Phospholipids and their metabolites as diagnostic biomarkers of human diseases

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in lipid research Pub Date : 2025-05-21 DOI:10.1016/j.plipres.2025.101340

Jeong-Hun Kang , Riki Toita , Takahito Kawano , Masaharu Murata , Arihiro Kano

引用次数: 0

Abstract

Phospholipids that occur predominantly in the plasma membrane of mammalian cells are phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylethanolamine (PE), sphingomyelin (SM), and phosphatidylinositol (or phosphoinositide; PI). These membrane phospholipids are a promising source of disease-related biomarkers. Phospholipids and their metabolites are altered by the type of disease or disease progression. Metabolomics has shown that increased or decreased levels of altered phospholipids and their metabolites can be useful indicators for the diagnosis of various human diseases. In this review, we discuss the utility of the five major membrane phospholipids (PC, PS, PE, and SM, and PI) and their metabolites as diagnostic biomarkers of human diseases.

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磷脂及其代谢物作为人类疾病的诊断生物标志物。

主要存在于哺乳动物细胞质膜中的磷脂有磷脂酰胆碱（PC）、磷脂酰丝氨酸（PS）、磷脂酰乙醇胺（PE）、鞘磷脂（SM）和磷脂酰肌醇(或磷酸肌醇；π)。这些膜磷脂是疾病相关生物标志物的一个有希望的来源。磷脂及其代谢物随疾病类型或疾病进展而改变。代谢组学表明，改变的磷脂及其代谢物水平的增加或减少可作为诊断各种人类疾病的有用指标。在这篇综述中，我们讨论了五种主要的膜磷脂（PC， PS， PE， SM和PI）及其代谢物作为人类疾病的诊断生物标志物的用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.