Phytochemistry最新文献

{"title":"Acyloxyneryl esters in Doronicum austriacum subsp. giganteum essential oil: structure elucidation, synthesis, and GC-MS/RI library development.","authors":"Milan Ž Dimitrijević, Irena Lj Raca, Niko S Radulović","doi":"10.1016/j.phytochem.2026.115122","DOIUrl":"https://doi.org/10.1016/j.phytochem.2026.115122","url":null,"abstract":"<p><p>The essential oil of the underground parts of Doronicum austriacum subsp. giganteum (Griseb.) Stoj. & Stef. (Asteraceae) was studied here for the first time. Based GC-FID peak-area normalization, neryl isobutyrate (44.2%) and neryl 2-methylbutyrate (28.8%) were the two most abundant identified constituents. Targeted chromatographic fractionation guided by GC-MS revealed a series of oxygenated acyclic monoterpene diesters that proved difficult to identify by conventional means. By combining the synthesis of authentic reference compounds with high-field NMR spectroscopy (HSQC, HMBC, NOESY) and diagnostic ¹³C-¹H coupling constants, nine previously undescribed natural products were identified, including 8- and 9-acyloxyneryl isobutyrates and the corresponding 2-methylbutyrate analogues. Systematic relationships between structure and linear retention indices on nonpolar and polar stationary phases provided transferable criteria for distinguishing C-8 vs C-9 oxygenation and neryl (Z) vs geranyl (E) geometry, and enabled estimation of chromatographic behavior for related, not-yet observed congeners. A re-evaluation of reported NMR patterns further suggests that a subset of literature \"acyloxyneryl/geranyl\" assignments may correspond to C-10-acylated isomers. Collectively, these findings expand the phytochemical space of acylated monoterpenes in Asteraceae roots and provide a validated spectral and retention-index reference framework for future studies of closely related metabolites.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"115122"},"PeriodicalIF":3.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPLC-UV-guided discovery of penicitrinoids A-K and the structure revision of fusariumin B: 3,4-seco-spiromeroterpenoids from the marine-derived fungus Penicillium citrinum F5025.","authors":"Meng-Ting Chen, Ping Wang, Jing-Jing Yang, Yong He, Cong-Jun Xu, Yong Rao, Wan-Shan Li, Ling Huang, Zhong-Ping Jiang","doi":"10.1016/j.phytochem.2026.115121","DOIUrl":"10.1016/j.phytochem.2026.115121","url":null,"abstract":"<p><p>Eleven previously undescribed 3,4-seco-spiromeroterpenoids, penicitrinoids A-K (1-11), one revised analogue (12), and three known compounds (13-15) were isolated under HPLC-UV guidance from the marine-derived fungus Penicillium citrinum F5025. Their structures and absolute configurations were unequivocally determined through HR-ESIMS, extensive 1D and 2D NMR analysis, ECD calculations, and a single-crystal X-ray diffraction study. Notably, Penicitrinoid A (1) represents the first example of a 3,4-seco-spiromeroterpenoid incorporating a tetrahydrofuran ring. Moreover, the previously reported structure of fusariumin B was revised and corresponds to compound 12. In antiviral assays, compounds 8 and 14 exhibited activity against influenza virus (strain ZX1109) with EC₅₀ values of 6.41 and 10.91 μM, respectively. Compound 8 also showed activity against Ross River virus (RRV) (EC₅₀ = 51.92 μM), while compound 10 was active against dengue virus (DENV-2) (EC₅₀ = 51.91 μM). Mechanistic studies indicated that the antiviral effects of compounds 8 and 10 against RRV and DENV-2 are primarily mediated through interference with viral RNA replication. This study not only expands the structural diversity of 3,4-seco-spiromeroterpenoids but also provides a foundation for their development as potential antiviral agents.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"115121"},"PeriodicalIF":3.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-alkaloidal constituents of Sophora flavescens:structure, activity and biosynthesis.","authors":"Nian Li, Yang Xu, Chengwu Jin, Qiuhong Zhang, Lixia Chen, Hua Li","doi":"10.1016/j.phytochem.2026.115101","DOIUrl":"10.1016/j.phytochem.2026.115101","url":null,"abstract":"<p><p>Sophora flavescens Aiton (Kushen) is a widely used medicinal herb known for its rich phytochemical composition. The plant contains alkaloids, flavonoids, triterpenoid saponins, and other bioactive constituents, among which non-alkaloids are of significant research interest. From 1968 to 2025, 158 non-alkaloids have been isolated. In this review, non-alkaloids were classified according to their skeleton frameworks and substitution patterns, including poly-isopentenyl, isoflavonoids, pterocarpans, benzofuran derivatives, etc. Then this paper systematically summarizes their biological activities, structure-activity relationships (SAR), as well as their NMR spectroscopic features and the biosynthesis of the side-chain cyclization in isopentenyl flavones. Pharmacological studies have shown that non-alkaloid compounds have many biological activities, including anti-inflammation, antioxidant, cytotoxic and anti-Alzheimer disease. This review provides a comprehensive reference for the structural elucidation, pharmacological evaluation, NMR characterization and biosynthesis of non-alkaloids from Sophora flavescens.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"115101"},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artefacts in natural products chemistry: formation mechanisms and avoidance strategies.","authors":"Olha Mykhailenko, Niels Agerbirk, Serhat Sezai Çiçek, Sebastian Granica, Alfonso Mangoni, Severina Pacifico, Lina Raudone, Dimitrina Zheleva-Dimitrova, Thomas Stegemann, Christian Zidorn","doi":"10.1016/j.phytochem.2026.115108","DOIUrl":"https://doi.org/10.1016/j.phytochem.2026.115108","url":null,"abstract":"<p><p>The formation of artefacts during the extraction and isolation of specialised metabolites is a significant issue in phytochemical research and related areas, including marine chemistry, and microbial metabolites studies. Artefacts arise when genuine natural products undergo chemical transformations induced by mechanical stress, heat, extraction, purification, storage conditions, enzymatic activity, and/or analytical procedures. Common transformation pathways include hydrolysis, oxidation, isomerisation, solvolysis, rearrangement, polymerisation, and alkylation (e.g., O-methylation). These processes are discussed using representative examples from major phytochemical classes, such as iridoids, sesquiterpene lactones, alkaloids, glucosinolates, and phenolic compounds. Considering these mechanisms of artefact formation, a best practice workflow is proposed in order to minimise artefact formation. The workflow includes systematic control strategies to reduce artefact generation and guidelines for defining appropriate control experiments prior to publishing natural products as genuine compounds. In this way, the reliability of the phytochemical literature can be enhanced. The proposed workflow covers recommendations for extraction planning, solvent selection, temperature and pH control, protection from light, oxygen and enzymes, stability testing, and transparent, systematic analytical validation. Awareness of the feasibility of artefact formation, together with transparent control experiments, will improve reproducibility, ensure structural accuracy, and facilitate more reliable interpretation of phytochemical data. Finally, guidance is provided on how to detect artefacts in previous publications and how to check for their occurrence in one's own work.</p>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"115108"},"PeriodicalIF":3.4,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven undescribed metabolites from Ganoderma lucidum-derived endophytic Talaromyces sp. GLQ04 and their anti-DLBCL (diffuse large B-cell lymphoma) activities","authors":"Shan Liu ,&nbsp;Hao Sun ,&nbsp;Pei-Ting Li ,&nbsp;Pei-Shan Li ,&nbsp;Xia Cheng ,&nbsp;Feng Wang ,&nbsp;Qi Luo","doi":"10.1016/j.phytochem.2026.114816","DOIUrl":"10.1016/j.phytochem.2026.114816","url":null,"abstract":"<div><div>Seven undescribed metabolites and four known compounds were isolated from a <em>Ganoderma lucidum</em>-derived endophytic fungus <em>Talaromyces sp.</em> GLQ04. Their structures including absolute configurations were assigned by using spectroscopic data and ECD calculations. Among them, (±)<strong>-3</strong> and (±)<strong>-5</strong> were obtained as a mixture. Chiral HPLC was employed to separate two pairs of enantiomers (+)<strong>-3</strong> and (−)-<strong>3</strong>, and (+)-<strong>5</strong> and (−)<strong>-5</strong>. The cytotoxic bioactivities of compounds <strong>1</strong>–<strong>9</strong> against DLBCL (diffuse large B-cell lymphoma) cells were evaluated. The results showed that compounds <strong>6</strong>, <strong>7</strong> and <strong>8</strong> exhibited inhibitory activities against DLBCL cells, with IC₅₀ values of 10.68 μM, 61.04 μM and 17.12 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114816"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report on whole genome sequencing of Chaetomium strumarium BRFC4 and its antagonistic activity against Fusarium wilt of banana","authors":"Arutselvan Vanitha ,&nbsp;Rajkumar Sudharsan ,&nbsp;Chinnan Kannan ,&nbsp;Annadurai Praveen ,&nbsp;Pulapet Sowmya ,&nbsp;Jaganathan Gowrishankar ,&nbsp;Markkandan Kesavan ,&nbsp;Mathiyalagan Ramya ,&nbsp;Rajapandiyan Krishnamoorthy ,&nbsp;Mohammad A. Alshuniaber ,&nbsp;Magdi A. Osman ,&nbsp;Mansour K. Gatasheh","doi":"10.1016/j.phytochem.2026.114807","DOIUrl":"10.1016/j.phytochem.2026.114807","url":null,"abstract":"<div><div><em>Fusarium</em> wilt of banana caused by <em>Fusarium oxysporum</em> f. sp. <em>cubense</em> is a globally devastating disease with limited control through conventional methods like crop rotation, soil amendments and fungicides. Biological control presents a sustainable alternative, especially <em>Chaetomium</em> species known for their multifaceted antagonistic mechanisms are gaining prominence. Nine <em>Chaetomium</em> isolates were obtained from the banana rhizosphere and characterized using internal transcribed spacer sequencing. The antagonistic potential of <em>Chaetomium</em> sp. against <em>F</em>. <em>oxysporum</em> f. sp. <em>cubense</em> was evaluated through dual culture and inverted plate assays. Among them, <em>Chaetomium. strumarium</em> exhibited strong antifungal activity showing direct hyphal interactions and structural damage to <em>F</em>. <em>oxysporum</em> f. sp. <em>cubense</em> under scanning electron microscopy. Pot culture experiments confirmed <em>C. strumarium</em> effectively suppressed wilt incidence and promoted plant growth. Whole genome sequencing of <em>C. strumarium</em> yielded a 33-megabase assembly with 54.58 per cent GC content and 10,045 protein-coding genes. Genome annotation revealed abundant carbohydrate-active enzymes particularly glycoside hydrolases and polysaccharide lyases along with 57 biosynthetic gene clusters linked to antifungal metabolite production. Gene Ontology enrichment analysis highlighted genes involved in stress response, metabolism and fungal antagonism. This study is the first to establish <em>C. strumarium</em> as a potent biocontrol agent against <em>F</em>. <em>oxysporum</em> f. sp. <em>cubense</em>, providing genomic insights into its mycoparasitism and specialized metabolite biosynthesis for sustainable banana wilt management.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114807"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oleanane saponins from Amesiodendron chinense: Dual inhibition of STAT3 and cytokines for immunosuppression","authors":"Ren-Chao Zhang ,&nbsp;Wen-Jing Gao ,&nbsp;Pei-Qian Wu ,&nbsp;Bin Zhou ,&nbsp;Jian-Min Yue","doi":"10.1016/j.phytochem.2026.114801","DOIUrl":"10.1016/j.phytochem.2026.114801","url":null,"abstract":"<div><div>Phytochemical analysis of <em>Amesiodendron Chinense</em> stems and leaves resulted in the isolation of 26 undescribed oleanane triterpenoid saponins, amesiodendroside A−Z (<strong>1</strong>–<strong>26</strong>), using a combination of bioactivity-guided fractionation and global natural products social molecular networking (GNPS). Compounds <strong>1</strong>−<strong>12</strong> were classified as disaccharides, whereas <strong>13</strong>−<strong>26</strong> constituted trisaccharides, which are characterized by an arabinose glycosidically linked to the C-3 position of oleanane, with glucose moieties appended to the C-2 and/or C-3 positions of the arabinose. They exhibit diverse acetylation profiles and oxidation state variations at C-16, C-23, and C-28, showing marked correlations between substitution patterns and the typical ¹H/¹³C NMR chemical shifts. Notably, compounds <strong>5</strong>, <strong>7</strong>, <strong>16</strong>, and <strong>25</strong> displayed significant immunosuppressive activities against the proliferation of T and B lymphocytes in vitro, and the preliminary structure-activity relationship was discussed. Furthermore, compounds <strong>7</strong> and <strong>25</strong> exhibited dual immunosuppressive effects by inducing apoptosis in activated T cells through the signal transducer and activator of transcription 3 (STAT3)-mediated mitochondrial pathway and potently suppressing key immunoregulatory cytokines (e.g., IFN-γ, IL-2, and IL-4).</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114801"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery, stereochemical analysis, and cytotoxicity of C14–C3' linked Aspidosperma-type trimer and dimers from Melodinus yunnanensis","authors":"Jing Chen,&nbsp;Jing Wu,&nbsp;Yang Yu,&nbsp;Mei-Fen Bao,&nbsp;Xiang-Hai Cai","doi":"10.1016/j.phytochem.2026.114817","DOIUrl":"10.1016/j.phytochem.2026.114817","url":null,"abstract":"<div><div>Given the promising biological significance of dimeric alkaloids, a phytochemical study of the <em>Melodinus yunnanensis</em> was undertaken, leading to the isolation of 20 <em>Aspidosperma</em>-type monoterpenoid indole alkaloids. These include one previously unreported trimer, melobisine A (<strong>1</strong>) – the first trimeric <em>Aspidosperma</em>-type alkaloid discovered from the genus <em>Melodinus</em> – along with 13 previously unreported dimers, melobisines B–N (<strong>2</strong>–<strong>14</strong>), and 6 known analogues. Their structures were elucidated through extensive spectroscopic data analysis. Based on this series of compounds, characteristic NMR data were analyzed to identify key indicators for the stereochemistry at C-3/3′ and the C-14/15 epoxy moieties, supported by computational ¹³C NMR results. All compounds were evaluated for cytotoxicity against SW480, HT-29, and HCT116 human cancer cell lines. The observed activities among monomers, dimers, and the trimer provide preliminary insights into the structure – activity relationships within this alkaloid class.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114817"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triterpenoid saponins from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi and their anti-inflammatory activities","authors":"Sheng Dong ,&nbsp;Anqi Lu ,&nbsp;Kexin Li ,&nbsp;Shiqing Zhao ,&nbsp;Jialong Zhao ,&nbsp;Jiuzhi Yuan ,&nbsp;Chongning Lv ,&nbsp;Jincai Lu","doi":"10.1016/j.phytochem.2026.114786","DOIUrl":"10.1016/j.phytochem.2026.114786","url":null,"abstract":"<div><div>The 60 % EtOH-eluted fraction (60 %EF) from the roots and rhizomes of <em>Clematis terniflora</em> var. <em>manshurica</em> (Rupr.) Ohwi exhibited potent anti-inflammatory activity with minimal cytotoxicity compared to other fractions. A total of 88 compounds were identified from this fraction by UPLC-Q-TOF-MS analysis, with triterpenoid saponins found to be the most abundant class. Subsequently, nine previously undescribed oleanane-type triterpenoid saponins (<strong>1</strong>–<strong>9</strong>), along with twenty known analogues (<strong>10</strong>–<strong>29</strong>), were obtained from the 60 % EF. Their structures were elucidated through comprehensive spectroscopic analysis, employing HRESIMS, 1D and 2D NMR techniques. The plausible biosynthetic pathways of the compounds <strong>1</strong>–<strong>9</strong> were also proposed. All isolates were assessed for anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages, among which <strong>4</strong> showed the strongest inhibition of NO and TNF-α production. Mechanistic studies using western blotting, molecular docking, and molecular dynamics simulations revealed that <strong>4</strong> suppresses NF-κB activation mainly by inhibiting IκBα phosphorylation and stabilizing IκBα protein levels, while also directly interacting with p65 to attenuate its phosphorylation. These findings provide new insights into the anti-inflammatory potential of triterpenoid saponins from <em>C. terniflora</em> var. <em>mandshurica</em> and highlight <strong>4</strong> as a promising NF-κB pathway modulator.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114786"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4-Hydroxyderricin from Angelica keiskei promotes the stability of BRCA1 in triple-negative breast cancer cells through inhibition of cathepsin S","authors":"Isoo Youn ,&nbsp;Hyelim Oh ,&nbsp;Taeeun Kim ,&nbsp;Sumin Park ,&nbsp;Yun-Seo Kil ,&nbsp;Soosung Kang ,&nbsp;Yun-Sil Lee ,&nbsp;Eun Kyoung Seo","doi":"10.1016/j.phytochem.2026.114805","DOIUrl":"10.1016/j.phytochem.2026.114805","url":null,"abstract":"<div><div>Breast cancer susceptibility gene 1 (BRCA1), a tumor suppressor protein, is closely associated with ovarian and breast cancers. Previously, cathepsin S (CTSS) was reported to prevent BRCA1-mediated apoptosis, contributing to chemoresistance in TNBC. In this study, we screened the CTSS inhibitory activity of 107 pure compounds derived from plant materials and identified 4-hydroxyderricin (<strong>12</strong>) from <em>Angelica keiskei</em> as a potent CTSS inhibitor. Compound <strong>12</strong> increased BRCA1 stability in TNBC cells in a CTSS-dependent manner. In an <em>in vivo</em> TNBC xenograft mouse model, combination treatment with paclitaxel and compound <strong>12</strong> significantly increased BRCA1 stability, reduced the final tumor weight, and decreased the number of Ki-67-positive proliferative cells. Our findings suggest that combination therapy with compound <strong>12</strong> can enhance BRCA1 function and improve chemotherapeutic efficacy. This study highlights CTSS inhibition as a promising therapeutic strategy for TNBC patients with wild-type BRCA1.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"246 ","pages":"Article 114805"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}