Astraeusols A-E: lanostane-type triterpenes from the wild edible mushroom Astraeus asiaticus

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-05-24 DOI:10.1016/j.phytochem.2025.114564

Jedsada Maliwong , Nitirat Chimnoi , Natsajee Nualkaew , Somsak Ruchirawat , Tripetch Kanchanapoom

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Abstract

Five previously undescribed lanostane-type triterpenes, astraeusols A-E (1–5), along with astraeusin M (6), astrasiate (7), astraeusin A (8), artabotryol A (9), artabotryol B (10), artabotryol C2 (11), cerevisterol (12), 6-epi-cerevisterol (13), and linoleic acid (14), were isolated from the fruiting bodies of the Thai wild edible mushroom Astraeus asiaticus. Astraeusols D (4) and E (5) were identified as lanostane triterpenes linked to phenylethylamine through amide linkages for the first time from a natural source. The configuration at C-25 of the original structure of artabotryol C2 (11) was revised from 25R to 25S. The structural determinations were based on physical data and spectroscopic evidence, including 1D and 2D NMR analyses.

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黄芪醇A-E：野生食用菌亚洲黄芪中的毛甾烷型三萜

从泰国野生食食菌asstraeus asiaticus的子实体中分离出5种先前未被描述的羊甾烷型三萜，黄芪醇A- e(1-5)，以及黄芪醇M(6)、黄芪酸(7)、黄芪醇A(8)、黄芪醇A(9)、黄芪醇B（10）、黄芪醇C2（11）、酒甾醇（12）、6-表酒甾醇（13）和亚油酸（14）。黄芪醇D(4)和E(5)首次从天然来源中鉴定为通过酰胺键与苯乙胺连接的羊甾烷三萜。artabtryol C2（11）原结构在C-25处的构型由25R修改为25S。结构确定是基于物理数据和光谱证据，包括1D和2D核磁共振分析。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.