Plant protoberberine alkaloids: structural diversity, biosynthesis, synthesis, biological activity, structure-activity relationships and clinical applications of berberine.

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-09-27 DOI:10.1016/j.phytochem.2025.114690

Weiqi Jiang, Wen Zhang, Chenxin Jing, Han Zhou, Zhi-Jun Zhang, Rui Wang, Ying-Qian Liu

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引用次数: 0

Abstract

Protoberberine alkaloids are a class of organic heterocyclic compounds categorized within the isoquinoline alkaloids, exhibiting significant therapeutic potential due to their potent biological activities. With advancements natural product chemistry, synthetic organic chemistry, biochemistry, and molecular biology, novel insights into their biosynthetic pathways, chemical synthesis pathways, mechanisms of action, and clinical applications have been elucidated. A comprehensive understanding of protoberberine alkaloids is instrumental in enhancing their commercial value and utilization of medicinal plant resources. Among these alkaloids, berberine stands out as a well-studied compound with broad-spectrum bioactivities. In this review, we summarized the progress in the study of protoberberine alkaloids, focusing on the recent advances in the biosynthetic pathway, the regulatory mechanism of biosynthesis, chemical synthesis, clinical applications and structure-activity relationship analysis of berberine. It is anticipated that this review will offer valuable insights for researchers in the fields of synthesis, medicinal chemistry, and bactericidal chemistry, who are engaged in exploring the chemistry and biology of protoberberine alkaloids.

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植物原小檗碱生物碱：小檗碱的结构多样性、生物合成、合成、生物活性、构效关系及临床应用。

原小檗碱生物碱是一类有机杂环化合物，属于异喹啉类生物碱，由于其强大的生物活性，显示出巨大的治疗潜力。随着天然产物化学、合成有机化学、生物化学和分子生物学的发展，人们对它们的生物合成途径、化学合成途径、作用机制和临床应用有了新的认识。对原小檗碱生物碱的全面认识有助于提高其商业价值和药用植物资源的利用。在这些生物碱中，小檗碱是一种被广泛研究的具有广谱生物活性的化合物。本文综述了小檗碱类生物碱的研究进展，重点介绍了小檗碱的生物合成途径、生物合成调控机制、化学合成、临床应用和构效关系分析等方面的研究进展。本综述将为合成、药物化学和杀菌化学等领域的研究人员探索原小檗碱生物碱的化学和生物学特性提供有价值的见解。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.