PharmaNutrition最新文献

{"title":"Combinations of bacterial probiotics and yeast postbiotics influence fat deposition and growth in the nematode C. elegans","authors":"Michael K. Fasseas ,&nbsp;Sushmita Maitra ,&nbsp;Maria Tintoré ,&nbsp;Jordi Cuñé ,&nbsp;Carlos de Lecea ,&nbsp;David Weinkove","doi":"10.1016/j.phanu.2024.100404","DOIUrl":"10.1016/j.phanu.2024.100404","url":null,"abstract":"<div><h3>Background</h3><p>Probiotics are live microorganisms with intended benefits on human health including obesity. As a small and fast-growing whole organism model, <em>Caenorhabditis elegans</em> has been used to assess the health effects of probiotics where mechanisms can be assessed through available genetic tools. Results from <em>C. elegans</em> can provide data on the effect of specific probiotic strains and combinations with prebiotics and postbiotics on health-related physiology to inform selections of interventions for further study. We hypothesized that specific combinations with prebiotics and postbiotics could both speed up worm development and reduce fat deposition, suggesting they allow for more effective nutrient utilization.</p></div><div><h3>Methods</h3><p>Here we expose <em>C. elegans</em> to the ABB S20 strain of <em>Lactiplantibacillus plantarum</em> in combination with different prebiotics and postbiotics. We then measure how these affect growth and development speed as well as fat deposition by measuring the time until the appearance of progeny and measuring Oil Red O staining respectively.</p></div><div><h3>Results</h3><p>Our results show that the combination of probiotic <em>L. plantarum</em> ABB S20 plus the postbiotic inactive yeasts <em>K. marxianus</em> ABB S8 and <em>S. boulardii</em> ABB S3 resulted in fast growth and reduced fat deposition compared to <em>L. plantarum</em> ABB S20 alone.</p></div><div><h3>Conclusion</h3><p>These results demonstrate the usefulness of <em>C. elegans</em> as a model to efficiently screen though combinations of probiotics, prebiotics and postbiotics to find those that are candidates to help with effective nutrition use and therefore weight management.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100404"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000306/pdfft?md5=73469150346069534ab8c7823973896f&pid=1-s2.0-S2213434424000306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurturing hope: Uncovering the potential of herbal remedies against amyotrophic lateral sclerosis","authors":"Mukta Gupta ,&nbsp;Md Sadique Hussain ,&nbsp;Riya Thapa ,&nbsp;Asif Ahmad Bhat ,&nbsp;Naresh Kumar","doi":"10.1016/j.phanu.2024.100406","DOIUrl":"10.1016/j.phanu.2024.100406","url":null,"abstract":"<div><h3>Background</h3><p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, as currently available medications such as riluzole and edaravone aim to slow disease progression and manage symptoms, they are often expensive, have adverse side effects, and offer limited therapeutic outcomes. Therefore, it is crucial to explore complementary and alternative medicines in ALS treatment along with their possible mechanism(s). This paper investigates the potential benefits of herbal remedies in ALS management, focusing on their ability to alleviate symptoms, improve quality of life, and potentially delay disease progression.</p></div><div><h3>Method</h3><p>The review includes articles published from 1999 to 2024 and were searched using various databases including Web of Science, Scopus, Google Scholar and Clinical trial. The search was performed using different keywords such as ‘amyotrophic lateral sclerosis’, ‘pathogenesis’, ‘prevalence’, ‘herbal products’, ‘natural medicines’, ‘safety’, ‘efficacy’, ‘clinical trials’, ‘herbal-drug interaction’, <em>‘in vitro’</em>, ‘<em>in vivo’</em>, phytochemicals, ‘alternative medicine’. Further studies were screening by assessing abstracts, cross references and previously published review and research articles.</p></div><div><h3>Results</h3><p>A number of herbal products are reported in preclinical and clinical studies indicating their efficacy against ALS. These prominent phytoconstituents exhibiting anti- amyotrophic lateral sclerosis effect are mainly present in different parts of the plant and include curcumin, epigallocatechin gallate, quercetin, resveratrol, tetrahydrocannabidiol, diallyl trisulfide, withanolides, genistein, and madecassoside. The plant extract containing these phytoconstituents exert their therapeutic effect <em>via</em> modulating inflammatory mediators, trapping free radicals, targeting various enzymes and/or by harnessing autophagy.</p></div><div><h3>Conclusion</h3><p>Although, various preclinical studies have shown beneficial effects of herbs in treating this debilitating disease. Further investigation is necessary to confirm the safety and efficacy of these botanical therapies in clinics.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100406"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of omega-3 supplementation on serum leptin levels: A systematic review and meta-analysis","authors":"Mostafa Shahraki Jazinaki ,&nbsp;Hossein Bahari ,&nbsp;Yasaman Aali ,&nbsp;Mohammad Rashidmayvan","doi":"10.1016/j.phanu.2024.100401","DOIUrl":"10.1016/j.phanu.2024.100401","url":null,"abstract":"<div><h3>Background</h3><p>Omega-3 fatty acids have gained attention for their potential impact on appetite regulation and energy balance. Research suggests that omega-3 supplementation may influence leptin production and sensitivity, potentially affecting body weight and metabolic health. Therefore, this meta-analysis aimed to assess the effect of omega-3 supplementation on serum leptin levels.</p></div><div><h3>Methods</h3><p>A comprehensive search of the literature was conducted up to March 2024 in PubMed, Scopus, and Web of Science to find suitable randomized clinical trials (RCTs). The selected trials were subjected to heterogeneity tests using the I² statistic. Random effects models were examined based on the heterogeneity tests, and the pooled data were calculated as weighted mean differences (WMD) with a 95 % confidence interval (CI).</p></div><div><h3>Results</h3><p>Of the 357 papers, 25 eligible RCTs (with 29 treatment arms) were included in the present meta-analysis. Our findings indicated that omega-3 supplementation failed to change serum leptin levels significantly (WMD: −0.38 ng/mL; 95 %CI: −1.96–1.19; P =0.63). However, significant heterogeneity was detected among the included studies (I² = 85.6 %, P &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>This meta-analysis revealed that omega-3 supplementation had no significant impact on circulating leptin levels. However, it seems that omega-3 supplementation with a dosage of more than 2 g/day may significantly reduce serum leptin levels.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100401"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eicosapentaenoic acid-rich omega-3 fatty acids supplementation may improve vision in dry age-related macular degeneration or Stargardt disease, as shown in MADEOS, a prospective, randomized, multicentre, double-blind, placebo-controlled pilot study","authors":"Ekatherine Prokopiou ,&nbsp;Panagiotis Kolovos ,&nbsp;Haritini Tsangari ,&nbsp;Saddek Mohand-Said ,&nbsp;Luca Rossetti ,&nbsp;Leonardo Mastropasqua ,&nbsp;Francesco Bandello ,&nbsp;Tassos Georgiou","doi":"10.1016/j.phanu.2024.100400","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100400","url":null,"abstract":"<div><h3>Background</h3><p>This study investigates the effects of eicosapentaenoic acid (EPA)-rich omega-3 fatty acids on dry age-related macular degeneration (AMD) and Stargardt disease.</p></div><div><h3>Methods</h3><p>MADEOS is a prospective, randomized, multicenter, double-blind, placebo-controlled pilot study, which assessed the impact of omega-3 fatty acids on best corrected visual acuity, blood omega-6/omega-3 ratio, and perceived vision and mood using a questionnaire in patients with dry AMD or Stargardt disease. Participants received either the active product (3660 mg of EPA and DHA; 14 patients) or placebo (sunflower oil; 7 patients) daily for 24 weeks. Measurements were taken at screening (Visit 1), 12 weeks (Visit 3), and 24 weeks (Visit 4). Comparisons were made within and between groups.</p></div><div><h3>Results</h3><p>The mean letters gained at Visits 3 and 4 were significantly different between the groups (p=0.002). The active group showed a mean gain of 6 ETDRS letters from Visit 1 to Visit 4 (p=0.003). The mean arachidonic acid/EPA ratio in the active group significantly decreased from Visit 1 (5.84 ± 1.05) to Visit 4 (1.47 ± 0.16, p=0.002). The questionnaire scores were similar at Visit 3 but higher for the active group at Visit 4 (9.38 ± 3.35 vs. 7.28 ± 2.36).</p></div><div><h3>Conclusion</h3><p>EPA-rich omega-3 supplementation may improve both objective and subjective vision in patients with dry AMD or Stargardt disease, offering a potentially simple, safe, and cost-effective approach to enhancing quality of life.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100400"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000264/pdfft?md5=85a4d81c7eda2b13633958603a317c07&pid=1-s2.0-S2213434424000264-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-curcumin supplementation for the management of migraine: A systematic scoping review and meta-analysis","authors":"Ernest Kissi Kontor ,&nbsp;Daha Garba Muhammad ,&nbsp;Jessica Kumah ,&nbsp;Derrick Sackitey ,&nbsp;Bismark Acheampong ,&nbsp;Godwin Odum Bortey ,&nbsp;Bismark Osei Owusu ,&nbsp;Nityanand Jain","doi":"10.1016/j.phanu.2024.100407","DOIUrl":"10.1016/j.phanu.2024.100407","url":null,"abstract":"<div><h3>Objectives</h3><p>Migraine is a common neurological disorder contributing significantly to global disability. Nano-curcumin, known for its anti-inflammatory and neuroprotective properties, has emerged as a promising candidate for migraine prophylaxis. Herein, we assessed the effects of nano-curcumin supplementation on headache attack, severity, and duration in adult patients.</p></div><div><h3>Methods</h3><p>Five biomedical databases were searched until March 2024 for randomized controlled trials (RCTs). 13 records fulfilled the inclusion criteria, eight of which were considered for meta-analysis. The risk of bias was assessed using ROB2. Outcomes were quantified using both Standardized Mean Difference (SMD) and Mean Difference (MD) along with the 95 % Confidence Intervals (CIs). Pooled intervention effects were estimated using both common-effects and random-effects models.</p></div><div><h3>Results</h3><p>Our analysis revealed that 80 mg nano-curcumin supplementation per day for two months in young adults reduced migraine attacks (SMD −0.55; 95 % CI: −1.07 to −0.02), severity (SMD −0.64; 95 % CI: −1.10 to −0.19), and duration (MD −2.90; 95 % CI: −4.66 to −1.13) when compared with placebo. When combined with nutraceuticals such as omega-3 and coenzyme Q10, nano-curcumin demonstrated enhanced efficacy in reducing migraine attacks (SMD 1.19; 95 % CI: 0.90–1.48). Among those who received nano-curcumin supplementation only, a before and after intervention analysis showed a reduction in migraine attacks (SMD −0.77; 95 % CI: −1.00 to −0.54), severity (SMD −0.92; 95 % CI: −1.50 to −0.33), and duration (SMD −0.63; 95 % CI: −1.05 to −0.20).</p></div><div><h3>Conclusions</h3><p>Evidence from literature suggests that nano-curcumin supplementation might be effective in reducing migraine symptoms. However, caution is advised, and further research is recommended to confirm these findings, considering the single institutional source of all studies.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100407"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal medicines and botanicals for managing insomnia, stress, anxiety, and depression: A critical review of the emerging evidence focusing on the Middle East and Africa","authors":"Morten Georg Jensen ,&nbsp;Michael Goode ,&nbsp;Michael Heinrich","doi":"10.1016/j.phanu.2024.100399","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100399","url":null,"abstract":"<div><h3>Background</h3><p>Mental health issues affect millions of people globally, imposing significant emotional and economic burdens. These involve multiple pathogenic mechanisms, including oxidative stress and neuroinflammation. With an annual global death estimated at 9 million, neurological disorders are the second leading cause of death. This review aims to explore the benefits of 15 medicinal plants available within MEA and provide researchers with knowledge on how these herbal medicines could alleviate symptoms associated with changes in mental health.</p></div><div><h3>Method</h3><p>Academic databases were searched to find relevant studies on traditional medicinal herbs used in the MEA for the treatment of mental health related issues like sleep, anxiety and depression.</p></div><div><h3>Result</h3><p>The MEA region has the highest prevalence of major depressive and anxiety disorders globally, with conventional treatments often involving medications that alter neurotransmitters, potentially leading to adverse effects. Given the concerns about long-term drug use, there is growing interest in multi-targeted approaches using medicinal plants. These offer a cost-effective, less hazardous alternative, especially for those with chronic, comorbid conditions. Medicinal plant-based food supplements are increasing within the MEA region, where cultural and traditional usage of such plants is extensive. However, the practical application of these supplements is often limited in real-world scenarios.</p></div><div><h3>Conclusion</h3><p>While medicinal plant-based food supplements show potential as a cost-effective and a more suitable alternative for individuals with chronic and comorbid conditions in the MEA region, further research is needed to overcome the limitations in their practical application including a focus on real world data.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100399"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000252/pdfft?md5=b322cc8b1a69edcdd888a444f75244e0&pid=1-s2.0-S2213434424000252-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rebuttal to the (pre-proof) paper published by S. Peters and H. Verhagen","authors":"Mathilde Touvier,&nbsp;Pilar Galan,&nbsp;Chantal Julia,&nbsp;Mélanie Deschasaux-Tanguy,&nbsp;Bernard Srour,&nbsp;Emmanuelle Kesse-Guyot,&nbsp;Valentina A. Andreeva,&nbsp;Serge Hercberg","doi":"10.1016/j.phanu.2024.100386","DOIUrl":"10.1016/j.phanu.2024.100386","url":null,"abstract":"","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100386"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily white tea intake reprograms hepatic metabolism and improves the enzymatic antioxidant defence system of rats with prediabetes","authors":"Ana C. Silveira ,&nbsp;Pedro Fontes Oliveira ,&nbsp;Marco G. Alves ,&nbsp;Luís Rato ,&nbsp;Branca M. Silva","doi":"10.1016/j.phanu.2024.100393","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100393","url":null,"abstract":"<div><h3>Background</h3><p>Prediabetes (PrDM) poses a significant risk for the development of Diabetes Mellitus (DM). Preventing the transition to type 2 DM is of utmost importance, and identifying novel dietary agents with both antioxidant and antidiabetic properties is crucial. This study aims to assess the potential of regular white tea (WTEA) consumption in alleviating the detrimental effects of PrDM on hepatic metabolism and redox state.</p></div><div><h3>Methods</h3><p>To achieve this, we divided 18 male Wistar rats into three groups: a control group and two prediabetes (PrDM) groups. In one of the PrDM groups, water consumption was replaced with white tea (WTEA). After a two-month period, we evaluated the hepatic metabolic profile using 1H NMR. Additionally, we measured total antioxidant potential, the activities of antioxidant enzymes, and various oxidative parameters, including protein nitration and carbonylation, lipid peroxidation, and levels of H2A.X and phosphorylated H2A.X.</p></div><div><h3>Results</h3><p>PrDM induced a decline in hepatic catabolic metabolism and the activities of key antioxidant enzymes, including superoxide dismutase, glutathione reductase, catalase, and levels of phosphorylated H2A.X. However, when PrDM rats consumed WTEA, a remarkable restoration occurred. Specifically, WTEA intake reinstated glutathione reductase and catalase activities and elevated superoxide dismutase activity in the liver compared to normoglycemic conditions. Moreover, enhancements were noted in overall antioxidant capacity and a reduction in lipid peroxidation in the rat liver.</p></div><div><h3>Conclusion</h3><p>PrDM significantly impacts liver metabolism and antioxidant defenses, but the consumption of WTEA, a plant-based functional beverage, exhibits potent hepatoprotective capabilities against PrDM-induced oxidative stress.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100393"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing hypertension using brewing bioactive peptides as angiotensin-converting enzyme inhibitors: Impact on vascular tone through ex vivo assays","authors":"Rita Ribeiro-Oliveira ,&nbsp;Pilar Rodríguez-Rodríguez ,&nbsp;Joana Beatriz Sousa ,&nbsp;Isabel M.P.L.V.O. Ferreira ,&nbsp;Silvia M. Arribas ,&nbsp;Carmen Diniz","doi":"10.1016/j.phanu.2024.100389","DOIUrl":"10.1016/j.phanu.2024.100389","url":null,"abstract":"<div><h3>Background</h3><p>Peptides derived from brewer’s spent grain (BSG) and yeast (BSY) are promising natural substitutes of synthetic drugs to manage hypertension as inhibitors of angiotensin-converting enzyme (ACE). However, their impact on the vascular function, so far, remains to be verified. Accordingly, we aimed to evaluate the effect of brewing peptides on the arterial vasocontractile response to angiotensin (Ang) I (through vascular ACE-inhibition) to estimate their antihypertensive potential. The impact of the oral route (gastrointestinal digestion, intestinal absorption, and liver metabolism) in brewing peptides was also investigated.</p></div><div><h3>Methods</h3><p>Iliac arteries from adult spontaneously hypertensive rats were studied with isometric tension recording. After ensuring the function integrity of the arteries, concentration-response curves to addition of Ang I (10⁻⁹-10⁻⁶ M) were performed after 30 min incubation with MIX (50:50 mixture of BSG:BSY) or BSG (0.86 mg/mL), or captopril (an ACE-inhibitory drug) or Krebs solution.</p></div><div><h3>Results</h3><p>MIX peptides (without simulated oral administration) enhanced Ang I-induced vasoconstriction, but lacked vascular effects after simulated oral administration. By contrast, BSG peptides (without simulated oral administration) did not exhibit vascular effects, whereas they promoted a marked decrease in vasocontraction evoked by the generated Ang II after simulation of the oral route, implying their capability to inhibit ACE. Additionally, to elucidate this inhibitory mechanism, Michaelis-Menten and Lineweaver-Burk plots indicated a mixed inhibition type.</p></div><div><h3>Conclusion</h3><p>With simulation of the oral route, BSG peptides were able to inhibit vascular ACE with a similar efficacy as the antihypertensive drug captopril, suggesting the potential to mitigate the burden of hypertension.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100389"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications","authors":"Mohd Fadzelly Abu Bakar","doi":"10.1016/j.phanu.2024.100388","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100388","url":null,"abstract":"<div><h3>Background</h3><p>Derived from Garcinia plants, garcinol has gained prominence for its versatile health benefits, ranging from antioxidant and anti-inflammatory properties to immunomodulation and anticancer effects. Notably, there is a growing interest in exploring its potential against obesity and related disorders. While hydroxycitric acid (HCA) has been linked to the anti-obesity effects of certain Garcinia fruits, recent research emphasizes the role of garcinol, either alone or in combination, in mediating these effects.</p></div><div><h3>Methods</h3><p>The review was conducted using the databases Medline, Scopus, Web of Science, and Google Scholar. The search was performed using the keywords 'obesity’, 'overweight', 'garcinol', '<em>in vitro</em>’, '<em>in vivo</em>’ and 'clinical studies.' Discussions focused on the effect of garcinol on body weight, obesity and its related complications.</p></div><div><h3>Results</h3><p>The findings revealed that garcinol, distinct from HCA, plays a central role in anti-obesity effects. Inhibiting fatty acid synthase emerged as a key mechanism, disrupting fatty acid synthesis and facilitating weight control. Garcinol demonstrated effectiveness in appetite suppression, fat reduction, modulation of obesity-related factors, and metabolic enhancement, collectively contributing to weight loss. Furthermore, the study established the bioavailability, pharmacokinetics, and biodistribution of garcinol, underscoring its anti-inflammatory properties as valuable in addressing obesity-associated inflammation.</p></div><div><h3>Conclusion</h3><p>While promising indications from cell, animal, and preliminary clinical studies highlight garcinol's anti-obesity potential, it is crucial to acknowledge that research in this domain is still in its early stages. To conclusively establish the effectiveness and safety of garcinol as an anti-obesity treatment, comprehensive studies, particularly involving human subjects, are imperative.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100388"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140192039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}