Adriele Debortoli da Silva , Natália Oliveira Izidoro , Leandro Roberto de Macedo , Ione Maria de Matos , Maísa Silva
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引用次数: 0
Abstract
Background
Grape supplementation has been suggested to contribute to improving parameters related to metabolic syndrome (MetS); however, the scientific literature in this field is controversial and inconclusive.
Objectives
We undertook a systematic review and meta-analysis of randomized controlled clinical trials on the effect of grape product on metabolic syndrome components, including blood pressure, anthropometric measurements, and glycemic and lipid profiles.
Methods
The online databases of PubMed, Scopus, Web of Science, and SciELO were systematically searched for relevant publications until December 2021. The review has been registered at PROSPERO (CRD42021287813). To compare the effects of grape product (seed extract, powder, extract, fruit, pomace, juice) with placebo, the mean differences with 95% confidence intervals (CI) were pooled based on the random-effects model. Subgroup analyses were performed to identify the source of heterogeneity, and assessment of study quality was conducted using the GRADE approach.
Results
In total, 27 randomized controlled trials (RCTs) were included in this systematic review, and 21 trials were selected for meta-analysis. Meta-analyses of the data showed that grape products had a significant effect on lipid levels, decreasing total and low density lipoprotein cholesterol and triacylglycerol levels. Grape supplementation also reduced systolic and diastolic arterial pressure. In addition, grape supplementation increased glucose serum and insulin levels. We found no significant differences in anthropometric measurements.
Conclusion
grape products may be beneficial for individuals with parameters related to MetS because they may have hypotensive and hypolipidemic properties.
背景葡萄补充剂有助于改善代谢综合征（MetS）相关参数；然而，这一领域的科学文献存在争议，也没有定论。目的：我们对葡萄制品对代谢综合征成分（包括血压、人体测量、血糖和血脂）影响的随机对照临床试验进行了系统回顾和荟萃分析。方法系统检索PubMed、Scopus、Web of Science和SciELO在线数据库中的相关出版物，直至2021年12月。审查已在PROSPERO注册（CRD42021287813）。为了比较葡萄产品（种子提取物、粉末、提取物、水果、果渣、果汁）与安慰剂的效果，基于随机效应模型汇总了95%置信区间（CI）的平均差异。进行亚组分析以确定异质性的来源，并使用GRADE方法评估研究质量。结果共有27项随机对照试验（RCT）被纳入本系统综述，21项试验被选择进行荟萃分析。数据的荟萃分析表明，葡萄制品对脂质水平有显著影响，降低总胆固醇和低密度脂蛋白胆固醇以及三酰甘油水平。补充葡萄还能降低收缩压和舒张压。此外，补充葡萄可提高血清葡萄糖和胰岛素水平。我们没有发现人体测量的显著差异。结论葡萄制品可能具有降压和降血脂的特性，对患有代谢综合征相关参数的个体有益。
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