Journal of Tissue Engineering and Regenerative Medicine最新文献

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Platelet-rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta-analysis 富血小板血浆在疤痕治疗中,建议还是不建议?系统回顾和荟萃分析
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-07-06 DOI: 10.1002/term.3338
Zahra Ebrahimi, Yousef Alimohamadi, Majid Janani, Pardis Hejazi, Mahboobeh Kamali, Azadeh Goodarzi
{"title":"Platelet-rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta-analysis","authors":"Zahra Ebrahimi,&nbsp;Yousef Alimohamadi,&nbsp;Majid Janani,&nbsp;Pardis Hejazi,&nbsp;Mahboobeh Kamali,&nbsp;Azadeh Goodarzi","doi":"10.1002/term.3338","DOIUrl":"https://doi.org/10.1002/term.3338","url":null,"abstract":"<p>Despite the rising trend for applying platelet-rich plasma (PRP) in the management of various types of scars, there is no convincing evidence supporting its use. This motivated us to review the randomized clinical trials that examine the effectiveness and safety of PRP, alone or in combination with other methods, for the management of atrophic or hypertrophic/keloidal scars. The Web of Science, Scopus, Google Scholar, and Cochrane Library databases were systematically searched until September 1<sup>st</sup>, 2020. Thirteen clinical trials were enrolled in the meta-analysis, and 10 more were reviewed for their results. The random effect meta-analysis method was used to assess the effect size of each outcome for each treatment type, and I<sup>2</sup> was used to calculate the statistical heterogeneity between the studies. Patients treated with PRP experienced an overall response rate of 23%, comparable to the results seen with laser or micro-needling (22% and 23%, respectively) When used alone, moderate improvement was the most frequently observed degree of response with PRP (36%) whereas, when added to laser or micro-needling, most patients experienced marked (33%, 43%, respectively) or excellent (32% and 23%, respectively) results. Concerning the hypertrophic/keloid scars, the only study meeting the required criteria reported a better improvement and fewer adverse effects when PRP was added to the intralesional corticosteroids. Platelet-rich plasma appears to be a safe and effective treatment for various types of atrophic scars. In addition, when added to ablative lasers or micro-needling, it seems to considerably add to the efficacy of treatment and reduce the side effects.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 10","pages":"875-899"},"PeriodicalIF":3.3,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6094606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Modeling the human heart ex vivo—current possibilities and strive for future applications 建模人类心脏离体电流的可能性,并争取未来的应用
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-24 DOI: 10.1002/term.3335
Ewelina Ka?u?na, Agnieszka Nadel, Agnieszka Zimna, Natalia Rozwadowska, Tomasz Kolanowski
{"title":"Modeling the human heart ex vivo—current possibilities and strive for future applications","authors":"Ewelina Ka?u?na,&nbsp;Agnieszka Nadel,&nbsp;Agnieszka Zimna,&nbsp;Natalia Rozwadowska,&nbsp;Tomasz Kolanowski","doi":"10.1002/term.3335","DOIUrl":"https://doi.org/10.1002/term.3335","url":null,"abstract":"<p>The high organ specification of the human heart is inversely proportional to its functional recovery after damage. The discovery of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has accelerated research in human heart regeneration and physiology. Nevertheless, due to the immaturity of iPSC-CMs, they are far from being an representative model of the adult heart physiology. Therefore, number of laboratories strive to obtain a heart tissues by engineering methods by structuring iPSC-CMs into complex and advanced platforms. By using the iPSC-CMs and arranging them in 3D cultures it is possible to obtain a human heart muscle with physiological capabilities potentially similar to the adult heart, while remaining in vitro. Here, we attempt to describe existing examples of heart muscle either in vitro or ex vivo models and discuss potential options for the further development of such structures. This will be a crucial step for ultimate derivation of complete heart tissue-mimicking organs and their future use in drug development, therapeutic approaches testing, pre-clinical studies, and clinical applications. This review particularly aims to compile available models of advanced human heart tissue for scientists considering which model would best fit their research needs.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 10","pages":"853-874"},"PeriodicalIF":3.3,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/term.3335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5791264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curcumin slow-release membrane promotes erectile function and penile rehabilitation in a rat model of cavernous nerve injury 姜黄素缓释膜促进海绵状神经损伤大鼠勃起功能和阴茎康复
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-18 DOI: 10.1002/term.3334
Luchen Yang, Zhengju Ren, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong
{"title":"Curcumin slow-release membrane promotes erectile function and penile rehabilitation in a rat model of cavernous nerve injury","authors":"Luchen Yang,&nbsp;Zhengju Ren,&nbsp;Zhenghuan Liu,&nbsp;Zhufeng Peng,&nbsp;Pan Song,&nbsp;Jing Zhou,&nbsp;Linchun Wang,&nbsp;Junhao Chen,&nbsp;Qiang Dong","doi":"10.1002/term.3334","DOIUrl":"https://doi.org/10.1002/term.3334","url":null,"abstract":"Male erectile dysfunction (ED) caused by cavernous nerve injury is a common complication of pelvic surgery, radiotherapy, transurethral surgery or other operations. However, clinical treatment for iatrogenic or traumatic male ED is difficult and not satisfactory. Many studies have shown that curcumin can promote the repair and regeneration of peripheral nerves; however, whether curcumin can rescue cavernous nerve injury is unknown, and the poor bioavailability of curcumin limits its application in vivo. Hence, the study was conducted. A curved slow‐release membrane was produced, and the properties were examined. In addition, the effects of the curcumin slow‐release membrane on cavernous nerve‐injured SD rats were studied. We found that polylactic acid‐glycolic acid‐polyethylene glycol (PLGA‐PEG) can be used as a good carrier material for curcumin, and curcumin‐loaded PLGA‐PEG membranes can effectively rescue the cavernous nerve in SD rats, restore the continuity of the cavernous nerve, and increase the expression of nNOS mRNA and proteins in penile tissue, which can improve the penile erectile function of injured SD rats, reduce the degree of penile tissue fibrosis, and effectively promote penis rehabilitation. The curcumin slow‐release membrane is proposed to be a new therapeutic approach for penile rehabilitation of cavernous nerve injury.","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 9","pages":"836-849"},"PeriodicalIF":3.3,"publicationDate":"2022-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5747529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A concise review of the orofacial mesenchymal stromal cells as a novel therapy for neurological diseases and injuries 口面间充质间质细胞作为神经系统疾病和损伤的新疗法的简要综述
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-18 DOI: 10.1002/term.3333
Zhili Dong, Liping Wu, Lu Zhao
{"title":"A concise review of the orofacial mesenchymal stromal cells as a novel therapy for neurological diseases and injuries","authors":"Zhili Dong,&nbsp;Liping Wu,&nbsp;Lu Zhao","doi":"10.1002/term.3333","DOIUrl":"https://doi.org/10.1002/term.3333","url":null,"abstract":"<p>Orofacial mesenchymal stromal cells (OFMSCs) are mesenchymal stromal cells isolated from the oral and facial regions, which possess typical mesenchymal stromal cell features such as self-renewing, multilineage differentiation, and immunoregulatory properties. Recently, increasing studies have been carried out on the neurotrophic and neuroregenerative properties of OFMSCs as well as their potential to treat neurological diseases. In this review, we summarize the current evidence and discuss the prospects regarding the therapeutic potential of OFMSCs as a new approach to treat different neurological diseases and injuries.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 9","pages":"775-787"},"PeriodicalIF":3.3,"publicationDate":"2022-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5919281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient engineering of human auricular cartilage through mesenchymal stem cell chaperoning 间充质干细胞陪伴高效工程化人耳软骨
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-11 DOI: 10.1002/term.3332
Xue Dong, Carly Askinas, Jongkil Kim, John E. Sherman, Lawrence J. Bonassar, Jason A. Spector
{"title":"Efficient engineering of human auricular cartilage through mesenchymal stem cell chaperoning","authors":"Xue Dong,&nbsp;Carly Askinas,&nbsp;Jongkil Kim,&nbsp;John E. Sherman,&nbsp;Lawrence J. Bonassar,&nbsp;Jason A. Spector","doi":"10.1002/term.3332","DOIUrl":"https://doi.org/10.1002/term.3332","url":null,"abstract":"<p>A major challenge to the clinical translation of tissue-engineered ear scaffolds for ear reconstruction is the limited auricular chondrocyte (hAuC) yield available from patients. Starting with a relatively small number of chondrocytes in culture results in dedifferentiation and loss of phenotype with subsequent expansion. To significantly decrease the number of chondrocytes required for human elastic cartilage engineering, we co-cultured human mesenchymal stem cells (hMSCs) with HAuCs to promote healthy elastic cartilage formation. HAuCs along with human bone marrow-derived hMSCs were encapsulated into 1% Type I collagen at 25 million/mL total cell density with different ratios (HAuCs/hMSCs: 10/90, 25/75, 50/50) and then injected into customized 3D-printed polylactic acid (PLA) ridged external scaffolds, which simulate the shape of the auricular helical rim, and implanted subcutaneously in nude rats for 1, 3 and 6 months. The explanted constructs demonstrated near complete volume preservation and topography maintenance of the ridged “helical” feature after 6 months with all ratios. Cartilaginous appearing tissue formed within scaffolds by 3 months, verified by histologic analysis demonstrating mature elastic cartilage within the constructs with chondrocytes seen in lacunae within a Type II collagen and proteoglycan-enriched matrix, and surrounded by a neoperichondrial external layer. Compressive mechanical properties comparable to human elastic cartilage were achieved after 6 months. Co-implantation of hAuCs and hMSCs in collagen within an external scaffold efficiently produced shaped human elastic cartilage without volume loss even when hAuC comprised only 10% of the implanted cell population, marking a crucial step toward the clinical translation of auricular tissue engineering.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 9","pages":"825-835"},"PeriodicalIF":3.3,"publicationDate":"2022-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6192696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Effects of low-intensity pulsed ultrasound stimulation on cell seeded 3D hybrid scaffold as a novel strategy for meniscus regeneration: An in vitro study 低强度脉冲超声刺激细胞种子三维杂交支架作为半月板再生新策略的影响:一项体外研究
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-11 DOI: 10.1002/term.3331
Melika Babaei, Nima Jamshidi, Farshad Amiri, Mohammad Rafienia
{"title":"Effects of low-intensity pulsed ultrasound stimulation on cell seeded 3D hybrid scaffold as a novel strategy for meniscus regeneration: An in vitro study","authors":"Melika Babaei,&nbsp;Nima Jamshidi,&nbsp;Farshad Amiri,&nbsp;Mohammad Rafienia","doi":"10.1002/term.3331","DOIUrl":"https://doi.org/10.1002/term.3331","url":null,"abstract":"<p>Menisci are fibrocartilaginous structures in the knee joint with an inadequate regenerative capacity, which causes low healing potential and further leads to osteoarthritis. Recently, three-dimensional (3D) printing techniques and ultrasound treatment have gained plenty of attention for meniscus tissue engineering. The present study investigates the effectiveness of low-intensity pulsed ultrasound stimulations (LIPUS) on the proliferation, viability, morphology, and gene expression of the chondrocytes seeded on 3D printed polyurethane scaffolds dip-coated with gellan gum, hyaluronic acid, and glucosamine. LIPUS stimulation was performed at 100, 200, and 300 mW/cm<sup>2</sup> intensities for 20 min/day. A faster gap closure (78.08 ± 2.56%) in the migration scratch assay was observed in the 200 mW/cm<sup>2</sup> group after 24 h. Also, inverted microscopic and scanning electron microscopic images showed no cell morphology changes during LIPUS exposure at different intensities. The 3D cultured chondrocytes under LIPUS treatment revealed a promotion in cell proliferation rate and viability as the intensity doses increased. Additionally, LIPUS could stimulate chondrocytes to overexpress the aggrecan and collagen II genes and improve their chondrogenic phenotype. This study recommends that the combination of LIPUS treatment and 3D hybrid scaffolds can be considered as a valuable treatment for meniscus regeneration based on our in vitro data.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 9","pages":"812-824"},"PeriodicalIF":3.3,"publicationDate":"2022-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6192695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries 人类心脏类器官模拟COVID-19细胞因子风暴引起的心脏损伤
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-11 DOI: 10.1002/term.3327
Dimitrios C. Arhontoulis, Charles M. Kerr, Dylan Richards, Kelsey Tjen, Nathaniel Hyams, Jefferey A. Jones, Kristine Deleon-Pennell, Donald Menick, Hanna Br?uninger, Diana Lindner, Dirk Westermann, Ying Mei
{"title":"Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries","authors":"Dimitrios C. Arhontoulis,&nbsp;Charles M. Kerr,&nbsp;Dylan Richards,&nbsp;Kelsey Tjen,&nbsp;Nathaniel Hyams,&nbsp;Jefferey A. Jones,&nbsp;Kristine Deleon-Pennell,&nbsp;Donald Menick,&nbsp;Hanna Br?uninger,&nbsp;Diana Lindner,&nbsp;Dirk Westermann,&nbsp;Ying Mei","doi":"10.1002/term.3327","DOIUrl":"https://doi.org/10.1002/term.3327","url":null,"abstract":"<p>Acute cardiac injuries occur in 20%–25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1<i>β</i> is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1<i>β</i> treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1<i>β</i> treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1<i>β</i> treated hCOs thus provide a defined and robust model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 9","pages":"799-811"},"PeriodicalIF":3.3,"publicationDate":"2022-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/term.3327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5642228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Transplantation of encapsulated autologous olfactory ensheathing cell populations expressing chondroitinase for spinal cord injury: A safety and feasibility study in companion dogs 表达软骨素酶的囊化自体嗅鞘细胞群移植治疗脊髓损伤的安全性和可行性研究
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-10 DOI: 10.1002/term.3328
Jon Prager, Joe Fenn, Mark Plested, Leticia Escauriaza, Tracy van der Merwe, Barbora King, Divya Chari, Liang-Fong Wong, Nicolas Granger
{"title":"Transplantation of encapsulated autologous olfactory ensheathing cell populations expressing chondroitinase for spinal cord injury: A safety and feasibility study in companion dogs","authors":"Jon Prager,&nbsp;Joe Fenn,&nbsp;Mark Plested,&nbsp;Leticia Escauriaza,&nbsp;Tracy van der Merwe,&nbsp;Barbora King,&nbsp;Divya Chari,&nbsp;Liang-Fong Wong,&nbsp;Nicolas Granger","doi":"10.1002/term.3328","DOIUrl":"https://doi.org/10.1002/term.3328","url":null,"abstract":"<p>Spinal cord injury (SCI) can cause irreversible paralysis, with no regenerative treatment clinically available. Dogs with natural SCI present an established model and can facilitate translation of experimental findings in rodents to people. We conducted a prospective, single arm clinical safety study in companion dogs with chronic SCI to characterize the feasibility of intraspinal transplantation of hydrogel-encapsulated autologous mucosal olfactory ensheathing cell (mOEC) populations expressing chondroitinase ABC (chABC). mOECs and chABC are both promising therapies for SCI, and mOECs expressing chABC drive greater voluntary motor recovery than mOECs alone after SCI in rats. Canine mOECs encapsulated in collagen hydrogel can be matched in stiffness to canine SCI. Four dogs with complete and chronic loss of function caudal to a thoraco-lumbar lesion were recruited. After baseline measures, olfactory mucosal biopsy was performed and autologous mOECs cultured and transduced to express chABC, then hydrogel-encapsulated and percutaneously injected into the spinal cord. Dogs were monitored for 6 months with repeat clinical examinations, spinal MRI, kinematic gait and von Frey assessment. No adverse effects or significant changes on neurological examination were detected. MRI revealed large and variable lesions, with no spinal cord compression or ischemia visible after hydrogel transplantation. Owners reported increased pelvic-limb reflexes with one dog able to take 2–3 unsupported steps, but gait-scoring and kinematic analysis showed no significant improvements. This novel combination approach to regeneration after SCI is therefore feasible and safe in paraplegic dogs in a clinical setting. A randomised-controlled trial in this translational model is proposed to test efficacy.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 9","pages":"788-798"},"PeriodicalIF":3.3,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/term.3328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6164499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Application of suture anchors for a clinically relevant rat model of rotator cuff tear 缝合锚钉在大鼠肩袖撕裂模型中的应用
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-07 DOI: 10.1002/term.3326
Yang Liu, Sai-Chuen Fu, Shi-Yi Yao, Xiao-Dan Chen, Patrick Shu-Hang Yung
{"title":"Application of suture anchors for a clinically relevant rat model of rotator cuff tear","authors":"Yang Liu,&nbsp;Sai-Chuen Fu,&nbsp;Shi-Yi Yao,&nbsp;Xiao-Dan Chen,&nbsp;Patrick Shu-Hang Yung","doi":"10.1002/term.3326","DOIUrl":"https://doi.org/10.1002/term.3326","url":null,"abstract":"<p>Current rat model of rotator cuff (RC) tear could not mimic the suture anchor (SA) repair technique in the clinical practice. We designed a novel SA for RC repair of rats to establish a clinically relevant animal model. Small suture anchors that fit the rat shoulder were assembled. 60 rats were assigned to the transosseous (TO) repair group or SA repair group (<i>n</i> = 30/group). Micro-computed tomography (Micro-CT) scanning, biomechanical test and histological analysis were implemented at 2, 4, and 8-week post-repair. The failure load and stiffness in the SA group were significantly higher than those of TO group at 4-week post-repair. Micro-computed tomography analysis showed the bone mineral density and trabecular thickness of the SA group were significantly lower than those of TO group. The SA group showed a better insertion continuity at 4-week post-repair compared to TO group. No significant difference in gait parameters was found between groups. Therefore, SA repair is applicable for the rat model of RC tears. The SA repair achieved superior RC tendon healing, but more extensive initial bone damage compared to TO repair, while the shoulder function was comparable. This model could replicate the current repair technique in the clinical situation and be considered for future preclinical studies on healing enhancement for RC tears. <b>Statement of Clinical Significance</b>: With high clinical relevance, this model may facilitate the translation from an animal study into clinical trials.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 8","pages":"757-770"},"PeriodicalIF":3.3,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/term.3326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6028685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information 问题信息
IF 3.3 3区 生物学
Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-01 DOI: 10.1002/wcs.1243
K. Aubrey
{"title":"Issue Information","authors":"K. Aubrey","doi":"10.1002/wcs.1243","DOIUrl":"https://doi.org/10.1002/wcs.1243","url":null,"abstract":"No abstract is available for this article.","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"16 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wcs.1243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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