PharmaNutrition最新文献

{"title":"Caffeic acid and its derivatives as multifunctional anticancer agents: From mechanisms to clinical prospects","authors":"Amol Patil,&nbsp;Durgacharan Bhagwat","doi":"10.1016/j.phanu.2026.100472","DOIUrl":"10.1016/j.phanu.2026.100472","url":null,"abstract":"<div><div>Caffeic acid (CA) is a naturally occurring phenolic compound found in coffee, fruits, vegetables, and herbs. It exhibits significant anticancer potential via multiple biological mechanisms. In healthy cells, CA acts as an antioxidant, while in cancer cells it exerts pro-oxidant effects that promote cytotoxicity. CA induces apoptosis through Bcl-2 suppression, cytochrome c release, and caspase activation. Furthermore, it inhibits tumor metastasis by downregulating Snail and matrix metalloproteinases, and counters multidrug resistance by inhibiting efflux pump activity. CA’s derivative, caffeic acid phenethyl ester (CAPE), shares these properties and exhibits synergistic effects with chemotherapeutic agents such as tamoxifen and doxorubicin. Despite compelling preclinical evidence, clinical application is limited by CA’s low bioavailability and rapid metabolism. Innovative drug delivery strategies, including nanoparticles, liposomes, and targeted systems, are being explored to overcome these challenges. Early-phase clinical trials in cancers are underway, investigating CA as a potential adjuvant or chemosensitizer. While clinical data remain sparse, CA holds promise as an integrative component in cancer therapy, warranting further investigation in well-designed clinical studies.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"35 ","pages":"Article 100472"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of Musa balbisiana fruit pulp and Garcinia candy on gut microbiota alterations of aged albino Wistar rats","authors":"Partha Pratim Sarma ,&nbsp;Santanu Das ,&nbsp;Swarnali Bhattacharjee ,&nbsp;Mojibur R. Khan ,&nbsp;Rajlakshmi Devi","doi":"10.1016/j.phanu.2025.100471","DOIUrl":"10.1016/j.phanu.2025.100471","url":null,"abstract":"<div><div>Fruits and vegetables, including their derivatives or preparations, play a crucial role in maintaining overall human health due to their rich nutrient content, including vitamins, minerals, fibre, and antioxidants. <em>Musa balbisiana</em> (MB) and <em>Garcinia pedunculata</em> (GP) are two versatile medicinal plants, widely used by the ethnic people of the Indian subcontinent for their remarkable health benefits, without much scientific study. In this study, we investigated the beneficial effects of these fruit preparations on lowering lipid parameters and gut microbiota in aged albino Wistar rats. Our results indicate the potential of MB and GC (a candy prepared from GP) in managing blood lipid profiles such as HDL, LDL, cholesterol, triglycerides, liver enzymes, and kidney parameters. Additionally, microbiota study revealed higher bacterial diversity (alpha diversity) and a significant increase in beneficial gut bacteria such as <em>Muribaculum</em>, <em>Phocaeicola</em>, and <em>Ruminococcus</em> following the administration of GC and MB. Additionally, dominant taxa at the genus level showed a strong association with serum biochemical markers. GC-MS analysis identified important fecal metabolites with a significant role in managing gut microbial metabolism and systemic physiological responses. Overall, this study suggests the beneficial effects of MB and GC in managing healthy aging and gut microbial composition, thereby maintaining healthy gastrointestinal physiology.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"35 ","pages":"Article 100471"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the preventive effects of phytochemicals on Benzo(a)pyrene-induced lung tumors in animal models","authors":"Juan Lu ,&nbsp;Wei Wei ,&nbsp;Zhixin Tang ,&nbsp;Kang Li ,&nbsp;Shouyue Zhang ,&nbsp;Shuai Wu ,&nbsp;Yuyao Yang ,&nbsp;Yang Liu ,&nbsp;Xiaohui Hua","doi":"10.1016/j.phanu.2026.100473","DOIUrl":"10.1016/j.phanu.2026.100473","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;Benzo[&lt;em&gt;a&lt;/em&gt;]pyrene (B[&lt;em&gt;a&lt;/em&gt;]P) is a ubiquitous environmental carcinogen strongly associated with lung cancer. While numerous phytochemicals have been identified as possessing preventive properties against B[&lt;em&gt;a&lt;/em&gt;]P-induced lung cancer, existing studies have primarily focused on the effects of individual phytochemicals. Therefore, we performed a meta-analysis to systematically evaluate and compare the preventive effects of various phytochemicals on B[&lt;em&gt;a&lt;/em&gt;]P-induced lung cancer.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We conducted a comprehensive search of the PubMed and Web of Science databases for publications regarding the preventive effects of phytochemicals in animal models of B[&lt;em&gt;a&lt;/em&gt;]P-induced lung tumors. We screened original articles providing data on lung tumor incidence, lung lipid peroxides, enzymatic and non-enzymatic antioxidants. Ultimately, 21 publications were included in our analysis, and statistical evaluation was performed using Review Manager 5.4.1.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Our findings indicate that phytochemicals significantly reduce the incidence of lung tumors [OR = 0.03, 95 % CI = (0.01, 0.09), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 0 %] and decrease lipid peroxide (LPO) levels [SMD = -3.71, 95 %CI = (-4.80, -2.62), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 0 %]. Additionally, phytochemicals significantly enhance the secretion of lung antioxidant enzymes, including superoxide dismutase (SOD) [SMD = 3.25, 95 % CI = (2.60, 3.90), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 42 %], catalase (CAT) [SMD = 2.94, 95 % CI = (2.44, 3.44), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 0 %], glutathione peroxidase (GPx) [SMD = 3.77, 95 % CI = (2.59, 4.96), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 68 %], Glutathione S-transferase (GST) [SMD = 2.79, 95 % CI = (2.21, 3.38), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 5 %], Glutathione reductase (GR) [SMD = 3.85, 95 % CI = (3.13, 4.57), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 23 %], and glutathione (GSH) [SMD = 4.07, 95 % CI = (2.38, 5.75), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 77 %]. Moreover, they promote the levels of non-enzymatic antioxidants in the lungs, such as Vitamin C (Vit C) [SMD = 2.66, 95 % CI = (1.64, 3.68), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 72 %] and Vitamin E (Vit E) [SMD = 3.32, 95 % CI = (2.34, 4.30), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001, I&lt;sup&gt;2&lt;/sup&gt; = 57 %]. In this study, we grouped all phytochemicals as a single category; however, varying mechanisms among different compounds may contribute to the observed heterogeneity in some results.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Phytochemicals exhibit a statistically significant preventive effect against B[&lt;em&gt;a&lt;/em&gt;]P-induced lung tumors in mice. Therefore, supplementation with appropriate phytochemicals, such as flavonoids, alkaloids, and carotenoids, may serve as a viable strategy for chemoprevention. However, given that this study is based on animal models, further re","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"35 ","pages":"Article 100473"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer insights: Significance of Murraya koenigii and their potential in prevention and therapeutic intervention","authors":"Jayashree Venugopal ,&nbsp;Surabhi Panneerselvam ,&nbsp;Gayathri rajaram ,&nbsp;Panneerselvam Theivendren","doi":"10.1016/j.phanu.2026.100478","DOIUrl":"10.1016/j.phanu.2026.100478","url":null,"abstract":"<div><div>The review aims at discussing the therapeutic potential of Murrayanine, a bioactive compound obtained by using <em>Murraya koenigii</em>, as a new strategy in the prevention and treatment of breast cancer. Due to the prevalence of breast cancer across the world and the constraints of traditional treatment methods, this review examines the multiple mechanisms of action of Murrayanine, such as inducing apoptosis and inhibiting cell growth, as well as altering major signalling pathways, such as PI3K/Akt, NF-kB, and MAPK. There is support of evidence regarding preclinical studies, which indicate that Murrayanine has strong anticancer activity in that it is effective against a range of cancer cell types, such as breast, colon, and lung cancer. It has been demonstrated to overcome multidrug resistance and minimise the levels of chemotherapy induced cytotoxicity to normal cells, thereby increasing the therapeutic efficacy of conventional chemotherapy agents, doxorubicin and paclitaxel. In addition, Murrayanine as an antioxidant and anti-inflammatory agent also adds to its protective effects by preventing oxidative stress and inflammation associated with cancer progression. The main conclusions indicate the synergistic value of Murrayanine with chemotherapy that can be used to enhance the treatment process, decrease the adverse effects. Nevertheless, its issues like low bioavailability and the necessity to engage more clinical validation should be resolved to make the full translation of Murrayanine to clinical practise possible. The review recommends further investigation of the role of Murrayanine in the integrative cancer therapy.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"35 ","pages":"Article 100478"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic effects of Lacticaseibacillus casei and its postbiotic on anxiety and learning behavior in rats","authors":"Buse Nur Sülük ,&nbsp;Nurhan Gumral ,&nbsp;Tuğba Kök Taş ,&nbsp;Ozlem Ozmen ,&nbsp;Rahime Aslankoc ,&nbsp;Cahide Aslan ,&nbsp;Oguzhan Kavrik","doi":"10.1016/j.phanu.2026.100477","DOIUrl":"10.1016/j.phanu.2026.100477","url":null,"abstract":"<div><div>Gut microbiota may regulate brain function through the gut-brain axis. Probiotics have been shown to influence emotional, cognitive behaviors, including anxiety and social interaction, by altering microbial composition and signaling pathways. Postbiotics are non-viable microbial cells or their metabolities that can exert health benefits similar to probiotics. This study hypothesized that <em>Lacticaseibacillus casei (L. casei)</em> and its postbiotic derivatives could alleviate anxiety and improve learning behaviors and by modulating oxidative stress and neurochemical pathways. Thirty-two male Wistar albino rats were divided into control, L. casei and postbiotic (mediators of <em>L. casei</em>) groups and received daily oral supplemantation for 42 days. Behavioral tests were performed between days 33–42 and the animals were sacrificed after tests. Prefrontal cortex, hippocampus and amygdala tissues were collected for histopathological, immunohistochemical and biochemical analyses. Behavioral tests, including Elevated Plus Maze(EPM), Novel Object Recognition(NOR), Forced Swimming Test(FST), and Morris Water Maze(MWM), revealed that both probiotic and postbiotic supplemantation reduced anxiety-like behaviors (e.g.,EPM open arm time, p = 0.024; FST immobility time, p = 0.008) and enhanced memory performance (e.g.,NOR, p = 0.031;MWM target quadrant time, p = 0.021). Biochemically, L. casei and postbiotic significantly decreased malondialdehyde (MDA) levels (p = 0.009, p = 0.003, respectively) and increased superoxide dismutase (SOD) activity (p = 0.041, p = 0.033, respectively). Although seratonin expression changes were not significant, behivioral improvements were evident. These findings suggest that L. casei and its postbiotics can be used as potential agents for anxiety reduction and cognitive enhancement through their antioxidative and neuromodulatory effects. This study emphasizes the therapeutic approach of postbiotics as an alternative to live probiotics in neurobehavioral modulation.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"35 ","pages":"Article 100477"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bovine milk-derived exosomes as natural multimodal therapeutic agents for peripheral and central pathophysiological conditions","authors":"Subhrajita Panda,&nbsp;Faraz Ahmad","doi":"10.1016/j.phanu.2025.100457","DOIUrl":"10.1016/j.phanu.2025.100457","url":null,"abstract":"<div><div>Bovine milk exosomes (BMEs) are dietary agents with incredible implications for human pathophysiology. As mediators of inter-species communication, they regulate cellular pathways of growth, metabolism and immunity. Natural origin, biocompatibility, and economic viability in terms of abundance and almost unlimited production, have been instrumental in generating considerable attention for their utilization as clinically-relevant therapeutic tools. Indeed, in spite of the lack of universally standardized isolation, characterization and quality-assessment protocols, BMEs have been investigated extensively as biomimetic nanoplatforms for drug delivery. However, the therapeutic actions of their endogenous cargo have remained largely unexplored. In particular, despite favourable <em>in silico</em> data, few studies have addressed the neuromodulant and neuroprotective utilities of BMEs and their endogenous payload. In this review, we first critically analyse techniques used for purification and physico-chemical characterization of BMEs. We then proceed to examine bioavailability of BMEs, with a particular focus on brain availability, and addressing potential safety issues. Next, we delineate the endogenous therapeutic actions of BMEs in diverse pathophysiological conditions such as gastrointestinal and resident microbial dyshomeostasis, metabolic, redox and inflammatory dysfunctions, and angiogenic, musculoskeletal and dermal ailments. Finally, evidences for the potential neuromodulant and protective actions of BMEs are presented. With their abilities to resist digestion in the gut and permeate the blood brain barrier (BBB), combined with the presence of a multitude of neuromodulatory bimolecular species as part of the endogenous payload, BMEs may be harnessed to serve as orally supplemented neuroprotective agents against multiple brain disorders.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100457"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D does not mitigate monocyte adhesion to vascular endothelial cells in an in vitro pro-inflammatory model","authors":"Mirko Marino ,&nbsp;Samuele Venturi ,&nbsp;Peter Møller ,&nbsp;Marco Rendine ,&nbsp;Daniela Martini ,&nbsp;Patrizia Riso ,&nbsp;Cristian Del Bo'","doi":"10.1016/j.phanu.2025.100454","DOIUrl":"10.1016/j.phanu.2025.100454","url":null,"abstract":"<div><div>Vitamin D deficiency has been associated with cardiovascular risk factors, including endothelial dysfunction, a critical step in the pathogenesis of atherosclerosis. This study aimed to evaluate the effects of 1α,25-dihydroxycholecalciferol (VD3) on monocyte (THP-1) adhesion to human umbilical vein endothelial cells (HUVECs) under a pro-inflammatory condition. Endothelial cell activation was induced with tumor necrosis factor-alpha (TNF-α, 100 ng/mL), and cells were treated with VD3 at concentrations ranging from 0.1 to 100 nM. Monocyte adhesion was quantified spectrophotometrically, while levels of vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and cluster of differentiation 15 (CD15) were assessed using ELISA. TNF-α significantly increased THP-1 cell adhesion to HUVECs compared to the control group (p &lt; 0.05). Co-treatment with VD3 at all concentrations tested did not reduce monocyte adhesion, showing levels similar to the TNF-α only group, and significantly higher than the negative control (p &lt; 0.05). Furthermore, TNF-α significantly upregulated VCAM-1 expression (p &lt; 0.05), which was unaffected by VD3. E-selectin and CD15 levels remained unchanged under all experimental conditions. These results do not support a modulatory role for VD3 in the early stages of atherogenesis, specifically in reducing endothelial cell activation and monocyte adhesion. While vitamin D has shown beneficial effects in other aspects of cardiovascular health, its impact on vascular inflammation and adhesion processes remains uncertain and needs further investigation.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100454"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide improves physiological outcomes in an arginine vasopressin rat model of pre-eclampsia","authors":"Rebecca Reddy ,&nbsp;Sooraj Baijnath ,&nbsp;Nalini Govender","doi":"10.1016/j.phanu.2025.100459","DOIUrl":"10.1016/j.phanu.2025.100459","url":null,"abstract":"<div><div>Pre-eclampsia (PE) is a hypertensive disorder of pregnancy that poses a substantial risk to both maternal and fetal health, especially in low-middle-income countries. Despite advancements in pregnancy-related research, effective treatment options for PE remain limited, emphasizing the need for innovative therapeutic strategies in regions that are under-resourced with the highest burden. In this light, there has been growing interest in the safety and efficacy of natural products, where nicotinamide (NAM) has emerged as a promising candidate for alternative PE management. This study aims to evaluate the therapeutic potential of NAM in a preclinical model of PE, specifically assessing its effects on blood pressure, placental and fetal development, and hematological parameters. Twenty-four pregnant female Sprague Dawley rats were subcutaneously administered arginine vasopressin (AVP) via mini osmotic pumps (infused at a rate of 200 ng/h). AVP-administered rodents received either NAM (p.o., 200 mg/kg body weight) or captopril (p.o., 40 mg/kg body weight (BW)) for two weeks. Our findings demonstrate that NAM effectively reduced both systolic and diastolic blood pressure in AVP-treated rats, reduced urinary protein levels and the urine protein-to-creatinine ratio (UPCR), alongside improvements in hematological parameters. Concerning pregnancy outcomes, NAM administrations significantly increased urine output and placental and individual pup weights. These findings highlight the preclinical efficacy of NAM in ameliorating the symptoms associated with hypertension in pregnancy, improving both maternal and fetal well-being, and paving the way for future research into the use of NAM.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100459"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145418244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic advances in hyperuricemia and anti-hyperuricemia therapies","authors":"Mingyue Ao ,&nbsp;Xi Zhang ,&nbsp;Ru Chen ,&nbsp;Chun Xiao ,&nbsp;Yinhua Liu ,&nbsp;Min Gao ,&nbsp;Ya Zhang","doi":"10.1016/j.phanu.2025.100456","DOIUrl":"10.1016/j.phanu.2025.100456","url":null,"abstract":"<div><div>Hyperuricemia (HUA) is a systemic metabolic disorder characterized by disturbances in uric acid metabolism and elevated serum uric acid levels, and it is a major risk factor for gout. It has risen to become the second largest metabolic disease threatening human health, and is known as one of the \"four highs\" along with hypertension, hyperlipidemia, and hyperglycemia. At present, clinical treatment for HUA can be divided into three categories: inhibiting uric acid production, promoting uric acid excretion, and decomposing uric acid. Although the mechanism is clear and the effect is significant, there are varying degrees of safety risks involved. Therefore, a growing number of studies are dedicated to finding new pathogenic mechanisms or potential therapeutic targets for HUA. It is of great significance to comprehensively understand HUA and develop feasible and effective treatment methods. In this review, we systematically elucidate the pathogenesis, related drug treatment progress, and strategies for regulating HUA by gut microbiota. At the same time, the effects of different dietary structures on gut microbiota and the impact of gut microbiota on purine and uric acid metabolism were explored. In addition, the intervention effects of probiotics and prebiotics on HUA were systematically evaluated, in order to provide theoretical basis for the research and development of uric acid lowering drugs.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100456"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145418243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The healing power of Manuka honey: A comprehensive review of its anti-cancer properties","authors":"Idrisa Kiryowa ,&nbsp;Aya Darwish ,&nbsp;Denis Baranenko ,&nbsp;Tamer M. El-Messery ,&nbsp;Mohamed Said Boulkrane","doi":"10.1016/j.phanu.2025.100462","DOIUrl":"10.1016/j.phanu.2025.100462","url":null,"abstract":"<div><div>Leptospermum scoparium, or Manuka honey, contains active elements such as methylglyoxal, methylsyringate, and leptosin that have been identified to possess anti-cancer property. These molecules eradicate cancer cells by a reduction of the AKT/mTOR pathway, the damping of the stress caused by oxidation, and the induction of apoptosis. Studies on animals have proved that those substances have capacities to inhibit the growth of tumors in breast, colorectal, and liver cancers, both in vitro and in vivo. Manuka honey not only protects the body from side effects of chemotherapeutics but also increases the efficiency of the drugs. The usage of this method in clinical practice still holds back due to the bioavailability, variations in the compounds, and the standardization of the dose. Manuka honey has become a potential adjunct therapy that not only enhances the treatment outcomes but also maintains the minimal side effects. This meta-analysis paper pinpoints not only limited potential but, in fact, multi-targeted therapeutic ability the honey possesses. However, despite the growing evidence supporting its biological activity, there are still several challenges to be addressed before its clinical application. These include issues related to bioavailability, standardization of formulations based on UMF classification, and the lack of well-controlled human clinical trials. Additionally, future research should focus on developing advanced delivery systems, such as nanoparticle formulations, to enhance the stability and targeted delivery of the bioactive components in manuka honey. In conclusion, manuka honey holds great promise as a complementary therapy in oncology. With its multi-target mechanisms and robust safety profile, it offers a valuable opportunity for incorporation into cancer treatment protocols. Addressing current application barriers will be essential to fully realize its therapeutic potential in clinical settings.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100462"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}