Probiotic-prebiotic therapeutic potential: A new horizon of microbial biotherapy to reduce female reproductive complications

IF 2.4 Q3 NUTRITION & DIETETICS
Kavita Rani , Gurjeet Kaur , Syed Azmal Ali
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引用次数: 1

Abstract

Background

Probiotics and associated prebiotics have emerged as a novel method for treating health issues in the last two decades. It has been shown that they can regulate the gut microbiota through different molecular mechanisms. Inappropriate lifestyle choices activate the hypothalamic-pituitary-adrenal axis, resulting in immense stress. This leads to an increased incidence of patients with metabolic syndrome and an altered gut microbiota further lead to gastrointestinal dysbiosis. Microbial dysbiosis can disrupt the control and synthesis of reproductive hormones, thus leading to infertility.

Methods

In this review, we gathered information from recent studies that show how probiotics and prebiotics could help support the treatment of reproductive disorders and hormone imbalances. We discussed the biochemical effects and proposed mechanisms of action of probiotics and prebiotics that may help with infertility in humans, as well as how these functional foods could be used to treat reproductive disorders.

Results

Probiotics could restore fertility because their metabolites trigger the release of signaling molecules that control hormone production in intestinal epithelial cells and other organs. The review provides a collection of evidence that the use of probiotics and prebiotics could be a new horizon of microbial biotherapy to reduce female reproductive complications.

Conclusions

Probiotics and prebiotics may offer a new approach to treat reproductive disorders and infertility by regulating gut microbiota and restoring the control and synthesis of reproductive hormones. The potential of using these functional foods as a microbial biotherapy to alleviate female reproductive complications warrants further investigation.

益生菌益生元治疗潜力:微生物生物治疗减少女性生殖并发症的新视野
背景在过去的二十年里,益生菌和相关的益生元已经成为一种治疗健康问题的新方法。研究表明,它们可以通过不同的分子机制调节肠道微生物群。不适当的生活方式选择会激活下丘脑-垂体-肾上腺轴,导致巨大的压力。这导致代谢综合征患者的发病率增加,肠道微生物群的改变进一步导致胃肠道微生态失调。微生物失调会破坏生殖激素的控制和合成,从而导致不孕。方法在这篇综述中,我们从最近的研究中收集了信息,这些研究表明益生菌和益生元如何有助于支持生殖障碍和激素失衡的治疗。我们讨论了益生菌和益生元的生物化学作用和拟议的作用机制,这些作用机制可能有助于人类不育,以及这些功能性食品如何用于治疗生殖障碍。结果益生菌可以恢复生育能力,因为它们的代谢产物会触发控制肠上皮细胞和其他器官激素产生的信号分子的释放。这篇综述提供了一系列证据,证明益生菌和益生元的使用可能是微生物生物治疗减少女性生殖并发症的新领域。结论益生菌和益生元可以通过调节肠道微生物群、恢复生殖激素的控制和合成,为治疗生殖障碍和不孕不育提供一种新的途径。使用这些功能性食品作为微生物生物疗法缓解女性生殖并发症的潜力值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
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