Schincarins G-R：从五味子茎中提取的3,4-次生烷三萜

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-05-26 DOI:10.1016/j.phytochem.2025.114562

Wanpeng Li , Xiaogang Peng , Xianggao Meng , Hengyi Yu , Hanli Ruan

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引用次数: 0

摘要

从五味子（Schisandra incarnata）茎的甲醇提取物中获得了12个先前描述过的3,4-二烷三萜，schincarins G-R（1-12）。通过光谱分析和单晶x射线衍射确定了它们的结构和绝对构型。Schincarins G和H代表了具有5/6/5三环碳融合骨架的3,4-二烷型三萜的第一个例子。Schincarins M和Q对cona诱导的T细胞增殖具有中等抑制作用，IC50分别为20.5和20.0 μM，对lps诱导的B细胞增殖具有中等抑制作用，IC50分别为15.0和22.2 μM。Schincarin L对lps诱导的B细胞增殖具有选择性抑制作用，IC50值为24.1 μM。

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Schincarins G‒R: 3,4-secolanostane triterpenoids from the stems of Schisandra incarnata

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Schincarins G‒R: 3,4-secolanostane triterpenoids from the stems of Schisandra incarnata

Twelve previously undescribed 3,4-secolanostane triterpenoids, schincarins G‒R (1–12), were obtained from the methanol extract of the stems of Schisandra incarnata. Their structures and absolute configurations were determined based on spectroscopic analysis and single-crystal X-ray diffraction. Schincarins G and H represent the first examples of 3,4-secolanostane-type triterpenoids featuring a tricyclic 5/6/5 fused carbon skeleton. Schincarins M and Q exhibit moderate inhibition against ConA-induced T cell proliferation with IC₅₀ values of 20.5 and 20.0 μM, respectively, and against LPS-induced B cell proliferation with IC₅₀ values of 15.0 and 22.2 μM, respectively. Schincarin L demonstrates selective inhibition against LPS-induced B cell proliferation with IC₅₀ value of 24.1 μM.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.