{"title":"匹伐他汀对血脂和多效性的综合研究综述","authors":"Amirhossein Sahebkar , Nasim Kiaie , Armita Mahdavi Gorabi , Massimo R. Mannarino , Vanessa Bianconi , Tannaz Jamialahmadi , Matteo Pirro , Maciej Banach","doi":"10.1016/j.plipres.2021.101127","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase<span> inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. </span></span>Pitavastatin<span> is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and </span></span>triacylglycerol<span>. It has been reported to have pleiotropic effects<span><span><span> such as decreasing inflammation and oxidative stress, regulating </span>angiogenesis<span> and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique </span></span>lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"84 ","pages":"Article 101127"},"PeriodicalIF":14.0000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101127","citationCount":"16","resultStr":"{\"title\":\"A comprehensive review on the lipid and pleiotropic effects of pitavastatin\",\"authors\":\"Amirhossein Sahebkar , Nasim Kiaie , Armita Mahdavi Gorabi , Massimo R. Mannarino , Vanessa Bianconi , Tannaz Jamialahmadi , Matteo Pirro , Maciej Banach\",\"doi\":\"10.1016/j.plipres.2021.101127\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase<span> inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. </span></span>Pitavastatin<span> is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and </span></span>triacylglycerol<span>. It has been reported to have pleiotropic effects<span><span><span> such as decreasing inflammation and oxidative stress, regulating </span>angiogenesis<span> and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique </span></span>lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.</span></span></p></div>\",\"PeriodicalId\":20650,\"journal\":{\"name\":\"Progress in lipid research\",\"volume\":\"84 \",\"pages\":\"Article 101127\"},\"PeriodicalIF\":14.0000,\"publicationDate\":\"2021-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.plipres.2021.101127\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in lipid research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0163782721000436\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in lipid research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0163782721000436","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
A comprehensive review on the lipid and pleiotropic effects of pitavastatin
The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. Pitavastatin is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and triacylglycerol. It has been reported to have pleiotropic effects such as decreasing inflammation and oxidative stress, regulating angiogenesis and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.
期刊介绍：
The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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