Can L-Methionine and S-Adenosyl-L-Methionine Effectively Mitigate Scopolamine-Induced Cognitive and Motor Deficits in Mice?

IF 2.4 Q3 NUTRITION & DIETETICS
Mohammadjaavad Aghababaei , Mahdi Mashhadi Akbar Boojar , Mehdi Saberi
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Abstract

Motor balance deficits often coincide with cognitive deficits in older adults. Current medications provide temporary relief with several potential side effects. Essential amino acids and their derivatives, such as S-Adenosyl-L-Methionine (SAMe), can improve nerve function, mood regulation, and neuroprotection against neurodegenerative diseases. This study investigated the protective effects of SAMe in scopolamine-degraded memory, and motor balance in an animal model.
To evaluate the possible effects of SAMe on cognitive and motor balance improvement, both Shuttle box and rotarod methods were performed in seven groups of animals (n=7). The mice groups received the saline (control), scopolamine, scopolamine+rivastigmine, scopolamine +methionine, and scopolamine+ three different doses of SAMe daily and separately for two weeks. Data were analyzed independently by one-way ANOVA and P<0.05 was considered significant.
SAMe 150 mg/kg worsened scopolamine-induced memory impairment (P<0.001), while methionine (100 mg/kg) or SAMe (only 100 mg/kg) together with scopolamine could reduce the duration of the animal's presence in the dark chamber (P<0.05). Daily administration of methionine and SAMe at the rate of 100 mg/kg daily could significantly improve the decrease in motor balance caused by scopolamine (P<0.05). Rivastigmine improved memory and motor balance impairment caused by scopolamine (P<0.05). No difference between SAMe and L-methionine for memory, and balance.
The results suggest that while L-methionine and SAMe may not be effective in improving memory impairments (Even SAMe high doses can aggravate the destruction of passive avoidance memory), they may be beneficial in enhancing motor balance.

Abstract Image

L-蛋氨酸和 S-腺苷-L-蛋氨酸能否有效缓解东莨菪碱诱导的小鼠认知和运动障碍?
运动平衡失调往往与老年人的认知障碍同时存在。目前的药物只能暂时缓解症状,但有一些潜在的副作用。必需氨基酸及其衍生物,如 S-腺苷-L-蛋氨酸(SAMe),可以改善神经功能、调节情绪,并对神经退行性疾病起到保护作用。为了评估 SAMe 对改善认知和运动平衡可能产生的影响,研究人员对七组动物(n=7)进行了梭箱法和旋转法实验。小鼠组每天分别接受生理盐水(对照组)、东莨菪碱、东莨菪碱+利伐斯的明、东莨菪碱+蛋氨酸和东莨菪碱+三种不同剂量的SAMe,持续两周。SAMe 150 mg/kg可加重东莨菪碱诱导的记忆损伤(P<0.001),而蛋氨酸(100 mg/kg)或SAMe(仅100 mg/kg)与东莨菪碱一起使用可缩短动物在暗室中的停留时间(P<0.05)。每天服用100毫克/千克蛋氨酸和SAMe可显著改善东莨菪碱导致的运动平衡能力下降(P<0.05)。利伐斯的明能改善东莨菪碱引起的记忆和运动平衡障碍(P<0.05)。结果表明,虽然L-蛋氨酸和SAMe可能无法有效改善记忆障碍(即使SAMe剂量过高也会加重被动回避记忆的破坏),但它们可能有益于增强运动平衡能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
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