植物脂结合蛋白与其配体的相互作用

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ze-Hua Guo, Shiu-Cheung Lung, Mohd Fadhli Hamdan, Mee-Len Chye
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引用次数: 5

摘要

脂质参与多种生物学功能,包括信号转导、细胞膜生物发生和碳储存。在质体中进行新的生物合成后,脂肪酸(FAs)作为酰基辅酶a酯被运输到内质网,在内质网中,甘油-3-磷酸通过肯尼迪途径经历一系列酰基辅酶a依赖性酰化,形成三酰基甘油,随后组装成油。或者,新合成的FAs通过PC:酰基-辅酶a交换过程(定义为“酰基编辑”)并入磷脂酰胆碱(PC)。不同亚细胞位置的酰基辅酶a结合蛋白(acbp)可以通过结合和运输酰基辅酶a酯和维持细胞内酰基辅酶a池来参与脂质转移。acbp广泛分布于植物界,存在于所有真核生物和一些真细菌中。在水稻和拟南芥中,六种形式的acbp共存,并根据其功能域分为四类。它们保守的四螺旋结构有利于与酰基辅酶a酯相互作用。acbp还与磷脂和蛋白质伴侣相互作用,在种子油脂调节、发育、病原体防御和胁迫反应中发挥作用。除了acbp外,脂质转移蛋白(LTPs)、膜联蛋白和脂滴相关蛋白等其他蛋白质也是重要的脂质结合蛋白。当膜联蛋白结合Ca2+和磷脂时,LTPs运输脂质分子,包括FAs,酰基辅酶a酯和磷脂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interactions between plant lipid-binding proteins and their ligands

Lipids participate in diverse biological functions including signal transduction, cellular membrane biogenesis and carbon storage. Following de novo biosynthesis in the plastids, fatty acids (FAs) are transported as acyl-CoA esters to the endoplasmic reticulum where glycerol-3-phosphate undergoes a series of acyl-CoA-dependent acylation via the Kennedy pathway to form triacylglycerols for subsequent assembly into oils. Alternatively, newly synthesized FAs are incorporated into phosphatidylcholine (PC) by a PC:acyl-CoA exchange process defined as “acyl editing”. Acyl-CoA-binding proteins (ACBPs) at various subcellular locations can function in lipid transfer by binding and transporting acyl-CoA esters and maintaining intracellular acyl-CoA pools. Widely distributed in the plant kingdom, ACBPs are found in all eukaryotes and some eubacteria. In both rice and Arabidopsis, six forms of ACBPs co-exist and are classified into four groups based on their functional domains. Their conserved four-helix structure facilitates interaction with acyl-CoA esters. ACBPs also interact with phospholipids as well as protein partners and function in seed oil regulation, development, pathogen defense and stress responses. Besides the ACBPs, other proteins such as the lipid transfer proteins (LTPs), annexins and lipid droplet-associated proteins are also important lipid-binding proteins. While annexins bind Ca2+ and phospholipids, LTPs transport lipid molecules including FAs, acyl-CoA esters and phospholipids.

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来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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