Curcumin slow-release membrane promotes erectile function and penile rehabilitation in a rat model of cavernous nerve injury

IF 3.1 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-06-18 DOI:10.1002/term.3334

Luchen Yang, Zhengju Ren, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong

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引用次数: 1

Abstract

Male erectile dysfunction (ED) caused by cavernous nerve injury is a common complication of pelvic surgery, radiotherapy, transurethral surgery or other operations. However, clinical treatment for iatrogenic or traumatic male ED is difficult and not satisfactory. Many studies have shown that curcumin can promote the repair and regeneration of peripheral nerves; however, whether curcumin can rescue cavernous nerve injury is unknown, and the poor bioavailability of curcumin limits its application in vivo. Hence, the study was conducted. A curved slow‐release membrane was produced, and the properties were examined. In addition, the effects of the curcumin slow‐release membrane on cavernous nerve‐injured SD rats were studied. We found that polylactic acid‐glycolic acid‐polyethylene glycol (PLGA‐PEG) can be used as a good carrier material for curcumin, and curcumin‐loaded PLGA‐PEG membranes can effectively rescue the cavernous nerve in SD rats, restore the continuity of the cavernous nerve, and increase the expression of nNOS mRNA and proteins in penile tissue, which can improve the penile erectile function of injured SD rats, reduce the degree of penile tissue fibrosis, and effectively promote penis rehabilitation. The curcumin slow‐release membrane is proposed to be a new therapeutic approach for penile rehabilitation of cavernous nerve injury.

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姜黄素缓释膜促进海绵状神经损伤大鼠勃起功能和阴茎康复

海绵体神经损伤引起的男性勃起功能障碍(ED)是盆腔手术、放疗、经尿道手术或其他手术的常见并发症。然而，医源性或外伤性男性ED的临床治疗困难且不令人满意。许多研究表明，姜黄素能促进周围神经的修复和再生;然而，姜黄素是否能拯救海绵状神经损伤尚不清楚，姜黄素较差的生物利用度限制了其在体内的应用。因此，进行了这项研究。制备了一种弯曲缓释膜，并对其性能进行了测试。此外，我们还研究了姜黄素缓释膜对海绵状神经损伤大鼠的作用。我们发现聚乳酸-乙醇酸-聚乙二醇(PLGA-PEG)可作为姜黄素的良好载体材料，且载姜黄素的PLGA-PEG膜可有效挽救SD大鼠海绵状神经，恢复海绵状神经的连续性，增加阴茎组织中nNOS mRNA和蛋白的表达，从而改善损伤SD大鼠阴茎勃起功能，降低阴茎组织纤维化程度，有效促进阴茎康复。姜黄素缓释膜是海绵状神经损伤后阴茎康复治疗的新途径。

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来源期刊

Journal of Tissue Engineering and Regenerative Medicine 生物-工程：生物医学

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs. The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.