PharmaNutrition最新文献

{"title":"The synbiotic solution: Evaluating safety and efficacy in antibiotic-associated dysbiosis - A randomized, double-blind, placebo-controlled pre-clinical study with sprague dawley rats","authors":"","doi":"10.1016/j.phanu.2024.100402","DOIUrl":"10.1016/j.phanu.2024.100402","url":null,"abstract":"<div><h3>Background</h3><p>Antibiotic therapy, vital for combating infections, often disrupts the intricate balance of gut bacteria, resulting in \"gut dysbiosis.\" This study aimed to assess the safety and efficacy of a Synbiotic supplement in alleviating antibiotic-associated dysbiosis in Sprague Dawley (SD) rats.</p></div><div><h3>Methods</h3><p>A double-blind, placebo-controlled pre-clinical study was conducted over a minimum of 10 consecutive days. The study employed five distinct groups for evaluation, with a focus on the Synbiotic group comprising probiotic and prebiotic components. The administered dose was 1 billion CFU with 100 mg Fossence®.</p></div><div><h3>Results</h3><p>The Synbiotic supplement demonstrated significant positive outcomes across diverse parameters. Compared to the disease control group, the Synbiotic group displayed enhancements in fecal output ratio, feed conversion ratio, total weight gain, and specific growth ratio. Histopathological data supported these findings, affirming the Synbiotic supplementation's potential in mitigating antibiotics' adverse effects on gut health. No mortalities or major symptoms were recorded, confirming the supplement's safety<strong>.</strong></p></div><div><h3>Conclusions</h3><p>The study underscores the efficacy of Synbiotics in enhancing gastrointestinal health in SD rats. The identified effective dose of 1 billion CFU with 100 mg Fossence® necessitates further clinical investigation. This suggests Synbiotics as a compelling approach to address antibiotic-associated gut dysbiosis, warranting further exploration in humans for potential applications in maintaining a healthy gut and overall well-being.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of omega-3 supplementation on serum leptin levels: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.phanu.2024.100401","DOIUrl":"10.1016/j.phanu.2024.100401","url":null,"abstract":"<div><h3>Background</h3><p>Omega-3 fatty acids have gained attention for their potential impact on appetite regulation and energy balance. Research suggests that omega-3 supplementation may influence leptin production and sensitivity, potentially affecting body weight and metabolic health. Therefore, this meta-analysis aimed to assess the effect of omega-3 supplementation on serum leptin levels.</p></div><div><h3>Methods</h3><p>A comprehensive search of the literature was conducted up to March 2024 in PubMed, Scopus, and Web of Science to find suitable randomized clinical trials (RCTs). The selected trials were subjected to heterogeneity tests using the I² statistic. Random effects models were examined based on the heterogeneity tests, and the pooled data were calculated as weighted mean differences (WMD) with a 95 % confidence interval (CI).</p></div><div><h3>Results</h3><p>Of the 357 papers, 25 eligible RCTs (with 29 treatment arms) were included in the present meta-analysis. Our findings indicated that omega-3 supplementation failed to change serum leptin levels significantly (WMD: −0.38 ng/mL; 95 %CI: −1.96–1.19; P =0.63). However, significant heterogeneity was detected among the included studies (I² = 85.6 %, P &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>This meta-analysis revealed that omega-3 supplementation had no significant impact on circulating leptin levels. However, it seems that omega-3 supplementation with a dosage of more than 2 g/day may significantly reduce serum leptin levels.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eicosapentaenoic acid-rich omega-3 fatty acids supplementation may improve vision in dry age-related macular degeneration or Stargardt disease, as shown in MADEOS, a prospective, randomized, multicentre, double-blind, placebo-controlled pilot study","authors":"Ekatherine Prokopiou ,&nbsp;Panagiotis Kolovos ,&nbsp;Haritini Tsangari ,&nbsp;Saddek Mohand-Said ,&nbsp;Luca Rossetti ,&nbsp;Leonardo Mastropasqua ,&nbsp;Francesco Bandello ,&nbsp;Tassos Georgiou","doi":"10.1016/j.phanu.2024.100400","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100400","url":null,"abstract":"<div><h3>Background</h3><p>This study investigates the effects of eicosapentaenoic acid (EPA)-rich omega-3 fatty acids on dry age-related macular degeneration (AMD) and Stargardt disease.</p></div><div><h3>Methods</h3><p>MADEOS is a prospective, randomized, multicenter, double-blind, placebo-controlled pilot study, which assessed the impact of omega-3 fatty acids on best corrected visual acuity, blood omega-6/omega-3 ratio, and perceived vision and mood using a questionnaire in patients with dry AMD or Stargardt disease. Participants received either the active product (3660 mg of EPA and DHA; 14 patients) or placebo (sunflower oil; 7 patients) daily for 24 weeks. Measurements were taken at screening (Visit 1), 12 weeks (Visit 3), and 24 weeks (Visit 4). Comparisons were made within and between groups.</p></div><div><h3>Results</h3><p>The mean letters gained at Visits 3 and 4 were significantly different between the groups (p=0.002). The active group showed a mean gain of 6 ETDRS letters from Visit 1 to Visit 4 (p=0.003). The mean arachidonic acid/EPA ratio in the active group significantly decreased from Visit 1 (5.84 ± 1.05) to Visit 4 (1.47 ± 0.16, p=0.002). The questionnaire scores were similar at Visit 3 but higher for the active group at Visit 4 (9.38 ± 3.35 vs. 7.28 ± 2.36).</p></div><div><h3>Conclusion</h3><p>EPA-rich omega-3 supplementation may improve both objective and subjective vision in patients with dry AMD or Stargardt disease, offering a potentially simple, safe, and cost-effective approach to enhancing quality of life.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000264/pdfft?md5=85a4d81c7eda2b13633958603a317c07&pid=1-s2.0-S2213434424000264-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal medicines and botanicals for managing insomnia, stress, anxiety, and depression: A critical review of the emerging evidence focusing on the Middle East and Africa","authors":"Morten Georg Jensen ,&nbsp;Michael Goode ,&nbsp;Michael Heinrich","doi":"10.1016/j.phanu.2024.100399","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100399","url":null,"abstract":"<div><h3>Background</h3><p>Mental health issues affect millions of people globally, imposing significant emotional and economic burdens. These involve multiple pathogenic mechanisms, including oxidative stress and neuroinflammation. With an annual global death estimated at 9 million, neurological disorders are the second leading cause of death. This review aims to explore the benefits of 15 medicinal plants available within MEA and provide researchers with knowledge on how these herbal medicines could alleviate symptoms associated with changes in mental health.</p></div><div><h3>Method</h3><p>Academic databases were searched to find relevant studies on traditional medicinal herbs used in the MEA for the treatment of mental health related issues like sleep, anxiety and depression.</p></div><div><h3>Result</h3><p>The MEA region has the highest prevalence of major depressive and anxiety disorders globally, with conventional treatments often involving medications that alter neurotransmitters, potentially leading to adverse effects. Given the concerns about long-term drug use, there is growing interest in multi-targeted approaches using medicinal plants. These offer a cost-effective, less hazardous alternative, especially for those with chronic, comorbid conditions. Medicinal plant-based food supplements are increasing within the MEA region, where cultural and traditional usage of such plants is extensive. However, the practical application of these supplements is often limited in real-world scenarios.</p></div><div><h3>Conclusion</h3><p>While medicinal plant-based food supplements show potential as a cost-effective and a more suitable alternative for individuals with chronic and comorbid conditions in the MEA region, further research is needed to overcome the limitations in their practical application including a focus on real world data.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434424000252/pdfft?md5=b322cc8b1a69edcdd888a444f75244e0&pid=1-s2.0-S2213434424000252-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily white tea intake reprograms hepatic metabolism and improves the enzymatic antioxidant defence system of rats with prediabetes","authors":"Ana C. Silveira ,&nbsp;Pedro Fontes Oliveira ,&nbsp;Marco G. Alves ,&nbsp;Luís Rato ,&nbsp;Branca M. Silva","doi":"10.1016/j.phanu.2024.100393","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100393","url":null,"abstract":"<div><h3>Background</h3><p>Prediabetes (PrDM) poses a significant risk for the development of Diabetes Mellitus (DM). Preventing the transition to type 2 DM is of utmost importance, and identifying novel dietary agents with both antioxidant and antidiabetic properties is crucial. This study aims to assess the potential of regular white tea (WTEA) consumption in alleviating the detrimental effects of PrDM on hepatic metabolism and redox state.</p></div><div><h3>Methods</h3><p>To achieve this, we divided 18 male Wistar rats into three groups: a control group and two prediabetes (PrDM) groups. In one of the PrDM groups, water consumption was replaced with white tea (WTEA). After a two-month period, we evaluated the hepatic metabolic profile using 1H NMR. Additionally, we measured total antioxidant potential, the activities of antioxidant enzymes, and various oxidative parameters, including protein nitration and carbonylation, lipid peroxidation, and levels of H2A.X and phosphorylated H2A.X.</p></div><div><h3>Results</h3><p>PrDM induced a decline in hepatic catabolic metabolism and the activities of key antioxidant enzymes, including superoxide dismutase, glutathione reductase, catalase, and levels of phosphorylated H2A.X. However, when PrDM rats consumed WTEA, a remarkable restoration occurred. Specifically, WTEA intake reinstated glutathione reductase and catalase activities and elevated superoxide dismutase activity in the liver compared to normoglycemic conditions. Moreover, enhancements were noted in overall antioxidant capacity and a reduction in lipid peroxidation in the rat liver.</p></div><div><h3>Conclusion</h3><p>PrDM significantly impacts liver metabolism and antioxidant defenses, but the consumption of WTEA, a plant-based functional beverage, exhibits potent hepatoprotective capabilities against PrDM-induced oxidative stress.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective vitamin D supplementation among women with gestational diabetes and perinatal outcomes: Results of a clinical trial","authors":"Nathalia Ferreira Antunes de Almeida ,&nbsp;Claudia Saunders ,&nbsp;Thais Rangel Bousquet Carrilho ,&nbsp;Lenita Zajdenverg ,&nbsp;Cleber Nascimento do Carmo ,&nbsp;Elisabete Caldeiras Queiroz Neves ,&nbsp;Juliana Braga ,&nbsp;Bárbara Folino Nascimento ,&nbsp;Mayara Santos ,&nbsp;Patricia de Carvalho Padilha","doi":"10.1016/j.phanu.2024.100395","DOIUrl":"10.1016/j.phanu.2024.100395","url":null,"abstract":"<div><h3>Background</h3><p>Gestational diabetes mellitus (GDM) is a common clinical condition worldwide that affects the health of women and their offspring. Theaim was to assess whether a protocol of vitamin D supplementation among women with GDM was efficient in increasing vitamin D levels at the end of pregnancy, and to explore whether the supplementation reduced the occurrence of adverse neonatal outcomes among those women.</p></div><div><h3>Methods</h3><p>A controlled clinical trial.Vitamin D was assessed at baseline (&lt; 28 gestational weeks) and after 8 weeks of intervention and categorized as adequate (<u>&gt;</u>30 ng/mL), insufficient (20–29.9 ng/mL), or deficient (&lt;20 ng/mL). Women with insufficiency received 2000 UI daily of vitamin D supplementation and those with deficiency received 7000 UI daily for 8 weeks. The outcomes 25-hydroxyvitamin D [25(OH)D] concentration at 28 weeks, glycemic control, total gestational weight gain, birth weight, and gestational age at birth. Statistical analyses included Chi-squared or Fisher’s exact tests for categorical variables and Kruskall–Wallis test for continuous variables to compare the groups.</p></div><div><h3>Results</h3><p>At baseline, 59 pregnant women with GDM allocated to the study group were evaluated at baseline.Vitamin D status changed between the first and second examinations in 70 % of the women investigated. The insufficient and deficient groups showed a tendency towards improvement in glycemic control (p = 0.096). No differences were identified between the groups in terms of the neonatal variables.</p></div><div><h3>Conclusion</h3><p>Supplementation was effective in adjusting serum vitamin D levels, and its effect on glycemic control appeared promising in this preliminary investigation.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular and molecular mechanisms of action of epigallocatechin gallate on bladder cancer: A comprehensive systematic review","authors":"Hussein Riyadh Abdul Kareem Al-Hetty ,&nbsp;Abdulrahman T. Ahmed ,&nbsp;Hiba Muwafaq Saleem ,&nbsp;Haitham L. Abdulhadi ,&nbsp;Thikra Majid Muhammed ,&nbsp;Loay H. Ali","doi":"10.1016/j.phanu.2024.100392","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100392","url":null,"abstract":"<div><h3>Background</h3><p>Bladder cancer is a common type of cancer that originates in the cells of the bladder. Research studies have indicated that green tea has positive effects on human health, including its ability to combat cancer. Catechins, which account for 12–25 percent of the dried weight of green tea, are one of its main components. In this study, we conducted a systematic review of the literature to examine the effects of epigallocatechin gallate (EGCG) on bladder cancer.</p></div><div><h3>Method</h3><p>The study followed the guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements . We searched various databases including Web of Sciences, PubMed, Embase, Science Direct, Scopus, and the Cochrane databases, up until October 2022<strong>.</strong> Two reviewers independently screened the data and assessed the risk of bias. After applying the inclusion criteria, a total of 34 studies were included in the analysis<strong>.</strong></p></div><div><h3>Results</h3><p>The evidence from the study indicates that EGCG can regulate the progression of bladder cancer through various mechanisms. These mechanisms include reducing inflammation, decreasing the production of reactive oxygen species (ROS), managing oxidative stress (OS), inhibiting angiogenesis, suppressing cancer cell proliferation, controlling the cell cycle, inducing autophagy, stimulating tumor gene suppressors (TGS), and promoting apoptosis.</p></div><div><h3>Conclusion</h3><p>Based on the substantial beneficial effects of EGCG on bladder cancer progression, it has the potential to be used as a therapeutic approach. However, it is important to note that there is a lack of clinical trials involving human subjects. Therefore, further research involving human participants is necessary to reach a more precise conclusion<strong>.</strong></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D administration on serum uric acid concentrations: A systematic review and meta-analysis of clinical trials","authors":"Luis E. Simental-Mendía ,&nbsp;Yéssika Weyman-Vela ,&nbsp;Mario Simental-Mendía","doi":"10.1016/j.phanu.2024.100391","DOIUrl":"10.1016/j.phanu.2024.100391","url":null,"abstract":"<div><h3>Background</h3><p>It has been suggested the potential uric acid-lowering effect of vitamin D; however, clinical trials evaluating the impact of vitamin D administration on serum uric acid levels are scarce. The aim of this meta-analysis of clinical trials was to examine the effect of vitamin D administration on serum uric acid concentrations.</p></div><div><h3>Methods</h3><p>A systematic search was performed in PubMed-MEDLINE, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases. Randomized clinical trials (parallel or cross-over design) with data at baseline and at the end of intervention. Trials without intervention, without control group, and incomplete data of uric acid concentrations were excluded. A random-effects model and sensitivity analysis generic inverse variance method were used for the meta-analysis.</p></div><div><h3>Results</h3><p>Meta-analysis was carried out using a random-effects model and sensitivity analysis. The meta-analysis of seven clinical trials, involving 959 participants, indicated a significant reduction of uric acid levels after vitamin D administration (WMD: −16.64 µmol/L, 95% CI: −25.25, −8.03, <em>p</em> &lt;0.001, <em>I</em>^<em>2</em> = 74%). Additionally, the impact of this vitamin on uric acid concentrations was robust in the leave-one-out sensitivity analysis.</p></div><div><h3>Discussion</h3><p>Given that few clinical trials were included, the number of subjects analyzed was limited. However, our results suggest that vitamin D administration is associated with a significant reduction in the levels of serum uric acid in randomized clinical trials.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics in plant-based food matrices: A review of their health benefits","authors":"Sara Sayonara da Cruz Nascimento ,&nbsp;Thaís Souza Passos ,&nbsp;Francisco Canindé de Sousa Júnior","doi":"10.1016/j.phanu.2024.100390","DOIUrl":"10.1016/j.phanu.2024.100390","url":null,"abstract":"<div><h3>Background</h3><p>Plant-based food matrices have been increasingly used as vehicles for probiotics due to their high nutritional and bioactive value. Therefore, this review summarizes the health benefits of plant-based food matrices probiotics focusing on <em>in vitro</em> and <em>in vivo</em> studies.</p></div><div><h3>Methods</h3><p>A narrative literature review was performed to select articles published between 2015 and 2024. The Scopus, Science Direct, Web of Science, PubMed, and EMBASE scientific databases were used. Full articles that evaluated the health benefits of consuming plant-based food matrices probiotics performed <em>in vitro</em> and <em>in vivo</em> (animal models and clinical trials in humans) were selected.</p></div><div><h3>Results</h3><p>From the scientific evidence, it was possible to highlight the health benefits of probiotics in plant-based food matrices and their association with bioactive compounds treating various diseases, proving beneficial effects in treating cancer, liver diseases, obesity, and related chronic diseases and inflammatory diseases. However, it was noted that clinical trials are still needed to confirm these effects in humans.</p></div><div><h3>Conclusions</h3><p>Plant-based food matrices probiotics have proven beneficial effects in various diseases based on <em>in vitro</em> and animal model studies. However, clinical trials are needed to confirm these effects.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing hypertension using brewing bioactive peptides as angiotensin-converting enzyme inhibitors: Impact on vascular tone through ex vivo assays","authors":"Rita Ribeiro-Oliveira ,&nbsp;Pilar Rodríguez-Rodríguez ,&nbsp;Joana Beatriz Sousa ,&nbsp;Isabel M.P.L.V.O. Ferreira ,&nbsp;Silvia M. Arribas ,&nbsp;Carmen Diniz","doi":"10.1016/j.phanu.2024.100389","DOIUrl":"10.1016/j.phanu.2024.100389","url":null,"abstract":"<div><h3>Background</h3><p>Peptides derived from brewer’s spent grain (BSG) and yeast (BSY) are promising natural substitutes of synthetic drugs to manage hypertension as inhibitors of angiotensin-converting enzyme (ACE). However, their impact on the vascular function, so far, remains to be verified. Accordingly, we aimed to evaluate the effect of brewing peptides on the arterial vasocontractile response to angiotensin (Ang) I (through vascular ACE-inhibition) to estimate their antihypertensive potential. The impact of the oral route (gastrointestinal digestion, intestinal absorption, and liver metabolism) in brewing peptides was also investigated.</p></div><div><h3>Methods</h3><p>Iliac arteries from adult spontaneously hypertensive rats were studied with isometric tension recording. After ensuring the function integrity of the arteries, concentration-response curves to addition of Ang I (10⁻⁹-10⁻⁶ M) were performed after 30 min incubation with MIX (50:50 mixture of BSG:BSY) or BSG (0.86 mg/mL), or captopril (an ACE-inhibitory drug) or Krebs solution.</p></div><div><h3>Results</h3><p>MIX peptides (without simulated oral administration) enhanced Ang I-induced vasoconstriction, but lacked vascular effects after simulated oral administration. By contrast, BSG peptides (without simulated oral administration) did not exhibit vascular effects, whereas they promoted a marked decrease in vasocontraction evoked by the generated Ang II after simulation of the oral route, implying their capability to inhibit ACE. Additionally, to elucidate this inhibitory mechanism, Michaelis-Menten and Lineweaver-Burk plots indicated a mixed inhibition type.</p></div><div><h3>Conclusion</h3><p>With simulation of the oral route, BSG peptides were able to inhibit vascular ACE with a similar efficacy as the antihypertensive drug captopril, suggesting the potential to mitigate the burden of hypertension.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}