在生物膜和模型膜的研究中需要更多地关注脂质种类

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Tore Skotland , Kirsten Sandvig
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引用次数: 6

摘要

细胞膜的脂质组成可以影响许多生理过程,如信号传导、细胞迁移、内吞作用和细胞内运输。本文就哺乳动物细胞中脂质分析和脂质结构与功能研究中我们认为尚未得到足够重视的几个方面作一综述。这包括两层膜之间的叶间偶联,以及脂质的作用,即脂质的完整结构的作用,包括脂链的长度和双键的位置。我们强调PS物种在膜功能中的作用。我们还讨论了不同生物样品中PS物种的巨大多样性及其可能的功能后果,并概述了来自40个不同样品的PS物种。此外,最近的研究表明,鞘脂和醚脂的水平似乎有一个共同的调节。我们回顾并讨论了表明这种协同调节的已发表数据。此外,我们指出了脂质组学领域的一些缺陷,并提出了改进建议。最后,我们讨论了使用生物膜中常见的脂类组成的不对称膜模型的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Need for more focus on lipid species in studies of biological and model membranes

The lipid composition of cellular membranes can impact a number of physiological processes such as signaling, cell migration, endocytosis and intracellular transport. In this article we focus on some aspects concerning analysis of lipids and research on lipid structure and function in mammalian cells that in our opinion have not obtained sufficient attention. This includes interleaflet coupling between the two layers of the membrane, and the role of lipid species, i.e. the role of the complete structure of the lipids, including lipid chain length and the position of double bonds. We highlight the role of PS species for membrane function. We also discuss the large diversity of PS species in different biological samples and the possible functional consequences, and we provide an overview of PS species from 40 different samples. Furthermore, recent studies show that there seems to be a coregulation concerning the levels of sphingolipids and ether lipids. We review and discuss the published data indicating such a coregulation. Moreover, we point to some of the pitfalls in the field of lipidomics and present suggestions for improvement. Finally, we discuss the importance of using asymmetric membrane models with a composition of lipid species that are common in biological membranes.

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来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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