PharmaNutrition最新文献

{"title":"Daily white tea intake reprograms hepatic metabolism and improves the enzymatic antioxidant defence system of rats with prediabetes","authors":"Ana C. Silveira ,&nbsp;Pedro Fontes Oliveira ,&nbsp;Marco G. Alves ,&nbsp;Luís Rato ,&nbsp;Branca M. Silva","doi":"10.1016/j.phanu.2024.100393","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100393","url":null,"abstract":"<div><h3>Background</h3><p>Prediabetes (PrDM) poses a significant risk for the development of Diabetes Mellitus (DM). Preventing the transition to type 2 DM is of utmost importance, and identifying novel dietary agents with both antioxidant and antidiabetic properties is crucial. This study aims to assess the potential of regular white tea (WTEA) consumption in alleviating the detrimental effects of PrDM on hepatic metabolism and redox state.</p></div><div><h3>Methods</h3><p>To achieve this, we divided 18 male Wistar rats into three groups: a control group and two prediabetes (PrDM) groups. In one of the PrDM groups, water consumption was replaced with white tea (WTEA). After a two-month period, we evaluated the hepatic metabolic profile using 1H NMR. Additionally, we measured total antioxidant potential, the activities of antioxidant enzymes, and various oxidative parameters, including protein nitration and carbonylation, lipid peroxidation, and levels of H2A.X and phosphorylated H2A.X.</p></div><div><h3>Results</h3><p>PrDM induced a decline in hepatic catabolic metabolism and the activities of key antioxidant enzymes, including superoxide dismutase, glutathione reductase, catalase, and levels of phosphorylated H2A.X. However, when PrDM rats consumed WTEA, a remarkable restoration occurred. Specifically, WTEA intake reinstated glutathione reductase and catalase activities and elevated superoxide dismutase activity in the liver compared to normoglycemic conditions. Moreover, enhancements were noted in overall antioxidant capacity and a reduction in lipid peroxidation in the rat liver.</p></div><div><h3>Conclusion</h3><p>PrDM significantly impacts liver metabolism and antioxidant defenses, but the consumption of WTEA, a plant-based functional beverage, exhibits potent hepatoprotective capabilities against PrDM-induced oxidative stress.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100393"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective vitamin D supplementation among women with gestational diabetes and perinatal outcomes: Results of a clinical trial","authors":"Nathalia Ferreira Antunes de Almeida ,&nbsp;Claudia Saunders ,&nbsp;Thais Rangel Bousquet Carrilho ,&nbsp;Lenita Zajdenverg ,&nbsp;Cleber Nascimento do Carmo ,&nbsp;Elisabete Caldeiras Queiroz Neves ,&nbsp;Juliana Braga ,&nbsp;Bárbara Folino Nascimento ,&nbsp;Mayara Santos ,&nbsp;Patricia de Carvalho Padilha","doi":"10.1016/j.phanu.2024.100395","DOIUrl":"10.1016/j.phanu.2024.100395","url":null,"abstract":"<div><h3>Background</h3><p>Gestational diabetes mellitus (GDM) is a common clinical condition worldwide that affects the health of women and their offspring. Theaim was to assess whether a protocol of vitamin D supplementation among women with GDM was efficient in increasing vitamin D levels at the end of pregnancy, and to explore whether the supplementation reduced the occurrence of adverse neonatal outcomes among those women.</p></div><div><h3>Methods</h3><p>A controlled clinical trial.Vitamin D was assessed at baseline (&lt; 28 gestational weeks) and after 8 weeks of intervention and categorized as adequate (<u>&gt;</u>30 ng/mL), insufficient (20–29.9 ng/mL), or deficient (&lt;20 ng/mL). Women with insufficiency received 2000 UI daily of vitamin D supplementation and those with deficiency received 7000 UI daily for 8 weeks. The outcomes 25-hydroxyvitamin D [25(OH)D] concentration at 28 weeks, glycemic control, total gestational weight gain, birth weight, and gestational age at birth. Statistical analyses included Chi-squared or Fisher’s exact tests for categorical variables and Kruskall–Wallis test for continuous variables to compare the groups.</p></div><div><h3>Results</h3><p>At baseline, 59 pregnant women with GDM allocated to the study group were evaluated at baseline.Vitamin D status changed between the first and second examinations in 70 % of the women investigated. The insufficient and deficient groups showed a tendency towards improvement in glycemic control (p = 0.096). No differences were identified between the groups in terms of the neonatal variables.</p></div><div><h3>Conclusion</h3><p>Supplementation was effective in adjusting serum vitamin D levels, and its effect on glycemic control appeared promising in this preliminary investigation.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"29 ","pages":"Article 100395"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular and molecular mechanisms of action of epigallocatechin gallate on bladder cancer: A comprehensive systematic review","authors":"Hussein Riyadh Abdul Kareem Al-Hetty ,&nbsp;Abdulrahman T. Ahmed ,&nbsp;Hiba Muwafaq Saleem ,&nbsp;Haitham L. Abdulhadi ,&nbsp;Thikra Majid Muhammed ,&nbsp;Loay H. Ali","doi":"10.1016/j.phanu.2024.100392","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100392","url":null,"abstract":"<div><h3>Background</h3><p>Bladder cancer is a common type of cancer that originates in the cells of the bladder. Research studies have indicated that green tea has positive effects on human health, including its ability to combat cancer. Catechins, which account for 12–25 percent of the dried weight of green tea, are one of its main components. In this study, we conducted a systematic review of the literature to examine the effects of epigallocatechin gallate (EGCG) on bladder cancer.</p></div><div><h3>Method</h3><p>The study followed the guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements . We searched various databases including Web of Sciences, PubMed, Embase, Science Direct, Scopus, and the Cochrane databases, up until October 2022<strong>.</strong> Two reviewers independently screened the data and assessed the risk of bias. After applying the inclusion criteria, a total of 34 studies were included in the analysis<strong>.</strong></p></div><div><h3>Results</h3><p>The evidence from the study indicates that EGCG can regulate the progression of bladder cancer through various mechanisms. These mechanisms include reducing inflammation, decreasing the production of reactive oxygen species (ROS), managing oxidative stress (OS), inhibiting angiogenesis, suppressing cancer cell proliferation, controlling the cell cycle, inducing autophagy, stimulating tumor gene suppressors (TGS), and promoting apoptosis.</p></div><div><h3>Conclusion</h3><p>Based on the substantial beneficial effects of EGCG on bladder cancer progression, it has the potential to be used as a therapeutic approach. However, it is important to note that there is a lack of clinical trials involving human subjects. Therefore, further research involving human participants is necessary to reach a more precise conclusion<strong>.</strong></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100392"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D administration on serum uric acid concentrations: A systematic review and meta-analysis of clinical trials","authors":"Luis E. Simental-Mendía ,&nbsp;Yéssika Weyman-Vela ,&nbsp;Mario Simental-Mendía","doi":"10.1016/j.phanu.2024.100391","DOIUrl":"10.1016/j.phanu.2024.100391","url":null,"abstract":"<div><h3>Background</h3><p>It has been suggested the potential uric acid-lowering effect of vitamin D; however, clinical trials evaluating the impact of vitamin D administration on serum uric acid levels are scarce. The aim of this meta-analysis of clinical trials was to examine the effect of vitamin D administration on serum uric acid concentrations.</p></div><div><h3>Methods</h3><p>A systematic search was performed in PubMed-MEDLINE, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases. Randomized clinical trials (parallel or cross-over design) with data at baseline and at the end of intervention. Trials without intervention, without control group, and incomplete data of uric acid concentrations were excluded. A random-effects model and sensitivity analysis generic inverse variance method were used for the meta-analysis.</p></div><div><h3>Results</h3><p>Meta-analysis was carried out using a random-effects model and sensitivity analysis. The meta-analysis of seven clinical trials, involving 959 participants, indicated a significant reduction of uric acid levels after vitamin D administration (WMD: −16.64 µmol/L, 95% CI: −25.25, −8.03, <em>p</em> &lt;0.001, <em>I</em>^<em>2</em> = 74%). Additionally, the impact of this vitamin on uric acid concentrations was robust in the leave-one-out sensitivity analysis.</p></div><div><h3>Discussion</h3><p>Given that few clinical trials were included, the number of subjects analyzed was limited. However, our results suggest that vitamin D administration is associated with a significant reduction in the levels of serum uric acid in randomized clinical trials.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100391"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics in plant-based food matrices: A review of their health benefits","authors":"Sara Sayonara da Cruz Nascimento ,&nbsp;Thaís Souza Passos ,&nbsp;Francisco Canindé de Sousa Júnior","doi":"10.1016/j.phanu.2024.100390","DOIUrl":"10.1016/j.phanu.2024.100390","url":null,"abstract":"<div><h3>Background</h3><p>Plant-based food matrices have been increasingly used as vehicles for probiotics due to their high nutritional and bioactive value. Therefore, this review summarizes the health benefits of plant-based food matrices probiotics focusing on <em>in vitro</em> and <em>in vivo</em> studies.</p></div><div><h3>Methods</h3><p>A narrative literature review was performed to select articles published between 2015 and 2024. The Scopus, Science Direct, Web of Science, PubMed, and EMBASE scientific databases were used. Full articles that evaluated the health benefits of consuming plant-based food matrices probiotics performed <em>in vitro</em> and <em>in vivo</em> (animal models and clinical trials in humans) were selected.</p></div><div><h3>Results</h3><p>From the scientific evidence, it was possible to highlight the health benefits of probiotics in plant-based food matrices and their association with bioactive compounds treating various diseases, proving beneficial effects in treating cancer, liver diseases, obesity, and related chronic diseases and inflammatory diseases. However, it was noted that clinical trials are still needed to confirm these effects in humans.</p></div><div><h3>Conclusions</h3><p>Plant-based food matrices probiotics have proven beneficial effects in various diseases based on <em>in vitro</em> and animal model studies. However, clinical trials are needed to confirm these effects.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100390"},"PeriodicalIF":3.2,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing hypertension using brewing bioactive peptides as angiotensin-converting enzyme inhibitors: Impact on vascular tone through ex vivo assays","authors":"Rita Ribeiro-Oliveira ,&nbsp;Pilar Rodríguez-Rodríguez ,&nbsp;Joana Beatriz Sousa ,&nbsp;Isabel M.P.L.V.O. Ferreira ,&nbsp;Silvia M. Arribas ,&nbsp;Carmen Diniz","doi":"10.1016/j.phanu.2024.100389","DOIUrl":"10.1016/j.phanu.2024.100389","url":null,"abstract":"<div><h3>Background</h3><p>Peptides derived from brewer’s spent grain (BSG) and yeast (BSY) are promising natural substitutes of synthetic drugs to manage hypertension as inhibitors of angiotensin-converting enzyme (ACE). However, their impact on the vascular function, so far, remains to be verified. Accordingly, we aimed to evaluate the effect of brewing peptides on the arterial vasocontractile response to angiotensin (Ang) I (through vascular ACE-inhibition) to estimate their antihypertensive potential. The impact of the oral route (gastrointestinal digestion, intestinal absorption, and liver metabolism) in brewing peptides was also investigated.</p></div><div><h3>Methods</h3><p>Iliac arteries from adult spontaneously hypertensive rats were studied with isometric tension recording. After ensuring the function integrity of the arteries, concentration-response curves to addition of Ang I (10⁻⁹-10⁻⁶ M) were performed after 30 min incubation with MIX (50:50 mixture of BSG:BSY) or BSG (0.86 mg/mL), or captopril (an ACE-inhibitory drug) or Krebs solution.</p></div><div><h3>Results</h3><p>MIX peptides (without simulated oral administration) enhanced Ang I-induced vasoconstriction, but lacked vascular effects after simulated oral administration. By contrast, BSG peptides (without simulated oral administration) did not exhibit vascular effects, whereas they promoted a marked decrease in vasocontraction evoked by the generated Ang II after simulation of the oral route, implying their capability to inhibit ACE. Additionally, to elucidate this inhibitory mechanism, Michaelis-Menten and Lineweaver-Burk plots indicated a mixed inhibition type.</p></div><div><h3>Conclusion</h3><p>With simulation of the oral route, BSG peptides were able to inhibit vascular ACE with a similar efficacy as the antihypertensive drug captopril, suggesting the potential to mitigate the burden of hypertension.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100389"},"PeriodicalIF":3.2,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rebuttal to the (pre-proof) paper published by S. Peters and H. Verhagen","authors":"Mathilde Touvier,&nbsp;Pilar Galan,&nbsp;Chantal Julia,&nbsp;Mélanie Deschasaux-Tanguy,&nbsp;Bernard Srour,&nbsp;Emmanuelle Kesse-Guyot,&nbsp;Valentina A. Andreeva,&nbsp;Serge Hercberg","doi":"10.1016/j.phanu.2024.100386","DOIUrl":"10.1016/j.phanu.2024.100386","url":null,"abstract":"","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100386"},"PeriodicalIF":3.2,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coming from opposite parts of the spectrum of interpreting studies about Nutri-Score: Suggestion of publication bias cannot be denied","authors":"Stephan Peters ,&nbsp;Hans Verhagen","doi":"10.1016/j.phanu.2024.100387","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100387","url":null,"abstract":"<div><h3>Background</h3><p>The front-of-pack label Nutri-Score is currently proposed as the system of choice in seven EU countries. However, there is still much scientific debate about the validation and efficacy of Nutri-Score and there is much discussion about author affiliation and study outcome.</p></div><div><h3>Methods</h3><p>Recently we published our paper: Nutri-Score and publication bias: A complete literature review of the substantiation of the effectiveness of the front-of-pack logo Nutri-Score Peters &amp; Verhagen, PharmaNutrition 27 C (2024) 100380. This paper received a commentary paper by the developers of Nutri-Score: M. Touvier et al., 2024 “Rebuttal to the paper published by S. Peters and H. Verhagen”. We herewith provide an invited commentary to that rebuttal paper, which further supports the observed publication bias.</p></div><div><h3>Results</h3><p>In this response to the rebuttal, we primarily respond on the scientific issues raised in the rebuttal and explain more about our alleged conflict of interest and our motivation to write the paper. Moreover, we basically thank the authors of the rebuttal paper for, perhaps ironically but essentially, confirming our analysis: there is a publication bias versus affiliation.</p></div><div><h3>Discussion</h3><p>Overall, the available evidence is clearly limited and biased, and more research is needed to substantiate or disprove the effectiveness of Nutri-Score.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100387"},"PeriodicalIF":3.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications","authors":"Mohd Fadzelly Abu Bakar","doi":"10.1016/j.phanu.2024.100388","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100388","url":null,"abstract":"<div><h3>Background</h3><p>Derived from Garcinia plants, garcinol has gained prominence for its versatile health benefits, ranging from antioxidant and anti-inflammatory properties to immunomodulation and anticancer effects. Notably, there is a growing interest in exploring its potential against obesity and related disorders. While hydroxycitric acid (HCA) has been linked to the anti-obesity effects of certain Garcinia fruits, recent research emphasizes the role of garcinol, either alone or in combination, in mediating these effects.</p></div><div><h3>Methods</h3><p>The review was conducted using the databases Medline, Scopus, Web of Science, and Google Scholar. The search was performed using the keywords 'obesity’, 'overweight', 'garcinol', '<em>in vitro</em>’, '<em>in vivo</em>’ and 'clinical studies.' Discussions focused on the effect of garcinol on body weight, obesity and its related complications.</p></div><div><h3>Results</h3><p>The findings revealed that garcinol, distinct from HCA, plays a central role in anti-obesity effects. Inhibiting fatty acid synthase emerged as a key mechanism, disrupting fatty acid synthesis and facilitating weight control. Garcinol demonstrated effectiveness in appetite suppression, fat reduction, modulation of obesity-related factors, and metabolic enhancement, collectively contributing to weight loss. Furthermore, the study established the bioavailability, pharmacokinetics, and biodistribution of garcinol, underscoring its anti-inflammatory properties as valuable in addressing obesity-associated inflammation.</p></div><div><h3>Conclusion</h3><p>While promising indications from cell, animal, and preliminary clinical studies highlight garcinol's anti-obesity potential, it is crucial to acknowledge that research in this domain is still in its early stages. To conclusively establish the effectiveness and safety of garcinol as an anti-obesity treatment, comprehensive studies, particularly involving human subjects, are imperative.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100388"},"PeriodicalIF":3.2,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140192039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural, functional, nutritional and clinical aspects of vitamin A: A review","authors":"Mariana S.S. Menezes ,&nbsp;Cristina M.M. Almeida","doi":"10.1016/j.phanu.2024.100383","DOIUrl":"10.1016/j.phanu.2024.100383","url":null,"abstract":"<div><h3>Background</h3><p>The importance of vitamin A to human health is neither a new nor emerging topic; however, information regarding its primary food sources, chemical structure, physiological role, pharmacokinetics, dosage, and relationship with various pathologies is not always concise and hence difficult to understand. Therefore, this review aims to summarise the available information on the role of vitamin A in health and disease in the context of advances in drug discovery and trials.</p></div><div><h3>Methods</h3><p>This review includes research articles published between 1974 and 2022 that were identified using multiple search engines such as PubMed, Google Scholar, and ScienceDirect. Select keywords were used to maximize the retrieval of relevant results. The criteria included original research and review articles on the topic. The selection of information sources was based on the publication date with a preference for papers published between 2012 and 2022. After excluding conference proceedings, redundant articles, non-English publications, and website publications from food and medical institutions, 106 articles were included.</p></div><div><h3>Results</h3><p>Vitamin A is a versatile vitamin that is involved in many physiological systems. Previous studies have discovered novel associations between vitamin A and various diseases and potential new indications for drug formulations.</p></div><div><h3>Conclusion</h3><p>Further studies are necessary to assess the efficacy and safety of vitamin A interventions, especially that of retinoids, in the treatment and prevention of several pathologies, some of which are yet to be examined. These future studies could provide better evidence of the clinical significance of retinoids.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"27 ","pages":"Article 100383"},"PeriodicalIF":3.2,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}