Carla Dayana Durães Abreu , Bruna Viana Caldas , Guilherme Henrique Mendes Ribeiro , Charles Martins Aguilar , Lucyana Conceição Farias , André Luiz Sena Guimarães , Alfredo Maurício Batista de Paula , Maria Beatriz Abreu Glória , Sérgio Henrique Sousa Santos
{"title":"饲粮中添加菊粉可通过降低脂肪组织中toll样受体4跨膜蛋白基因和白细胞介素6的表达来改善代谢参数","authors":"Carla Dayana Durães Abreu , Bruna Viana Caldas , Guilherme Henrique Mendes Ribeiro , Charles Martins Aguilar , Lucyana Conceição Farias , André Luiz Sena Guimarães , Alfredo Maurício Batista de Paula , Maria Beatriz Abreu Glória , Sérgio Henrique Sousa Santos","doi":"10.1016/j.phanu.2022.100316","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span><span>Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. </span>Probiotic </span>dietary supplementation is a viable health option.</p></div><div><h3>Methods</h3><p><span>Male Swiss mice<span> were fed with two diets for four weeks: standard and standard + Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in </span></span>adipose tissue were analyzed.</p></div><div><h3>Results</h3><p><span>The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein<span> gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving </span></span>insulin sensitivity.</p></div><div><h3>Conclusion</h3><p>The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative.</p></div><div><h3>Data Availability Statement</h3><p>The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue\",\"authors\":\"Carla Dayana Durães Abreu , Bruna Viana Caldas , Guilherme Henrique Mendes Ribeiro , Charles Martins Aguilar , Lucyana Conceição Farias , André Luiz Sena Guimarães , Alfredo Maurício Batista de Paula , Maria Beatriz Abreu Glória , Sérgio Henrique Sousa Santos\",\"doi\":\"10.1016/j.phanu.2022.100316\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><span><span>Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. </span>Probiotic </span>dietary supplementation is a viable health option.</p></div><div><h3>Methods</h3><p><span>Male Swiss mice<span> were fed with two diets for four weeks: standard and standard + Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in </span></span>adipose tissue were analyzed.</p></div><div><h3>Results</h3><p><span>The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein<span> gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving </span></span>insulin sensitivity.</p></div><div><h3>Conclusion</h3><p>The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative.</p></div><div><h3>Data Availability Statement</h3><p>The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.</p></div>\",\"PeriodicalId\":20049,\"journal\":{\"name\":\"PharmaNutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PharmaNutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213434422000299\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213434422000299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue
Background
Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. Probiotic dietary supplementation is a viable health option.
Methods
Male Swiss mice were fed with two diets for four weeks: standard and standard + Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in adipose tissue were analyzed.
Results
The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving insulin sensitivity.
Conclusion
The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative.
Data Availability Statement
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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