补充小檗碱对血脂和肥胖指数的影响:荟萃分析综述

IF 2.4 Q3 NUTRITION & DIETETICS
Zeynab Kavyani , Erfan shahhosseini , Amir Hossein Moridpour , Maryam Falahatzadeh , Mahdi Vajdi , Vali Musazadeh , Gholamreza Askari
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引用次数: 0

摘要

背景:一些荟萃分析报道,补充小檗碱可以改善血脂和肥胖指数,但研究结果仍然存在矛盾。因此,我们对荟萃分析进行了综合综述,以检验黄连素补充剂是否对血脂和肥胖指数有影响。方法系统检索截至2022年12月的PubMed、Scopus、Embase、Web of Science、Google Scholar等数据库。结果补充小檗碱能有效降低低密度脂蛋白胆固醇(LDL-C) (ESSMD: - 0.56 mg/dL;95% CI: - 0.74至- 0.38,p <0.001),总胆固醇(TC) (ESSMD: - 0.57 mg/dL, 95% CI: - 0.69 ~ - 0.44, p <0.001),甘油三酯(TG) (ESSMD:−0.47 mg/dL;95% CI: - 0.56 ~ - 0.37, p <0.001),根据SMD分析。此外,小檗碱显著增加高密度脂蛋白胆固醇(HDL-C) (ESSMD: 0.14 mg/dL;95% CI: 0.08-0.20, p <0.001),根据SMD分析。此外,研究结果表明,小檗碱导致腰围(WC)显著降低(ES WMD: - 1.30 cm;95% CI: - 1.91 ~ - 0.69, p <0.001),但与体重无关(ESWMD:−0.86 kg;95% CI:−2.12 ~ 0.41),体重指数(BMI) (ESWMD:−0.57 kg/m2;95% CI:−1.21 ~ 0.06,p = 0.078, ESSMD:−0.28 kg/m2;95% CI:−070 ~ 0.14,p = 0.186),腰高比(WHR)水平(ESSMD:−0.40;95% CI:−1.26 ~ 0.47,p = 0.369)。结论本研究结果显示,添加小檗碱可有效改善体重和血脂,但对肥胖指标的影响有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of berberine supplementation on lipid profile and obesity indices: An umbrella review of meta-analysis

Background

Several meta-analyses reported berberine supplementation improves lipid profile and obesity indices, but findings remain conflicting.

Aim of the review

Therefore, we carried out an umbrella review of meta-analysis in order to examine whether berberine supplementation on lipid profile and obesity indices.

Methods

A systematic search was conducted on PubMed, Scopus, Embase, Web of Science, and Google Scholar up to December 2022.

Results

Berberine supplementation was effective in reducing low-density lipoprotein cholesterol (LDL-C) (ESSMD: −0.56 mg/dL; 95% CI: −0.74 to −0.38, p < 0.001), total cholesterol (TC) (ESSMD: −0.57 mg/dL, 95% CI: −0.69 to −0.44, p < 0.001), triglyceride (TG) (ESSMD: −0.47 mg/dL; 95% CI: −0.56 to −0.37, p < 0.001) according to SMD analysis. In addition, berberine significantly increased high-density lipoprotein cholesterol (HDL-C) (ESSMD: 0.14 mg/dL; 95% CI: 0.08–0.20, p < 0.001) according to SMD analysis. Also, the findings showed that berberine resulted in a significant decrease in waist circumference (WC) (ES WMD: −1.30 cm; 95% CI: −1.91 to −0.69, p < 0.001), but not in body weight (ESWMD: −0.86 kg; 95% CI: −2.12 to 0.41), body mass index (BMI) (ESWMD: −0.57 kg/m2; 95% CI: −1.21 to 0.06, p = 0.078, and ESSMD: −0.28 kg/m2; 95% CI: −070 to 0.14, p = 0.186), and waist-to-height ratio (WHR) levels (ESSMD: −0.40; 95% CI: −1.26 to 0.47, p = 0.369).

Conclusion

The results of our study revealed that the supplementation of berberine could be effective in improving WC, and lipid profile, although the impact of this supplement on obesity indices needs further investigation.

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来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
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