Phytochemistry最新文献

{"title":"Seven undescribed metabolites from Ganoderma lucidum-derived endophytic Talaromyces sp. GLQ04 and their anti-DLBCL (diffuse large B-cell lymphoma) activities","authors":"Shan Liu ,&nbsp;Hao Sun ,&nbsp;Pei-Ting Li ,&nbsp;Pei-Shan Li ,&nbsp;Xia Cheng ,&nbsp;Feng Wang ,&nbsp;Qi Luo","doi":"10.1016/j.phytochem.2026.114816","DOIUrl":"10.1016/j.phytochem.2026.114816","url":null,"abstract":"<div><div>Seven undescribed metabolites and four known compounds were isolated from a <em>Ganoderma lucidum</em>-derived endophytic fungus <em>Talaromyces sp.</em> GLQ04. Their structures including absolute configurations were assigned by using spectroscopic data and ECD calculations. Among them, (±)<strong>-3</strong> and (±)<strong>-5</strong> were obtained as a mixture. Chiral HPLC was employed to separate two pairs of enantiomers (+)<strong>-3</strong> and (−)-<strong>3</strong>, and (+)-<strong>5</strong> and (−)<strong>-5</strong>. The cytotoxic bioactivities of compounds <strong>1</strong>–<strong>9</strong> against DLBCL (diffuse large B-cell lymphoma) cells were evaluated. The results showed that compounds <strong>6</strong>, <strong>7</strong> and <strong>8</strong> exhibited inhibitory activities against DLBCL cells, with IC₅₀ values of 10.68 μM, 61.04 μM and 17.12 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114816"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report on whole genome sequencing of Chaetomium strumarium BRFC4 and its antagonistic activity against Fusarium wilt of banana","authors":"Arutselvan Vanitha ,&nbsp;Rajkumar Sudharsan ,&nbsp;Chinnan Kannan ,&nbsp;Annadurai Praveen ,&nbsp;Pulapet Sowmya ,&nbsp;Jaganathan Gowrishankar ,&nbsp;Markkandan Kesavan ,&nbsp;Mathiyalagan Ramya ,&nbsp;Rajapandiyan Krishnamoorthy ,&nbsp;Mohammad A. Alshuniaber ,&nbsp;Magdi A. Osman ,&nbsp;Mansour K. Gatasheh","doi":"10.1016/j.phytochem.2026.114807","DOIUrl":"10.1016/j.phytochem.2026.114807","url":null,"abstract":"<div><div><em>Fusarium</em> wilt of banana caused by <em>Fusarium oxysporum</em> f. sp. <em>cubense</em> is a globally devastating disease with limited control through conventional methods like crop rotation, soil amendments and fungicides. Biological control presents a sustainable alternative, especially <em>Chaetomium</em> species known for their multifaceted antagonistic mechanisms are gaining prominence. Nine <em>Chaetomium</em> isolates were obtained from the banana rhizosphere and characterized using internal transcribed spacer sequencing. The antagonistic potential of <em>Chaetomium</em> sp. against <em>F</em>. <em>oxysporum</em> f. sp. <em>cubense</em> was evaluated through dual culture and inverted plate assays. Among them, <em>Chaetomium. strumarium</em> exhibited strong antifungal activity showing direct hyphal interactions and structural damage to <em>F</em>. <em>oxysporum</em> f. sp. <em>cubense</em> under scanning electron microscopy. Pot culture experiments confirmed <em>C. strumarium</em> effectively suppressed wilt incidence and promoted plant growth. Whole genome sequencing of <em>C. strumarium</em> yielded a 33-megabase assembly with 54.58 per cent GC content and 10,045 protein-coding genes. Genome annotation revealed abundant carbohydrate-active enzymes particularly glycoside hydrolases and polysaccharide lyases along with 57 biosynthetic gene clusters linked to antifungal metabolite production. Gene Ontology enrichment analysis highlighted genes involved in stress response, metabolism and fungal antagonism. This study is the first to establish <em>C. strumarium</em> as a potent biocontrol agent against <em>F</em>. <em>oxysporum</em> f. sp. <em>cubense</em>, providing genomic insights into its mycoparasitism and specialized metabolite biosynthesis for sustainable banana wilt management.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114807"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oleanane saponins from Amesiodendron chinense: Dual inhibition of STAT3 and cytokines for immunosuppression","authors":"Ren-Chao Zhang ,&nbsp;Wen-Jing Gao ,&nbsp;Pei-Qian Wu ,&nbsp;Bin Zhou ,&nbsp;Jian-Min Yue","doi":"10.1016/j.phytochem.2026.114801","DOIUrl":"10.1016/j.phytochem.2026.114801","url":null,"abstract":"<div><div>Phytochemical analysis of <em>Amesiodendron Chinense</em> stems and leaves resulted in the isolation of 26 undescribed oleanane triterpenoid saponins, amesiodendroside A−Z (<strong>1</strong>–<strong>26</strong>), using a combination of bioactivity-guided fractionation and global natural products social molecular networking (GNPS). Compounds <strong>1</strong>−<strong>12</strong> were classified as disaccharides, whereas <strong>13</strong>−<strong>26</strong> constituted trisaccharides, which are characterized by an arabinose glycosidically linked to the C-3 position of oleanane, with glucose moieties appended to the C-2 and/or C-3 positions of the arabinose. They exhibit diverse acetylation profiles and oxidation state variations at C-16, C-23, and C-28, showing marked correlations between substitution patterns and the typical ¹H/¹³C NMR chemical shifts. Notably, compounds <strong>5</strong>, <strong>7</strong>, <strong>16</strong>, and <strong>25</strong> displayed significant immunosuppressive activities against the proliferation of T and B lymphocytes in vitro, and the preliminary structure-activity relationship was discussed. Furthermore, compounds <strong>7</strong> and <strong>25</strong> exhibited dual immunosuppressive effects by inducing apoptosis in activated T cells through the signal transducer and activator of transcription 3 (STAT3)-mediated mitochondrial pathway and potently suppressing key immunoregulatory cytokines (e.g., IFN-γ, IL-2, and IL-4).</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114801"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery, stereochemical analysis, and cytotoxicity of C14–C3' linked Aspidosperma-type trimer and dimers from Melodinus yunnanensis","authors":"Jing Chen,&nbsp;Jing Wu,&nbsp;Yang Yu,&nbsp;Mei-Fen Bao,&nbsp;Xiang-Hai Cai","doi":"10.1016/j.phytochem.2026.114817","DOIUrl":"10.1016/j.phytochem.2026.114817","url":null,"abstract":"<div><div>Given the promising biological significance of dimeric alkaloids, a phytochemical study of the <em>Melodinus yunnanensis</em> was undertaken, leading to the isolation of 20 <em>Aspidosperma</em>-type monoterpenoid indole alkaloids. These include one previously unreported trimer, melobisine A (<strong>1</strong>) – the first trimeric <em>Aspidosperma</em>-type alkaloid discovered from the genus <em>Melodinus</em> – along with 13 previously unreported dimers, melobisines B–N (<strong>2</strong>–<strong>14</strong>), and 6 known analogues. Their structures were elucidated through extensive spectroscopic data analysis. Based on this series of compounds, characteristic NMR data were analyzed to identify key indicators for the stereochemistry at C-3/3′ and the C-14/15 epoxy moieties, supported by computational ¹³C NMR results. All compounds were evaluated for cytotoxicity against SW480, HT-29, and HCT116 human cancer cell lines. The observed activities among monomers, dimers, and the trimer provide preliminary insights into the structure – activity relationships within this alkaloid class.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114817"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triterpenoid saponins from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi and their anti-inflammatory activities","authors":"Sheng Dong ,&nbsp;Anqi Lu ,&nbsp;Kexin Li ,&nbsp;Shiqing Zhao ,&nbsp;Jialong Zhao ,&nbsp;Jiuzhi Yuan ,&nbsp;Chongning Lv ,&nbsp;Jincai Lu","doi":"10.1016/j.phytochem.2026.114786","DOIUrl":"10.1016/j.phytochem.2026.114786","url":null,"abstract":"<div><div>The 60 % EtOH-eluted fraction (60 %EF) from the roots and rhizomes of <em>Clematis terniflora</em> var. <em>manshurica</em> (Rupr.) Ohwi exhibited potent anti-inflammatory activity with minimal cytotoxicity compared to other fractions. A total of 88 compounds were identified from this fraction by UPLC-Q-TOF-MS analysis, with triterpenoid saponins found to be the most abundant class. Subsequently, nine previously undescribed oleanane-type triterpenoid saponins (<strong>1</strong>–<strong>9</strong>), along with twenty known analogues (<strong>10</strong>–<strong>29</strong>), were obtained from the 60 % EF. Their structures were elucidated through comprehensive spectroscopic analysis, employing HRESIMS, 1D and 2D NMR techniques. The plausible biosynthetic pathways of the compounds <strong>1</strong>–<strong>9</strong> were also proposed. All isolates were assessed for anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages, among which <strong>4</strong> showed the strongest inhibition of NO and TNF-α production. Mechanistic studies using western blotting, molecular docking, and molecular dynamics simulations revealed that <strong>4</strong> suppresses NF-κB activation mainly by inhibiting IκBα phosphorylation and stabilizing IκBα protein levels, while also directly interacting with p65 to attenuate its phosphorylation. These findings provide new insights into the anti-inflammatory potential of triterpenoid saponins from <em>C. terniflora</em> var. <em>mandshurica</em> and highlight <strong>4</strong> as a promising NF-κB pathway modulator.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114786"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4-Hydroxyderricin from Angelica keiskei promotes the stability of BRCA1 in triple-negative breast cancer cells through inhibition of cathepsin S","authors":"Isoo Youn ,&nbsp;Hyelim Oh ,&nbsp;Taeeun Kim ,&nbsp;Sumin Park ,&nbsp;Yun-Seo Kil ,&nbsp;Soosung Kang ,&nbsp;Yun-Sil Lee ,&nbsp;Eun Kyoung Seo","doi":"10.1016/j.phytochem.2026.114805","DOIUrl":"10.1016/j.phytochem.2026.114805","url":null,"abstract":"<div><div>Breast cancer susceptibility gene 1 (BRCA1), a tumor suppressor protein, is closely associated with ovarian and breast cancers. Previously, cathepsin S (CTSS) was reported to prevent BRCA1-mediated apoptosis, contributing to chemoresistance in TNBC. In this study, we screened the CTSS inhibitory activity of 107 pure compounds derived from plant materials and identified 4-hydroxyderricin (<strong>12</strong>) from <em>Angelica keiskei</em> as a potent CTSS inhibitor. Compound <strong>12</strong> increased BRCA1 stability in TNBC cells in a CTSS-dependent manner. In an <em>in vivo</em> TNBC xenograft mouse model, combination treatment with paclitaxel and compound <strong>12</strong> significantly increased BRCA1 stability, reduced the final tumor weight, and decreased the number of Ki-67-positive proliferative cells. Our findings suggest that combination therapy with compound <strong>12</strong> can enhance BRCA1 function and improve chemotherapeutic efficacy. This study highlights CTSS inhibition as a promising therapeutic strategy for TNBC patients with wild-type BRCA1.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114805"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alkaloids and anthraquinones of Hemerocallis fulva var. kwanso roots and their PTP1B inhibitory activity","authors":"Thi Thanh Le ,&nbsp;Manh Tuan Ha ,&nbsp;Trong Trieu Tran ,&nbsp;Seung Eui Min ,&nbsp;Kang-Hyun Han ,&nbsp;Jeong Ah Kim ,&nbsp;Byung Sun Min","doi":"10.1016/j.phytochem.2026.114800","DOIUrl":"10.1016/j.phytochem.2026.114800","url":null,"abstract":"<div><div>Phytochemical investigation of the roots of <em>Hemerocallis fulva</em> var. <em>kwanso</em> Regel led to the isolation and structural elucidation of five previously undescribed compounds, including three alkaloids (<strong>1</strong>‒<strong>3</strong>) and two anthraquinones (<strong>4</strong> and <strong>5</strong>), together with fourteen known ones (<strong>6</strong>‒<strong>19</strong>). Structural elucidation was achieved through comprehensive spectroscopic analyses combined with ECD calculations. Enzyme inhibition assays revealed that a <em>β</em>-carboline alkaloid (<strong>14</strong>) exhibited significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, with an IC₅₀ value of 31.56 μM. Further enzyme kinetic and molecular docking analyses confirmed that compound <strong>14</strong> functioned as a non-competitive PTP1B inhibitor, with a <em>K</em>_<em>i</em> value of 30.16 ± 0.57 μM.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114800"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1H NMR-guided isolation of ophiobolins from Bipolaris maydis and their bioactivities","authors":"Yong Shen ,&nbsp;Xiaotian Zhang ,&nbsp;Qin Li ,&nbsp;Mengru Yu ,&nbsp;Yongqi Li ,&nbsp;Luosheng Wan ,&nbsp;Xing Sun ,&nbsp;Chunmei Chen ,&nbsp;Yonghui Zhang ,&nbsp;Hucheng Zhu","doi":"10.1016/j.phytochem.2026.114802","DOIUrl":"10.1016/j.phytochem.2026.114802","url":null,"abstract":"<div><div>Ophiobolins present characteristic ¹H NMR resonances, which distinctly differ from other metabolites reported from <em>Bipolaris maydis</em>, and were used for an NMR-guided isolation in this research. As a result, 17 undescribed ophiobolin-sesterterpenoids, ophiobolinoids A–Q (<strong>1</strong>–<strong>17</strong>), were isolated from <em>Bipolaris maydis</em>. Ophiobolinoids A–C possessed a rare oxygen bridge connecting C-3 and C-21. Their structures were elucidated by comprehensive spectroscopic analyses, DP4+ calculations, ECD calculations, and X-ray diffraction analyses. Specifically, ophibolinoid C showed a weak inhibitory effect on NO production in LPS-induced RAW264.7 cells.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114802"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eremophilane-type sesquiterpenes from Ligularia hodgsonii: isolation, structural characterization, and pro-angiogenic potential","authors":"Zhenhua Wan ,&nbsp;Huilin Peng ,&nbsp;Chunping Tang ,&nbsp;Jiangjiang Qin ,&nbsp;Bintao Hu ,&nbsp;Changqiang Ke ,&nbsp;Sheng Yao ,&nbsp;Ligen Lin ,&nbsp;Yang Ye","doi":"10.1016/j.phytochem.2026.114785","DOIUrl":"10.1016/j.phytochem.2026.114785","url":null,"abstract":"<div><div>A comprehensive chemical investigation of the rhizomes and roots of <em>Ligularia hodgsonii</em> Hook. was undertaken, which resulted in the identification of 11 previously undescribed eremophilane-type sesquiterpenes (<strong>1</strong>−<strong>4</strong>, <strong>7</strong>−<strong>12</strong>, and <strong>14</strong>), in addition to five known analogues (<strong>5</strong>−<strong>6</strong>, <strong>13</strong>, and <strong>15</strong>−<strong>16</strong>). The structures of previously undescribed compounds were fully characterized through comprehensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data, single-crystal X-ray diffraction experiment, and time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculation. Compounds <strong>1</strong>–<strong>12</strong> represent six pairs of epimers at the C-11 position, and an empirical pattern to distinguish the C-11 stereochemistry was therefore established based on their characteristic Cotton effects in the ECD spectra, which was subsequently applied to revise the absolute configuration of the known compound <strong>13</strong>. Furthermore, the pro-angiogenic activity of some isolated compounds was evaluated in human umbilical vein endothelial cells (HUVECs). Compound <strong>14</strong> exhibited potent effect by promoting HUVEC migration and facilitating the formation of capillary-like tubular networks, while compounds <strong>7</strong>, <strong>11</strong>, <strong>13</strong>, and <strong>15</strong> interrupted wound healing in HUVECs. The findings provide the first insights into the bioactivity of eremophilane-type sesquiterpenes responsible for the wound-healing therapeutic effect of <em>L. hodgsonii</em>.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114785"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146065997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotany, phytochemistry and pharmacological activities of the Blumea Genus: A comprehensive review","authors":"Kalyani Saikia ,&nbsp;Lunasmrita Saikia ,&nbsp;Dhrubajyoti Gogoi ,&nbsp;Mrinal Kashyap Sarma ,&nbsp;Sm Abdul Aziz Barbhuiya ,&nbsp;Partha Pratim Dutta","doi":"10.1016/j.phytochem.2026.114819","DOIUrl":"10.1016/j.phytochem.2026.114819","url":null,"abstract":"<div><div>The genus <em>Blumea</em> (Asteraceae) has long been valued in traditional medicine across Asia and other regions for its use in managing wounds, infections, respiratory and digestive disorders, inflammatory conditions, and chronic ailments. Its use is well documented in Ayurveda, Unani, Siddha, and folk medicine, where various plant parts are prepared as decoctions, infusions, poultices, or herbal teas. Particular species also hold culinary and cultural significance, reflecting their socio-ethnobotanical importance. This review provides an integrated assessment of the ethnobotany, phytochemistry, and pharmacological activities of <em>Blumea</em> species, while identifying future research directions. A systematic literature search was conducted using SciFinder, PubMed, Scopus, and Google Scholar (May 2000-October 2025) with the keywords “<em>Blumea</em>,” “Phytochemistry,” “Pharmacological activity,” and “Ethnobotany,” supplemented by manual screening for additional studies. Phytochemical investigations reveal that <em>Blumea</em> species are particularly rich in terpenoids, flavonoids, steroids, and alkaloids, which contribute to their diverse bioactivities. A total of 148 compounds have been reported, many of which are supported by preclinical studies demonstrating anti-inflammatory, antioxidant, cytotoxic, neuroprotective, antihyperlipidemic, antihypertensive, wound-healing, and metabolic effects. Promising evidence also supports their potential in diabetes, cardiovascular, and neurological disorders. Additionally, emerging applications include cosmetic formulations, though toxicological evaluations remain limited. Despite this therapeutic promise, challenges such as environmental variability, insufficient clinical validation, and a lack of standardised methodologies hinder translational progress. Overall, the review highlights the medicinal potential of <em>Blumea</em> for systematic isolation of bioactive constituents, mechanistic insights, sustainable utilisation, and translational studies to bridge traditional knowledge with modern drug development.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114819"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}