从真菌曲霉中提取的具有除草活性的结构多样的聚酮。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI:10.1016/j.phytochem.2025.114631

Fei Liu, Shanshan Hong, Xiaoxia Gu, Qian Zhang, Qin Li, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu

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引用次数: 0

摘要

从内生真菌aculeatus Aspergillus aculeatus中分离到15个未描述的聚酮化合物acleatides A- o和1个已知化合物xylarinol A。通过光谱数据、电子圆二色性（ECD）计算和比较、Mo2(OAc)4诱导ECD、Rh2(OCOCF3)4诱导ECD以及改进的Mosher法对其结构进行了鉴定。A和B是第一个带有C6侧链的苯并[c]奥西平衍生物，而c - i则具有具有独特C8侧链的苯并呋喃环体系。生物活性方面，马鞭草苷J和K的IC50值分别为3.01±0.40和3.33±0.52 μM，具有显著的除草活性。

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Structurally diverse polyketides with herbicidal activity from the fungus Aspergillus aculeatus.

Fifteen undescribed polyketides aculeatides A-O and one known compound xylarinol A were isolated from the endophytic fungus Aspergillus aculeatus. Their structures were identified by spectroscopic data, electronic circular dichroism (ECD) calculations and comparisons, Mo₂(OAc)₄-induced ECD, Rh₂(OCOCF₃)₄-induced ECD, and the modified Mosher's method. Aculeatides A and B represent the first benzo[c]oxepine derivatives bearing a C6 side chain, while aculeatides C-I possessed a benzofuran ring system featuring a unique C8 side chain. Biologically, aculeatides J and K showed significant herbicidal activities with IC₅₀ values of 3.01 ± 0.40 and 3.33 ± 0.52 μM.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.