Phytochemistry最新文献_第9页

Diterpenoids from the brown alga Dictyota dichotoma with nematicidal activity against the plant parasitic nematode Aphelenchoides besseyi 褐藻Dictyota dichotoma二萜对植物寄生线虫的杀线虫活性研究。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-09-27 DOI: 10.1016/j.phytochem.2025.114691

Manami Iida , Tatsuo Nehira , Aki Kato , Shigeru Hoshino , Hisashi Ômura , Shinji Ohta

引用次数: 0

Cytotoxic tetralone homology dimers from mangrove-associated fungus Cytospora heveae NSHSJ-2 红树林相关真菌Cytospora heveae NSHSJ-2的细胞毒性四酮同源二聚体。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-10-13 DOI: 10.1016/j.phytochem.2025.114704

Yufeng Liu , Tao Chen , Ge Zou , Guang Shao , Guangying Chen , Zhigang She

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Wine-red lignin revisited, dirigent proteins, and native lignin macromolecular configuration 酒红木质素重访，直接蛋白，和天然木质素大分子结构。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-09-20 DOI: 10.1016/j.phytochem.2025.114683

Dhrubojyoti D. Laskar , Michaël Jourdes , Gregory L. Helms , Qingyan Meng , Nancy A. Somerville , John R. Cort , Laurence B. Davin , Norman G. Lewis

{"title":"Wine-red lignin revisited, dirigent proteins, and native lignin macromolecular configuration","authors":"Dhrubojyoti D. Laskar , Michaël Jourdes , Gregory L. Helms , Qingyan Meng , Nancy A. Somerville , John R. Cort , Laurence B. Davin , Norman G. Lewis","doi":"10.1016/j.phytochem.2025.114683","DOIUrl":"10.1016/j.phytochem.2025.114683","url":null,"abstract":"<div><div>The wine-red coloration of xylem in antisense cinnamyl alcohol dehydrogenase (CAD) down-regulated tobacco (Nicotiana tabacum) has long been reported as due to wine-red colored lignin. To investigate validity of the wine-red lignin report, both wild type (WT) and anti-sense CAD down-regulated tobacco stem xylem tissues were examined, with the red pigment found to be facilely removed by treatment with an 0.5 % HCl in MeOH solution at 4 °C. The red pigment in the xylem tissues was rapidly reconstituted in both pre-treated antisense CAD and WT xylem tissues by incubation with sinapyl aldehyde in MeOH solution, and then facilely removed by subsequent 0.5 % HCl in MeOH treatment. Only sinapyl aldehyde was demonstrated as contributing to the red pigmentation, this being consistent with its anionic quinone methide canonical form. No evidence was obtained for a wine-red lignin. Additionally, lignin-derived isolates from both antisense CAD and WT lines essentially differed only in presence of small amounts (ca. 1.41 %) of 8–O–4′ linked sinapyl aldehyde end groups and a slightly smaller molecular weight distribution (MWD) of the lignin from the antisense CAD line. No evidence was obtained that poly-hydroxycinnamyl aldehydes contributed to bulk lignification; the slightly lower MWD may result from hydroxycinnamyl aldehydes functioning as terminators of polymerization during lignification. More importantly, these findings are placed in context of what is now known about 1) lignin macromolecular assembly proper in planta, 2) dirigent protein functions, 3D structures, and active sites as entry points to distinct plant phenol metabolic classes, including lignins, 3) AlphaFold2 modeling of Dir-e subfamily proteins involved in lignification, and 4) what urgently remains to be done in the study of lignification.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114683"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Challenges in chiral discrimination at the H-2 and H-10 positions of dihydrobenzofuran from Artemisia capillaris 毛蒿二氢苯并呋喃H-2和H-10位点手性判别的挑战。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-10-23 DOI: 10.1016/j.phytochem.2025.114711

Junping Chen , Maoni Ren , Liangyu Huang , Yuxia Lou , Xinyao Hou , Yuge Zhang , Guozheng Huang , Jianguo Cao

{"title":"Challenges in chiral discrimination at the H-2 and H-10 positions of dihydrobenzofuran from Artemisia capillaris","authors":"Junping Chen , Maoni Ren , Liangyu Huang , Yuxia Lou , Xinyao Hou , Yuge Zhang , Guozheng Huang , Jianguo Cao","doi":"10.1016/j.phytochem.2025.114711","DOIUrl":"10.1016/j.phytochem.2025.114711","url":null,"abstract":"<div><div>A phytochemical investigation into the low-polarity fraction of Artemisia capillaris facilitated the isolation of twenty-two natural compounds. These compounds, termed Artemicapillasin O-X (1a/1b-4a/4b, 5a, 6a/6b-8a/8b, 9a, 10b, 11b, 12a, and 12b), were identified as previously undescribed 2,3-dihydrobenzofuran (2,3-DHB) derivatives. Their structures were elucidated using NMR analysis, which included coupling constant analysis, chiroptical characterization (electronic circular dichroism [ECD] and optical rotatory dispersion [ORD]), computational approaches (DP4+ probability analysis and dJ/iJ-DP4 protocol), and X-ray diffraction. Subsequent analyses identified that for 2,3-DHB derivatives featuring only two chiral centers at C-2 and C-10, the determination of absolute configuration relies on coupling constants, Cotton effects in CD spectra, and ORD measurements. A novel rule, termed Chen's Rule, was established to facilitate rapid discrimination of stereochemical relationships between H-2 and H-10 in 2,3-DHB derivatives. This rule prompted structural revisions of similar compounds reported in the prior literature. Furthermore, all compounds were assayed at a concentration of 100 μM for their inhibitory activity against xanthine oxidase (XOD) in vitro, where compounds 7a and 7b displayed moderate effects, whereas the others demonstrated negligible activity.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114711"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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More than just flavour and fragrance – the chemistry and pharmacological potential of anethole 不仅仅是味道和香味-茴香脑的化学和药理潜力。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-10-15 DOI: 10.1016/j.phytochem.2025.114708

Ruchi Badoni Semwal , Deepak Kumar Semwal , Ankit Kumar , Maxleene Sandasi , Alvaro Viljoen

{"title":"More than just flavour and fragrance – the chemistry and pharmacological potential of anethole","authors":"Ruchi Badoni Semwal , Deepak Kumar Semwal , Ankit Kumar , Maxleene Sandasi , Alvaro Viljoen","doi":"10.1016/j.phytochem.2025.114708","DOIUrl":"10.1016/j.phytochem.2025.114708","url":null,"abstract":"<div><div>Anethole, a naturally-occurring aromatic phenylpropene compound, is commonly present in the essential oils derived from botanically diverse plants, including anise, star anise, fennel and basil. It is highly regarded for its therapeutic properties, imparting various health benefits spanning many different conditions. This comprehensive and critical review unites the knowledge on anethole up to the year 2024, available from the scientific platforms Scopus, PubMed and Web of Science, retrieved using the search term “Anethole\". A bibliometrics overview is also provided which outlines the trend in the publication output over time, the major contributing authors, collaborative networks and popular research topics on this molecule. The collected data suggests that, in addition to its significance in the flavour and fragrance sectors, anethole exhibits a host of diverse medicinal activities. In-depth research highlights its contributing potential in addressing cancer, infections, wounds, and conditions related to the liver, lungs and skin. However, the research on anethole lacks comprehensive investigations into its mechanisms of action and synergistic effects with other compounds, hindering the understanding of its full therapeutic potential. While it holds promise beyond culinary uses, further research is needed to address this knowledge void and develop targeted therapeutic interventions.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114708"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant protoberberine alkaloids: structural diversity, biosynthesis, synthesis, biological activity, structure-activity relationships and clinical applications of berberine 植物原小檗碱生物碱：小檗碱的结构多样性、生物合成、合成、生物活性、构效关系及临床应用。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-09-27 DOI: 10.1016/j.phytochem.2025.114690

Weiqi Jiang , Wen Zhang , Chenxin Jing , Han Zhou , Zhi-Jun Zhang , Rui Wang , Ying-Qian Liu

{"title":"Plant protoberberine alkaloids: structural diversity, biosynthesis, synthesis, biological activity, structure-activity relationships and clinical applications of berberine","authors":"Weiqi Jiang , Wen Zhang , Chenxin Jing , Han Zhou , Zhi-Jun Zhang , Rui Wang , Ying-Qian Liu","doi":"10.1016/j.phytochem.2025.114690","DOIUrl":"10.1016/j.phytochem.2025.114690","url":null,"abstract":"<div><div>Protoberberine alkaloids are a class of organic heterocyclic compounds categorized within the isoquinoline alkaloids, exhibiting significant therapeutic potential due to their potent biological activities. With advancements natural product chemistry, synthetic organic chemistry, biochemistry, and molecular biology, novel insights into their biosynthetic pathways, chemical synthesis pathways, mechanisms of action, and clinical applications have been elucidated. A comprehensive understanding of protoberberine alkaloids is instrumental in enhancing their commercial value and utilization of medicinal plant resources. Among these alkaloids, berberine stands out as a well-studied compound with broad-spectrum bioactivities. In this review, we summarized the progress in the study of protoberberine alkaloids, focusing on the recent advances in the biosynthetic pathway, the regulatory mechanism of biosynthesis, chemical synthesis, clinical applications and structure-activity relationship analysis of berberine. It is anticipated that this review will offer valuable insights for researchers in the fields of synthesis, medicinal chemistry, and bactericidal chemistry, who are engaged in exploring the chemistry and biology of protoberberine alkaloids.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114690"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory metabolites from the leaves of Ohwia caudata 大藤叶的抗炎代谢物。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-10-14 DOI: 10.1016/j.phytochem.2025.114707

Qianqian Zhang , Ping Zhang , Yijin Wu , Huimin Li , Jingya Ruan , Jiaming Cheng , Yi Zhang , Tao Wang

{"title":"Anti-inflammatory metabolites from the leaves of Ohwia caudata","authors":"Qianqian Zhang , Ping Zhang , Yijin Wu , Huimin Li , Jingya Ruan , Jiaming Cheng , Yi Zhang , Tao Wang","doi":"10.1016/j.phytochem.2025.114707","DOIUrl":"10.1016/j.phytochem.2025.114707","url":null,"abstract":"<div><div>Ohwia caudata, a significant traditional Chinese medicine, exhibits anti-inflammatory properties and is clinically used to treat dysentery, gastroenteritis, and other inflammatory conditions. However, the bioactive constituents responsible for its anti-inflammatory activity remain poorly understood. In the study, a phytochemical investigation of O. caudata leaves led to the isolation and structural elucidation of twenty-one previously undescribed compounds, including ohcanosides A–T (1–20) and (1R)-1,2,3,4-tetrahydro-7,8-dihydroxy-1-isoquinolinecarboxylic acid (21), along with three known isolates (22–24). All the known compounds were reported from the Ohwia genus for the first time. To assess the anti-inflammatory potential of these isolates, a LPS-stimulated RAW264.7 macrophage model was employed. The results demonstrated that compounds 3, 7–10, 14, 15, 17, 19, 20, and 22–24 significantly inhibited nitric oxide (NO) production in a concentration-dependent manner (3, 10, and 30 μM). Molecular docking studies further revealed strong binding affinities between compounds 9, 10, 14, and 17 and phosphatidylinositol 3-kinase (PI3K), with binding energy values below −5 kcal/mol, suggesting stable receptor-ligand interactions. Additionally, Western blot analysis confirmed that these compounds exert their anti-inflammatory effects by downregulating key proteins (PI3K, Akt, and p-Akt) in the PI3K/Akt signaling pathway. These findings provide valuable insights into the anti-inflammatory mechanisms of O. caudata and highlight its potential as a source of novel anti-inflammatory agents.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114707"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Phlecarinatones H–O: Abietane-type diterpenoids from Phlegmariurus carinatus with proliferative inhibitory effect on glioma’ [Phytochemistry 232 (2025) 114356/PHYTO_114356] “Phlecarinatones H-O：从Phlegmariurus carinatus中提取的abietane型二萜类化合物对胶质瘤的增殖抑制作用”的更正[植物化学232 (2025)114356/PHYTO_114356]。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-11-17 DOI: 10.1016/j.phytochem.2025.114718

Hua Wang , Qiang Wang , Yong-Hong Chen , Xi Chen , Dong-Kun Zheng , Zhen Xie , Du-Min Feng , Lin Liu , Jing Li , Yang Liu

引用次数: 0

An unprecedented alternariol-zinnol hybrid and six undescribed zinnol derivatives from the phytopathogen Alternaria solani and their cytotoxic activities 报道了一种史无前例的异交霉烯-紫霉烯杂交种和6种未被描述的植物病原菌稻霉烯衍生物及其细胞毒活性。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-10-26 DOI: 10.1016/j.phytochem.2025.114713

Ming Hu , Run-Cheng Yan , Qiao-Ling Wei, Jiang-Li Su, Bi-Juan Yang, Wen-Chao Tu, Gan-Peng Li, Xing-De Wu

{"title":"An unprecedented alternariol-zinnol hybrid and six undescribed zinnol derivatives from the phytopathogen Alternaria solani and their cytotoxic activities","authors":"Ming Hu , Run-Cheng Yan , Qiao-Ling Wei, Jiang-Li Su, Bi-Juan Yang, Wen-Chao Tu, Gan-Peng Li, Xing-De Wu","doi":"10.1016/j.phytochem.2025.114713","DOIUrl":"10.1016/j.phytochem.2025.114713","url":null,"abstract":"<div><div>Chemical investigation of the plant pathogen Alternaria solani, associated with Hypoestes phyllostachya, led to the isolation of alternsolain A (1), an unprecedented alternariol-zinnol hybrid, and alternsolains B-G (2–7), six previously undescribed zinnol derivatives containing two pairs of enantiomers, (±)-alternsolains E (5) and F (6), along with five known compounds (8–12). Their structures were elucidated using comprehensive spectral analysis, single-crystal X-ray diffraction, NMR computational techniques, and electronic circular dichroism calculations. Compound 1 possessed a previously unreported carbon skeleton formed through the linkage of alternariol and zinnol via C-8-C-4′ bond. Compound 2 featured a rare dimeric skeleton composed of two zinnol units connected by an ether bond. Plausible biosynthetic pathways for 1 and 2 were also postulated. Additionally, compound 9 showed potent cytotoxic activities against HL-60, MDA-MB-231, and SW480 human cancer cell lines, with IC50 values of 10.73 ± 0.08, 19.40 ± 0.97, and 29.72 ± 1.61 μM, respectively. These results enrich the diversity of zinnols and may provide active compounds for the development of new anticancer drugs.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114713"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145392166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Suspensaditerpenes A–Q, anti-inflammatory labdane and nor-labdane diterpenoids from the seeds of Forsythia suspensa 连翘种子中悬浮液萜类A-Q、抗炎液丹和非悬浮液丹二萜类。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-02-01 Epub Date: 2025-09-26 DOI: 10.1016/j.phytochem.2025.114688

Hui-Ying Li , Meng-Yu Bao , Hao-Ming Xiong , Can-Can Wang , Li-Ping Bai , Wei Zhang , Cheng-Yu Chen , Zhi-Hong Jiang , Guo-Yuan Zhu

{"title":"Suspensaditerpenes A–Q, anti-inflammatory labdane and nor-labdane diterpenoids from the seeds of Forsythia suspensa","authors":"Hui-Ying Li , Meng-Yu Bao , Hao-Ming Xiong , Can-Can Wang , Li-Ping Bai , Wei Zhang , Cheng-Yu Chen , Zhi-Hong Jiang , Guo-Yuan Zhu","doi":"10.1016/j.phytochem.2025.114688","DOIUrl":"10.1016/j.phytochem.2025.114688","url":null,"abstract":"<div><div>Phytochemical investigation of the seeds of Forsythia suspensa resulted in the isolation and characterization of 17 undescribed labdane and nor-labdane diterpenoids, named suspensaditerpenes A−Q (1−17), along with 13 known ones (18−30). Their structures were elucidated by a combination of NMR, HR-MS, and X-ray diffraction analyses. Structurally, 5, 10, and 13 are labdane diterpenoids featuring a lactone ring at the side chain, marking their first description in F. suspensa. Compounds 4, 14, 15, and 25 are 14,15-dinor-diterpenoids, among which 14 and 15 have a rare 6/6/5 ring skeleton. Furthermore, all known compounds were isolated from F. suspensa for the first time. The in vitro anti-inflammatory activities assay showed that 5, 8, 13, and 14 significantly inhibited the LPS-induced NO production at 20 μM in LPS-induced RAW264.7 cells, while the remaining 24 compounds demonstrated slight NO inhibitory activity. Further studies showed that 5 suppressed the LPS-induced expression of iNOS, p-p65, and NLRP3 proteins as well as NF-κB nuclear translocation in RAW264.7 cells.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"242 ","pages":"Article 114688"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0