PharmaNutrition最新文献

{"title":"The guardians of macular health: Omega 3 fatty acids","authors":"","doi":"10.1016/j.phanu.2024.100408","DOIUrl":"10.1016/j.phanu.2024.100408","url":null,"abstract":"","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurturing hope: Uncovering the potential of herbal remedies against amyotrophic lateral sclerosis","authors":"","doi":"10.1016/j.phanu.2024.100406","DOIUrl":"10.1016/j.phanu.2024.100406","url":null,"abstract":"<div><h3>Background</h3><p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, as currently available medications such as riluzole and edaravone aim to slow disease progression and manage symptoms, they are often expensive, have adverse side effects, and offer limited therapeutic outcomes. Therefore, it is crucial to explore complementary and alternative medicines in ALS treatment along with their possible mechanism(s). This paper investigates the potential benefits of herbal remedies in ALS management, focusing on their ability to alleviate symptoms, improve quality of life, and potentially delay disease progression.</p></div><div><h3>Method</h3><p>The review includes articles published from 1999 to 2024 and were searched using various databases including Web of Science, Scopus, Google Scholar and Clinical trial. The search was performed using different keywords such as ‘amyotrophic lateral sclerosis’, ‘pathogenesis’, ‘prevalence’, ‘herbal products’, ‘natural medicines’, ‘safety’, ‘efficacy’, ‘clinical trials’, ‘herbal-drug interaction’, <em>‘in vitro’</em>, ‘<em>in vivo’</em>, phytochemicals, ‘alternative medicine’. Further studies were screening by assessing abstracts, cross references and previously published review and research articles.</p></div><div><h3>Results</h3><p>A number of herbal products are reported in preclinical and clinical studies indicating their efficacy against ALS. These prominent phytoconstituents exhibiting anti- amyotrophic lateral sclerosis effect are mainly present in different parts of the plant and include curcumin, epigallocatechin gallate, quercetin, resveratrol, tetrahydrocannabidiol, diallyl trisulfide, withanolides, genistein, and madecassoside. The plant extract containing these phytoconstituents exert their therapeutic effect <em>via</em> modulating inflammatory mediators, trapping free radicals, targeting various enzymes and/or by harnessing autophagy.</p></div><div><h3>Conclusion</h3><p>Although, various preclinical studies have shown beneficial effects of herbs in treating this debilitating disease. Further investigation is necessary to confirm the safety and efficacy of these botanical therapies in clinics.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-curcumin supplementation for the management of migraine: A systematic scoping review and meta-analysis","authors":"","doi":"10.1016/j.phanu.2024.100407","DOIUrl":"10.1016/j.phanu.2024.100407","url":null,"abstract":"<div><h3>Objectives</h3><p>Migraine is a common neurological disorder contributing significantly to global disability. Nano-curcumin, known for its anti-inflammatory and neuroprotective properties, has emerged as a promising candidate for migraine prophylaxis. Herein, we assessed the effects of nano-curcumin supplementation on headache attack, severity, and duration in adult patients.</p></div><div><h3>Methods</h3><p>Five biomedical databases were searched until March 2024 for randomized controlled trials (RCTs). 13 records fulfilled the inclusion criteria, eight of which were considered for meta-analysis. The risk of bias was assessed using ROB2. Outcomes were quantified using both Standardized Mean Difference (SMD) and Mean Difference (MD) along with the 95 % Confidence Intervals (CIs). Pooled intervention effects were estimated using both common-effects and random-effects models.</p></div><div><h3>Results</h3><p>Our analysis revealed that 80 mg nano-curcumin supplementation per day for two months in young adults reduced migraine attacks (SMD −0.55; 95 % CI: −1.07 to −0.02), severity (SMD −0.64; 95 % CI: −1.10 to −0.19), and duration (MD −2.90; 95 % CI: −4.66 to −1.13) when compared with placebo. When combined with nutraceuticals such as omega-3 and coenzyme Q10, nano-curcumin demonstrated enhanced efficacy in reducing migraine attacks (SMD 1.19; 95 % CI: 0.90–1.48). Among those who received nano-curcumin supplementation only, a before and after intervention analysis showed a reduction in migraine attacks (SMD −0.77; 95 % CI: −1.00 to −0.54), severity (SMD −0.92; 95 % CI: −1.50 to −0.33), and duration (SMD −0.63; 95 % CI: −1.05 to −0.20).</p></div><div><h3>Conclusions</h3><p>Evidence from literature suggests that nano-curcumin supplementation might be effective in reducing migraine symptoms. However, caution is advised, and further research is recommended to confirm these findings, considering the single institutional source of all studies.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological activities from açaí (Euterpe spp. Mart.) seeds and their pharmacological aspects: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.phanu.2024.100405","DOIUrl":"10.1016/j.phanu.2024.100405","url":null,"abstract":"<div><h3>Background</h3><p>Açaí seeds, a by-product of açaí processing (1445 tons year⁻¹), make up 85 % of the fruit's weight and are rich in phenolic compounds, such as phenolic acids, (epi)catechins, and procyanidins. Their chemical profile suggests significant pharmacological potential, leading to growing interest in their therapeutic applications.</p></div><div><h3>Methods</h3><p>A systematic review was conducted following PRISMA guidelines, covering studies from 2006 to 2023.</p></div><div><h3>Results</h3><p>The review included 72 studies, 13 of which were cluster randomized trials in rodents. Açaí seed extract (ASE) displayed a robust phenolic profile with varying polymerization degrees. Preclinical investigations demonstrated ASE's therapeutic efficacy, showing potent antioxidant activities, upregulation of antioxidant enzymes via Nrf2 activation, and selective cytotoxicity against various cancer cell lines. ASE also exhibited efficacy in reducing oxidative stress, inflammatory cytokines, and inhibiting adipogenesis, addressing metabolic syndrome in rodents. Promising effects were observed on hypertension, hyperglycemia, dyslipidemia, and liver diseases, indicating broad health benefits.</p></div><div><h3>Conclusion</h3><p>Despite study heterogeneity, ASE's shows potential as a therapeutic agent., necessitating further clinical investigations to comprehensively evaluate its safety and efficacy in human health.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combinations of bacterial probiotics and yeast postbiotics influence fat deposition and growth in the nematode C. elegans","authors":"","doi":"10.1016/j.phanu.2024.100404","DOIUrl":"10.1016/j.phanu.2024.100404","url":null,"abstract":"<div><h3>Background</h3><p>Probiotics are live microorganisms with intended benefits on human health including obesity. As a small and fast-growing whole organism model, <em>Caenorhabditis elegans</em> has been used to assess the health effects of probiotics where mechanisms can be assessed through available genetic tools. Results from <em>C. elegans</em> can provide data on the effect of specific probiotic strains and combinations with prebiotics and postbiotics on health-related physiology to inform selections of interventions for further study. We hypothesized that specific combinations with prebiotics and postbiotics could both speed up worm development and reduce fat deposition, suggesting they allow for more effective nutrient utilization.</p></div><div><h3>Methods</h3><p>Here we expose <em>C. elegans</em> to the ABB S20 strain of <em>Lactiplantibacillus plantarum</em> in combination with different prebiotics and postbiotics. We then measure how these affect growth and development speed as well as fat deposition by measuring the time until the appearance of progeny and measuring Oil Red O staining respectively.</p></div><div><h3>Results</h3><p>Our results show that the combination of probiotic <em>L. plantarum</em> ABB S20 plus the postbiotic inactive yeasts <em>K. marxianus</em> ABB S8 and <em>S. boulardii</em> ABB S3 resulted in fast growth and reduced fat deposition compared to <em>L. plantarum</em> ABB S20 alone.</p></div><div><h3>Conclusion</h3><p>These results demonstrate the usefulness of <em>C. elegans</em> as a model to efficiently screen though combinations of probiotics, prebiotics and postbiotics to find those that are candidates to help with effective nutrition use and therefore weight management.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000306/pdfft?md5=73469150346069534ab8c7823973896f&pid=1-s2.0-S2213434424000306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6-Hydroxydopamine-induced decrease in dopaminergic neurons is avoided by effusol and dehydroeffusol, unique phenanthrenes of Juncus effusus","authors":"","doi":"10.1016/j.phanu.2024.100403","DOIUrl":"10.1016/j.phanu.2024.100403","url":null,"abstract":"<div><h3>Background</h3><p>Excess influx of extracellular Zn²⁺ into nigral dopaminergic neurons play a crucial role for 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease in rats. On the basis of neurodegeneration by Zn²⁺ dysregulation, we aimed to clarify the effect of effusol and dehydroeffusol, unique phenanthrenes from <em>Juncus effusus</em> on dopaminergic degeneration.</p></div><div><h3>Methods</h3><p>The decrease in dopaminergic neurons was assessed by tyrosine hydroxylase immunostaining 14 days after 6-OHDA injection into the substantia nigra pars compacta (SNpc) of rats.</p></div><div><h3>Results</h3><p>The decrease in dopaminergic neurons induced by 6-OHDA was avoided by co-injection of 1<em>-</em>naphthyl acetyl spermine (NASPM), a selective blocker of Zn²⁺-permeable GluR2-lacking AMPA receptors, which blocked the increase in intracellular Zn²⁺, supporting the involvement of Zn²⁺ dysregulation in dopaminergic degeneration. Moreover, either effusol or dehydroeffusol was co-injected with 6-OHDA into the SNpc. The decrease in dopaminergic neurons was avoided by effusol and dehydroeffusol. The increases in intracellular Zn²⁺ and H₂O₂ in the SNpc induced by 6-OHDA were also avoided by effusol and dehydroeffusol.</p></div><div><h3>Conclusions</h3><p>The present study first indicates that effusol and dehydroeffusol avoid the decrease in dopaminergic neurons in the SNpc via reducing production of reactive oxygen species induced by intracellular Zn²⁺ dysregulation after injection of 6-OHDA into the rat SNpc. It is likely that effusol and dehydroeffusol serve as nutraceutical components to protect dopaminergic degeneration, perhaps via regulating presynaptic excitation of glutamatergic neurons in the SNpc.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synbiotic solution: Evaluating safety and efficacy in antibiotic-associated dysbiosis - A randomized, double-blind, placebo-controlled pre-clinical study with sprague dawley rats","authors":"","doi":"10.1016/j.phanu.2024.100402","DOIUrl":"10.1016/j.phanu.2024.100402","url":null,"abstract":"<div><h3>Background</h3><p>Antibiotic therapy, vital for combating infections, often disrupts the intricate balance of gut bacteria, resulting in \"gut dysbiosis.\" This study aimed to assess the safety and efficacy of a Synbiotic supplement in alleviating antibiotic-associated dysbiosis in Sprague Dawley (SD) rats.</p></div><div><h3>Methods</h3><p>A double-blind, placebo-controlled pre-clinical study was conducted over a minimum of 10 consecutive days. The study employed five distinct groups for evaluation, with a focus on the Synbiotic group comprising probiotic and prebiotic components. The administered dose was 1 billion CFU with 100 mg Fossence®.</p></div><div><h3>Results</h3><p>The Synbiotic supplement demonstrated significant positive outcomes across diverse parameters. Compared to the disease control group, the Synbiotic group displayed enhancements in fecal output ratio, feed conversion ratio, total weight gain, and specific growth ratio. Histopathological data supported these findings, affirming the Synbiotic supplementation's potential in mitigating antibiotics' adverse effects on gut health. No mortalities or major symptoms were recorded, confirming the supplement's safety<strong>.</strong></p></div><div><h3>Conclusions</h3><p>The study underscores the efficacy of Synbiotics in enhancing gastrointestinal health in SD rats. The identified effective dose of 1 billion CFU with 100 mg Fossence® necessitates further clinical investigation. This suggests Synbiotics as a compelling approach to address antibiotic-associated gut dysbiosis, warranting further exploration in humans for potential applications in maintaining a healthy gut and overall well-being.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of omega-3 supplementation on serum leptin levels: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.phanu.2024.100401","DOIUrl":"10.1016/j.phanu.2024.100401","url":null,"abstract":"<div><h3>Background</h3><p>Omega-3 fatty acids have gained attention for their potential impact on appetite regulation and energy balance. Research suggests that omega-3 supplementation may influence leptin production and sensitivity, potentially affecting body weight and metabolic health. Therefore, this meta-analysis aimed to assess the effect of omega-3 supplementation on serum leptin levels.</p></div><div><h3>Methods</h3><p>A comprehensive search of the literature was conducted up to March 2024 in PubMed, Scopus, and Web of Science to find suitable randomized clinical trials (RCTs). The selected trials were subjected to heterogeneity tests using the I² statistic. Random effects models were examined based on the heterogeneity tests, and the pooled data were calculated as weighted mean differences (WMD) with a 95 % confidence interval (CI).</p></div><div><h3>Results</h3><p>Of the 357 papers, 25 eligible RCTs (with 29 treatment arms) were included in the present meta-analysis. Our findings indicated that omega-3 supplementation failed to change serum leptin levels significantly (WMD: −0.38 ng/mL; 95 %CI: −1.96–1.19; P =0.63). However, significant heterogeneity was detected among the included studies (I² = 85.6 %, P &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>This meta-analysis revealed that omega-3 supplementation had no significant impact on circulating leptin levels. However, it seems that omega-3 supplementation with a dosage of more than 2 g/day may significantly reduce serum leptin levels.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eicosapentaenoic acid-rich omega-3 fatty acids supplementation may improve vision in dry age-related macular degeneration or Stargardt disease, as shown in MADEOS, a prospective, randomized, multicentre, double-blind, placebo-controlled pilot study","authors":"Ekatherine Prokopiou ,&nbsp;Panagiotis Kolovos ,&nbsp;Haritini Tsangari ,&nbsp;Saddek Mohand-Said ,&nbsp;Luca Rossetti ,&nbsp;Leonardo Mastropasqua ,&nbsp;Francesco Bandello ,&nbsp;Tassos Georgiou","doi":"10.1016/j.phanu.2024.100400","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100400","url":null,"abstract":"<div><h3>Background</h3><p>This study investigates the effects of eicosapentaenoic acid (EPA)-rich omega-3 fatty acids on dry age-related macular degeneration (AMD) and Stargardt disease.</p></div><div><h3>Methods</h3><p>MADEOS is a prospective, randomized, multicenter, double-blind, placebo-controlled pilot study, which assessed the impact of omega-3 fatty acids on best corrected visual acuity, blood omega-6/omega-3 ratio, and perceived vision and mood using a questionnaire in patients with dry AMD or Stargardt disease. Participants received either the active product (3660 mg of EPA and DHA; 14 patients) or placebo (sunflower oil; 7 patients) daily for 24 weeks. Measurements were taken at screening (Visit 1), 12 weeks (Visit 3), and 24 weeks (Visit 4). Comparisons were made within and between groups.</p></div><div><h3>Results</h3><p>The mean letters gained at Visits 3 and 4 were significantly different between the groups (p=0.002). The active group showed a mean gain of 6 ETDRS letters from Visit 1 to Visit 4 (p=0.003). The mean arachidonic acid/EPA ratio in the active group significantly decreased from Visit 1 (5.84 ± 1.05) to Visit 4 (1.47 ± 0.16, p=0.002). The questionnaire scores were similar at Visit 3 but higher for the active group at Visit 4 (9.38 ± 3.35 vs. 7.28 ± 2.36).</p></div><div><h3>Conclusion</h3><p>EPA-rich omega-3 supplementation may improve both objective and subjective vision in patients with dry AMD or Stargardt disease, offering a potentially simple, safe, and cost-effective approach to enhancing quality of life.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000264/pdfft?md5=85a4d81c7eda2b13633958603a317c07&pid=1-s2.0-S2213434424000264-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal medicines and botanicals for managing insomnia, stress, anxiety, and depression: A critical review of the emerging evidence focusing on the Middle East and Africa","authors":"Morten Georg Jensen ,&nbsp;Michael Goode ,&nbsp;Michael Heinrich","doi":"10.1016/j.phanu.2024.100399","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100399","url":null,"abstract":"<div><h3>Background</h3><p>Mental health issues affect millions of people globally, imposing significant emotional and economic burdens. These involve multiple pathogenic mechanisms, including oxidative stress and neuroinflammation. With an annual global death estimated at 9 million, neurological disorders are the second leading cause of death. This review aims to explore the benefits of 15 medicinal plants available within MEA and provide researchers with knowledge on how these herbal medicines could alleviate symptoms associated with changes in mental health.</p></div><div><h3>Method</h3><p>Academic databases were searched to find relevant studies on traditional medicinal herbs used in the MEA for the treatment of mental health related issues like sleep, anxiety and depression.</p></div><div><h3>Result</h3><p>The MEA region has the highest prevalence of major depressive and anxiety disorders globally, with conventional treatments often involving medications that alter neurotransmitters, potentially leading to adverse effects. Given the concerns about long-term drug use, there is growing interest in multi-targeted approaches using medicinal plants. These offer a cost-effective, less hazardous alternative, especially for those with chronic, comorbid conditions. Medicinal plant-based food supplements are increasing within the MEA region, where cultural and traditional usage of such plants is extensive. However, the practical application of these supplements is often limited in real-world scenarios.</p></div><div><h3>Conclusion</h3><p>While medicinal plant-based food supplements show potential as a cost-effective and a more suitable alternative for individuals with chronic and comorbid conditions in the MEA region, further research is needed to overcome the limitations in their practical application including a focus on real world data.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000252/pdfft?md5=b322cc8b1a69edcdd888a444f75244e0&pid=1-s2.0-S2213434424000252-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}