PharmaNutrition最新文献

{"title":"Cellular and molecular mechanisms of action of epigallocatechin gallate on bladder cancer: A comprehensive systematic review","authors":"Hussein Riyadh Abdul Kareem Al-Hetty ,&nbsp;Abdulrahman T. Ahmed ,&nbsp;Hiba Muwafaq Saleem ,&nbsp;Haitham L. Abdulhadi ,&nbsp;Thikra Majid Muhammed ,&nbsp;Loay H. Ali","doi":"10.1016/j.phanu.2024.100392","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100392","url":null,"abstract":"<div><h3>Background</h3><p>Bladder cancer is a common type of cancer that originates in the cells of the bladder. Research studies have indicated that green tea has positive effects on human health, including its ability to combat cancer. Catechins, which account for 12–25 percent of the dried weight of green tea, are one of its main components. In this study, we conducted a systematic review of the literature to examine the effects of epigallocatechin gallate (EGCG) on bladder cancer.</p></div><div><h3>Method</h3><p>The study followed the guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements . We searched various databases including Web of Sciences, PubMed, Embase, Science Direct, Scopus, and the Cochrane databases, up until October 2022<strong>.</strong> Two reviewers independently screened the data and assessed the risk of bias. After applying the inclusion criteria, a total of 34 studies were included in the analysis<strong>.</strong></p></div><div><h3>Results</h3><p>The evidence from the study indicates that EGCG can regulate the progression of bladder cancer through various mechanisms. These mechanisms include reducing inflammation, decreasing the production of reactive oxygen species (ROS), managing oxidative stress (OS), inhibiting angiogenesis, suppressing cancer cell proliferation, controlling the cell cycle, inducing autophagy, stimulating tumor gene suppressors (TGS), and promoting apoptosis.</p></div><div><h3>Conclusion</h3><p>Based on the substantial beneficial effects of EGCG on bladder cancer progression, it has the potential to be used as a therapeutic approach. However, it is important to note that there is a lack of clinical trials involving human subjects. Therefore, further research involving human participants is necessary to reach a more precise conclusion<strong>.</strong></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100392"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D administration on serum uric acid concentrations: A systematic review and meta-analysis of clinical trials","authors":"Luis E. Simental-Mendía ,&nbsp;Yéssika Weyman-Vela ,&nbsp;Mario Simental-Mendía","doi":"10.1016/j.phanu.2024.100391","DOIUrl":"10.1016/j.phanu.2024.100391","url":null,"abstract":"<div><h3>Background</h3><p>It has been suggested the potential uric acid-lowering effect of vitamin D; however, clinical trials evaluating the impact of vitamin D administration on serum uric acid levels are scarce. The aim of this meta-analysis of clinical trials was to examine the effect of vitamin D administration on serum uric acid concentrations.</p></div><div><h3>Methods</h3><p>A systematic search was performed in PubMed-MEDLINE, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases. Randomized clinical trials (parallel or cross-over design) with data at baseline and at the end of intervention. Trials without intervention, without control group, and incomplete data of uric acid concentrations were excluded. A random-effects model and sensitivity analysis generic inverse variance method were used for the meta-analysis.</p></div><div><h3>Results</h3><p>Meta-analysis was carried out using a random-effects model and sensitivity analysis. The meta-analysis of seven clinical trials, involving 959 participants, indicated a significant reduction of uric acid levels after vitamin D administration (WMD: −16.64 µmol/L, 95% CI: −25.25, −8.03, <em>p</em> &lt;0.001, <em>I</em>^<em>2</em> = 74%). Additionally, the impact of this vitamin on uric acid concentrations was robust in the leave-one-out sensitivity analysis.</p></div><div><h3>Discussion</h3><p>Given that few clinical trials were included, the number of subjects analyzed was limited. However, our results suggest that vitamin D administration is associated with a significant reduction in the levels of serum uric acid in randomized clinical trials.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100391"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics in plant-based food matrices: A review of their health benefits","authors":"Sara Sayonara da Cruz Nascimento ,&nbsp;Thaís Souza Passos ,&nbsp;Francisco Canindé de Sousa Júnior","doi":"10.1016/j.phanu.2024.100390","DOIUrl":"10.1016/j.phanu.2024.100390","url":null,"abstract":"<div><h3>Background</h3><p>Plant-based food matrices have been increasingly used as vehicles for probiotics due to their high nutritional and bioactive value. Therefore, this review summarizes the health benefits of plant-based food matrices probiotics focusing on <em>in vitro</em> and <em>in vivo</em> studies.</p></div><div><h3>Methods</h3><p>A narrative literature review was performed to select articles published between 2015 and 2024. The Scopus, Science Direct, Web of Science, PubMed, and EMBASE scientific databases were used. Full articles that evaluated the health benefits of consuming plant-based food matrices probiotics performed <em>in vitro</em> and <em>in vivo</em> (animal models and clinical trials in humans) were selected.</p></div><div><h3>Results</h3><p>From the scientific evidence, it was possible to highlight the health benefits of probiotics in plant-based food matrices and their association with bioactive compounds treating various diseases, proving beneficial effects in treating cancer, liver diseases, obesity, and related chronic diseases and inflammatory diseases. However, it was noted that clinical trials are still needed to confirm these effects in humans.</p></div><div><h3>Conclusions</h3><p>Plant-based food matrices probiotics have proven beneficial effects in various diseases based on <em>in vitro</em> and animal model studies. However, clinical trials are needed to confirm these effects.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100390"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coming from opposite parts of the spectrum of interpreting studies about Nutri-Score: Suggestion of publication bias cannot be denied","authors":"Stephan Peters ,&nbsp;Hans Verhagen","doi":"10.1016/j.phanu.2024.100387","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100387","url":null,"abstract":"<div><h3>Background</h3><p>The front-of-pack label Nutri-Score is currently proposed as the system of choice in seven EU countries. However, there is still much scientific debate about the validation and efficacy of Nutri-Score and there is much discussion about author affiliation and study outcome.</p></div><div><h3>Methods</h3><p>Recently we published our paper: Nutri-Score and publication bias: A complete literature review of the substantiation of the effectiveness of the front-of-pack logo Nutri-Score Peters &amp; Verhagen, PharmaNutrition 27 C (2024) 100380. This paper received a commentary paper by the developers of Nutri-Score: M. Touvier et al., 2024 “Rebuttal to the paper published by S. Peters and H. Verhagen”. We herewith provide an invited commentary to that rebuttal paper, which further supports the observed publication bias.</p></div><div><h3>Results</h3><p>In this response to the rebuttal, we primarily respond on the scientific issues raised in the rebuttal and explain more about our alleged conflict of interest and our motivation to write the paper. Moreover, we basically thank the authors of the rebuttal paper for, perhaps ironically but essentially, confirming our analysis: there is a publication bias versus affiliation.</p></div><div><h3>Discussion</h3><p>Overall, the available evidence is clearly limited and biased, and more research is needed to substantiate or disprove the effectiveness of Nutri-Score.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100387"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and sociodemographic factors associated with overweight in children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD): A cross-sectional study","authors":"Joana Dias da Costa ,&nbsp;Giuseppe Mario Carmine Pastura ,&nbsp;Cleber Nascimento do Carmo ,&nbsp;Renata Ribeiro Spinelli ,&nbsp;Pamela Melo Krok Fedeszen ,&nbsp;Letícia Victoria Souza da Cunha ,&nbsp;Beatriz Bastos de Araújo ,&nbsp;Patricia de Carvalho Padilha","doi":"10.1016/j.phanu.2024.100375","DOIUrl":"10.1016/j.phanu.2024.100375","url":null,"abstract":"<div><h3>Background</h3><p>Overweight has been increasing globally in various age groups, including children and adolescents. Despite efforts to reduce instances of childhood obesity, research has shown that children and adolescents with attention deficit hyperactivity disorder (ADHD) tend to be overweight more often than the general population. In this context, the aim of this study is to evaluate the clinical and sociodemographic factors associated with overweight in children and adolescents with ADHD treated at a university hospital in Rio de Janeiro.</p></div><div><h3>Methods</h3><p>This cross-sectional study included 40 children and adolescents aged 6–18 years who were diagnosed with ADHD. Height/age and body mass index (BMI)/age indices were used for anthropometric assessment, and the percentages of fat mass (%FM) and fat-free mass (%FFM) were estimated using bioelectrical impedance. Clinical (lipid profile and comorbidities) and sociodemographic variables were also obtained. The association between clinical and sociodemographic variables and overweight status was investigated using multiple correspondence analysis (MCA). The significance level was set at p &lt; 0.05.</p></div><div><h3>Results</h3><p>Excessive weight occurred in 42.5% (n = 17) of the participants, 67% (n = 20) had inadequat% FM, and 27.5% (n = 11) had dyslipidemia. According to the MCA, “greater number of people in the family”, “lower maternal education”, “presence of comorbidities, and “generalized anxiety disorder” were more frequent among those with excess weight.</p></div><div><h3>Conclusion</h3><p>The findings provide insights on the clinical and sociodemographic variables associated with being overweight in children and adolescents with ADHD, which may contribute to the early detection of possible inadequacies in anthropometric status.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"28 ","pages":"Article 100375"},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139633644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-derived phenolic acids in the treatment of pulmonary hypertension: A review of the underlying mechanisms","authors":"Elaheh Mirhadi ,&nbsp;Wael Almahmeed ,&nbsp;Prashant Kesharwani ,&nbsp;Amirhossein Sahebkar","doi":"10.1016/j.phanu.2024.100381","DOIUrl":"10.1016/j.phanu.2024.100381","url":null,"abstract":"<div><h3>Background</h3><p>Pulmonary arterial hypertension (PAH) is a progressive and debilitating disease, as the currently available medications such as endothelin receptor antagonists, nitric oxide, and prostacyclin agonists only provide symptomatic relief without offering a complete cure. Therefore, it is crucial to explore novel approaches that target the underlying cellular and molecular signaling pathways involved in PAH.</p></div><div><h3>Method</h3><p>Phenolic acids represent a class of phytochemical compounds that possess well-established antioxidant and anti-inflammatory properties, making them of significant interest in the treatment of PAH. In this review, we specifically focus on three bioactive components: salvianolic acids, magnesium lithospermate B extracted from <em>Salvia miltiorrhiza</em>, and osthole, which is a coumarin-type compound.</p></div><div><h3>Results</h3><p>By examining the therapeutic potential of these compounds, we aim to shed light on their role in mitigating the effects of PAH and contribute to the development of innovative treatment strategies. In the progression of PAH, various functional signaling molecules and pathways are inhibited by phenolic acids. These include p38MAPK, P38, ROS, ROCK, Ras, MEK 1/2, ERK 1/2, TGF β, BMPR-2, Smad 1/5/8, NOX2, NOX4, CDK 4/6. On the other hand, PI3K and AKT pathways are upregulated.</p></div><div><h3>Conclusion</h3><p>The lack of definitive treatment for PAH highlights the importance of further studies and evaluations to translate these therapies to the clinic, given the outstanding characteristics of phenolic acids.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"27 ","pages":"Article 100381"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of flaxseed as an effective approach for improving lipid profile parameters: An updated systematic review and meta-analysis of randomized controlled trials","authors":"Amir Hossein Moridpour ,&nbsp;Masomeh Goodarzi ,&nbsp;Zeynab Kavyani ,&nbsp;Negarsadat Nademi ,&nbsp;Maziar Daneshvar ,&nbsp;Vali Musazadeh ,&nbsp;Amir Hossein Faghfouri","doi":"10.1016/j.phanu.2023.100366","DOIUrl":"https://doi.org/10.1016/j.phanu.2023.100366","url":null,"abstract":"<div><h3>Background</h3><p>Numerous studies have shown the beneficial effects of flaxseed on lipid profile parameters; however, some others have reported contradictory results.</p></div><div><h3>Aim of the review</h3><p>The current study, therefore, aimed to provide a thorough understanding of the effects of flaxseed on lipid profile parameters in adults.</p></div><div><h3>Methods</h3><p>To this end, a comprehensive systematic search was conducted to collect the required trials from PubMed, Scopus<span><span>, Embase, </span>Cochrane Library, Web of Science databases, and Google Scholar up to December 2022.</span></p></div><div><h3>Results</h3><p>75 trials were included in our meta-analysis (two trials were only presented as a systematic review). Our study results indicated that the flaxseed supplementation significantly decreased the total levels of cholesterol (TC) (SMD: −0.57; 95% CI: −0.80, −0.33, <em>P</em><span> &lt; 0.001), triglyceride (TG) (SMD: −0.61; 95% CI: −0.87, −0.35, </span><em>P</em> &lt; 0.001), low-density lipoprotein-cholesterol (LDL-C) (SMD: −0.36; 95% CI: −0.61, −0.11; <em>P</em> = 0.005), and LDL-C/HDL-C ratios (SMD: −0.92, 95% CI: −1.35, −0.49, <em>P</em> &lt; 0.010). However, flaxseed did not change the levels of high-density lipoprotein-cholesterol (HDL-C) (SMD: 0.16; 95% CI: −0.03, 0.35, <em>P</em> = 0.097), and TC/HDL-C ratio (SMD: −0.35; 95% CI: −0.81, 0.11; <em>P</em> = 0.139).</p></div><div><h3>Conclusion</h3><p>It was concluded that the flaxseed supplementation may have improved the lipid profile. Therefore, it was recommended that flaxseed should be used as an adjuvant anti-hyperlipidemic agent.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"27 ","pages":"Article 100366"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the modulatory effect of zeaxanthin isolated from maize kernels on cellular signaling pathways associated with hyperglycemia-induced HepG2 cell proliferation","authors":"T. Maradagi ,&nbsp;N.M. Stephen ,&nbsp;R. Kumar ,&nbsp;K.N. Ramudu ,&nbsp;G. Ponesakki","doi":"10.1016/j.phanu.2024.100376","DOIUrl":"https://doi.org/10.1016/j.phanu.2024.100376","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Carotenoids are the group of antioxidant </span>phytonutrients<span><span>, found to repress carcinogenesis by modulating multiple cellular signaling pathways. Since diabetes patients have two to three folds increased risk of liver cancer, the present study aimed to explore the role of </span>zeaxanthin on various molecular targets of high glucose-mediated human </span></span>hepatocellular carcinoma<span> (HepG2) cell proliferation.</span></p></div><div><h3>Methods</h3><p><span><span>The antiproliferative effect<span> of zeaxanthin was examined by WST-1 assay. The DCFH-DA fluorescence dye was used to measure the intracellular </span></span>ROS<span> levels. The modulatory effect of zeaxanthin on the protein expression<span> of MAPK-p38, Akt, and ERK, and antioxidant markers such as Nrf2, SOD2, HO1, and catalase, and </span></span></span>apoptosis<span><span> markers, Bcl2, P53, and cleaved caspase 3 was measured by </span>western blotting. Apoptosis-inducing effect of zeaxanthin in high glucose subjected HepG2 cells was examined using DAPI staining.</span></p></div><div><h3>Results</h3><p>Zeaxanthin exhibits an effective growth inhibition in high glucose subjected HepG2 cells. It drastically repressed high glucose-mediated elevation of ROS levels. Further, zeaxanthin suppressed hyperglycemia-mediated ROS-driven p38 activation to mitigate HepG2 cell proliferation. Zeaxanthin also switched on the apoptosis pathway in hyperglycemic HepG2 cells. The apoptosis induction by zeaxanthin was confirmed with downregulated Bcl2 and P53 and upregulated cleaved caspase 3 protein expression.</p></div><div><h3>Conclusions</h3><p>The current findings substantiate the previous findings that zeaxanthin has greater potential than lutein in sensitizing hyperglycemic HepG2 cells by modulating multiple signaling pathways. The study highlights the importance of zeaxanthin as a powerful phytonutrient which possesses chemotherapeutic potential against diabetes-associated liver cancer progression.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"27 ","pages":"Article 100376"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139549011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities and challenges in using NIH’s Dietary Supplement Label Database for research on non-nutrient ingredients: Use case for ingredients in honeybee products","authors":"Alessandra Durazzo ,&nbsp;Massimo Lucarini ,&nbsp;Johanna T. Dwyer ,&nbsp;Barbara C. Sorkin ,&nbsp;Michael Heinrich ,&nbsp;Pamela Pehrsson","doi":"10.1016/j.phanu.2024.100377","DOIUrl":"10.1016/j.phanu.2024.100377","url":null,"abstract":"<div><h3>Background</h3><p><span>Non-nutrient bioactive ingredients of foods such as bee products are often of interest in preclinical and </span>clinical research<span> to explore their possible beneficial effects. The National Institute of Health’s Dietary Supplement Label Database (DSLD) contains over 165,000 labels of dietary supplements marketed in the United States of America (US), including declarations on labels for many ingredients such as those in honeybee products which have been used in foods and traditional medicines for centuries worldwide and are now also appearing in dietary supplements.</span></p></div><div><h3>Methods</h3><p>This article presents a use case for honeybee products that describes and tests the utility of the DSLD and other databases available in the US as research tools for identifying and quantifying the prevalence of such ingredients. It focuses on the limitations to the information on product composition in these databases and describes how to code the ingredients using the LanguaL™ and FoodEx2 classification and description systems and the strengths and limitations of information on honeybee product ingredients, including propolis, bee pollen, royal jelly, beeswax.</p></div><div><h3>Results and conclusions</h3><p>Codes for the ingredients are provided for identifying their presence in LanguaL™ and FoodEx2 classification and description systems used in Europe and elsewhere. The prevalence of dietary supplement products containing these ingredients in DSLD and on the US market is low compared to some other products and ingredients. Unfortunately label declarations in DSLD do not provide quantitative information and so the data can be used only to screen for their presence, but cannot be used for quantitative exposure estimates by researchers and regulators.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"27 ","pages":"Article 100377"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of supplementation with a multi-species synbiotic on serum lipid profile, abundance of beneficial gut bacteria and firmicutes to bacteroidetes ratio in patients with dyslipidemia; a randomized, double-blind, placebo-controlled, clinical trial","authors":"Shekoufeh Salamat ,&nbsp;Mohammad Reza Tabandeh ,&nbsp;Alireza Jahan-Mihan ,&nbsp;Anahita Mansoori","doi":"10.1016/j.phanu.2023.100367","DOIUrl":"https://doi.org/10.1016/j.phanu.2023.100367","url":null,"abstract":"<div><h3>Background</h3><p><span><span><span><span>Dysbiosis an imbalance of </span>gut microbiota (GM) may contribute to the development of </span>metabolic disorders<span> including dyslipidemia<span>. Synbiotics have been suggested to modulate GM composition and in turn, they may alter </span></span></span>lipid metabolism. We aimed to evaluate the effects of synbiotic supplementation on </span>serum lipid<span><span> profile, abundance of dominant gut bacteria, and also the Firmicutes to </span>Bacteroidetes (F/B) ratio in adults with dyslipidemia.</span></p></div><div><h3>Methods</h3><p><span>Fifty-six adults with dyslipidemia were enrolled in a randomized, clinical trial. Participants were randomly allocated to receive either synbiotic or placebo sachets for 12 weeks. Each synbiotic sachet contains (a total dose of 3 ×10</span>¹⁰<span><span><span><span> colony forming units<span>, CFU/gram) six species of probiotic<span> microorganisms with 5-gram inulin and </span></span></span>fructooligosaccharide (FOS) in equal amounts as </span>prebiotics. Serum lipid profile, </span>fecal bacteria<span><span> abundance, dietary intake, physical activity level (PAL), and </span>anthropometric measures, were assessed at the baseline and after intervention.</span></span></p></div><div><h3>Results</h3><p>No significant changes were observed in participants' dietary intake, PA, and anthropometric indices within and between groups after 12 weeks of intervention. High-density lipoprotein-cholesterol (HDL-C) showed a significant increase (p = 0.0008), while no significant change in other lipid profile components was observed. The abundance of fecal <span><em>Firmicutes, Bacteroidetes, </em><em>Lactobacillus</em></span>, and <span><em>Bifidobacterium</em></span> was significantly increased in the synbiotic group (p &lt; 0.0001, p &lt; 0.0001, p &lt; 0.0001, and p = 0.032 respectively). However, 12 weeks of synbiotic supplementation didn’t affect F/B Ratio (p = 0.43) at the end of the study.</p></div><div><h3>Conclusions</h3><p>Twelve weeks of supplementation with multi-species synbiotic may improve HDL-C and enhance the abundance of beneficial gut bacteria in patients with dyslipidemia.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"27 ","pages":"Article 100367"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138656947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}