PharmaNutrition最新文献

{"title":"Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue","authors":"Carla Dayana Durães Abreu ,&nbsp;Bruna Viana Caldas ,&nbsp;Guilherme Henrique Mendes Ribeiro ,&nbsp;Charles Martins Aguilar ,&nbsp;Lucyana Conceição Farias ,&nbsp;André Luiz Sena Guimarães ,&nbsp;Alfredo Maurício Batista de Paula ,&nbsp;Maria Beatriz Abreu Glória ,&nbsp;Sérgio Henrique Sousa Santos","doi":"10.1016/j.phanu.2022.100316","DOIUrl":"10.1016/j.phanu.2022.100316","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. </span>Probiotic </span>dietary supplementation is a viable health option.</p></div><div><h3>Methods</h3><p><span>Male Swiss mice<span> were fed with two diets for four weeks: standard and standard + Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in </span></span>adipose tissue were analyzed.</p></div><div><h3>Results</h3><p><span>The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein<span> gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving </span></span>insulin sensitivity.</p></div><div><h3>Conclusion</h3><p>The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative.</p></div><div><h3>Data Availability Statement</h3><p>The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100316"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55190194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green coffee extract (Coffea canephora) improved the intestinal barrier and slowed colorectal cancer progression and its associated inflammation in rats","authors":"Caroline Woelffel Silva ,&nbsp;Keila Rodrigues Zanardi ,&nbsp;Mariana Grancieri ,&nbsp;Neuza Maria Brunoro Costa ,&nbsp;Leonardo Oliveira Trivillin ,&nbsp;Mirelle Lomar Viana ,&nbsp;Pollyanna Ibrahim Silva ,&nbsp;André Gustavo Vasconcelos Costa","doi":"10.1016/j.phanu.2022.100314","DOIUrl":"10.1016/j.phanu.2022.100314","url":null,"abstract":"<div><h3>Background and aim</h3><p><span>Cancer is directly associated with inflammation and oxidative stress<span><span>. Thanks to its antioxidant activity, green coffee may have anticarcinogenic effects. The objective of this study was to assess the effect of an aqueous </span>green coffee extract on local colorectal morphophysiological and systemic inflammatory and oxidative changes in an animal model of </span></span>colorectal cancer (CRC).</p></div><div><h3>Methods</h3><p><span><span><span>CRC was induced in male Wistar rats for 5 weeks by </span>dimethylhydrazine. After 10 weeks of carcinogenesis, the rats were divided: Healthy Control (HC, without cancer induction and without extract), Colorectal Cancer (CRC, with cancer induction and without extract), Health Green Coffee (HGC, without cancer induction and with extract) and colorectal cancer treatment with Green Coffee (CGC, with cancer induction and with extract) groups. The data were analyzed using the Student’s t-test or </span>ANOVA and the Newman-Keuls </span><em>post-hoc</em> test (p &lt; 0.05).</p></div><div><h3>Results</h3><p><span>Green coffee extract was source of caffeine, chlorogenic acid<span>, and trigonelline that had </span></span><span><em>in silico</em></span><span><span> interaction with NF-κB. This extract contributed to the intestinal barrier integrity by decreasing </span>lactulose<span><span> and mannitol </span>urinary excretion<span>, increasing fecal IgA levels and reducing malignant tumors in the colon and rectum. In addition, it reduced the systemic production of the inflammatory cytokines<span> TNFα and IL-6. However, green coffee extract had no effect on aberrant crypt foci (ACF) or colonic pH and no difference was found in oxidative changes.</span></span></span></span></p></div><div><h3>Conclusions</h3><p>Green coffee extract has intestinal benefits, through the action of its bioactive compounds in the microenvironment of the neoplastic lesion, thereby opening research avenues for new studies.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100314"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45070953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anti-proliferative effect of β-carotene against a triple-negative breast cancer cell line is cancer cell-specific and JNK-dependent","authors":"Ana Antunes ,&nbsp;Francisca Carmo ,&nbsp;Sara Pinto ,&nbsp;Nelson Andrade ,&nbsp;Fátima Martel","doi":"10.1016/j.phanu.2022.100320","DOIUrl":"10.1016/j.phanu.2022.100320","url":null,"abstract":"<div><h3>Background</h3><p>Breast cancer is a major cause of cancer-related mortality in women worldwide. Triple-negative breast cancer presents an aggressive behavior and a poor response to therapeutic. Cancer progression is associated with reprogramming of metabolic pathways for glutamine, glucose and folic acid.</p></div><div><h3>Methods</h3><p>In this study, we characterized the antitumoral effect (effects on cell proliferation, culture growth, viability, migration, oxidative stress levels, cell cycle and apoptosis) of carotenoids on a triple-negative human breast cancer cell line (MDA-MB-231 cell line) and investigated interference with nutrient cellular uptake as a contributing mechanism.</p></div><div><h3>Results</h3><p>Of the four tested carotenoids (β-carotene, crocin, fucoxanthin, astaxanthin), β-carotene presented the most interesting antitumoral effect, by reducing cell proliferation, migration, viability and culture growth, inducing apoptosis and by interfering with cell cycle (S phase arrest). β-carotene significantly increased ³H-deoxy-<span>D</span>-glucose uptake but did not affect neither ³H-glutamine nor ³H-folic acid uptake. Also, it did not interfere with oxidative stress levels. The anti-proliferative effect of β-carotene involves the JNK intracellular pathway, and this carotenoid was able to enhance the anti-proliferative effect of doxorubicin. Importantly, β-carotene did not affect cell viability, proliferation, cell cycle and migration rates of MCF-12A cells, a non-tumoral human breast epithelial cell line.</p></div><div><h3>Conclusion</h3><p>β-carotene presents potential as co-adjuvant to doxorubicin for triple-negative breast cancer treatment.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100320"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213434422000330/pdfft?md5=2aa2390a0a83a7657500c8c81b9d8329&pid=1-s2.0-S2213434422000330-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46435480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A specific combination of nutraceutical Ingredients exerts cytoprotective effects in human cholinergic neurons","authors":"Elisa Zappelli ,&nbsp;Simona Daniele ,&nbsp;Matteo Vergassola ,&nbsp;Lorenzo Ceccarelli ,&nbsp;Elisa Chelucci ,&nbsp;Giorgina Mangano ,&nbsp;Lucia Durando ,&nbsp;Lorella Ragni ,&nbsp;Claudia Martini","doi":"10.1016/j.phanu.2022.100317","DOIUrl":"10.1016/j.phanu.2022.100317","url":null,"abstract":"<div><h3>Background</h3><p><span><span><span><span>Brain aging is associated with an excessive reactive oxygen species (ROS) formation that causes cell injury through proteins oxidation and DNA damage. These changes have been identified as contributing factors in age-related memory decline. In this sense, </span>treatments able to protect </span>central nervous system (CNS) from </span>oxidative stress<span> and to sustain membrane plasticity, may represent new candidates to counter the development of aging effects. Several studies have indicated vitamin E<span>, folic acid, magnesium and omega-3 as </span></span></span>nutraceuticals protecting CNS from oxidative stress.</p></div><div><h3>Methods</h3><p><span>A specific association of these active nutrients was tested in human cholinergic neurons, chosen as a </span>cellular model<span> related to learning and memory processes. Cortisol was used as an oxidative stress insult to explore the beneficial properties of the nutraceuticals.</span></p></div><div><h3>Results</h3><p>In summary, the specific ratio of active ingredients in the above selected food<span> supplement prevented the decrease in ATP content and in cell viability exerted by cortisol. At the same time, it prevented ROS formation, DNA damage, autophagy processes and decrease in the expression of cellular well-being genes induced by cell treatment with cortisol. The effects on ATP content, ROS formation and cellular viability were evidenced when the nutraceutical mix when administered following cortisol treatment, too. Notably, these peculiar evidences were significantly higher with respect to those elicited by the single components of the food supplement.</span></p></div><div><h3>Conclusions</h3><p>Overall, these results confirm the beneficial effects of the simultaneous administration of vitamin E, folic acid, magnesium and omega-3.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100317"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47177736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced nutraceutical functions of herbal oily extract employing formulation technology: The present and future","authors":"Mizuki Ogino,&nbsp;Kohei Yamada,&nbsp;Hideyuki Sato,&nbsp;Satomi Onoue","doi":"10.1016/j.phanu.2022.100318","DOIUrl":"10.1016/j.phanu.2022.100318","url":null,"abstract":"<div><h3>Background</h3><p>In spite of attractive nutraceutical<span> functions, herbal products<span><span> for oral use have many drawbacks, including poor oral-absorption and storage stability, leading to limited usability and efficacy. Considerable attention has been drawn to formulation studies on herbal materials for improvement of </span>biopharmaceutical and nutraceutical properties. The aim of this review is to provide an illustrative overview of industrial and academic formulation researches on herbal materials for overcoming their problems.</span></span></p></div><div><h3>Methods</h3><p>The literature search was conducted for recent findings in the development of herbal formulations with enhanced nutraceutical effects.</p></div><div><h3>Results</h3><p><span>A number of formulations have been applied to herbal materials, includes emulsions, self-emulsifying drug delivery systems<span>, liposomes, solid nanostructured particles, solid dispersions, and cyclodextrin-complexation. These formulation strategies can provide improved dissolution properties and </span></span>oral absorption, a wide safety margin, better handling, and/or enhanced storage stability, possibly resulting in higher product values. Whereas nutraceutical properties have a higher priority, the selection of a suitable formulation would also be necessary for each herbal extract, considering manufacturability, safety concerns, and usability. Herbal medicines still include many unknowns for daily use, and evidence on some nutraceutical properties is insufficient; therefore, they should continue to be researched in more detail.</p></div><div><h3>Conclusion</h3><p>Strategic use of formulation approaches might provide a bright future for self-medication with herbal products.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100318"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42081225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro effects of vitamins C and E on adipocyte function and redox status in obesity","authors":"Asmahan Imessaoudene ,&nbsp;Amel Z. Merzouk ,&nbsp;Baya Guermouche ,&nbsp;Hafida Merzouk ,&nbsp;Sid Ahmed Merzouk","doi":"10.1016/j.phanu.2022.100315","DOIUrl":"10.1016/j.phanu.2022.100315","url":null,"abstract":"<div><h3>Background</h3><p><span>Obesity is associated with a chronic inflammatory state and evident oxidative stress<span>. Antioxidant supplementation may have beneficial effects on adipocyte function and on oxidative stress. Therefore, in this study, we investigated the in vitro effects of </span></span>vitamins C<span><span>, E on redox and metabolic parameters in adipocytes of control and obese </span>Wistar rats.</span></p></div><div><h3>Methods</h3><p><span>Adipocytes were isolated from abdominal adipose tissue<span> and were cultured in RPMI medium for 24 h, in the presence or the absence of vitamins (C, E at 50 µM). Glucose consumption, lactate and glycerol release, ATP and </span></span>triglyceride contents, redox balance were investigated with biochemical methods.</p></div><div><h3>Results</h3><p>The results showed altered glucose consumption and lactate and glycerol efflux, high triglycerides, low ATP contents (P &lt; 0.01), associated to an intracellular oxidative stress in adipocytes of obese rats. Vitamins C and E restored adipocyte function in obesity. Vitamin E<span><span> increased lipolysis<span> in adipocytes during obesity (P &lt; 0.01). Redox balance was also modulated by antioxidants, including a reduction in intracellular hydroperoxides<span> and carbonyl proteins levels and an increase in catalase and </span></span></span>SOD<span> activities and glutathione contents in adipocytes of obese rats.</span></span></p></div><div><h3>Conclusion</h3><p>Treatments with vitamins had beneficial effects on adipocyte function, and should be considered in therapeutic approaches for normalizing adipose function in obesity.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100315"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42294935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-, prebiotics, and other healthful supplements taking the stage in Rome","authors":"Francesco Visioli ,&nbsp;Lucio Capurso","doi":"10.1016/j.phanu.2022.100321","DOIUrl":"10.1016/j.phanu.2022.100321","url":null,"abstract":"","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100321"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47240977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of curcumin on endothelial function in humans and their proposed physiological mechanism: Insights in formulating curcumin products supplementation","authors":"Gustavo Vieira de Oliveira ,&nbsp;Thiago Silveira Alvares","doi":"10.1016/j.phanu.2022.100313","DOIUrl":"10.1016/j.phanu.2022.100313","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Curcumin, a polyphenolic </span>curcuminoid from </span>Curcuma longa<span> L. root and rhizome<span><span>, presents a positive effect on cardiovascular disease. Since endothelial dysfunction precedes cardiovascular disease, many studies have suggested curcumin supplementation to improve </span>endothelial function<span>. However, the mechanisms by which curcumin can enhance endothelial function are poorly explored. Furthermore, formulated curcumin products have been utilized to improve curcumin bioavailability, which can have an additional impact on human health. Therefore, this narrative review aims to discuss the current evidence showing the effect of curcumin on endothelial function in humans, exploring the mechanisms by which curcumin can improve endothelial function. In addition, we discuss whether formulated curcumin products could generate a more robust impact on endothelial function than non-formulated curcumin.</span></span></span></p></div><div><h3>Methods</h3><p>Research articles were retrieved based on a search of the following databases: PubMed, ScienceDirect, and Google Scholar using the following keywords and synonyms combined: (“curcumin” or “turmeric” or “curcuma” or “<em>Curcuma longa</em>” or “<span><em>curcuma</em><em> domestica</em></span>”) AND (“endothelial function” or “vascular function” or “nitric oxide”).</p></div><div><h3>Results</h3><p>Curcumin supplementation seems to improve endothelial function in humans. Such effects can be attributed to curcumin's antioxidant and anti-inflammatory properties and the regulation of adhesion molecule levels, all of which can increase NO bioavailability.</p></div><div><h3>Conclusion</h3><p>Curcumin supplementation has been demonstrated to improve endothelial function, but the current data is insufficient to determine whether the delivery methods enhance such effects. Therefore, future studies investigating the impact of curcumin formulations on endothelial function are warranted.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"22 ","pages":"Article 100313"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45478827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10-Hydroxy-2-decenoic acid-derived aldehydes attenuate anaphylactic hypothermia in vivo","authors":"Akira Sato ,&nbsp;Takahiro Fukase ,&nbsp;Keiichi Ebina","doi":"10.1016/j.phanu.2022.100301","DOIUrl":"10.1016/j.phanu.2022.100301","url":null,"abstract":"<div><h3>Background</h3><p>A royal jelly-derived unique fatty acid, 10-hydroxy-2-decenoic acid (10-HDA), attenuates anaphylactic hypothermia by inhibiting the bioactivities of platelet-activating factor (PAF) and histamine, which are known mediators of anaphylaxis in vivo. Here, we investigated the effects of 10-HDA and its two metabolites, 2-decenedioic acid (2-DA) and 3-hydroxysebacic acid (3-HSA), on anaphylactic hypothermia targeting PAF and histamine in vivo.</p></div><div><h3>Methods</h3><p>The effects of 10-HDA and its metabolites on the bioactivities of PAF and histamine, and anaphylactic hypothermia were evaluated in a rat hind paw edema model and an anaphylactic mouse model.</p></div><div><h3>Results</h3><p><span><span>The metabolites, 2-DA and 3-HSA, barely inhibited histamine- and PAF-induced paw edema in rats. Oral ingestion<span> of 10-HDA (0.002 % and 0.02 %) with food<span> attenuated anaphylactic hypothermia in a dose-dependent manner, whereas intraperitoneal injection<span> of 2-DA or 3-HSA did not inhibit hypothermia. 4-Methylpyrazole, an inhibitor of alcohol dehydrogenase, which converts 10-HDA to its aldehydes, 10-oxo-decenoic acid (10-ODA) and 10-oxo-3-hydroxysebacic acid (10-OHSA), inhibited 10-HDA-induced attenuation of anaphylactic hypothermia. In contrast, </span></span></span></span>cyanamide, an inhibitor of </span>aldehyde dehydrogenase, which converts 10-ODA and 10-OHSA to 2-DA and 3-HSA enhanced the attenuation effect of 10-HDA.</p></div><div><h3>Conclusions</h3><p>The results suggest that 10-HDA-derived aldehydes, 10-ODA and 10-OHSA, may play a key role in the attenuation of anaphylactic hypothermia in vivo.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"21 ","pages":"Article 100301"},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45678003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of intestinal immune cell responses by eubiotic or dysbiotic microbiota in inflammatory bowel diseases","authors":"Federica Facciotti","doi":"10.1016/j.phanu.2022.100303","DOIUrl":"10.1016/j.phanu.2022.100303","url":null,"abstract":"<div><h3>Background</h3><p><span><span><span>Alterations of the gut microbiota<span> have been linked to aberrant mucosal immune responses, leading to different intestinal and extraintestinal disorders, including </span></span>inflammatory bowel diseases (IBD) in genetically susceptible hosts. Thus, restoration of immune </span>homeostasis<span> through the manipulation of the gut microbiota is now considered a possible therapeutic approach to treat IBD patients. Management of IBD patients is currently including the customization of microbe-targeted therapies, such as antibiotics, </span></span>prebiotics<span>, live biotherapeutics and faecal microbiota transplantation. In this narrative review, we will discuss recent advancements in the understanding of host-microbes interactions in IBD and the basis to promote homeostatic immune responses through microbe-targeted therapies.</span></p></div><div><h3>Methods</h3><p>We interrogated with no limit of publication time, the PubMed and Scopus databases using the following keywords: microbiota, inflammatory bowel diseases, IBD, immune system, microbe-targeted therapies.</p></div><div><h3>Results</h3><p><span>Therapeutic restoration of homeostatic immune function in IBD patients currently include the manipulation of the gut microbiota through antibiotics, prebiotics, probiotics, and faecal microbiota transplantation. Nonetheless, differences in efficacy has been reported according to existing microbe-targeted therapies, opening the venue for the search of novel approaches such as </span>phage therapies and combinatorial therapies.</p></div><div><h3>Conclusions</h3><p>Alterations in the composition of the gut microbiota have been implicated in a wide variety of pathologies, including IBD. Microbiome-modulating therapies have proven promising treatments<span> targeting inflammation by modulating the microbiota to correct patients’ dysbiosis, normalize immune system responses and repair epithelial barrier deficiencies.</span></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"21 ","pages":"Article 100303"},"PeriodicalIF":3.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43298411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}