益生菌能降低妇女绝经后骨质疏松症的风险吗?

IF 2.4 Q3 NUTRITION & DIETETICS
Iskandar Azmy Harahap, Joanna Suliburska
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引用次数: 5

摘要

背景更年期是女性月经的自然停止,会增加患骨质疏松症的风险。骨质疏松症是一种因雌激素水平下降而导致骨骼脆弱和骨折易感性的疾病。几项研究已经证实,摄入益生菌可以改善骨骼健康,但一些研究报告了不确定的结果。在这篇文献综述中,讨论了绝经后妇女补充益生菌的最新发现、发展和趋势。方法对所选文章进行文献计量学分析,然后进行文献综述。这些研究在2010年至2022年间登记在Scopus数据库中。关于绝经后妇女益生菌干预的最新进展,在ClinicalTrials.gov数据库中进行了文献检索。结果越来越多的证据表明,乳酸杆菌菌株可以通过改善钙吸收和骨密度来对骨质疏松症产生有益作用。具体而言,某些益生菌菌株,如嗜酸乳杆菌,已被证明可以通过产生短链脂肪酸来提高钙的生物利用度,从而降低肠道pH值,使钙更容易溶解和吸收。此外,益生菌可以调节免疫系统,减少炎症,对骨骼健康也有益。结论益生菌是绝经后妇女骨质疏松症的一种很有前途的治疗剂,表现出骨代谢、钙吸收、基因表达和肠道微生物群组成之间的生理相互作用。然而,为了确定益生菌在预防和治疗骨质疏松症中的剂量和安全性,需要对其在绝经后骨质疏松症妇女中的作用进行长期临床研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can probiotics decrease the risk of postmenopausal osteoporosis in women?

Background

Menopause, the natural cessation of menstruation in women, increases the risk of osteoporosis—an illness characterized by bone fragility and fracture susceptibility due to decreased estrogen levels. Several studies have confirmed that probiotics ingestion can increase bone health, but some have reported inconclusive results. In this literature review, the latest findings, developments, and trends in probiotics supplementation in postmenopausal women were discussed.

Methods

Selected articles were first subjected to a bibliometric analysis and then a literature review. These studies were registered in the Scopus database between 2010 and 2022. For more recent developments in probiotics interventions in postmenopausal women, a literature search was conducted in the ClinicalTrials.gov database.

Results

There is growing evidence to suggest that Lactobacillus strain can have a beneficial effect on osteoporosis by improving calcium absorption and bone mineral density. Specifically, certain strains of probiotics, such as Lactobacillus acidophilus, have been shown to increase the bioavailability of calcium by producing short-chain fatty acids that lower gut pH, making it easier for calcium to dissolve and be absorbed. In addition, probiotics can modulate the immune system and reduce inflammation, which is also beneficial for bone health.

Conclusions

These findings suggested probiotics as a promising therapeutic agent in postmenopausal women with osteoporosis, showing a physiological interaction between bone metabolism, calcium absorption, gene expression, and gut microbiota composition. However, to determine the dose and safety of probiotics in the prevention and treatment of osteoporosis, long-term clinical studies of their effects in postmenopausal women with osteoporosis are needed.

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来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
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