Phytochemistry最新文献_第10页

Hyperwilsol A, a highly modified 2-nor-polycyclic polyprenylated acylphloroglucinol possessing an unusual 6/6/5/5 spirotetracyclic skeleton from Hypericum wilsonii Hyperwilsol A是一种高度改性的2-非多环聚丙烯化酰基间苯三酚，具有罕见的6/6/5/5螺四环骨架

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-26 DOI: 10.1016/j.phytochem.2025.114561

Zi-Xuan Wang, Na-Na Chen, Qi-Qi Zhao, Hongbo Wei, Lingli Liu, Xi-Tao Yan

{"title":"Hyperwilsol A, a highly modified 2-nor-polycyclic polyprenylated acylphloroglucinol possessing an unusual 6/6/5/5 spirotetracyclic skeleton from Hypericum wilsonii","authors":"Zi-Xuan Wang, Na-Na Chen, Qi-Qi Zhao, Hongbo Wei, Lingli Liu, Xi-Tao Yan","doi":"10.1016/j.phytochem.2025.114561","DOIUrl":"10.1016/j.phytochem.2025.114561","url":null,"abstract":"<div><div>Hypericum species are rich in polycyclic polyprenylated acylphloroglucinols (PPAPs), a class of structurally complex metabolites with diverse biological activities. A phytochemical investigation of the aerial parts of Hypericum wilsonii led to the discovery of four previously undescribed PPAPs, hyperwilsols A–D (1–4), along with 16 known related compounds (5–20). Notably, hyperwilsol A (1) featured a highly modified 6/6/5/5 tetracyclic system based on a rare spiro[1,2-dioxane-3,11'-[3,12]dioxatricyclo[6.4.0.01,5]dodecane] scaffold. The structures with absolute configurations were established by spectroscopic analysis, computer-assisted structure elucidation method, single-crystal X-ray diffraction, and NMR and ECD calculations. Additionally, all isolates were evaluated for their anti-neuroinflammatory and neuroprotective effects. Hyperuralone A (16) and yezo'otogirin A (17) exhibited inhibition of lipopolysaccharide-induced nitric oxide production in BV-2 cells, with their IC50 values of 7.11 ± 0.50 and 10.18 ± 1.75 μM, respectively. Hyperwilsols A–C (1–3), hyperscabin K (9), and hypelodin B (10) showed noticeable neuroprotective activity against H2O2-induced PC-12 cell injury. These findings not only enriched the structural diversity of natural PPAPs but also highlighted their potential in the prevention and treatment of neurodegenerative diseases.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"238 ","pages":"Article 114561"},"PeriodicalIF":3.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schincarins G‒R: 3,4-secolanostane triterpenoids from the stems of Schisandra incarnata Schincarins G-R：从五味子茎中提取的3,4-次生烷三萜

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-26 DOI: 10.1016/j.phytochem.2025.114562

Wanpeng Li , Xiaogang Peng , Xianggao Meng , Hengyi Yu , Hanli Ruan

引用次数: 0

Discovery of the rare dimeric guaianes and their monomers from the Daphne penicillata Rehd 青霉属植物中罕见二聚愈创木烷及其单体的发现。

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-26 DOI: 10.1016/j.phytochem.2025.114560

Tian-Ming Lv , Zhi‐Yuan Li , Li-Li Lou , Le Chen , Xiao‐Xiao Huang , Shao‐Jiang Song

引用次数: 0

Assessing heterogeneous pollution risks from polystyrene micro(nano)plastics and cadmium to physiology and biochemistry in parsley via a split-root system 通过分根系统评估聚苯乙烯微（纳米）塑料和镉对欧芹生理生化的异质性污染风险

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-26 DOI: 10.1016/j.phytochem.2025.114565

Ciara Chun Chen, Zehui Huang, Xuesong Zhao, Zhengguo Song, Minling Gao

{"title":"Assessing heterogeneous pollution risks from polystyrene micro(nano)plastics and cadmium to physiology and biochemistry in parsley via a split-root system","authors":"Ciara Chun Chen, Zehui Huang, Xuesong Zhao, Zhengguo Song, Minling Gao","doi":"10.1016/j.phytochem.2025.114565","DOIUrl":"10.1016/j.phytochem.2025.114565","url":null,"abstract":"<div><div>The coexistence of micro(nano)plastics and heavy metals in agricultural ecosystems has garnered significant attention due to their complex threats to crop productivity and food safety. This study investigated the impacts of polystyrene (PS) micro(nano)plastics and cadmium (Cd) on the growth and biochemical characteristics of parsley, utilizing a split-root system to better capture the often-overlooked heterogeneous pollution patterns present in real agricultural environments. Localized responses were assessed through fresh weight and oxidative stress indicators including reactive oxygen species, antioxidant enzymes, and lipid peroxidation in split roots. Systemic responses were evaluated by fresh weight and bioactive substances including flavonoids, polyphenols, ascorbic acid (AsA), and α-pinene in leaves. Results for localized responses demonstrated that the growth inhibition and oxidative damage occurred in split roots under the coupled stresses were primarily driven by Cd. Notably, these effects were confined to the Cd exposure site, leaving the Cd-uncontaminated portion unharmed, highlighting the plant's self-protective mechanism to localize damage under heterogeneous pollution. Observations on systemic responses indicated that the leaf growth was not substantially hindered unless both sides of the split roots were exposed to Cd, which was attributed to the plant defense mechanism primarily activated by Cd and promoted by excessive PS nanoplastics. This mechanism particularly involved the antioxidant properties of non-flavonoid polyphenols, AsA, and α-pinene, exhibiting a multifaceted strategy employed by parsley to cope with complex contaminations. This work enhances our understanding of plant resilience in agricultural settings and offers insights for developing more nuanced agricultural practices.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"238 ","pages":"Article 114565"},"PeriodicalIF":3.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nudifloids O–R, four undescribed diterpenoids from Callicarpa nudiflora with anti-inflammatory activity nudiflids O-R，四种未描述的来自于海葵中具有抗炎活性的二萜类化合物

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-24 DOI: 10.1016/j.phytochem.2025.114563

Si-Qi Chen , Ji-Hui Zhang , Xia Tang , Miao-Yu Lai , Xue-Qing Lv , Zhong-Qiu Liu , Li-Xin Duan , Yuan-Yuan Cheng , Guo-Cai Wang , Peng Wu

{"title":"Nudifloids O–R, four undescribed diterpenoids from Callicarpa nudiflora with anti-inflammatory activity","authors":"Si-Qi Chen , Ji-Hui Zhang , Xia Tang , Miao-Yu Lai , Xue-Qing Lv , Zhong-Qiu Liu , Li-Xin Duan , Yuan-Yuan Cheng , Guo-Cai Wang , Peng Wu","doi":"10.1016/j.phytochem.2025.114563","DOIUrl":"10.1016/j.phytochem.2025.114563","url":null,"abstract":"<div><div>Four undescribed 3,4-seco-labdane diterpenoid derivatives (nudifloids O–R) along with 12 known terpenoids were isolated from the aerial part of Callicarpa nudiflora Hook. et Arn. Nudifloids O and P (compounds 1 and 2) represent the first examples of 3,4-seco-labdane diterpenoid coupled with 2-methylene-3-butenal likely via the Diels–Alder reaction, forming a rare cyclohexene moiety. The structures including absolute configurations were elucidated using comprehensive spectral data, calculated 13C NMR-DP4+ probability analysis, and electronic circular dichroism. Putative biosynthetic pathways for nudifloids O and P were proposed. All isolates were evaluated for their inhibitory activities on NO and IL-1β production in the LPS-stimulated RAW 264.7 macrophage cells. Nudifloids P (compound 2) showed potent inhibitory activities against IL-1β and NO production.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"238 ","pages":"Article 114563"},"PeriodicalIF":3.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astraeusols A-E: lanostane-type triterpenes from the wild edible mushroom Astraeus asiaticus 黄芪醇A-E：野生食用菌亚洲黄芪中的毛甾烷型三萜

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-24 DOI: 10.1016/j.phytochem.2025.114564

Jedsada Maliwong , Nitirat Chimnoi , Natsajee Nualkaew , Somsak Ruchirawat , Tripetch Kanchanapoom

引用次数: 0

Bioactive withanolides from the leaves of Athenaea velutina (Sendtn.) D'Arcy 芦竹叶中具有生物活性的withanolides达奇。

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-23 DOI: 10.1016/j.phytochem.2025.114549

Késya Amanda Dantas Rocha , Edilberto Rocha Silveira , Tércio de Freitas Paulo , Alejandro Pedro Ayala , Bruno Marques Soares , Sarah Sant’Anna Maranhão , Cláudia do Ó Pessoa , Iury Araújo Paz , Maria Lidia Barroso Rodrigues , Nilberto Robson Falcão do Nascimento , Kirley Marques Canuto , Otília Deusdenia Loiola Pessoa

{"title":"Bioactive withanolides from the leaves of Athenaea velutina (Sendtn.) D'Arcy","authors":"Késya Amanda Dantas Rocha , Edilberto Rocha Silveira , Tércio de Freitas Paulo , Alejandro Pedro Ayala , Bruno Marques Soares , Sarah Sant’Anna Maranhão , Cláudia do Ó Pessoa , Iury Araújo Paz , Maria Lidia Barroso Rodrigues , Nilberto Robson Falcão do Nascimento , Kirley Marques Canuto , Otília Deusdenia Loiola Pessoa","doi":"10.1016/j.phytochem.2025.114549","DOIUrl":"10.1016/j.phytochem.2025.114549","url":null,"abstract":"<div><div>Withanolides are a substantial bio-diverse group of naturally occurring steroidal lactones. Herein, ten still undescribed withanolides (1–10), along with the knowns withaferin A (11), 2,3-dihidrowithaferin A (12), and two other non-withanolides, vomifoliol (13) and the N-trans-p-coumaroyltyramine (14), were isolated from the hexane/EtOAc 1:1 leaf extract of Athenaea velutina (Sendtn.) D'Arcy (Solanaceae). The structures of the undescribed withanolides were elucidated by an extensive analysis of their spectroscopic data: 1D and 2D NMR, HRESIMS, single-crystal X-ray diffraction, and ECD calculations. The antiproliferative properties of the withanolides were evaluated against the human cancer cell lines: central nervous system (SNB-19), prostate (PC-3), colon (HCT-116), and leukemia (HL-60), and a murine fibroblast-like cell (L-929). Withanolides 15–17, isolated from the same plant in a previous work, were included for the pharmacological tests. Compounds 15 and 16 exhibited cytotoxic activity for all cancer cells, while 2 was selectively more cytotoxic to HL-60 cells. In addition, the withanolides were evaluated in guinea pig cardiac tissues. Compounds 15 and 16 showed cardiotonic activity, devoid of a positive chronotropic effect which is a good pharmacological profile for an inotrope agent.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"238 ","pages":"Article 114549"},"PeriodicalIF":3.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UV-guided separation of polyacetylenol glycosides from the edible roots of Codonopsis pilosula and their anti-inflammatory activity 紫外引导下党参食用根中聚乙酰醇苷的分离及其抗炎活性研究

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-22 DOI: 10.1016/j.phytochem.2025.114554

Xilan Jiang , Lun Wang , Yao Chen , Yi Zuo , Mengdan Liu , Bin Chen , Dong Fu , Yujiao He , Mingkui Wang , Ting Shen , Fu Li

{"title":"UV-guided separation of polyacetylenol glycosides from the edible roots of Codonopsis pilosula and their anti-inflammatory activity","authors":"Xilan Jiang , Lun Wang , Yao Chen , Yi Zuo , Mengdan Liu , Bin Chen , Dong Fu , Yujiao He , Mingkui Wang , Ting Shen , Fu Li","doi":"10.1016/j.phytochem.2025.114554","DOIUrl":"10.1016/j.phytochem.2025.114554","url":null,"abstract":"<div><div>The UV-guided separation of polyacetylenes from the edible roots of Codonopsis pilosula resulted in the elucidation of nine previously undescribed C14-polyacetylenol glycosides, named codonopilodiynosides II-VIII (1−7) and codonopiloenynenosides C and D (8 and 9), along with sixteen known analogues (10−25). The structures of the undescribed polyacetylenes were elucidated by spectroscopic data including UV, IR, HRESIMS, NMR, modified Mosher's analysis and Mo2(OAc)4-induced ECD experiments. The inhibitory effects of the isolated compounds on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells were tested. Compounds 1, 11 and 25 exhibited better in vitro anti-inflammatory activity with IC50 values ranging from 35.49 ± 0.09 to 51.85 ± 0.11 μM than dexamethasone with IC50 value of 80.22 ± 0.24 μM. Besides, compounds 1, 11 and 25 decreased the levels of TNF-α and IL-6 in a dose-dependent manner. The results indicated the roots of C. pilosula might be developed into drugs for treating inflammation related diseases.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"238 ","pages":"Article 114554"},"PeriodicalIF":3.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guidelines and practical considerations for liquid or gas chromatography tandem mass spectrometry-based studies in Phytochemistry Ecological Biochemistry and Chemistry article types 植物化学、生态生物化学和化学文章类型中基于液相或气相色谱串联质谱的研究的指南和实际考虑。

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-22 DOI: 10.1016/j.phytochem.2025.114553

Caitlin C. Rering, Geoffrey T. Broadhead, John J. Beck

{"title":"Guidelines and practical considerations for liquid or gas chromatography tandem mass spectrometry-based studies in Phytochemistry Ecological Biochemistry and Chemistry article types","authors":"Caitlin C. Rering, Geoffrey T. Broadhead, John J. Beck","doi":"10.1016/j.phytochem.2025.114553","DOIUrl":"10.1016/j.phytochem.2025.114553","url":null,"abstract":"<div><div>Plants are foundational to all life on earth. As such, they and their metabolites are central to research spanning many disciplines and interests. Phytochemistry is dedicated to exploring the stunning array of plant metabolites and their impacts on other organisms. The Phytochemistry article type Ecological Biochemistry and Chemistry welcomes research articles reporting results of plant-based chemical ecology studies that explore chemically mediated interactions between plants, the environment, microbes, and/or insects. This may include studies involving plant adaptation to biotic and abiotic stressors via defense metabolites, attraction or facilitation of mutualists with rewards, and chemical communication between organisms. In this Editorial Comment we provide guidelines for future Ecological Biochemistry and Chemistry-article type authors, with particular focus on gas and liquid chromatography with mass spectrometry detection, to ensure Phytochemistry articles remain reproducible, of high-quality, and highly cited. Our commentary covers the entire analytical workflow, including experimental design, sample collection and extraction, instrumental methods, chemical data analysis, statistical analyses, and reporting.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"238 ","pages":"Article 114553"},"PeriodicalIF":3.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspidosperma-type bisindole alkaloids from Melodinus suaveolens and their antiproliferative activities 甜麦冬中spispiertype双吲哚类生物碱及其抗增殖活性

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-05-22 DOI: 10.1016/j.phytochem.2025.114556

Jing Wu , Wei Wu , Mei-Feng Bao, Yang Yu, Xiang-Hai Cai

引用次数: 0