Progress in lipid research最新文献

The plant lipid contactome: emerging roles of inter-organelle contact sites in lipid metabolism 植物脂质接触组：细胞器间接触位点在脂质代谢中的新作用

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2025-12-26 DOI: 10.1016/j.plipres.2025.101372

Carolina Huercano , Miriam Moya-Barrientos , Oliver Cuevas , Carlos Cardenas , Joaquín J. Salas , Victoria Sanchez-Vera , Noemi Ruiz-Lopez

{"title":"The plant lipid contactome: emerging roles of inter-organelle contact sites in lipid metabolism","authors":"Carolina Huercano , Miriam Moya-Barrientos , Oliver Cuevas , Carlos Cardenas , Joaquín J. Salas , Victoria Sanchez-Vera , Noemi Ruiz-Lopez","doi":"10.1016/j.plipres.2025.101372","DOIUrl":"10.1016/j.plipres.2025.101372","url":null,"abstract":"<div><div>Membrane contact sites (MCSs) are fundamental hubs of inter-organelle communication that mediate the non-vesicular exchange of lipids, ions, and metabolites, thereby sustaining cellular homeostasis. In plants, the “contactome”—the dynamic network of all membrane contact sites—has evolved distinctive features to accommodate the requirements of a sessile, photosynthetic lifestyle and the presence of plastids. Within this network, the endoplasmic reticulum (ER) functions as a central hub for lipid biosynthesis and distribution, forming functionally important contacts with multiple organelles. Recent advances in high-resolution imaging, lipidomics, and molecular genetics are beginning to uncover the complexity of these inter-organelle connections and their contribution to lipid homeostasis in plants. This review summarizes current knowledge of the plant contactome, with a focus on lipid transfer proteins and lipid-modifying enzymes that maintain lipid balance during organelle biogenesis, plant development, and stress adaptation. Plant lipid transfer at membrane contact sites can be broadly divided into two mechanistic modes: precision-regulated “shuttles,” exemplified by the Ca<sup>2+</sup>-dependent SYT1-mediated diacylglycerol transfer at ER–plasma membrane interfaces, and high-capacity lipid transfer mechanisms, such those mediated by ATG2, that support rapid lipid flux during autophagosome biogenesis. Knowledge of lipid metabolism at plant membrane contact sites is still in its initial stages, and many of the underlying mechanisms remain unexplored. Major challenges include understanding how these sites integrate stress responses, metabolic fluxes, and organelle dynamics. Addressing these questions will be essential to unravel the unique aspects of plant lipid biology and may open opportunities for improving stress resilience and metabolic engineering in crops.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"101 ","pages":"Article 101372"},"PeriodicalIF":14.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145845028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-guided dissection of the genetic variations within human LPA locus and its role in the development of cardiovascular diseases 人类LPA基因座遗传变异的结构导向解剖及其在心血管疾病发展中的作用

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2025-12-24 DOI: 10.1016/j.plipres.2025.101375

Ivan Antipenko , Anna Stepanova , Maxim Shkurnikov , Kianoush Jeiran , Ancha Baranova , Alexander Tonevitsky

{"title":"Structure-guided dissection of the genetic variations within human LPA locus and its role in the development of cardiovascular diseases","authors":"Ivan Antipenko , Anna Stepanova , Maxim Shkurnikov , Kianoush Jeiran , Ancha Baranova , Alexander Tonevitsky","doi":"10.1016/j.plipres.2025.101375","DOIUrl":"10.1016/j.plipres.2025.101375","url":null,"abstract":"<div><div>Lipoprotein (a) [Lp(a)] is a highly heterogeneous lipoprotein particle promoting panvascular disease. Structurally, it consists of an LDL-like core covalently bound to apolipoprotein (a) [apo(a)]. Molecular determinants linking various genetic variants of apo(a) constituent of Lp(a) to vascular pathology remain incompletely defined.</div><div>We have built a model allowing dissection which variations in <em>LPA</em> gene are functional, and which are mere associates of these functional variations. Copy number changes in kringle IV type 2 (KIV-2), together with a spectrum of single nucleotide polymorphisms (SNPs), regulate apo(a) size, expression, and function. These variants can be broadly categorized into Lp(a)-increasing, Lp(a)-lowering, and null alleles, with distinct prevalence across populations. Notably, risk alleles such as <em>rs10455872</em> and <em>rs3798220</em> account for substantial variance in circulating Lp(a) and confer elevated susceptibility to coronary artery disease, whereas splice-altering and nonsense alleles markedly reduce Lp(a) concentrations.</div><div>The therapeutic implications of modifying circulating Lp(a) levels are profound. While conventional lipid-lowering therapies exert little influence on Lp(a), antisense oligonucleotides (<em>pelacarsen</em>) and small interfering RNA agents (<em>olpasiran, SLN360</em>) achieve robust Lp(a) reductions. Integrating genetic insights with structural modeling provides a framework to disentangle functional from proxy associations within <em>LPA</em> and neutralize the cardiovascular hazard conferred by elevated levels of Lp(a).</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"101 ","pages":"Article 101375"},"PeriodicalIF":14.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neurobiology of fatty acids: Metabolism, signaling, and roles in neurodegenerative diseases 脂肪酸的神经生物学：代谢、信号传导和在神经退行性疾病中的作用

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2026-02-07 DOI: 10.1016/j.plipres.2026.101378

Rocío Rojas , Alicia Pellitero , Betül Arslan , Alberto Pérez-Samartín , Carlos Matute

引用次数: 0

Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions 二酰基甘油激酶：细胞和生理功能的分子机制。

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2026-01-06 DOI: 10.1016/j.plipres.2025.101373

Tomohiro Kimura , Richard M. Epand

{"title":"Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions","authors":"Tomohiro Kimura , Richard M. Epand","doi":"10.1016/j.plipres.2025.101373","DOIUrl":"10.1016/j.plipres.2025.101373","url":null,"abstract":"<div><div>Diacylglycerol (DAG) and phosphatidic acid (PA), being positioned in the central hub of glycerophospholipid biosynthesis pathways, are lipids vital for the structural and functional integrity of the cell. DAG kinases (DGKs) are the enzymes responsible for the conversion of DAG to PA to regulate the dynamically changing spatiotemporal levels of these lipids in various organelles and cellular structures. DAG and PA thereby function intricately in mechanistic events like cell signaling in association with the intracellular lipid profiles controlling membrane physiology. In mammalian cells, there are ten DGK isoforms, i.e., α, β, γ, δ, η, κ, ε, ζ, ι, θ, and their splice variants. Recent advancement of structural prediction algorism enables us to gain unparalleled insights into their molecular architectures, despite limited experimental data available to date. The structural information gives fundamental clues to understand pertinent cellular events that are reviewed in this work on a broad range of topics in health and disease. Upon cell stimuli, DAG is formed by hydrolysis of a phospholipid such as phosphatidylinositol (PI) 4,5-bisphosphate (PI(4,5)P<sub>2</sub>) via a phospholipase C (PLC). While relationship of the DGK activity with specific lipid acyl-chain species is being recognized, that with the <em>sn</em>-1 ether linkage like the vinyl ether has not yet been revealed. Importance of these relationships may be evident, considering the known regulation of the PLC activity by lipid rafts. Elucidation of molecular details of DGK functions in the context of membrane biophysics is thus essential for our understanding of cellular events in the individual tissues and organs.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"101 ","pages":"Article 101373"},"PeriodicalIF":14.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stearoyl-CoA desaturase in development and disease 硬脂酰辅酶a去饱和酶在发育和疾病中的作用。

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2025-12-29 DOI: 10.1016/j.plipres.2025.101374

Sampurna Ghosh , Roman Caceres , Sunny Congrove , James M. Ntambi , Biplab Dasgupta

{"title":"Stearoyl-CoA desaturase in development and disease","authors":"Sampurna Ghosh , Roman Caceres , Sunny Congrove , James M. Ntambi , Biplab Dasgupta","doi":"10.1016/j.plipres.2025.101374","DOIUrl":"10.1016/j.plipres.2025.101374","url":null,"abstract":"<div><div>The conversion of straight chain saturated fatty acids to their bent, unsaturated counterparts significantly increases their structural and functional complexity. Desaturation of fatty acids, where double bonds are introduced is an enzymatic reaction. Exploring 56 eukaryotic genomes, 275 desaturase homologs have been identified. Membrane-bound desaturases are the dominant form and are ubiquitous in bacteria and eukaryotes. Four subfamilies of desaturases introduce double bonds at distinct locations. Among them, the First Desaturase subfamily introduces the first double bond among which the stearoyl-CoA desaturases (SCDs) are the most predominant. SCD is a rate-limiting enzyme that generates monounsaturated fatty acids (MUFA) from saturated fatty acids (SFA) at the endoplasmic reticulum membrane, where SCD is localized. The MUFAs are utilized to produce a variety of cell membrane components including triglycerides, phospholipids, and cholesterol esters which play important roles in membrane fluidity, organelle function, and signal transduction. SCD activity is a critical regulator of SFA to MUFA ratio and, therefore, of overall cell function, growth, and survival. In this review, we will provide the latest updates on the expected as well as unanticipated roles of SCD in development, metabolism and disease with a focus on cancer and the central nervous system.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"101 ","pages":"Article 101374"},"PeriodicalIF":14.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phospholipids in plant systems: metabolism, regulation and functional insights 磷脂在植物系统：代谢，调节和功能的见解

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2026-01-29 DOI: 10.1016/j.plipres.2026.101377

Qiong Xiao , Stacy D. Singer , Yuki Nakamura , Guanqun Chen

{"title":"Phospholipids in plant systems: metabolism, regulation and functional insights","authors":"Qiong Xiao , Stacy D. Singer , Yuki Nakamura , Guanqun Chen","doi":"10.1016/j.plipres.2026.101377","DOIUrl":"10.1016/j.plipres.2026.101377","url":null,"abstract":"<div><div>Phospholipids are essential components of cellular membranes in plants and play important roles in several biological processes including membrane biogenesis, signaling, and stress response. Here, we systematically review the metabolic pathways that coordinate the assembly and degradation of phospholipids, as well as the functional roles of phospholipids in plant growth. To achieve this, we summarize recent biochemical and physiological studies of key enzymes involved in these pathways, and highlight the regulation of phospholipid metabolism at the transcriptional, post-transcriptional, and post-translational levels. These processes facilitate dynamic adjustments in phospholipid levels in response to environmental stressors and signaling pathways, and are crucial for maintaining phospholipid homeostasis and plant development. In addition, beyond their roles in maintaining the structural integrity of biological membranes, we also discuss crosstalk between phospholipid metabolic pathways, glycolipid production, and lipid droplet formation. Collectively, these insights contribute to a deeper understanding of phospholipid dynamics and their multifunctional roles in plants.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"101 ","pages":"Article 101377"},"PeriodicalIF":14.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Properties and biochemistry of phosphatidylcholine: diacylglycerol cholinephosphotransferase 磷脂酰胆碱的性质和生物化学：二酰基甘油胆碱磷酸酶

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2025-11-21 DOI: 10.1016/j.plipres.2025.101361

Brandon A. Ulch , Alyssa C. Clews , Caroline A. Reisiger , Li-Hua Zhu , Robert T. Mullen , Matthew S. Kimber , Yang Xu

{"title":"Properties and biochemistry of phosphatidylcholine: diacylglycerol cholinephosphotransferase","authors":"Brandon A. Ulch , Alyssa C. Clews , Caroline A. Reisiger , Li-Hua Zhu , Robert T. Mullen , Matthew S. Kimber , Yang Xu","doi":"10.1016/j.plipres.2025.101361","DOIUrl":"10.1016/j.plipres.2025.101361","url":null,"abstract":"<div><div>Plant oils, primarily composed of triacylglycerols (TAGs), are essential for both food and industrial applications. TAGs consist of three fatty acids esterified to a glycerol backbone, and their value and functionality are largely determined by their fatty acid composition. Hence, enhancing the fatty acid profile of plant oils is a primary focus for improving their economic and practical potential. Phosphatidylcholine: Diacylglycerol Cholinephosphotransferase (PDCT), encoded by the <em>REDUCED OLEATE DESATURATION1</em> (<em>ROD1</em>) gene in <em>Arabidopsis thaliana</em>, catalyzes the interconversion between phosphatidylcholine, the site of fatty acid modification, and diacylglycerol, the precursor of TAG assembly. PDCT plays a key role in determining the fatty acid composition and quality of oils, making it an attractive target for engineering crops with tailored oil profiles. This review systematically examines the biochemical, genetic, and molecular biology research on PDCT over the past decades, focusing on its phylogeny, physiological roles, regulation, biochemical characterization, structural features, and biotechnological applications. We also analyze the predicted structure of PDCT, which suggests a domain-swapped homodimer configuration based on AlphaFold3 modeling, and we discuss potential catalytic mechanisms. Finally, we highlight key open questions in the field and propose future research directions.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"101 ","pages":"Article 101361"},"PeriodicalIF":14.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From kinetoplastids to cancer: A magical myristate tour 从着丝质体到癌症：神奇的肉豆蔻之旅

IF 14.9 1区医学

Progress in lipid research Pub Date : 2026-06-01 Epub Date: 2025-12-03 DOI: 10.1016/j.plipres.2025.101362

Kyle Lethcoe, Robert O. Ryan

{"title":"From kinetoplastids to cancer: A magical myristate tour","authors":"Kyle Lethcoe, Robert O. Ryan","doi":"10.1016/j.plipres.2025.101362","DOIUrl":"10.1016/j.plipres.2025.101362","url":null,"abstract":"<div><div>Myristic acid (14:0) is a relatively minor fatty acid in terms of abundance yet, in certain biological settings, it has a major impact. Although normally synthesized via the classical fatty acid biosynthesis pathway, in specific cases where larger quantities of myristate are required, animals express distinct thioesterase enzymes that hydrolyze the acyl-S-fatty acid synthase thioester bond prior to further chain elongation. In the parasitic kinetoplastid, <em>Trypanosoma brucei</em>, myristate is required for biosynthesis of dimyristoyl-glycosylphosphatidylinositol membrane anchors, to which variable surface glycoproteins are attached. This extracellular coat protein is changed periodically, allowing the parasite to evade host adaptive immunity. In protein N-myristoylation, this acyl chain is attached to N-terminal glycine residues via an amide bond. A search for inhibitors of N-myristoyltransferase (NMT) activity led to discovery of pyrazole sulfonamide compounds with potent <em>T. brucei</em> NMT inhibitory activity. While clinical development of these inhibitors for parasite-induced disease has not been realized, the observation that pyrazole sulfonamides possess anticancer activity led to drug development studies. Findings obtained with a specific pyrazole sulfonamide compound, branded as zelenirstat, have yielded promising results in cell culture studies, animal models and human clinical trials. This review describes research undertaken to validate zelenirstat as a cancer therapy option.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"101 ","pages":"Article 101362"},"PeriodicalIF":14.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Announcing executive editor team changes 宣布执行编辑团队的变动

IF 13.6 1区医学

Progress in lipid research Pub Date : 2026-02-03 DOI: 10.1016/j.plipres.2026.101376

Danielle Descoteaux, Andy Deelen

引用次数: 0

N-Acylethanolamines in cancer: mechanisms and therapeutic potential of lipid regulators of tumor behavior 肿瘤中的n -酰基乙醇胺：肿瘤行为的脂质调节剂的机制和治疗潜力

IF 14.9 1区医学

Progress in lipid research Pub Date : 2025-11-01 DOI: 10.1016/j.plipres.2025.101358

M.F. Nanì , M.M. Rinaldi , M. Miraglia, R. Amico, P. De Cicco , B. Romano

{"title":"N-Acylethanolamines in cancer: mechanisms and therapeutic potential of lipid regulators of tumor behavior","authors":"M.F. Nanì , M.M. Rinaldi , M. Miraglia, R. Amico, P. De Cicco , B. Romano","doi":"10.1016/j.plipres.2025.101358","DOIUrl":"10.1016/j.plipres.2025.101358","url":null,"abstract":"<div><div><em>N</em>-Acylethanolamines (NAEs) are endogenous bioactive lipids generated from membrane glycerophospholipids, with key members including arachidonoylethanolamide (anandamide, AEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA). These molecules engage multiple receptor systems such as cannabinoid (CB) receptors, peroxisome proliferator-activated receptors (PPARs), and transient receptor potential (TRP) channels to regulate inflammation, apoptosis, and metabolic signaling. Mounting evidence indicates that NAEs also exert multifaceted effects on tumor biology, influencing several hallmarks of cancer including proliferative signaling, angiogenesis, immune modulation, and resistance to cell death. Moreover, emerging congeners such as stearoylethanolamide (SEA) and linoleoylethanolamide (LEA) are gaining recognition for their roles in tumor-associated metabolic reprogramming and the control of inflammatory microenvironments. The enzymatic machinery that governs NAE synthesis (NAPE-PLD) and degradation (including FAAH and NAAA) represents a promising therapeutic axis for modulating NAE signaling in cancer. This review integrates current insights into the mechanistic functions of NAEs in oncogenesis, with a focus on their signaling networks, interaction with the tumor microenvironment, and the translational relevance of targeting NAE pathways in cancer therapy.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"100 ","pages":"Article 101358"},"PeriodicalIF":14.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0