PharmaNutrition最新文献

{"title":"Oral administration of lithium chloride ameliorate spinal cord injury-induced hyperalgesia in male rats","authors":"Golnoosh Rahimi ,&nbsp;Sara Mirsadeghi ,&nbsp;Saeid Rahmani ,&nbsp;Amin Izadi ,&nbsp;Zahra Ghodsi ,&nbsp;Seyed Mohammad Ghodsi ,&nbsp;Vafa Rahimi-Movaghar ,&nbsp;Sahar Kiani","doi":"10.1016/j.phanu.2022.100307","DOIUrl":"10.1016/j.phanu.2022.100307","url":null,"abstract":"<div><h3>Background</h3><p><span>Numerous studies have described the neuroprotective<span> effect of lithium in spinal cord injury in addition to its ameliorative impact on </span></span>pain sensation<span>. In the present study, we aim to examine the efficacy of 85 mg/kg as well as 50 mg/kg dosage of the lithium chloride (LiCl) through oral consumption in spinal cord injured rats and their effect on gene expression of three candidate genes, corresponding to the hyper-sensitization.</span></p></div><div><h3>Methods</h3><p><span><span><span>Adult Wistar (male) rats were divided into four experimental groups: control; oral administration of LiCl with 85 mg/kg and 50 mg/kg dosage; and 10 % </span>sucrose<span> receiver as the vehicle. BBB and heat plantar tests were performed weekly throughout four weeks to evaluate motor improvement and neuropathic pain amelioration, i.e., the alleviation in </span></span>hyperalgesia. Then, the expression pattern of </span><em>Kcnd2</em>, <em>ERK</em> and <em>Gria2</em> genes were assessed.</p></div><div><h3>Results</h3><p><span>The BBB results demonstrated that LiCl with both dosages does not allow remarkable improvement in motor function during four weeks of treatment. The heat plantar tests show substantial recovery in LiCl treated groups versus vehicle and control after four weeks of evaluation. According to Real-time PCR</span><em>, Kcnd2</em> and <em>Gria2</em> were up-regulated in the presence of lithium in a dose-dependent manner while <em>ERK</em> expression was not differed remarkably.</p></div><div><h3>Conclusion</h3><p><span>Our results suggested that LiCl allows hyperalgesia palliation<span>, however, did not reinforce persistent motor improvement. Also, oral lithium consumption with 50 mg/kg concentration, entails considerable restoration in gene expression level of </span></span><em>Kcnd2</em> and <em>Gria2</em>.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45987780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine intake increases countermovement jump performance in well-trained high jumpers","authors":"Ana C. Santos-Mariano ,&nbsp;Gislaine Cristina-Souza ,&nbsp;Pâmela Souza Santos ,&nbsp;Pablo Ramon Domingos ,&nbsp;Pedro De-Oliveira ,&nbsp;Romulo Bertuzzi ,&nbsp;Cintia Rodacki ,&nbsp;Adriano E. Lima-Silva","doi":"10.1016/j.phanu.2022.100305","DOIUrl":"10.1016/j.phanu.2022.100305","url":null,"abstract":"<div><h3>Background</h3><p>Caffeine (CAF) has been shown to be an efficient ergogenic in improving the performance of countermovement jump tests (CMJ). However, it has not been evaluated whether this improvement reproduces itself in well-trained high jumpers.</p></div><div><h3>Methods</h3><p><span>To determine the effect of caffeine ingestion<span> on CMJ performance, eight (5 men and 3 women) well-trained high-jumpers performed three CMJ one hour after the ingestion of cellulose (PLA) or CAF (5 mg.kg</span></span>⁻¹<span> body mass). The kinematic and kinetic parameters obtained during the CMJ were recorded using a force platform.</span></p></div><div><h3>Results</h3><p>Compared with the PLA, CAF increased CMJ height (+11.74 ± 12.78%, P = 0.040), peak power (+8.75 ± 7.74%, P = 0.012), peak velocity (+5.55 ± 6.11%, P = 0.038), and velocity at peak power (+5.92 ± 6.91%, P = 0.051). CAF intake had no influence on contact time (P = 0.751), peak force (P = 0.920), rate of force development (P = 0.546), and GRF at peak power (P = 0.155). The percentage gain in jump height with CAF ingestion was significantly correlated with the percentage gain in peak power (P = 0.006) and velocity at peak power (P = 0.001), but not with the percentage gain in GRF at peak power (P = 0.835).</p></div><div><h3>Conclusion</h3><p>CAF ingestion improves jumping performance during a CMJ in well-trained high jumpers, probably due to gains in jump velocity. Considering the difficulties of improving performance in well-trained athletes, our findings suggest that CAF is a powerful ergogenic supplement for this population.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46997683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetogenic mechanisms of probiotic action in food matrices: A review","authors":"Vanessa Moraes Ramalho Castro,&nbsp;Rosa Helena Luchese","doi":"10.1016/j.phanu.2022.100302","DOIUrl":"https://doi.org/10.1016/j.phanu.2022.100302","url":null,"abstract":"<div><h3>Background</h3><p><span>Disturbances in the gut microbiome<span><span> can lead to increased intestinal permeability and immune response, and consequently to the onset of diabetes. </span>Fermented foods<span> contain lactic acid bacteria and bioactive metabolites, the postbiotics, such as </span></span></span>exopolysaccharides<span> and peptides, that have the potential to exert a wide range of metabolic functions and influencing gene expression related to glucose and insulin metabolism. This review discusses the potential therapeutic effects of probiotics in diabetes, in addition to a balanced diet with a focus on dairy.</span></p></div><div><h3>Methods</h3><p>Articles were found by using a combination of keyword searches in the Scopus and Science Direct databases. Were selected preferably the articles from the last seven years and 16 of them have been compiled to allow for further discussion about the mechanisms of antidiabetogenic activity.</p></div><div><h3>Results</h3><p><span><span>The main findings from the administration of probiotics in the treatment of diabetes were: decreased insulin resistance, decreased </span>plasma glucose<span><span>, reduced intestinal permeability, decreased absorption of LPS, increased GLP-1 production, and decreased </span>inflammatory cytokines. The antidiabetogenic probiotic activity may be due to the i) bioactives formed as a result of fermentation, the postbiotics; ii) bioactives present in food matrices with antidiabetogenic action and to the iii) biactives naturally present in matrices with </span></span>prebiotic action. However, the knowledge about postbiotics formed by probiotic bacteria in different food matrices is still incipient.</p></div><div><h3>Conclusion</h3><p><span>The modulation of the gut microbiota through the use of probiotics associated with healthy eating habits can help regulate </span>lipid metabolism<span><span>, improving insulin sensitivity and </span>glycemic control.</span></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137073324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digested protein from chia seed (Salvia hispanica L) prevents obesity and associated inflammation of adipose tissue in mice fed a high-fat diet","authors":"Mariana Grancieri ,&nbsp;Thaisa Agrizzi Verediano ,&nbsp;Cintia Tomaz Sant'Ana ,&nbsp;Andressa de Assis ,&nbsp;Renata Lopes Toledo ,&nbsp;Elvira Gonzalez de Mejia ,&nbsp;Hercia Stampini Duarte Martino","doi":"10.1016/j.phanu.2022.100298","DOIUrl":"10.1016/j.phanu.2022.100298","url":null,"abstract":"<div><h3>Background and aim</h3><p><span>Overweight and obesity are associated with the development of several health complications, such as diabetes, cancer, and cardiovascular disease. Chia seed is a rich source of </span>proteins and peptides<span><span> with potential anti-inflammatory and antioxidant effects. This study aimed to evaluate the effects of digested proteins (DP) from chia seed to prevent adipogenesis and </span>adipose tissue inflammation in mice fed a high-fat diet.</span></p></div><div><h3>Methods and results</h3><p><span>C57Bl/6 black mice were fed a high-fat diet plus DP (400 mg/kg of body/day) for 9 weeks. DP from chia seed reduced levels of plasma total cholesterol<span><span> (−17.5%), LDL (−42.8%), triacylglycerides (−12.3%), % body fat (−26.98%), and waist circumference (−5.5%) in </span>obese mice (</span></span><em>p</em><span> &lt; 0.05). Furthermore, treatment with DP reduced (</span><em>p</em><span><span> &lt; 0.05) adipocytes area, foci of inflammation, levels of p-NF-κB p65, PPARγ, mRNA </span>SREBP1<span><span><span> (sterol regulatory element-binding transcription), and TNF-α. DP also increased mRNA adiponectin on adipose tissue in animals DP-treated, compared with no-DP-treated animals. However, mRNA </span>LPL and </span>HDL levels were not changed (p &gt; 0.05). The peptides from DP had </span></span><span><em>in silico</em></span> high interaction with metalloproteinase-2.</p></div><div><h3>Conclusions</h3><p>When using this experimental model, DP from chia seed had an anti-inflammatory and anti-adipogenic effect. These results suggest the effectiveness of digested proteins from chia seed against central obesity and its associated inflammation.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43553688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A healthier daily diet is associated with greater immune fitness","authors":"Evi C. van Oostrom ,&nbsp;Kiki EW Mulder ,&nbsp;Marjolijn CE Verheul ,&nbsp;Pauline A. Hendriksen ,&nbsp;Suzan Thijssen ,&nbsp;Aletta D. Kraneveld ,&nbsp;Berber Vlieg-Boerstra ,&nbsp;Johan Garssen ,&nbsp;Joris C. Verster","doi":"10.1016/j.phanu.2022.100306","DOIUrl":"10.1016/j.phanu.2022.100306","url":null,"abstract":"<div><h3>Introduction</h3><p>The aim of this cross-sectional study was to investigate the association between a healthier diet, perceived immune fitness, and biomarkers of the immune system.</p></div><div><h3>Methods</h3><p>N = 108 participants (31 men and 77 women), 18–30 years old, completed a questionnaire, comprising the Healthy Diet Scale (HDS) and a 1-item scale assessing perceived immune fitness. In addition, saliva samples were collected and C-reactive protein (CRP) and cytokine concentrations of interleukin (IL)− 1β and IL-8 were determined.</p></div><div><h3>Results</h3><p>Overall, a significant correlation was found between the HDS score and perceived immune fitness (r = 0.221, p = 0.021), suggesting that a healthier diet was associated with a better immune fitness. The HSD score correlated significantly and negatively with saliva CRP concentrations (r = −0.240, p = 0.013). No significant correlations were found with other biomarkers. In women, the HDS correlated significantly with perceived immune fitness (r = 0.247, p = 0.030) and CRP levels ( r = −0.281, p = 0.014). In men, correlations with perceived immune fitness ( r = −0.219, p = 0.237) and the biomarkers were not significant.</p></div><div><h3>Discussion</h3><p>Significant associations between attaining a healthy diet, perceived immune fitness and CRP were found. More research is needed to investigate the observed sex differences and underlying mechanisms.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434422000196/pdfft?md5=85fcc8f362c0afe58ab9cec27e5f0755&pid=1-s2.0-S2213434422000196-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42943640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crocin suppresses inflammation-induced apoptosis in rmTBI mouse model via modulation of Nrf2 transcriptional activity","authors":"Marwa Salem,&nbsp;Mariam Shaheen,&nbsp;Jamilah Borjac","doi":"10.1016/j.phanu.2022.100308","DOIUrl":"10.1016/j.phanu.2022.100308","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Repetitive mild traumatic brain injury (rmTBI) has been considered a serious health issue. </span>Crocin<span>, a bioactive carotenoid in </span></span><span><em>Crocus sativus</em></span><span> (saffron) is well known for its anti-inflammatory and anti-oxidant properties. The aim of this study is to investigate the neuroprotective role of crocin in a repetitive mild traumatic brain injury (rmTBI) mouse model and thus fits the pharmacological scope of </span><em>pharmanutrition.</em></p></div><div><h3>Methods</h3><p>Balb c mice were divided into four groups, sham, crocin sham, TBI and crocin TBI. Injured groups received seven multiple closed brain injuries. Treated groups were injected with crocin (30 mg/kg) 30 min before each hit. Brain cortices<span> were extracted 24 h post the last injury for molecular analysis. Brain cytokine levels of IL-6 and IL-10 were measured using ELISA. Also, using RT-PCR, the expression levels of the following genes, Bcl-2, caspase3, Bax, P53, NF-κB, Nrf2, HO-1 and NQO1 were assessed.</span></p></div><div><h3>Results</h3><p><span><span>There was a significant increase in the level of the inflammatory cytokine Il-6. Crocin administration induced a decrease in IL-6 accompanied with elevation in the anti-apoptotic cytokine IL-10. Crocin induced a decrease in the gene expression of the apoptotic factors caspase3, Bax and P53 in injured mice and enhanced the mRNA levels of the anti-apoptotic Bcl-2. Also, crocin enhanced the </span>gene expression levels of </span>transcription factor Nrf2<span> and the antioxidant enzymes HO-1 and NQO-1 whereas reduced the expression of NF-κB.</span></p></div><div><h3>Conclusion</h3><p>Crocin exerted its neuroprotective effect following rmTBI. Crocin proves to play a prospect role in conferring protection against concussions.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42269910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistant starch: A promising ingredient and health promoter","authors":"Natália Crialeison Balbo Vall Ribeiro ,&nbsp;Amanda E. Ramer-Tait ,&nbsp;Cinthia Baú Betim Cazarin","doi":"10.1016/j.phanu.2022.100304","DOIUrl":"10.1016/j.phanu.2022.100304","url":null,"abstract":"<div><p>Resistant starch<span><span> (RS) consists of a glucose plant polymer that is extremely abundant in nature and easily obtained through simple technological processes in the food<span> industry. Its molecular conformation, as well as its specific localization within the plant tissues, makes this molecule sterically inaccessible to the activity of amylolytic enzymes, which can degrade any other type of starch. Such a characteristic allows resistant starch to act as dietary fiber when ingested by humans, and it is used as a substrate by the </span></span>gut microbiota<span>. By metabolizing the resistant starch, the microbiota<span><span><span> can produce organic fatty acids of low molecular weight, mainly butyrate, </span>propionate, and acetate, also known as short-chain fatty acids (SCFA). Besides being a valuable energy source for colonocytes, SCFA promotes a plethora of beneficial and systemic effects on human metabolism. Researchers worldwide have been investigating the broad spectrum of benefits generated by the inclusion of resistant starch in the diet, including its effect on counteracting </span>metabolic diseases<span>. The worldwide abundance, easy access, and variety of industrial applications of resistant starch make it a functional food of great interest to the scientific community and for the development of new dietetic approaches capable of promoting health for the world’s population. This review will cover physiological aspects associated with RS intake and its impact on microbiota and health, especially to counteract chronic non-communicable diseases.</span></span></span></span></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45214392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult dominant polycystic kidney disease: A prototypical disease for pharmanutrition interventions","authors":"Maria Serena Lonardo ,&nbsp;Bruna Guida ,&nbsp;Nunzia Cacciapuoti ,&nbsp;Mariastella Di Lauro ,&nbsp;Mauro Cataldi","doi":"10.1016/j.phanu.2022.100294","DOIUrl":"10.1016/j.phanu.2022.100294","url":null,"abstract":"<div><h3>Background</h3><p><span><span><span>Adult Dominant Polycystic Kidney Disease (ADPKD) is an inherited disease, associated with the development of liquid-filled cysts in the kidneys and other organs, causing renal failure. Most patients with ADPKD have mutations in either </span>PKD1 or PKD2 genes, which encode for the two components of ion channels located in cilia and </span>endoplasmic reticulum<span>. These mutations cause an increase in intracellular cAMP and activate mTOR<span>, the AMPK<span> pathway and Jak/Stat-dependent gene transcription<span> ultimately leading to enhanced cell proliferation and survival in cyst epithelium and to fluid release in cyst cavities. The aim of the present review is to discuss the main literature evidence suggesting that these pathologically activated transduction pathways can be targeted with an integrated pharmacological and nutritional, </span></span></span></span></span><em>pharmanutrition</em>, strategy.</p></div><div><h3>Methods</h3><p>We interrogated with no limit of publication time, the PubMed and Scopus databases using the following keywords: ADPKD, pharmacological treatment, nutritional intervention, diet, transduction pathways.</p></div><div><h3>Results</h3><p><span>In ADPKD, mTOR enhanced activity may be counteracted both with specific drugs, which have intrinsic dose-limiting toxicities, and with time-restricted feeding or </span>ketogenic diets<span>, and these two approaches could, theoretically, synergize. Likewise, cAMP accumulation in the cytoplasm can be counteracted pharmacologically with V2 receptor<span> antagonists or somatostatin analogues and with nutritional interventions such as hypoosmolar diets, with or without high water intake.</span></span></p></div><div><h3>Conclusions</h3><p>Nutritional interventions impinge on the same transduction pathways targeted by drugs currently used or in development for ADPKD. The use of diet intervention in combination with drugs could help lowering drug dose and, consequently, dose-dependent drug toxicity.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42443367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic risk, biomarkers of low-grade subclinical inflammation and flavonoid intake: A cross-sectional study in Argentina","authors":"Baraquet M. Lucía ,&nbsp;Del Rosso Sebastián ,&nbsp;Oberto M. Georgina ,&nbsp;Defagó M. Daniela ,&nbsp;Perovic N. Raquel","doi":"10.1016/j.phanu.2022.100297","DOIUrl":"10.1016/j.phanu.2022.100297","url":null,"abstract":"<div><h3>Background</h3><p><span>Flavonoids<span>, the most abundant polyphenols present in the diet, may help to reduce the risk of cardiometabolic disease. Hence, the aim of this study was to know the potential associations between flavonoid source food intake, markers of low-grade inflammation and </span></span>cardiometabolic risk status.</p></div><div><h3>Methods</h3><p><span>194 adult subjects attending at the Cardiology<span> Division, Hospital Nacional de Clínicas, Córdoba, Argentina participated in the study. A validated food-frequency questionnaire was applied to establish the flavonoid source food intake. Clinical-pathological and anthropometric variables [height, weight, and waist circumference, and serum concentrations of high-sensitive C-reactive protein (hs-CRP) and cytokines (INF-γ, TNFα, IL-6, IL-8, IL-10, IL-18, IL-23) were measured. A cardiometabolic risk clustering score was constructed and correlation’s coefficients and </span></span>multiple linear regression models were used to assess the relation between flavonoid source foods consumption of and markers of low-grade inflammation.</p></div><div><h3>Results</h3><p>40.4% of the subjects were obese and 60.3% showed a very high risk of developing cardiovascular diseases according to the WC classification. 43.3% had a high risk of cardiometabolic dysregulation and the hs-CRP levels indicated a high risk of developing cardiovascular disease in the future both in men and women. The predominant intake of flavonoids was from source food of flavanones<span><span><span>, flavones and </span>flavonols. Negative associations between </span>isoflavone source food intake and TNFα, IL-6 and IL-8 concentrations (P ≤ 0.05) were observed.</span></p></div><div><h3>Conclusions</h3><p>The results of the present study provide evidence of the inverse association between isoflavone source foods intake and inflammation. Further studies are needed to confirm retrieved association.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43198812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetogenins from Annonaceae plants: potent antitumor and neurotoxic compounds","authors":"Naiara Nascimento das Chagas Lima ,&nbsp;Denise Carreiro Faustino ,&nbsp;Kyan James Allahdadi ,&nbsp;Luciana Souza de Aragão França ,&nbsp;Laise Cedraz Pinto","doi":"10.1016/j.phanu.2022.100295","DOIUrl":"10.1016/j.phanu.2022.100295","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Acetogenins are compounds found in </span>Annonaceae<span>, such as soursop (</span></span><em>A. muricata</em>) and pine cone (<em>A. squamosa</em><span><span>), and present cytotoxic properties, with antiproliferative and antitumor effects. However, they have also been implicated in the neurotoxic effects that are associated with atypical Parkinsonism. This study aimed to perform a </span>systematic review and identify the cytotoxic and selective mechanisms for neoplastic cells and neurotoxic acetogenins.</span></p></div><div><h3>Methods</h3><p>This study aimed to perform a systematic review and identify the cytotoxic and selective mechanisms for neoplastic cells and neurotoxic acetogenins.</p></div><div><h3>Results</h3><p><span><span>The antitumor mechanisms of action were through apoptotic actions, negative regulation of the tumor growth factor and </span>genotoxicity. The evidenced neurotoxic mechanisms were </span><em>via</em><span><span> the inhibition of neuronal mitochondrial complex I and dysfunctions of the </span>tau protein<span>. Acetogenins demonstrated punctual and selective anti-cancer action, though its selectivity remains unclear, and effects associated with neurodegeneration.</span></span></p></div><div><h3>Conclusion</h3><p>The evidences of neurotoxicity and cytotoxicity converges in a selectivity relationship associated with cells that require high energy demand and this seems to be a key feature that can help to understand these synergistic effects. Chronic exposure to acetogenins can potentiate neural damage, thus, moderate consumption of infusions, extracts and pulp of Annonaceae fruits is recommended.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46606267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}