PharmaNutrition最新文献

{"title":"Resistant starch: A promising ingredient and health promoter","authors":"Natália Crialeison Balbo Vall Ribeiro ,&nbsp;Amanda E. Ramer-Tait ,&nbsp;Cinthia Baú Betim Cazarin","doi":"10.1016/j.phanu.2022.100304","DOIUrl":"10.1016/j.phanu.2022.100304","url":null,"abstract":"<div><p>Resistant starch<span><span> (RS) consists of a glucose plant polymer that is extremely abundant in nature and easily obtained through simple technological processes in the food<span> industry. Its molecular conformation, as well as its specific localization within the plant tissues, makes this molecule sterically inaccessible to the activity of amylolytic enzymes, which can degrade any other type of starch. Such a characteristic allows resistant starch to act as dietary fiber when ingested by humans, and it is used as a substrate by the </span></span>gut microbiota<span>. By metabolizing the resistant starch, the microbiota<span><span><span> can produce organic fatty acids of low molecular weight, mainly butyrate, </span>propionate, and acetate, also known as short-chain fatty acids (SCFA). Besides being a valuable energy source for colonocytes, SCFA promotes a plethora of beneficial and systemic effects on human metabolism. Researchers worldwide have been investigating the broad spectrum of benefits generated by the inclusion of resistant starch in the diet, including its effect on counteracting </span>metabolic diseases<span>. The worldwide abundance, easy access, and variety of industrial applications of resistant starch make it a functional food of great interest to the scientific community and for the development of new dietetic approaches capable of promoting health for the world’s population. This review will cover physiological aspects associated with RS intake and its impact on microbiota and health, especially to counteract chronic non-communicable diseases.</span></span></span></span></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45214392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult dominant polycystic kidney disease: A prototypical disease for pharmanutrition interventions","authors":"Maria Serena Lonardo ,&nbsp;Bruna Guida ,&nbsp;Nunzia Cacciapuoti ,&nbsp;Mariastella Di Lauro ,&nbsp;Mauro Cataldi","doi":"10.1016/j.phanu.2022.100294","DOIUrl":"10.1016/j.phanu.2022.100294","url":null,"abstract":"<div><h3>Background</h3><p><span><span><span>Adult Dominant Polycystic Kidney Disease (ADPKD) is an inherited disease, associated with the development of liquid-filled cysts in the kidneys and other organs, causing renal failure. Most patients with ADPKD have mutations in either </span>PKD1 or PKD2 genes, which encode for the two components of ion channels located in cilia and </span>endoplasmic reticulum<span>. These mutations cause an increase in intracellular cAMP and activate mTOR<span>, the AMPK<span> pathway and Jak/Stat-dependent gene transcription<span> ultimately leading to enhanced cell proliferation and survival in cyst epithelium and to fluid release in cyst cavities. The aim of the present review is to discuss the main literature evidence suggesting that these pathologically activated transduction pathways can be targeted with an integrated pharmacological and nutritional, </span></span></span></span></span><em>pharmanutrition</em>, strategy.</p></div><div><h3>Methods</h3><p>We interrogated with no limit of publication time, the PubMed and Scopus databases using the following keywords: ADPKD, pharmacological treatment, nutritional intervention, diet, transduction pathways.</p></div><div><h3>Results</h3><p><span>In ADPKD, mTOR enhanced activity may be counteracted both with specific drugs, which have intrinsic dose-limiting toxicities, and with time-restricted feeding or </span>ketogenic diets<span>, and these two approaches could, theoretically, synergize. Likewise, cAMP accumulation in the cytoplasm can be counteracted pharmacologically with V2 receptor<span> antagonists or somatostatin analogues and with nutritional interventions such as hypoosmolar diets, with or without high water intake.</span></span></p></div><div><h3>Conclusions</h3><p>Nutritional interventions impinge on the same transduction pathways targeted by drugs currently used or in development for ADPKD. The use of diet intervention in combination with drugs could help lowering drug dose and, consequently, dose-dependent drug toxicity.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42443367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic risk, biomarkers of low-grade subclinical inflammation and flavonoid intake: A cross-sectional study in Argentina","authors":"Baraquet M. Lucía ,&nbsp;Del Rosso Sebastián ,&nbsp;Oberto M. Georgina ,&nbsp;Defagó M. Daniela ,&nbsp;Perovic N. Raquel","doi":"10.1016/j.phanu.2022.100297","DOIUrl":"10.1016/j.phanu.2022.100297","url":null,"abstract":"<div><h3>Background</h3><p><span>Flavonoids<span>, the most abundant polyphenols present in the diet, may help to reduce the risk of cardiometabolic disease. Hence, the aim of this study was to know the potential associations between flavonoid source food intake, markers of low-grade inflammation and </span></span>cardiometabolic risk status.</p></div><div><h3>Methods</h3><p><span>194 adult subjects attending at the Cardiology<span> Division, Hospital Nacional de Clínicas, Córdoba, Argentina participated in the study. A validated food-frequency questionnaire was applied to establish the flavonoid source food intake. Clinical-pathological and anthropometric variables [height, weight, and waist circumference, and serum concentrations of high-sensitive C-reactive protein (hs-CRP) and cytokines (INF-γ, TNFα, IL-6, IL-8, IL-10, IL-18, IL-23) were measured. A cardiometabolic risk clustering score was constructed and correlation’s coefficients and </span></span>multiple linear regression models were used to assess the relation between flavonoid source foods consumption of and markers of low-grade inflammation.</p></div><div><h3>Results</h3><p>40.4% of the subjects were obese and 60.3% showed a very high risk of developing cardiovascular diseases according to the WC classification. 43.3% had a high risk of cardiometabolic dysregulation and the hs-CRP levels indicated a high risk of developing cardiovascular disease in the future both in men and women. The predominant intake of flavonoids was from source food of flavanones<span><span><span>, flavones and </span>flavonols. Negative associations between </span>isoflavone source food intake and TNFα, IL-6 and IL-8 concentrations (P ≤ 0.05) were observed.</span></p></div><div><h3>Conclusions</h3><p>The results of the present study provide evidence of the inverse association between isoflavone source foods intake and inflammation. Further studies are needed to confirm retrieved association.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43198812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetogenins from Annonaceae plants: potent antitumor and neurotoxic compounds","authors":"Naiara Nascimento das Chagas Lima ,&nbsp;Denise Carreiro Faustino ,&nbsp;Kyan James Allahdadi ,&nbsp;Luciana Souza de Aragão França ,&nbsp;Laise Cedraz Pinto","doi":"10.1016/j.phanu.2022.100295","DOIUrl":"10.1016/j.phanu.2022.100295","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Acetogenins are compounds found in </span>Annonaceae<span>, such as soursop (</span></span><em>A. muricata</em>) and pine cone (<em>A. squamosa</em><span><span>), and present cytotoxic properties, with antiproliferative and antitumor effects. However, they have also been implicated in the neurotoxic effects that are associated with atypical Parkinsonism. This study aimed to perform a </span>systematic review and identify the cytotoxic and selective mechanisms for neoplastic cells and neurotoxic acetogenins.</span></p></div><div><h3>Methods</h3><p>This study aimed to perform a systematic review and identify the cytotoxic and selective mechanisms for neoplastic cells and neurotoxic acetogenins.</p></div><div><h3>Results</h3><p><span><span>The antitumor mechanisms of action were through apoptotic actions, negative regulation of the tumor growth factor and </span>genotoxicity. The evidenced neurotoxic mechanisms were </span><em>via</em><span><span> the inhibition of neuronal mitochondrial complex I and dysfunctions of the </span>tau protein<span>. Acetogenins demonstrated punctual and selective anti-cancer action, though its selectivity remains unclear, and effects associated with neurodegeneration.</span></span></p></div><div><h3>Conclusion</h3><p>The evidences of neurotoxicity and cytotoxicity converges in a selectivity relationship associated with cells that require high energy demand and this seems to be a key feature that can help to understand these synergistic effects. Chronic exposure to acetogenins can potentiate neural damage, thus, moderate consumption of infusions, extracts and pulp of Annonaceae fruits is recommended.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46606267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic factors and parental views associated with use of an omega-3 supplement for their children","authors":"Benjamin Haddon Parmenter ,&nbsp;Akkarach Bumrungpert ,&nbsp;George Anthony Thouas","doi":"10.1016/j.phanu.2022.100289","DOIUrl":"10.1016/j.phanu.2022.100289","url":null,"abstract":"<div><h3>Background</h3><p>Omega-3 fatty acids reportedly improve child learning and behavioral outcomes. However, sociodemographic factors and parental perceptions driving omega-3 supplementation in children are not fully understood.</p></div><div><h3>Methods</h3><p>In a cross-sectional study design, we examined factors associated with use of a commercial omega-3 supplement for children (1–18 years) among 280 Thai, Chinese and Vietnamese parents.</p></div><div><h3>Results</h3><p>After adjustment for demographic and lifestyle factors, multivariable logistic regression showed that omega-3 supplement use was higher in children with greater quality of life [OR, 4.81 (95% CI: 1.64, 14.10)] and whose parents had more advanced education [OR, 2.29 (95% CI: 1.02, 5.15)]. Parents who viewed the omega-3 supplement as proven by research [OR, 5.01 (95% CI: 1.83, 13.74)], safe [OR, 7.44 (95% CI: 2.66, 20.80)] and natural [OR, 2.47 (95% CI: 1.09, 5.60)] were more likely to use the product for their child, as were those who reported positive social feedback regarding the product [OR, 2.44 (95% CI: 1.33, 4.48)].</p></div><div><h3>Conclusion</h3><p>Omega-3 supplement use among children residing in Asia was associated with better socio-demographic and lifestyle characteristics. Parental views concerning the safety and efficacy of the omega-3 product were major predictors of supplementation practices.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434422000020/pdfft?md5=1f3e9eecbdc52c4d9872eb624b6fb507&pid=1-s2.0-S2213434422000020-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41910033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological activities of Eugenia uniflora L. (pitangueira) extracts in oxidative stress-induced pathologies: A systematic review and meta‐analysis of animal studies","authors":"Wanessa Azevedo de Brito ,&nbsp;Magda Rhayanny Assunção Ferreira ,&nbsp;Diego de Sousa Dantas ,&nbsp;Luiz Alberto Lira Soares","doi":"10.1016/j.phanu.2022.100290","DOIUrl":"10.1016/j.phanu.2022.100290","url":null,"abstract":"<div><h3>Background</h3><p><span><em>Eugenia</em><em> uniflora</em></span><span><span> L. (EU) is widely distributed geographically and has been used in traditional medicine<span><span> owing to its range of therapeutic properties associated with antioxidant action. To determine the viability of this species as an herbal with promising pharmaceutical applications, we assessed the evidence from preclinical studies about the antioxidant potential of EU extracts as a natural source for prevention and </span>treatment of diseases associated with </span></span>oxidative stress.</span></p></div><div><h3>Methods</h3><p>The search was conducted in the electronic databases: PubMed, ScienceDirect, and SciELO. <em>In vivo</em> studies related to the antioxidant properties and preclinical assays of this species were included. The risk of bias was assessed in all studies and meta-analysis was carried to summarize effect size of EU extracts.</p></div><div><h3>Results</h3><p><span>From 738 reports, 7 studies were included in qualitative synthesis and 4 in meta-analysis. Studies using extracts or fractions, and different pharmacological activities were reported. Meta-analysis showed positive effects of EU </span><em>versus</em><span><span> control on superoxide dismutase levels in </span>hippocampus<span> (MD=6.59; 95% CI=4.56–8.63) and on cortex (MD=7.57; 95% CI=5.92–9.21); and glutathione<span> peroxidase (GPx) on hippocampus (MD = 11.85; 95%CI = 10.42–13.29). However, EU extracts did not show significant effects on GPx levels on cortex (p = 0.56); on acetylcholinesterase on cortex (p = 0.05), and hippocampus (p = 0.66); and glutathione levels on liver (p = 0.38).</span></span></span></p></div><div><h3>Conclusion</h3><p><span>In general, the studies have heterogeneity and some concerns about risk of bias, specially about randomization and blind outcome assessment. Current evidence of </span><em>in vivo</em><span> studies supports antioxidant action of EU extracts in brain tissue by increase of endogenous antioxidant molecules.</span></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55190123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea","authors":"Logesh Rajan ,&nbsp;Arun Radhakrishnan ,&nbsp;Keshav Narayan Alagarsamy ,&nbsp;Abhay Srivastava ,&nbsp;Sanjiv Dhingra ,&nbsp;Anthony Booker ,&nbsp;Viven Rolfe ,&nbsp;Dhanabal Palaniswamy ,&nbsp;Suresh Kumar Mohankumar","doi":"10.1016/j.phanu.2022.100296","DOIUrl":"10.1016/j.phanu.2022.100296","url":null,"abstract":"<div><p>Cardiovascular disease is a chronic multifactorial health complication that is either directly or indirectly associated with pathophysiological mechanisms, including pro-oxidation, pro-inflammation, vascular and endothelial dysfunction, impaired platelet function, thrombosis, and others. The therapeutic options to circumvent cardiovascular complications include several phytomedicines, including green tea polyphenols. However, while many experimental and clinical studies report distinct mechanisms by which the polyphenols of green tea elicit a beneficial role in cardiometabolic health, the translation and applications of green tea polyphenols in clinics have yet to gain their optimal use on the broader population. This review critically appraises the various reported mechanisms of green tea polyphenols in modulating cardio-metabolic health and associated phyto-genomic challenges. Further, our review highlights the probability of gene polymorphic associated therapeutic variations in individuals using green tea for cardio-metabolic effects and the necessity to personalize green tea for clinical use, thereby improvising the risk-benefit ratio.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434422000093/pdfft?md5=5ec1b42d9e56ffa835e50d192b04dd5d&pid=1-s2.0-S2213434422000093-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55190151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-derived compounds, vitagens, vitagenes and mitochondrial function","authors":"Rafael Franco ,&nbsp;Gemma Navarro ,&nbsp;Eva Martínez-Pinilla","doi":"10.1016/j.phanu.2021.100287","DOIUrl":"10.1016/j.phanu.2021.100287","url":null,"abstract":"<div><p>There is great interest in identifying natural products that can be approved as nutraceuticals. A good option is to induce transcription of vitagenes, which would lead to increased expression of proteins that provide the means to maintain homeostasis. In fact, the induction of vitagenes is considered relevant during aging, especially if aging is accompanied by neurodegenerative diseases. Care must be taken to avoid confusing vitagenes, which are genes, and vitagens, which are vitamin-like low-molecular weight compounds; both concepts are recalled here. Although mitochondria are key factors in several chronic diseases of the nervous system, the amount of vitagenes that is associated with better mitochondrial function (bioenergetics, oxidative stress, biogenesis, dynamics, etc.) is limited. Plant molecules have been used for centuries to improve well-being, and some have a directly or indirectly impact on mitochondrial function. However, there is little knowledge about whether plant-derived products can induce vitagenes related to the enhancement of the multiple actions exerted by mitochondria; studies are needed to detect natural plant compounds that increase the transcription of genes related to the function of this cellular organelle. This study is expected to identify new vitagenes whose induction provides benefits in aging and/or neurodegenerative diseases.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434421000396/pdfft?md5=8599e9cdb5bf6c673a9e2bf19f90502f&pid=1-s2.0-S2213434421000396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43981124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The impact of beetroot juice intake on muscle oxygenation and performance during rhythmic handgrip exercise” [PharmaNutrition 14 (2020) 100215]","authors":"Mônica Volino-Souza ,&nbsp;Gustavo Vieira de Oliveira ,&nbsp;Elisa Barros-Santos ,&nbsp;Carlos Adam Conte-Junior ,&nbsp;Thiago Silveira Alvares","doi":"10.1016/j.phanu.2021.100286","DOIUrl":"10.1016/j.phanu.2021.100286","url":null,"abstract":"","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434421000384/pdfft?md5=23714ae63ae11997ced5c4e90f3d2ce4&pid=1-s2.0-S2213434421000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48079531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of functional food in prevention of malnutrition","authors":"Mukhtar H. Ahmed ,&nbsp;Dávid Vasas ,&nbsp;Arez Hassan ,&nbsp;Judit Molnár","doi":"10.1016/j.phanu.2022.100288","DOIUrl":"https://doi.org/10.1016/j.phanu.2022.100288","url":null,"abstract":"<div><h3>Background</h3><p>Malnutrition is a serious condition that develops when the human body is deprived of or does not obtain the right amount of vital nutrients like vitamins, minerals, proteins, carbohydrates, lipids and some other essential substances that the body needs to function. It can have a significant impact on people’s health including stunted growth, low body weight and muscle wasting.</p></div><div><h3>Purpose</h3><p>This study is aimed to determine the factors that could cause malnutrition in humans, something that is considered as a major global issue nowadays and is associated with negative aspects on patient’s activities.</p></div><div><h3>Methods</h3><p>Electronic searches were conducted on the Google Scholar database, Medline and PubMed up to the 11of December 2021. All studies reporting an association between foods and malnutrition were included.</p></div><div><h3>Results</h3><p>The search yielded 637 references, included 52 clinical trials, 11 meta-analysis, 45 randomised clinical trials (RCT) and 201 reviews. Among the manuscripts, 25 studies provided evidence for the association between malnutrition and micronutrients. The results showed that in addition to insufficient intake of the essential nutrient, several chronic diseases including gastrointestinal tract diseases, cancer and sometimes post-surgery complications are also associated with malnutrition.</p></div><div><h3>Conclusion</h3><p>Only a limited number of studies reported a direct link between functional foods and malnutrition, which all agree that there is clear evidence in favour of functional foods being effective in preventing and reducing the impact of malnutrition. Other studies looked at for this review would suggest that they may even be effective in improving the quality of life.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434422000019/pdfft?md5=1870760483b83962aa18a670c2499a04&pid=1-s2.0-S2213434422000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137267562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}