太复杂而不能失败?针对脂肪酸代谢的癌症治疗

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in lipid research Pub Date : 2022-01-01 DOI:10.1016/j.plipres.2021.101143

Rimsha Munir , Jan Lisec , Johannes V. Swinnen , Nousheen Zaidi

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引用次数: 23

摘要

鉴于脂肪酸在肿瘤病理生理中的核心作用，利用脂肪酸代谢作为一种潜在的抗肿瘤治疗方法已受到广泛关注。目前已经发现了几种针对脂肪酸代谢的天然和合成化合物，并确定了它们对癌细胞增殖和存活的影响。本文将讨论最具临床可行性的抑制剂或药物，靶向9个相互关联的脂肪酸代谢相关过程中的各种蛋白质或酶。我们将讨论这些过程的一般意义以及它们对癌细胞进展的抑制作用。此外，还将评估它们的作用机制、局限性和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Too complex to fail? Targeting fatty acid metabolism for cancer therapy

Given the central role of fatty acids in cancer pathophysiology, the exploitation of fatty acid metabolism as a potential antineoplastic therapy has gained much attention. Several natural and synthetic compounds targeting fatty acid metabolism were hitherto identified, and their effectiveness against cancer cell proliferation and survival was determined. This review will discuss the most clinically viable inhibitors or drugs targeting various proteins or enzymes mapped on nine interconnected fatty acid metabolism-related processes. We will discuss the general significance of each of these processes and the effects of their inhibition on cancer cell progression. Moreover, their mechanisms of action, limitations, and future perspectives will be assessed.

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.