{"title":"Impact of dietary supplementation with coenzyme Q10 on periodontitis: A systematic review and meta-analysis","authors":"Haniyeh Golafrouz , Farzad Shidfar , Arezoo Piran , Zohreh Sajadi Hezaveh","doi":"10.1016/j.phanu.2022.100328","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span>To explore the impact of CoQ10 supplementation on </span>periodontitis, a </span>systematic review<span> of controlled trials (PROSPERO: CRD42021274876) was performed from 1970 to November 2022 through Web of Science (ISI), Google Scholar, Embase<span>, CENTRAL, PubMed/MEDLINE, Scopus<span>, and ProQuest. A random-effect model was used considering clinical attachment loss (CAL), </span></span></span></span>plaque index (PI), gingival index (GI), bleeding index (BI), and probing depth (PD). Of 97 records, eight trials were included. CoQ10 supplementation significantly reduce CAL (WMD, –0.66 (–0.81 to –0.50), P < 0.0001; I</span><sup>2</sup><span> = 93.4 %) and GI (WMD, –0.20 (–0.40–0.00), P = 0.05; I</span><sup>2</sup> = 98.5 %), but it could not affect PI (WMD, –0.07 (–0.16–0.02), P = 0.11, I<sup>2</sup> = 91.2 %), PD (WMD, –0.28 (–0.67–0.12), P = 0.17; I<sup>2</sup> = 98.4 %), and BI (WMD, –0.58 (–1.40–0.24), P = 0.17; I<sup>2</sup> = 99.5 %) significantly. CoQ10 had a stronger reduction effect on PI and GI in individuals ≥ 40 years old and in doses of ≤ 60 mg CoQ10. Longer duration of CoQ10 supplementation was also more effective in reducing PD. CAL reduced greater when CoQ10 was administered for longer than 12 weeks, in a dose of > 60 mg, and in younger individuals. CoQ10 supplementation in periodontitis may have beneficial effect on GI and CAL. Further investigations in this regard are needed to draw conclusive results.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"23 ","pages":"Article 100328"},"PeriodicalIF":2.4000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221343442200041X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
To explore the impact of CoQ10 supplementation on periodontitis, a systematic review of controlled trials (PROSPERO: CRD42021274876) was performed from 1970 to November 2022 through Web of Science (ISI), Google Scholar, Embase, CENTRAL, PubMed/MEDLINE, Scopus, and ProQuest. A random-effect model was used considering clinical attachment loss (CAL), plaque index (PI), gingival index (GI), bleeding index (BI), and probing depth (PD). Of 97 records, eight trials were included. CoQ10 supplementation significantly reduce CAL (WMD, –0.66 (–0.81 to –0.50), P < 0.0001; I2 = 93.4 %) and GI (WMD, –0.20 (–0.40–0.00), P = 0.05; I2 = 98.5 %), but it could not affect PI (WMD, –0.07 (–0.16–0.02), P = 0.11, I2 = 91.2 %), PD (WMD, –0.28 (–0.67–0.12), P = 0.17; I2 = 98.4 %), and BI (WMD, –0.58 (–1.40–0.24), P = 0.17; I2 = 99.5 %) significantly. CoQ10 had a stronger reduction effect on PI and GI in individuals ≥ 40 years old and in doses of ≤ 60 mg CoQ10. Longer duration of CoQ10 supplementation was also more effective in reducing PD. CAL reduced greater when CoQ10 was administered for longer than 12 weeks, in a dose of > 60 mg, and in younger individuals. CoQ10 supplementation in periodontitis may have beneficial effect on GI and CAL. Further investigations in this regard are needed to draw conclusive results.
为了探讨补充辅酶Q10对牙周炎的影响,从1970年到2022年11月,通过Web of Science(ISI)、Google Scholar、Embase、CENTRAL、PubMed/MEDLINE、Scopus和ProQuest对对照试验(PROSPERO:CDR42021274876)进行了系统综述。使用随机效应模型,考虑临床附着丧失(CAL)、牙菌斑指数(PI)、牙龈指数(GI)、出血指数(BI)和探查深度(PD)。在97项记录中,包括8项试验。补充辅酶Q10显著降低CAL(WMD,-0.66(-0.81至-0.50),P<;0.0001;I2=93.4%)和GI(WMD,-0.20(-0.40-0.00),P=0.05;I2=98.5%),但不影响PI(WMD,-0.07(-0.16-0.02),P=0.11,I2=91.2%)、PD(WMD)-0.28(-0.67-0.12),P=0.17;I2=98.4%),BI(WMD,–0.58(–1.40–0.24),P=0.17;I2=99.5%)。CoQ10对≥40岁和剂量≤60 mg的个体的PI和GI具有更强的降低作用。补充CoQ10的持续时间越长,对降低PD也越有效。当CoQ10给药超过12周时,CAL降低得越大,剂量>;60mg,以及在年轻个体中。补充辅酶Q10治疗牙周炎可能对GI和CAL有有益影响。需要对此进行进一步研究才能得出结论性结果。