barceló ,&nbsp;Karim Pérez-Romero ,&nbsp;Ramón M. Rodríguez ,&nbsp;Cristina Huergo ,&nbsp;Ibai Calvo ,&nbsp;José A. Fernández ,&nbsp;Gwendolyn Barceló-Coblijn","doi":"10.1016/j.plipres.2025.101319","DOIUrl":"10.1016/j.plipres.2025.101319","url":null,"abstract":"<div><div>Lipid imaging mass spectrometry (LIMS) allows for establishing the bidimensional distribution of lipid species within a tissue section. One of the main advantages is the generation of spatial information on lipid species distribution at a spatial (lateral) resolution bordering on single-cell resolution with no need to isolate cells. Thus, LIMS images demonstrate, with a level of detail never described before, that lipid profiles are highly sensitive to cell type and pathophysiological state. The wealth and relevance of the information conveyed by LIMS makes up for the lack of a separation stage before sample injection into the mass analyzer, which can somehow be circumvented by other means. Hence, the possibility of describing the lipidome at the cellular level while preserving the microenvironment offers an incomparable opportunity to investigate physiological and pathological contexts. However, to fully grasp the biological implications of the lipid profiles, it is essential to contextualize LIMS data within the broader multiscale ‘omic’ landscape, entailing genomics, epigenomics, and proteomics, each offering a unique window into the regulatory layers of the cell. In this line, the number of techniques that can be combined with LIMS to delve into the molecular mechanisms underlying differential lipid profiles is continuously increasing. Herein, we aim to describe the key features of LIMS analyses, from sample preparation to data interpretation, as well as the current methodologies to enrich and complete the final outcome. While the field is rapidly advancing, we consider there is solid evidence to foresee the incorporation of LIMS into clinical environments.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101319"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioavailability of EPA and DHA in humans – A comprehensive review EPA和DHA在人体内的生物利用度综述。
IF 14 1区 医学
Progress in lipid research Pub Date : 2025-01-01 DOI: 10.1016/j.plipres.2024.101318
Sepideh Alijani , Andreas Hahn , William S. Harris , Jan Philipp Schuchardt
{"title":"Bioavailability of EPA and DHA in humans – A comprehensive review","authors":"Sepideh Alijani ,&nbsp;Andreas Hahn ,&nbsp;William S. Harris ,&nbsp;Jan Philipp Schuchardt","doi":"10.1016/j.plipres.2024.101318","DOIUrl":"10.1016/j.plipres.2024.101318","url":null,"abstract":"<div><div>The bioavailability of long-chain omega-3 fatty acids is a critical yet often overlooked factor influencing their efficacy. This review evaluates the bioavailability of EPA/DHA from acute (single-dose) and chronic human studies, focusing on (a) chemical forms such as triacylglycerols (TAG, natural and re-esterified, rTAG), non-esterified fatty acids (NEFA), and phospholipids (PL) from sources like fish, krill, and microalgae, and (b) delivery methods like microencapsulation and emulsification. Bioavailability for isolated chemically forms followed the order: NEFA &gt; PL &gt; rTAG &gt; unmodified TAG &gt; ethyl esters (EE). However, varying oil compositions complicate conclusions about source-specific bioavailability. Significant differences observed in acute bioavailability studies (e.g., faster absorption) often did not translate into long-term impacts in chronic supplementation studies. This raises questions about the clinical relevance of acute findings, especially given that n-3 PUFA supplements are typically consumed long-term. Methodological limitations, such as inappropriate biomarkers, short sampling windows, and inadequate product characterization, hinder the reliability and comparability of studies. The review emphasizes the need for standardized protocols and robust chronic studies to clarify the clinical implications of bioavailability differences. Future research should prioritize biomarkers that reflect sustained n-3 PUFA status to better understand the health benefits of various EPA and DHA formulations.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101318"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Betaine lipids: Biosynthesis, functional diversity and evolutionary perspectives 甜菜碱脂:生物合成、功能多样性和进化观点。
IF 14 1区 医学
Progress in lipid research Pub Date : 2025-01-01 DOI: 10.1016/j.plipres.2025.101320
Sarah Salomon, Océane Oliva, Alberto Amato, Olivier Bastien, Morgane Michaud, Juliette Jouhet
{"title":"Betaine lipids: Biosynthesis, functional diversity and evolutionary perspectives","authors":"Sarah Salomon,&nbsp;Océane Oliva,&nbsp;Alberto Amato,&nbsp;Olivier Bastien,&nbsp;Morgane Michaud,&nbsp;Juliette Jouhet","doi":"10.1016/j.plipres.2025.101320","DOIUrl":"10.1016/j.plipres.2025.101320","url":null,"abstract":"<div><div>Betaine lipids (BL) are relatively understudied non‑phosphorus glycerolipids. They are predominantly found in algae but have also been detected in other unicellular eukaryotes, fungi, bacteria, and some bryophytes and pteridophytes. These extraplastidial lipids are considered as substitute for phospholipids in organisms, particularly under phosphate (Pi) deficiency. This review provides a broader perspective on the roles and functions of BL, revealing their functional diversity across species and environments. It also discuss the biosynthetic pathways of BL. Indeed, the pathway for DGTS (1(3),2-diacylglyceryl-3(1)-<em>O</em>-4′-(<em>N,N,N</em>-trimethyl)-homoserine), the most widespread and studied BL form, is completely known, whereas the pathway for DGTA (1(3),2-diacylglyceryl-3(1)-<em>O</em>-2′-(<em>N,N,N</em>-trimethyl)-β-alanine) is only partially understood. In this review, the role of the <em>BTA1</em> gene, responsible for the synthesis of DGTS, is discussed. It is revealed to be essential in DGTA synthesis as it enables the production of its intermediate, DGTS. A phylogenetic analysis, conducted on <em>BTA1</em> gene, does not seem to link the phylogenetic position of <em>BTA1</em> with the BL species produced but confirms the distribution trends, with a BL diversification in marine environments and the gradual disappearance of DGTS in the evolution of the green lineage. Further research is needed to elucidate the specific roles and biosynthetic pathways of BL across different species.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101320"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis 活性胆固醇如何协调细胞胆固醇平衡:假设检验
IF 14 1区 医学
Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101304
Yvonne Lange , Theodore L. Steck
{"title":"How active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis","authors":"Yvonne Lange ,&nbsp;Theodore L. Steck","doi":"10.1016/j.plipres.2024.101304","DOIUrl":"10.1016/j.plipres.2024.101304","url":null,"abstract":"<div><div>How do cells coordinate the diverse elements that regulate their cholesterol homeostasis? Our model postulates that membrane cholesterol forms simple complexes with bilayer phospholipids. The phospholipids in the plasma membrane are of high affinity; consequently, they are fully complexed with the sterol. This sets the resting level of plasma membrane cholesterol. Cholesterol in excess of the stoichiometric equivalence point of these complexes has high chemical activity; we refer to it as <em>active cholesterol</em>. It equilibrates with the low affinity phospholipids in the intracellular membranes where it serves as a negative feedback signal to a manifold of regulatory proteins that rein in ongoing cholesterol accretion. We tested the model with a review of the literature regarding fourteen homeostatic proteins in enterocytes. It provided strong albeit indirect support for the following hypothesis. Active cholesterol inhibits cholesterol uptake and biosynthesis by suppressing both the expression and the activity of the gene products activated by SREBP-2; namely, HMGCR, LDLR and NPC1L1. It also reduces free cell cholesterol by serving as the substrate for its esterification by ACAT and for the synthesis of side-chain oxysterols, 27-hydroxycholesterol in particular. The oxysterols drive cholesterol depletion by promoting the destruction of HMGCR and stimulating sterol esterification as well as the activation of LXR. The latter fosters the expression of multiple homeostatic proteins, including four transporters for which active cholesterol is the likely substrate. By nulling active cholesterol, the manifold maintains the cellular sterol at its physiologic set point.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101304"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting PPARα 的脂质感应:在控制肝细胞基因调控网络和禁食代谢反应中的作用
IF 14 1区 医学
Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101303
Anne Fougerat , Justine Bruse , Arnaud Polizzi , Alexandra Montagner , Hervé Guillou , Walter Wahli
{"title":"Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting","authors":"Anne Fougerat ,&nbsp;Justine Bruse ,&nbsp;Arnaud Polizzi ,&nbsp;Alexandra Montagner ,&nbsp;Hervé Guillou ,&nbsp;Walter Wahli","doi":"10.1016/j.plipres.2024.101303","DOIUrl":"10.1016/j.plipres.2024.101303","url":null,"abstract":"<div><div>Peroxisome proliferator-activated receptors (PPARs) constitute a small family of three nuclear receptors that act as lipid sensors, and thereby regulate the transcription of genes having key roles in hepatic and whole-body energy homeostasis, and in other processes (e.g., inflammation), which have far-reaching health consequences. Peroxisome proliferator-activated receptor isotype α (PPARα) is expressed in oxidative tissues, particularly in the liver, carrying out critical functions during the adaptive fasting response. Advanced omics technologies have provided insight into the vast complexity of the regulation of PPAR expression and activity, as well as their downstream effects on the physiology of the liver and its associated metabolic organs. Here, we provide an overview of the gene regulatory networks controlled by PPARα in the liver in response to fasting. We discuss impacts on liver metabolism, the systemic repercussions and benefits of PPARα-regulated ketogenesis and production of fibroblast growth factor 21 (FGF21), a fasting- and stress-inducible metabolic hormone. We also highlight current challenges in using novel methods to further improve our knowledge of PPARα in health and disease.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101303"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing oil content in Brassica oilseed species 提高甘蓝类油菜籽的含油量。
IF 14 1区 医学
Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101306
Randall J. Weselake , David A. Fell , Xiaoyu Wang , Simon Scofield , Guanqun Chen , John L. Harwood
{"title":"Increasing oil content in Brassica oilseed species","authors":"Randall J. Weselake ,&nbsp;David A. Fell ,&nbsp;Xiaoyu Wang ,&nbsp;Simon Scofield ,&nbsp;Guanqun Chen ,&nbsp;John L. Harwood","doi":"10.1016/j.plipres.2024.101306","DOIUrl":"10.1016/j.plipres.2024.101306","url":null,"abstract":"<div><div>Brassica oilseed species are the third most important in the world, providing approximately 15 % of the total vegetable oils. Three species (<em>Brassica rapa, B. juncea, B. napus</em>) dominate with <em>B. napus</em> being the most common in Canada, China and Europe. Originally, <em>B. napus</em> was a crop producing seed with high erucic acid content, which still persists today, to some extent, and is used for industrial purposes. In contrast, cultivars which produce seed used for food and feed are low erucic acid cultivars which also have reduced glucosinolate content. Because of the limit to agricultural land, recent efforts have been made to increase productivity of oil crops, including Brassica oilseed species. In this article, we have detailed research in this regard. We have covered modern genetic, genomic and metabolic control analysis approaches to identifying potential targets for the manipulation of seed oil content. Details of work on the use of quantitative trait loci, genome-wide association and comparative functional genomics to highlight factors influencing seed oil accumulation are given and functional proteins which can affect this process are discussed. In summary, a wide variety of inputs are proving useful for the improvement of Brassica oilseed species, as major sources of global vegetable oil.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101306"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long chain polyunsaturated fatty acid (LC-PUFA) composition of fish sperm: nexus of dietary, evolutionary, and biomechanical drivers 鱼类精子的长链多不饱和脂肪酸(LC-PUFA)组成:膳食、进化和生物力学驱动因素的联系。
IF 14 1区 医学
Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101305
Deepali Rahi Roy , Koushik Roy , Stephane Panserat , Vlastimil Stejskal , Jan Mraz , Giovanni M. Turchini
{"title":"Long chain polyunsaturated fatty acid (LC-PUFA) composition of fish sperm: nexus of dietary, evolutionary, and biomechanical drivers","authors":"Deepali Rahi Roy ,&nbsp;Koushik Roy ,&nbsp;Stephane Panserat ,&nbsp;Vlastimil Stejskal ,&nbsp;Jan Mraz ,&nbsp;Giovanni M. Turchini","doi":"10.1016/j.plipres.2024.101305","DOIUrl":"10.1016/j.plipres.2024.101305","url":null,"abstract":"<div><div>Long-chain polyunsaturated fatty acids (LC-PUFA) like arachidonic acid (ARA, 20:4n-6), eicosapentaenoic acid (EPA, 20:5n-3), and docosahexaenoic acid (DHA, 22:6n-3) constitute one-third to half of fish sperm lipids. Fish sperm is rich in phospholipid (PL)—primarily phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin. DHA is generally the most abundant LC-PUFA in each PL class, followed by competition between ARA and EPA. While the total n-6: n-3 PUFA ratio does not correlate significantly with sperm biomechanics, LC-PUFA do. DHA positively influences sperm biomechanics, while ARA and EPA may be negatively associated. Fish sperm maintains lower (≤1) total n-6 PUFA per unit of n-3 PUFA but keep a higher (&gt;1) ARA per unit EPA. A weak dietary influence on sperm EPA and DHA exists but not on ARA. The DHA: EPA ratio in fish sperm is often &gt;1, though values &lt;1 occur. Certain species cannot fortify DHA sufficiently during spermatogenesis, diverging through whole genome duplications. Fish sperm can show ARA: EPA ratios greater or less than 1, due to shifts in prostaglandin pathways in different evolutionary eras. DHA-rich PL bilayers provide unique packing and fusogenic properties, with ARA/EPA-derived eicosanoids guiding sperm rheotaxis/chemotaxis, modulated by DHA-derived resolvins. Docosapentaenoic acid (DPA, 22:5n-3) sometimes substitutes for DHA in fish sperm.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101305"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery 以细菌磷脂及其合成途径为目标,发现抗生素。
IF 14 1区 医学
Progress in lipid research Pub Date : 2024-11-01 DOI: 10.1016/j.plipres.2024.101307
Meirong Song , Shang Chen , Wenhan Lin , Kui Zhu
{"title":"Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery","authors":"Meirong Song ,&nbsp;Shang Chen ,&nbsp;Wenhan Lin ,&nbsp;Kui Zhu","doi":"10.1016/j.plipres.2024.101307","DOIUrl":"10.1016/j.plipres.2024.101307","url":null,"abstract":"<div><div>Bacterial infections in humans and animals caused by multidrug-resistant (MDR) pathogens pose a serious threat to public health. New antibacterial targets are extremely urgent to solve the dilemma of cross-resistance. Phospholipids are critical components in bacterial envelopes and involve diverse crucial processes to maintain homeostasis and modulate metabolism. Targeting phospholipids and their synthesis pathways has been largely overlooked because conventional membrane-targeted substances are non-specific with cytotoxicity. In this review, we first introduce the structure and physiological function of phospholipids in bacteria. Subsequently, we describe the chemical diversity of novel ligands targeting phospholipids, structure-activity relationships (SAR), modes of action (MOA), and pharmacological effects. Finally, we prospect the advantage of bacterial phospholipids as promising antibacterial targets. In conclusion, these findings will shed light on discovering and developing new antibacterial drugs to combat MDR bacteria-associated infections.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101307"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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