Progress in lipid research最新文献_第10页

Biophysical insights into modulating lipid digestion in food emulsions 调节食品乳剂中脂质消化的生物物理见解

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101129

Alejandra Acevedo-Fani, Harjinder Singh

{"title":"Biophysical insights into modulating lipid digestion in food emulsions","authors":"Alejandra Acevedo-Fani, Harjinder Singh","doi":"10.1016/j.plipres.2021.101129","DOIUrl":"10.1016/j.plipres.2021.101129","url":null,"abstract":"<div><p>During the last decade, major scientific advances on understanding the mechanisms of lipid digestion and metabolism have been made, with a view to addressing health issues (such as obesity) associated with overconsumption of lipid-rich and sucrose-rich foods. As lipids in common foods exist in the form of emulsions, the structuring of emulsions has been one the main strategies for controlling the rate of lipid digestion and absorption, at least from a colloid science viewpoint. Modulating the kinetics of lipid digestion and absorption offers interesting possibilities for developing foods that can provide control of postprandial lipaemia and control the release of lipophilic compounds. Food emulsions can be designed to achieve considerable differences in the kinetics of lipid digestion but most research has been applied to relatively simple model systems and in in vitro digestion models. Further research to translate this knowledge into more complex food systems and to validate the results in human studies is required. One promising approach to delay/control lipid digestion is to alter the stomach emptying rate of lipids, which is largely affected by interactions of emulsion droplets with the food matrices. Food matrices with different responses to the gastric environment and with different interactions between oil droplets and the food matrix can be designed to influence lipid digestion. This review focuses on key scientific advances made during the last decade on understanding the physicochemical and structural modifications of emulsified lipids, mainly from a biophysical science perspective. The review specifically explores different approaches by which the structure and stability of emulsions may be altered to achieve specific lipid digestion kinetics.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101129"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S016378272100045X/pdfft?md5=de7c86d2420fbf4c2a73176a7653abf4&pid=1-s2.0-S016378272100045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39674078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Lipid nutrition: “In silico” studies and undeveloped experiments 脂质营养学:“计算机”研究和未开发的实验

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101142

Bill Lands

{"title":"Lipid nutrition: “In silico” studies and undeveloped experiments","authors":"Bill Lands","doi":"10.1016/j.plipres.2021.101142","DOIUrl":"10.1016/j.plipres.2021.101142","url":null,"abstract":"<div><p>This review examines lipids and lipid-binding sites on proteins in relation to cardiovascular disease. Lipid nutrition involves food energy from ingested fatty acids plus fatty acids formed from excess ingested carbohydrate and protein. Non-esterified fatty acids (NEFA) and lipoproteins have many detailed attributes not evident in their names. Recognizing attributes of lipid-protein interactions decreases unexpected outcomes. Details of double bond position and configuration interacting with protein binding sites have unexpected consequences in acyltransferase and cell replication events. Highly unsaturated fatty acids (HUFA) have n-3 and n-6 motifs with documented differences in intensity of destabilizing positive feedback loops amplifying pathophysiology. However, actions of NEFA have been neglected relative to cholesterol, which is co-produced from excess food. Native low-density lipoproteins (LDL) bind to a high-affinity cell surface receptor which poorly recognizes biologically modified LDLs. NEFA increase negative charge of LDL and decrease its processing by “normal” receptors while increasing processing by “scavenger” receptors. A positive feedback loop in the recruitment of monocytes and macrophages amplifies chronic inflammatory pathophysiology. Computer tools combine multiple components in lipid nutrition and predict balance of energy and n-3:n-6 HUFA. The tools help design and execute precise clinical nutrition monitoring that either supports or disproves expectations.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101142"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782721000588/pdfft?md5=7c86f735dd452dc28d2b964e9d8458d6&pid=1-s2.0-S0163782721000588-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39655557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues 更新的ANGPTL3-4-8模型作为甘油三酯在脂肪和氧化组织之间分配的机制

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-01-01 DOI: 10.1016/j.plipres.2021.101140

Ren Zhang, Kezhong Zhang

{"title":"An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues","authors":"Ren Zhang, Kezhong Zhang","doi":"10.1016/j.plipres.2021.101140","DOIUrl":"10.1016/j.plipres.2021.101140","url":null,"abstract":"<div><p>In mammals, triglyceride<span><span> (TG), the main form of lipids for storing and providing energy, is stored in white adipose tissue (WAT) after food intake, while during fasting it is routed to oxidative tissues (heart and skeletal muscle) for energy production, a process referred to as TG partitioning. </span>Lipoprotein lipase<span><span> (LPL), a rate-limiting enzyme in this fundamental </span>physiological process<span><span>, hydrolyzes circulating TG to generate </span>free fatty acids that are taken up by peripheral tissues. The postprandial activity of LPL declines in oxidative tissues but rises in WAT, directing TG to WAT; the reverse is true during fasting. However, the molecular mechanism in regulating tissue-specific LPL activity during the fed-fast cycle has not been completely understood. Research on angiopoietin-like (ANGPTL) proteins (A3, A4, and A8) has resulted in an ANGPTL3-4-8 model to explain the TG partitioning between WAT and oxidative tissues. Food intake induces A8 expression in the liver and WAT. Liver A8 activates A3 by forming the A3-8 complex, which is then secreted into the circulation. The A3-8 complex acts in an endocrine manner to inhibit LPL in oxidative tissues. WAT A8 forms the A4-8 complex, which acts locally to block A4's LPL-inhibiting activity. Therefore, the postprandial activity of LPL is low in oxidative tissues but high in WAT, directing circulating TG to WAT. Conversely, during fasting, reduced A8 expression in the liver and WAT disables A3 from inhibiting oxidative-tissue LPL and restores WAT A4's LPL-inhibiting activity, respectively. Thus, the fasting LPL activity is high in oxidative tissues but low in WAT, directing TG to the former. According to the model, we hypothesize that A8 antagonism has the potential to simultaneously reduce TG and increase HDL-cholesterol plasma levels. Future research on A3, A4, and A8 can hopefully provide more insights into human health, disease, and therapeutics.</span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"85 ","pages":"Article 101140"},"PeriodicalIF":13.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9699507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

A comprehensive review on the lipid and pleiotropic effects of pitavastatin 匹伐他汀对血脂和多效性的综合研究综述

IF 13.6 1区医学

Progress in lipid research Pub Date : 2021-11-01 DOI: 10.1016/j.plipres.2021.101127

Amirhossein Sahebkar , Nasim Kiaie , Armita Mahdavi Gorabi , Massimo R. Mannarino , Vanessa Bianconi , Tannaz Jamialahmadi , Matteo Pirro , Maciej Banach

{"title":"A comprehensive review on the lipid and pleiotropic effects of pitavastatin","authors":"Amirhossein Sahebkar , Nasim Kiaie , Armita Mahdavi Gorabi , Massimo R. Mannarino , Vanessa Bianconi , Tannaz Jamialahmadi , Matteo Pirro , Maciej Banach","doi":"10.1016/j.plipres.2021.101127","DOIUrl":"10.1016/j.plipres.2021.101127","url":null,"abstract":"<div><p><span><span>The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase<span> inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. </span></span>Pitavastatin<span> is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and </span></span>triacylglycerol<span>. It has been reported to have pleiotropic effects<span><span><span> such as decreasing inflammation and oxidative stress, regulating </span>angiogenesis<span> and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique </span></span>lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"84 ","pages":"Article 101127"},"PeriodicalIF":13.6,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39406233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

PARPs in lipid metabolism and related diseases parp在脂质代谢及相关疾病中的作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2021-11-01 DOI: 10.1016/j.plipres.2021.101117

Magdolna Szántó , Rebecca Gupte , W. Lee Kraus , Pal Pacher , Peter Bai

{"title":"PARPs in lipid metabolism and related diseases","authors":"Magdolna Szántó , Rebecca Gupte , W. Lee Kraus , Pal Pacher , Peter Bai","doi":"10.1016/j.plipres.2021.101117","DOIUrl":"10.1016/j.plipres.2021.101117","url":null,"abstract":"<div><p>PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases were originally identified as DNA repair factors, nevertheless, recent advances have shed light on their role in lipid metabolism. To date, PARP1, PARP2, PARP3, tankyrases, PARP9, PARP10, PARP14 were reported to have multi-pronged connections to lipid metabolism. The activity of PARP enzymes is fine-tuned by a set of cholesterol-based compounds as oxidized cholesterol derivatives, steroid hormones or bile acids. In turn, PARPs modulate several key processes of lipid homeostasis (lipotoxicity, fatty acid and steroid biosynthesis, lipoprotein homeostasis, fatty acid oxidation, etc.). PARPs are also cofactors of lipid-responsive nuclear receptors and transcription factors through which PARPs regulate lipid metabolism and lipid homeostasis. PARP activation often represents a disruptive signal to (lipid) metabolism, and PARP-dependent changes to lipid metabolism have pathophysiological role in the development of hyperlipidemia, obesity, alcoholic and non-alcoholic fatty liver disease, type II diabetes and its complications, atherosclerosis, cardiovascular aging and skin pathologies, just to name a few. In this synopsis we will review the evidence supporting the beneficial effects of pharmacological PARP inhibitors in these diseases/pathologies and propose repurposing PARP inhibitors already available for the treatment of various malignancies.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"84 ","pages":"Article 101117"},"PeriodicalIF":13.6,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39358796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Making extra room for carotenoids in plant cells: New opportunities for biofortification 在植物细胞中为类胡萝卜素创造额外的空间:生物强化的新机会

IF 13.6 1区医学

Progress in lipid research Pub Date : 2021-11-01 DOI: 10.1016/j.plipres.2021.101128

Salvador Torres-Montilla, Manuel Rodriguez-Concepcion

{"title":"Making extra room for carotenoids in plant cells: New opportunities for biofortification","authors":"Salvador Torres-Montilla, Manuel Rodriguez-Concepcion","doi":"10.1016/j.plipres.2021.101128","DOIUrl":"10.1016/j.plipres.2021.101128","url":null,"abstract":"<div><p>Plant carotenoids are essential for photosynthesis and photoprotection and provide colors in the yellow to red range to non-photosynthetic organs such as petals and ripe fruits. They are also the precursors of biologically active molecules not only in plants (including hormones and retrograde signals) but also in animals (including retinoids such as vitamin A). A carotenoid-rich diet has been associated with improved health and cognitive capacity in humans, whereas the use of carotenoids as natural pigments is widespread in the agrofood and cosmetic industries. The nutritional and economic relevance of carotenoids has spurred a large number of biotechnological strategies to enrich plant tissues with carotenoids. Most of such approaches to alter carotenoid contents in plants have been focused on manipulating their biosynthesis or degradation, whereas improving carotenoid sink capacity in plant tissues has received much less attention. Our knowledge on the molecular mechanisms influencing carotenoid storage in plants has substantially grown in the last years, opening new opportunities for carotenoid biofortification. Here we will review these advances with a particular focus on those creating extra room for carotenoids in plant cells either by promoting the differentiation of carotenoid-sequestering structures within plastids or by transferring carotenoid production to the cytosol.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"84 ","pages":"Article 101128"},"PeriodicalIF":13.6,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782721000448/pdfft?md5=62ca7e13d47cfe40f9ad713cdfcf1b08&pid=1-s2.0-S0163782721000448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39423468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade 表面辅助激光解吸/电离质谱成像生物样品中的脂质:近十年的简要回顾

IF 13.6 1区医学

Progress in lipid research Pub Date : 2021-07-01 DOI: 10.1016/j.plipres.2021.101114

Wendy H. Müller, Edwin De Pauw, Johann Far, Cedric Malherbe, Gauthier Eppe

{"title":"Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade","authors":"Wendy H. Müller, Edwin De Pauw, Johann Far, Cedric Malherbe, Gauthier Eppe","doi":"10.1016/j.plipres.2021.101114","DOIUrl":"10.1016/j.plipres.2021.101114","url":null,"abstract":"<div><p><span><span>Knowing the spatial location of the lipid species present in biological samples is of paramount importance for the elucidation of pathological and </span>physiological processes. In this context, </span>mass spectrometry imaging<span> (MSI) has emerged as a powerful technology allowing the visualization of the spatial distributions of biomolecules, including lipids, in complex biological samples. Among the different ionization methods available, the emerging surface-assisted laser desorption/ionization (SALDI) MSI offers unique capabilities for the study of lipids. This review describes the specific advantages of SALDI-MSI for lipid analysis, including the ability to perform analyses in both ionization modes with the same nanosubstrate, the detection of lipids characterized by low ionization efficiency in MALDI-MS, and the possibilities of surface modification to improve the detection of lipids. The complementarity of SALDI and MALDI-MSI is also discussed. Finally, this review presents data processing strategies applied in SALDI-MSI of lipids, as well as examples of applications of SALDI-MSI in biomedical lipidomics.</span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"83 ","pages":"Article 101114"},"PeriodicalIF":13.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39146514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators 生物催化合成多种脂质介质的脂氧合酶分子研究

IF 13.6 1区医学

Progress in lipid research Pub Date : 2021-07-01 DOI: 10.1016/j.plipres.2021.101110

Jung-Ung An , Seong-Eun Kim , Deok-Kun Oh

{"title":"Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators","authors":"Jung-Ung An , Seong-Eun Kim , Deok-Kun Oh","doi":"10.1016/j.plipres.2021.101110","DOIUrl":"10.1016/j.plipres.2021.101110","url":null,"abstract":"<div><p><span><span><span>Oxylipins derived mainly from C20- and C22-polyunsaturated fatty acids (PUFAs), termed </span>lipid<span><span> mediators (LMs), are essential signalling messengers involved in human physiological responses associated with homeostasis and healing process for infection and inflammation. Some LMs involved in the resolution of inflammation and infection are termed specialized pro-resolving mediators (SPMs), which are generated by human M2 macrophages or polymorphonuclear leukocytes and have the potential to protect and treat hosts from bacterial and viral infections by </span>phagocytosis<span> activation. Lipoxygenases (LOXs) biosynthesize regio- and stereoselective LMs. Thus, understanding the regio- and </span></span></span>stereoselectivities<span> of LOXs for PUFAs at a molecular level is important for the biocatalytic synthesis of diverse LMs. Here, we elucidate the catalytic mechanisms and discuss regio- and stereoselectivities and their changes of LOXs determined by insertion direction and position of the substrate and oxygen at a molecular level for the </span></span>biosynthesis<span> of diverse human LMs. Recently, the biocatalytic synthesis of PUFAs to human LMs or analogues has been conducted using microbial LOXs. Such microbial LOXs involved in the biosynthesis of LMs are expected to exert significantly higher activity and stability than human LOXs. Diverse regio- and stereoselective LOXs can be obtained from microorganisms, which represent a wealth of genomic sources. We reconstruct the biosynthetic pathways of LOX-catalyzed LMs in humans and other organisms. Furthermore, we suggest the effective methods of biocatalytic synthesis of diverse human LMs from PUFAs or glucose by using microbial LOXs, increasing the stability and activity of LOXs, combining the reactions of LOXs, and constructing metabolic pathways.</span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"83 ","pages":"Article 101110"},"PeriodicalIF":13.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39244647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Regulation of EGFR activation and signaling by lipids on the plasma membrane 质膜上脂质对EGFR激活和信号传导的调控

IF 13.6 1区医学

Progress in lipid research Pub Date : 2021-07-01 DOI: 10.1016/j.plipres.2021.101115

Do-Hyeon Kim , Hong Minh Triet , Sung Ho Ryu

引用次数: 10

Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers 脂肪酸及其蛋白质在神经系统、心血管疾病和癌症中的进化作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2021-07-01 DOI: 10.1016/j.plipres.2021.101116

Rahul Mallick , Sanjay Basak , Asim K. Duttaroy

{"title":"Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers","authors":"Rahul Mallick , Sanjay Basak , Asim K. Duttaroy","doi":"10.1016/j.plipres.2021.101116","DOIUrl":"10.1016/j.plipres.2021.101116","url":null,"abstract":"<div><p>The dysregulation of fat metabolism is involved in various disorders, including neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids (LCFAs) with 14 or more carbons plays a pivotal role in cellular metabolic homeostasis. Therefore, the uptake and metabolism of LCFAs must constantly be in tune with the cellular, metabolic, and structural requirements of cells. Many metabolic diseases are thought to be driven by the abnormal flow of fatty acids either from the dietary origin and/or released from adipose stores. Cellular uptake and intracellular trafficking of fatty acids are facilitated ubiquitously with unique combinations of fatty acid transport proteins and cytoplasmic fatty acid-binding proteins in every tissue. Extensive data are emerging on the defective transporters and metabolism of LCFAs and their clinical implications. Uptake and metabolism of LCFAs are crucial for the brain's functional development and cardiovascular health and maintenance. In addition, data suggest fatty acid metabolic transporter can normalize activated inflammatory response by reprogramming lipid metabolism in cancers.</p><p>Here we review the current understanding of how LCFAs and their proteins contribute to the pathophysiology of three crucial diseases and the mechanisms involved in the processes.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"83 ","pages":"Article 101116"},"PeriodicalIF":13.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39208797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32