PharmaNutrition最新文献

{"title":"The gut brain axis, effect of dietary changes and probiotics supplement on depression symptoms","authors":"Salma Hosny Abd-allah Mohamed,&nbsp;Ghada Mahmoud Khafagy,&nbsp;Inas El Sayed,&nbsp;Hala Ahmed Hussein","doi":"10.1016/j.phanu.2024.100424","DOIUrl":"10.1016/j.phanu.2024.100424","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression is a prevalent mental condition that adversely affects the lives of millions globally. Research has examined the correlation between alterations in gut microbiota composition and depression, leading to increasing interest in the possible use of probiotics to restore gut microbiota balance and enhance mental health outcomes.</div></div><div><h3>Aim</h3><div>Our aim is to examine the impact of probiotic supplementation on depression in healthy people. By assessing the impact of non-pharmacological therapies aimed at the gut-brain axis, we aspire to contribute to the advancement of accessible and efficacious treatments for depression.</div></div><div><h3>Methods</h3><div>We assessed socioeconomic status and depression score at baseline in a randomized controlled experiment of healthy people. We then randomly allocated individuals to the intervention group, which got probiotic supplements and health information regarding probiotic-rich diets, or the control group, which received their regular diet. At the end of 12 weeks, we repeated the same measurements.</div></div><div><h3>Results</h3><div>The study indicated a notable enhancement in depression levels within the intervention group. The median depression score declined from 8 (IQR: 6–9) prior to the intervention to 3 (IQR: 3–5) following the intervention, indicating a 62.5 % enhancement. The control group had a marginal deterioration in depression ratings within the same timeframe, with the median score rising from 8 (IQR: 6–9) to 8.5 (IQR: 7–10), indicating a 6.25 % drop.</div></div><div><h3>Conclusions</h3><div>Probiotics exert a beneficial influence on both the occurrence and intensity of depression symptoms in healthy people, greatly alleviating these symptoms.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"30 ","pages":"Article 100424"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of liraglutide on C-reactive protein (CRP) in adults with type 2 diabetes: A GRADE-assessed systematic review and dose-response meta-analysis of controlled trials","authors":"Nazanin Mozaffari ,&nbsp;Mohammad Vesal Bideshki ,&nbsp;Mohsen Mohammadi Sartang ,&nbsp;Mehrdad Behzadi","doi":"10.1016/j.phanu.2024.100409","DOIUrl":"10.1016/j.phanu.2024.100409","url":null,"abstract":"<div><h3>Background</h3><p>Liraglutide (LRG) is an analog of glucagon-like-peptide-1 which has beneficial effects on controlling glycemic in diabetes patients. However, the effect of liraglutide on the C-reactive protein (CRP) was controversial in different studies. So, this study aimed to investigate the effect of LRG on CRP in adults with type 2 diabetes (T2DM).</p></div><div><h3>Methods</h3><p>Through March 2024, Web of Science, PubMed, and Scopus electronic databases were searched for pertinent studies. Calculation of 95 % confidence intervals (CIs) and mean differences was done using random effects model. Standard methods assessed dose-response, meta-regression, sensitivity, and publication bias. GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to calculate evidence certainty.</p></div><div><h3>Results</h3><p>Finally, after reviewing 9 eligible studies with 10 arms including 1494 participants, a significant decrease in CRP levels was observed after treatment with LRG (WMD = −0.692 mg/L, 95 % CI: −1.01, −0.37, P&lt;0.001). According to the results of the subgroup, LRG had greater effects in obese patients (Body mass index ≥30), high-quality studies, dosages &gt;1.6 mg/d and durations ≥24 weeks. Linear (P&lt;0.001) and non-linear (P _{dose-response} =0.009) dose-response associations were observed between LRG dosages and CRP levels. According to the GRADE, evidence for CRP was high.</p></div><div><h3>Conclusions</h3><p>LRG had beneficial effects on CRP levels in adults with T2DM, especially in obese patients.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"30 ","pages":"Article 100409"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietitians’ knowledge and practice regarding inflammaging and related interventions: A pilot survey","authors":"Cato Wiegers,&nbsp;Sofia el Sarraf,&nbsp;Olaf F.A. Larsen","doi":"10.1016/j.phanu.2024.100420","DOIUrl":"10.1016/j.phanu.2024.100420","url":null,"abstract":"<div><h3>Background</h3><div>The global population is aging rapidly, which is associated with an increase in chronic diseases. One of the possible underlying causes of these chronic diseases is inflammaging, characterised by the general low-grade inflammation that occurs in the body as we age. However, it is unclear to what extent this concept is already being considered as a base for prevention or therapy.</div></div><div><h3>Methods</h3><div>In this study, the willingness of practicing dietitians in the Netherlands to apply interventions targeting inflammaging was evaluated. Beforehand, a literature study was executed to identify possible parameters for intervention, covering most nutritional, biological, and medical aspects related to inflammaging. Based on the findings of the literature study, dietitians were asked about their awareness of the concept, the willingness to adopt more knowledge, and practical approaches regarding their clients.</div></div><div><h3>Results</h3><div>It was found that of the 56 surveyed dietitians, approximately two-third were already aware of the concept, and among this group, another two-third indicated that inflammaging plays a role in their provision of dietary advice. Generally, the information provided by the dietitians was in line with what was identified in literature.</div></div><div><h3>Conclusions</h3><div>As a first pilot, it appears that dietitians recognise the impact of nutrition and lifestyle factors on the progression of inflammaging. The willingness to adopt evidence-based practices signifies the importance of continued education and professional development in this area. Eventually, focusing on inflammaging in policy making could be a supporting factor for healthcare systems in the shift from curative to preventive care.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"30 ","pages":"Article 100420"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced absorption of omega-3 fatty acids from a novel krill oil-derived phospholipid formulation compared to fish oil ethyl esters: A randomized, two-way crossover pharmacokinetic study","authors":"Christiane Schoen ,&nbsp;Line Johnsen ,&nbsp;Antje Micka ,&nbsp;Manfred Wilhelm ,&nbsp;Yunpeng Ding","doi":"10.1016/j.phanu.2024.100417","DOIUrl":"10.1016/j.phanu.2024.100417","url":null,"abstract":"<div><h3>Background</h3><div>Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) offer many health benefits, yet the absorption from standard ethyl ester (EE) formulation requires concurrent intake of a fatty meal. This study aimed to evaluate the absorption of EPA and DHA from a novel omega-3 formulation, Phospholipids + EPA/DHA (PL+), which combines high phospholipdi krill oil (KO) and EE, in comparison to a standard EE product under a low-fat dietary condition in healthy adults.</div></div><div><h3>Methods</h3><div>In this randomized, cross-over, single-dose study, the pharmacokinetic profiles of EPA and DHA from PL+ and EE product was assessed. Each products contained approximately 1200 mg EPA+DHA. Participants consumed a single dose of the capsules under a low-fat diet regimen, with plasma samples collected at baseline and over a 72-hour period after dosing. Following a 14-day washout period, participants crossed over to the alternate treatment. Plasma concentrations of EPA, DHA, and combined EPA+DHA were analyzed.</div></div><div><h3>Results</h3><div>Twelve participants (six women and six men) were included, completed all study visits and were included in the analyses. The participants' mean age was 34.3 years (SD = 12.4), and the mean BMI was 22.6 kg/m² (SD = 3.2). The baseline-corrected incremental area under the curve (iAUC_0–12h) for combined EPA+DHA was significantly higher for PL+ (255.5 [SD = 81.4] μg/mL*h) compared to EE (34.2 [SD = 33.4] μg/mL*h; P &lt; 0.001). The treatment ratio of iAUC_0–12h for PL+ relative to EE was 10.5 (95 % CI: 6.1 – 18.1; P &lt; 0.001). Similar patterns were observed for iAUC_0–24h and iAUC_0–72h for combined EPA+DHA, as well as for EPA and DHA individually. Sensitivity analyses by adjusting the minimal difference on dose between products yielded consistent findings.</div></div><div><h3>Conclusions</h3><div>The results indicate that PL+ technology significantly enhances the absorption of EPA and DHA compared to standard EE alone in a low-fat dietary condition. These outcomes suggest that the absorption of EE formulations can be significantly improved through combination with high phospholipid krill oil, as evidenced by the performance of the PL+ formulation.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"30 ","pages":"Article 100417"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can L-Methionine and S-Adenosyl-L-Methionine Effectively Mitigate Scopolamine-Induced Cognitive and Motor Deficits in Mice?","authors":"Mohammadjaavad Aghababaei ,&nbsp;Mahdi Mashhadi Akbar Boojar ,&nbsp;Mehdi Saberi","doi":"10.1016/j.phanu.2024.100415","DOIUrl":"10.1016/j.phanu.2024.100415","url":null,"abstract":"<div><div>Motor balance deficits often coincide with cognitive deficits in older adults. Current medications provide temporary relief with several potential side effects. Essential amino acids and their derivatives, such as S-Adenosyl-L-Methionine (SAMe), can improve nerve function, mood regulation, and neuroprotection against neurodegenerative diseases. This study investigated the protective effects of SAMe in scopolamine-degraded memory, and motor balance in an animal model.</div><div>To evaluate the possible effects of SAMe on cognitive and motor balance improvement, both Shuttle box and rotarod methods were performed in seven groups of animals (n=7). The mice groups received the saline (control), scopolamine, scopolamine+rivastigmine, scopolamine +methionine, and scopolamine+ three different doses of SAMe daily and separately for two weeks. Data were analyzed independently by one-way ANOVA and P&lt;0.05 was considered significant.</div><div>SAMe 150<!--> <!-->mg/kg worsened scopolamine-induced memory impairment (P&lt;0.001), while methionine (100<!--> <!-->mg/kg) or SAMe (only 100<!--> <!-->mg/kg) together with scopolamine could reduce the duration of the animal's presence in the dark chamber (P&lt;0.05). Daily administration of methionine and SAMe at the rate of 100<!--> <!-->mg/kg daily could significantly improve the decrease in motor balance caused by scopolamine (P&lt;0.05). Rivastigmine improved memory and motor balance impairment caused by scopolamine (P&lt;0.05). No difference between SAMe and L-methionine for memory, and balance.</div><div>The results suggest that while L-methionine and SAMe may not be effective in improving memory impairments (Even SAMe high doses can aggravate the destruction of passive avoidance memory), they may be beneficial in enhancing motor balance.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"30 ","pages":"Article 100415"},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological activities from açaí (Euterpe spp. Mart.) seeds and their pharmacological aspects: A systematic review and meta-analysis","authors":"Kaio Kelvin Barros Dias ,&nbsp;Gabriel Araújo de Jesus ,&nbsp;Ana Alice Farias da Costa ,&nbsp;Fabíola Fernandes Costa ,&nbsp;Geraldo Narciso da Rocha Filho ,&nbsp;Rodrigo Juliano Oliveira ,&nbsp;Renata Coelho Rodrigues Noronha ,&nbsp;Luís Adriano Santos do Nascimento","doi":"10.1016/j.phanu.2024.100405","DOIUrl":"10.1016/j.phanu.2024.100405","url":null,"abstract":"<div><h3>Background</h3><p>Açaí seeds, a by-product of açaí processing (1445 tons year⁻¹), make up 85 % of the fruit's weight and are rich in phenolic compounds, such as phenolic acids, (epi)catechins, and procyanidins. Their chemical profile suggests significant pharmacological potential, leading to growing interest in their therapeutic applications.</p></div><div><h3>Methods</h3><p>A systematic review was conducted following PRISMA guidelines, covering studies from 2006 to 2023.</p></div><div><h3>Results</h3><p>The review included 72 studies, 13 of which were cluster randomized trials in rodents. Açaí seed extract (ASE) displayed a robust phenolic profile with varying polymerization degrees. Preclinical investigations demonstrated ASE's therapeutic efficacy, showing potent antioxidant activities, upregulation of antioxidant enzymes via Nrf2 activation, and selective cytotoxicity against various cancer cell lines. ASE also exhibited efficacy in reducing oxidative stress, inflammatory cytokines, and inhibiting adipogenesis, addressing metabolic syndrome in rodents. Promising effects were observed on hypertension, hyperglycemia, dyslipidemia, and liver diseases, indicating broad health benefits.</p></div><div><h3>Conclusion</h3><p>Despite study heterogeneity, ASE's shows potential as a therapeutic agent., necessitating further clinical investigations to comprehensively evaluate its safety and efficacy in human health.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100405"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synbiotic solution: Evaluating safety and efficacy in antibiotic-associated dysbiosis - A randomized, double-blind, placebo-controlled pre-clinical study with sprague dawley rats","authors":"A.V. Sarangarajan ,&nbsp;Adarsh Jain ,&nbsp;Jenifer L. Ferreir ,&nbsp;Anushree ,&nbsp;Aniket Dhanawat ,&nbsp;Pankita Ahir ,&nbsp;Sanjeev Acharya","doi":"10.1016/j.phanu.2024.100402","DOIUrl":"10.1016/j.phanu.2024.100402","url":null,"abstract":"<div><h3>Background</h3><p>Antibiotic therapy, vital for combating infections, often disrupts the intricate balance of gut bacteria, resulting in \"gut dysbiosis.\" This study aimed to assess the safety and efficacy of a Synbiotic supplement in alleviating antibiotic-associated dysbiosis in Sprague Dawley (SD) rats.</p></div><div><h3>Methods</h3><p>A double-blind, placebo-controlled pre-clinical study was conducted over a minimum of 10 consecutive days. The study employed five distinct groups for evaluation, with a focus on the Synbiotic group comprising probiotic and prebiotic components. The administered dose was 1 billion CFU with 100 mg Fossence®.</p></div><div><h3>Results</h3><p>The Synbiotic supplement demonstrated significant positive outcomes across diverse parameters. Compared to the disease control group, the Synbiotic group displayed enhancements in fecal output ratio, feed conversion ratio, total weight gain, and specific growth ratio. Histopathological data supported these findings, affirming the Synbiotic supplementation's potential in mitigating antibiotics' adverse effects on gut health. No mortalities or major symptoms were recorded, confirming the supplement's safety<strong>.</strong></p></div><div><h3>Conclusions</h3><p>The study underscores the efficacy of Synbiotics in enhancing gastrointestinal health in SD rats. The identified effective dose of 1 billion CFU with 100 mg Fossence® necessitates further clinical investigation. This suggests Synbiotics as a compelling approach to address antibiotic-associated gut dysbiosis, warranting further exploration in humans for potential applications in maintaining a healthy gut and overall well-being.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100402"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6-Hydroxydopamine-induced decrease in dopaminergic neurons is avoided by effusol and dehydroeffusol, unique phenanthrenes of Juncus effusus","authors":"Misa Katahira ,&nbsp;Haruna Tamano ,&nbsp;Toshiyuki Fukuda ,&nbsp;Hiroki Ikeda ,&nbsp;Yasuhito Akagi ,&nbsp;Shinji Ikeura ,&nbsp;Atsushi Takeda","doi":"10.1016/j.phanu.2024.100403","DOIUrl":"10.1016/j.phanu.2024.100403","url":null,"abstract":"<div><h3>Background</h3><p>Excess influx of extracellular Zn²⁺ into nigral dopaminergic neurons play a crucial role for 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease in rats. On the basis of neurodegeneration by Zn²⁺ dysregulation, we aimed to clarify the effect of effusol and dehydroeffusol, unique phenanthrenes from <em>Juncus effusus</em> on dopaminergic degeneration.</p></div><div><h3>Methods</h3><p>The decrease in dopaminergic neurons was assessed by tyrosine hydroxylase immunostaining 14 days after 6-OHDA injection into the substantia nigra pars compacta (SNpc) of rats.</p></div><div><h3>Results</h3><p>The decrease in dopaminergic neurons induced by 6-OHDA was avoided by co-injection of 1<em>-</em>naphthyl acetyl spermine (NASPM), a selective blocker of Zn²⁺-permeable GluR2-lacking AMPA receptors, which blocked the increase in intracellular Zn²⁺, supporting the involvement of Zn²⁺ dysregulation in dopaminergic degeneration. Moreover, either effusol or dehydroeffusol was co-injected with 6-OHDA into the SNpc. The decrease in dopaminergic neurons was avoided by effusol and dehydroeffusol. The increases in intracellular Zn²⁺ and H₂O₂ in the SNpc induced by 6-OHDA were also avoided by effusol and dehydroeffusol.</p></div><div><h3>Conclusions</h3><p>The present study first indicates that effusol and dehydroeffusol avoid the decrease in dopaminergic neurons in the SNpc via reducing production of reactive oxygen species induced by intracellular Zn²⁺ dysregulation after injection of 6-OHDA into the rat SNpc. It is likely that effusol and dehydroeffusol serve as nutraceutical components to protect dopaminergic degeneration, perhaps via regulating presynaptic excitation of glutamatergic neurons in the SNpc.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100403"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The guardians of macular health: Omega 3 fatty acids","authors":"Joseph V. Varre ,&nbsp;Noel Daniel ,&nbsp;Wonjong Ryoo ,&nbsp;Stephan van Vliet","doi":"10.1016/j.phanu.2024.100408","DOIUrl":"10.1016/j.phanu.2024.100408","url":null,"abstract":"","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100408"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective vitamin D supplementation among women with gestational diabetes and perinatal outcomes: Results of a clinical trial","authors":"Nathalia Ferreira Antunes de Almeida ,&nbsp;Claudia Saunders ,&nbsp;Thais Rangel Bousquet Carrilho ,&nbsp;Lenita Zajdenverg ,&nbsp;Cleber Nascimento do Carmo ,&nbsp;Elisabete Caldeiras Queiroz Neves ,&nbsp;Juliana Braga ,&nbsp;Bárbara Folino Nascimento ,&nbsp;Mayara Santos ,&nbsp;Patricia de Carvalho Padilha","doi":"10.1016/j.phanu.2024.100395","DOIUrl":"10.1016/j.phanu.2024.100395","url":null,"abstract":"<div><h3>Background</h3><p>Gestational diabetes mellitus (GDM) is a common clinical condition worldwide that affects the health of women and their offspring. Theaim was to assess whether a protocol of vitamin D supplementation among women with GDM was efficient in increasing vitamin D levels at the end of pregnancy, and to explore whether the supplementation reduced the occurrence of adverse neonatal outcomes among those women.</p></div><div><h3>Methods</h3><p>A controlled clinical trial.Vitamin D was assessed at baseline (&lt; 28 gestational weeks) and after 8 weeks of intervention and categorized as adequate (<u>&gt;</u>30 ng/mL), insufficient (20–29.9 ng/mL), or deficient (&lt;20 ng/mL). Women with insufficiency received 2000 UI daily of vitamin D supplementation and those with deficiency received 7000 UI daily for 8 weeks. The outcomes 25-hydroxyvitamin D [25(OH)D] concentration at 28 weeks, glycemic control, total gestational weight gain, birth weight, and gestational age at birth. Statistical analyses included Chi-squared or Fisher’s exact tests for categorical variables and Kruskall–Wallis test for continuous variables to compare the groups.</p></div><div><h3>Results</h3><p>At baseline, 59 pregnant women with GDM allocated to the study group were evaluated at baseline.Vitamin D status changed between the first and second examinations in 70 % of the women investigated. The insufficient and deficient groups showed a tendency towards improvement in glycemic control (p = 0.096). No differences were identified between the groups in terms of the neonatal variables.</p></div><div><h3>Conclusion</h3><p>Supplementation was effective in adjusting serum vitamin D levels, and its effect on glycemic control appeared promising in this preliminary investigation.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100395"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}