Phytochemistry最新文献

{"title":"Potential anti-H1N1 schitriterpenoids from Kadsura japonica L. vines.","authors":"Hung-Tse Huang, Chun-Tang Chiou, Yu-Chi Lin, Li-Jie Zhang, Chih-Hua Chao, Ping-Jyun Sung, Jih-Jung Chen, Tsung-Lin Li, I-Wen Lo, Chia-Ching Liaw","doi":"10.1016/j.phytochem.2025.114632","DOIUrl":"10.1016/j.phytochem.2025.114632","url":null,"abstract":"<p><p>Lethal contagious pathogens wreak havoc on human life and the global economy, especially influenza and other respiratory pathogens, as exemplified by the enduring impact of COVID-19. This study reports that triterpenoids isolated from the stems of medicinal plants Kadsura japonica L. (Schisandraceae), which exhibit potent anti-viral activity against collected influenza viruses. Collectively, four undescribed schitriterpenoids named kadsujanonols J-M (1-4) along with five previously reported, schincarin D (5), ananosin E (6), changnanic acid (7), longipedlactone A (8), and schiglansin S (9), were isolated and identified. Their chemical structures were determined using ¹H-, ¹³C-, and 2D-NMR spectra in conjunction with spectroscopic analyses, such as UV, IR, ECD, and HRESIMS. These schitriterpenoids were then subjected to antiviral examination against the collected H1N1 influenza viruses, in which several, changnanic acid (7) in particular, unveiled excellent anti-H1N1 activity compared to Tamiflu.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"114632"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structurally diverse polyketides with herbicidal activity from the fungus Aspergillus aculeatus.","authors":"Fei Liu, Shanshan Hong, Xiaoxia Gu, Qian Zhang, Qin Li, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu","doi":"10.1016/j.phytochem.2025.114631","DOIUrl":"10.1016/j.phytochem.2025.114631","url":null,"abstract":"<p><p>Fifteen undescribed polyketides aculeatides A-O and one known compound xylarinol A were isolated from the endophytic fungus Aspergillus aculeatus. Their structures were identified by spectroscopic data, electronic circular dichroism (ECD) calculations and comparisons, Mo₂(OAc)₄-induced ECD, Rh₂(OCOCF₃)₄-induced ECD, and the modified Mosher's method. Aculeatides A and B represent the first benzo[c]oxepine derivatives bearing a C6 side chain, while aculeatides C-I possessed a benzofuran ring system featuring a unique C8 side chain. Biologically, aculeatides J and K showed significant herbicidal activities with IC₅₀ values of 3.01 ± 0.40 and 3.33 ± 0.52 μM.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"114631"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bergamotane-family sesquiterpenes from histone deacetylase inhibitor modified cultures of the fungicolous fungus Montagnula donacina (Niessl) Wanas., E.B.G. Jones & K.D. Hyde.","authors":"Li-Li Guo, Yu Wang, Xinyang Li, He-Ping Chen, Ji-Kai Liu","doi":"10.1016/j.phytochem.2025.114630","DOIUrl":"10.1016/j.phytochem.2025.114630","url":null,"abstract":"<p><p>Epigenetic modification is an effective strategy for uncovering novel metabolites in fungi. In this study, chemical epigenetic manipulation was applied to culture of the fungicolous fungus Montagnula donacina, resulting in significant changes of its specialised metabolite profile. Seventeen undescribed (nor)-bergamotane-type sesquiterpenoids (1-17) were isolated from the culture broth of M. donacina that treated with epigenetic modifier vorinostat. Their structures were established via extensive spectroscopic methods and computational analyses. Compound 1 features a previously undescribed 12-nor-10(9→8)abeo-bergamotane scaffold, postulated to arise via multi-step oxidation and rearrangement reactions from the precursor massarinolin C. All compounds were evaluated for cytotoxicity against the human cancer line HL-60 and for their ability to inhibit nitric oxide production. Compounds 4, 5, and 17 showed moderate inhibition effects on nitric oxide production with inhibition rates of 61.5 %, 24.0 %, and 43.8 % at a concentration of 50 μM, respectively. This study expands the knowledge of bergamotane-type sesquiterpenes and underscores the effectiveness of epigenetic manipulation as a strategy to activate silent biosynthetic pathways and generate novel specialised metabolites in fungi.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"114630"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional characterization and directed evolution of Cicer arietinum glutathione transferases for enhanced hydroperoxidase activity and ligandin function","authors":"Anni Kontouri ,&nbsp;Nikolaos Georgakis ,&nbsp;Anastassios C. Papageorgiou ,&nbsp;Nikolaos Ε. Labrou","doi":"10.1016/j.phytochem.2025.114692","DOIUrl":"10.1016/j.phytochem.2025.114692","url":null,"abstract":"<div><div>Tau class glutathione transferases (GSTUs) play essential roles in plant defense by facilitating the nucleophilic attack of glutathione (GSH) to a wide range of electrophilic xenobiotics. In addition to their conjugating activity, these enzymes possess hydroperoxidase function, enabling the detoxification of harmful organic hydroperoxides into less reactive alcohols. In this study, we identified three closely related GST isoenzymes (96–98 % sequence identity) from <em>Cicer arietinum</em> (<em>Ca</em>GSTUs) through computational homology screening. Full-length cDNAs encoding these GSTs were cloned, recombinantly produced in <em>E. coli</em>, and purified for functional characterization. Enzyme kinetics were evaluated using model substrates, cumene hydroperoxide (CuOOH) and 1-chloro-2,4-dinitrobenzene (CDNB), revealing that <em>Ca</em>GSTU1-1 displayed superior hydroperoxidase activity and thermal stability. Based on these properties, <em>Ca</em>GSTU1-1 was selected as the parental scaffold for directed evolution via DNA shuffling, using the homologous <em>Glycine</em> max isoenzyme <em>Gm</em>GSTU4-4. Screening of the generated chimeric library resulted in the identification of a new variant, <em>CaGm</em>GSTU, which demonstrated a fourfold enhancement in catalytic turnover and efficiency toward both substrates. Additionally, <em>CaGm</em>GSTU exhibited altered ligand-binding characteristics, including increased affinity for selected pesticides. Structural modeling and viscosity-dependence kinetics indicated that these enhancements were primarily driven by changes in enzyme flexibility. Given the widespread toxicity of hydroperoxides and related pollutants, <em>CaGm</em>GSTU represents a promising tool for detoxification applications in environmental and agricultural biotechnology.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114692"},"PeriodicalIF":3.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diterpenoids from the brown alga Dictyota dichotoma with nematicidal activity against the plant parasitic nematode Aphelenchoides besseyi","authors":"Manami Iida ,&nbsp;Tatsuo Nehira ,&nbsp;Aki Kato ,&nbsp;Shigeru Hoshino ,&nbsp;Hisashi Ômura ,&nbsp;Shinji Ohta","doi":"10.1016/j.phytochem.2025.114691","DOIUrl":"10.1016/j.phytochem.2025.114691","url":null,"abstract":"<div><div>Three previously undescribed diterpenoids, designated amijial (<strong>1</strong>), dictyoepoxyperoxide (<strong>2</strong>), and hydroperoxyacetyldictyolal (<strong>3</strong>), were isolated from the brown alga <em>Dictyota dichotoma</em> along with eight known diterpenoids. Structural analysis revealed that <strong>1</strong> features a unique xenicane-related skeleton with a cyclic hemiacetal structure. The nematicidal activity of the isolated compounds was evaluated against the plant-parasitic nematode <em>Aphelenchoides besseyi</em>. Compounds bearing the α,β-unsaturated 1,4-dialdehyde structural motif exhibited higher activity.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114691"},"PeriodicalIF":3.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant protoberberine alkaloids: structural diversity, biosynthesis, synthesis, biological activity, structure-activity relationships and clinical applications of berberine.","authors":"Weiqi Jiang, Wen Zhang, Chenxin Jing, Han Zhou, Zhi-Jun Zhang, Rui Wang, Ying-Qian Liu","doi":"10.1016/j.phytochem.2025.114690","DOIUrl":"10.1016/j.phytochem.2025.114690","url":null,"abstract":"<p><p>Protoberberine alkaloids are a class of organic heterocyclic compounds categorized within the isoquinoline alkaloids, exhibiting significant therapeutic potential due to their potent biological activities. With advancements natural product chemistry, synthetic organic chemistry, biochemistry, and molecular biology, novel insights into their biosynthetic pathways, chemical synthesis pathways, mechanisms of action, and clinical applications have been elucidated. A comprehensive understanding of protoberberine alkaloids is instrumental in enhancing their commercial value and utilization of medicinal plant resources. Among these alkaloids, berberine stands out as a well-studied compound with broad-spectrum bioactivities. In this review, we summarized the progress in the study of protoberberine alkaloids, focusing on the recent advances in the biosynthetic pathway, the regulatory mechanism of biosynthesis, chemical synthesis, clinical applications and structure-activity relationship analysis of berberine. It is anticipated that this review will offer valuable insights for researchers in the fields of synthesis, medicinal chemistry, and bactericidal chemistry, who are engaged in exploring the chemistry and biology of protoberberine alkaloids.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"114690"},"PeriodicalIF":3.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suspensaditerpenes A–Q, anti-inflammatory labdane and nor-labdane diterpenoids from the seeds of Forsythia suspensa","authors":"Hui-Ying Li ,&nbsp;Meng-Yu Bao ,&nbsp;Hao-Ming Xiong ,&nbsp;Can-Can Wang ,&nbsp;Li-Ping Bai ,&nbsp;Wei Zhang ,&nbsp;Cheng-Yu Chen ,&nbsp;Zhi-Hong Jiang ,&nbsp;Guo-Yuan Zhu","doi":"10.1016/j.phytochem.2025.114688","DOIUrl":"10.1016/j.phytochem.2025.114688","url":null,"abstract":"<div><div>Phytochemical investigation of the seeds of <em>Forsythia suspensa</em> resulted in the isolation and characterization of 17 undescribed labdane and nor-labdane diterpenoids, named suspensaditerpenes A−Q (<strong>1</strong>−<strong>17</strong>), along with 13 known ones (<strong>18</strong>−<strong>30</strong>). Their structures were elucidated by a combination of NMR, HR-MS, and X-ray diffraction analyses. Structurally, <strong>5</strong>, <strong>10</strong>, and <strong>13</strong> are labdane diterpenoids featuring a lactone ring at the side chain, marking their first description in <em>F. suspensa</em>. Compounds <strong>4</strong>, <strong>14</strong>, <strong>15</strong>, and <strong>25</strong> are 14,15-dinor-diterpenoids, among which <strong>14</strong> and <strong>15</strong> have a rare 6/6/5 ring skeleton. Furthermore, all known compounds were isolated from <em>F. suspensa</em> for the first time. The <em>in vitro</em> anti-inflammatory activities assay showed that <strong>5</strong>, <strong>8</strong>, <strong>13</strong>, and <strong>14</strong> significantly inhibited the LPS-induced NO production at 20 μM in LPS-induced RAW264.7 cells, while the remaining 24 compounds demonstrated slight NO inhibitory activity. Further studies showed that <strong>5</strong> suppressed the LPS-induced expression of iNOS, p-p65, and NLRP3 proteins as well as NF-κB nuclear translocation in RAW264.7 cells.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114688"},"PeriodicalIF":3.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, characterization, and anti-neuroinflammatory activity of sesquiterpenoids from Pogostemon esquirolii","authors":"Yebi Qin ,&nbsp;Xinyan Shao ,&nbsp;Yinzheng Xie ,&nbsp;Hailin Lu ,&nbsp;Kaien Chen ,&nbsp;Xi Zheng ,&nbsp;Guodong Chen ,&nbsp;Lishe Gan ,&nbsp;Song Ang ,&nbsp;Dongli Li","doi":"10.1016/j.phytochem.2025.114685","DOIUrl":"10.1016/j.phytochem.2025.114685","url":null,"abstract":"<div><div>The phytochemical assessment of <em>Pogostemon esquirolii</em> resulted in the isolation and identification of sixteen sesquiterpenoids, including eudesmane-type (<strong>1</strong>–<strong>6</strong>, <strong>9</strong>, and <strong>11</strong>), bisabolane-type (<strong>8</strong> and <strong>10</strong>), caryolane-type (<strong>13</strong>–<strong>14</strong>), guaiacane-type (<strong>15</strong>–<strong>16</strong>), and other types (<strong>7</strong> and <strong>12</strong>). Of them, compounds <strong>1</strong>–<strong>10</strong>, namely pogostesquines A–J, are ten previously undescribed ones. Compound <strong>7</strong> possessed an unusual backbone with the isopropyl group substituted at C-8 instead of C-7. Their structures were confirmed by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, and ECD calculations. All the compounds were reported from this plant for the first time. Biological evaluation revealed that compound <strong>4</strong> exhibited the most anti-neuroinflammatory activity by inhibiting NO production in LPS-induced BV2 mouse microglial cells. Subsequently, network pharmacology analyses indicated that compound <strong>4</strong> primarily alleviated neuroinflammation-induced cognitive dysfunction through the TNF signaling pathway. Molecular docking studies, molecular dynamics simulations techniques, and western blotting analysis further clarified that compound <strong>4</strong> could downregulate the expression of TNF-α and IL-6, and inhibit the activity of inflammation-associated inducible enzymes iNOS and COX-2. Concurrently, it was further demonstrated that compound <strong>4</strong> could inhibit the activation of NF-κB and MAPK signaling pathways via the TNF pathway.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114685"},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and biological studies on rare and endangered plants endemic to China. Part XLVII. Sesquiterpene lactones from the leaves of Michelia opipara and their anti-inflammation effects","authors":"Jiang Wan ,&nbsp;Xin Chen ,&nbsp;Can Wang ,&nbsp;Ying-Peng Tong ,&nbsp;Yeun-Mun Choo ,&nbsp;Xiao-Fei Shen ,&nbsp;Yu-Feng Wang ,&nbsp;Chun-Xiao Jiang ,&nbsp;Jin-Feng Hu","doi":"10.1016/j.phytochem.2025.114687","DOIUrl":"10.1016/j.phytochem.2025.114687","url":null,"abstract":"<div><div>Six previously undescribed mono-acetylated sesquiterpene lactones (named opiparolides A‒F, <strong>1</strong>–<strong>6</strong>, resp.), along with five structurally related known compounds, were isolated and characterized from the renewable leaves of the endangered Chinese endemic plant <em>Michelia opipara</em> (family Magnoliaceae) using an LC-MS/MS-based Ion Identity Molecular Networking (IIMN) strategy in combination with conventional chromatographic techniques. The chemical structures and absolute configurations of the compounds were unambiguously determined through comprehensive analyses, including NMR spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS), GIAO-based NMR calculations with DP4+ analysis, and electronic circular dichroism (ECD) spectroscopy. Opiparolides A (<strong>1</strong>) and B (<strong>2</strong>) were identified as germacrane-type sesquiterpene lactones characterized by a typical <em>α</em>-methylene-<em>γ</em>-lactone moiety, while opiparolides C–F (<strong>3</strong>–<strong>6</strong>) are classified as C-15-functionalized eudesmane-type sesquiterpene lactones containing an <em>α</em>,<em>β</em>-unsaturated pentatomic lactone ring. Compounds <strong>1</strong>–<strong>6</strong> were evaluated for their inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages, exhibiting IC₅₀ values ranging from 8.6 to 16.8 μM. The interactions of sesquiterpene lactones <strong>1</strong> and <strong>6</strong> with the NO signaling pathway were examined through molecular docking studies. Moreover, molecular dynamics simulations further explored the structure and molecular properties of compound <strong>6</strong>-iNOS complex. The findings highlight the critical importance of preserving plant species diversity as a reservoir for chemically diverse natural products with potential therapeutic applications in inflammation treatment.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114687"},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hop bitter acids from the pistillate flower of Humulus lupulus L. and their anti-inflammatory and anti-dengue virus activities","authors":"Biao Sun ,&nbsp;Yun-Lin Ao ,&nbsp;Xia Cao ,&nbsp;Jia-Bing Zhang ,&nbsp;Xia Zhang ,&nbsp;Dong-Hao Lu ,&nbsp;Man Lin ,&nbsp;Jun-Shan Liu ,&nbsp;Xiao-Qi Zhang","doi":"10.1016/j.phytochem.2025.114689","DOIUrl":"10.1016/j.phytochem.2025.114689","url":null,"abstract":"<div><div>Nine undescribed hop bitter acids, humulupulones A–I (<strong>1</strong>–<strong>9</strong>), along with three known ones (<strong>10</strong>–<strong>12</strong>) were isolated from the pistillate flower of <em>Humulus lupulus</em> L. (hops). Structurally, compounds <strong>1</strong> and <strong>2</strong> possess an unprecedented nitrogen-containing skeleton in <em>α</em>-acids, and this is the first time that nitrogen has replaced oxygen at the same position, thereby forming a new skeleton consisting of a fused <em>α</em>-acid and a dimethyl-substituted pyridine. Compound <strong>3</strong> is a rare pyridine-2,4-dione derivative simultaneously incorporating prenyl and isopropyl moieties. Compounds <strong>7</strong>–<strong>10</strong> were separated into four pairs of enantiomers by chiral HPLC separation. Their structures were unambiguously established by comprehensive spectroscopic analysis, X-ray crystallography, and ECD calculations. Moreover, compounds <strong>2</strong>, <strong>4</strong>, and <strong>7</strong> exhibited significant anti-inflammatory activities in the CuSO₄-induced zebrafish inflammation model. Compounds <strong>4</strong>, <strong>5</strong>, <strong>7</strong>–<strong>10</strong> and <strong>12</strong> possessed significant anti-dengue virus (DENV) activities at the viral adsorption and entry stages with IC₅₀ values ranging from 0.29 μM to 70.09 μM, while compounds <strong>7</strong>, <strong>10</strong>, and <strong>11</strong> exerted anti-DENV activities at the viral replication stage with IC₅₀ values of 71.47 ± 7.30, 19.36 ± 6.77, and 16.18 ± 3.49 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114689"},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}