PharmaNutrition最新文献

{"title":"Understanding the potential of Tropaeolum majus, a non-conventional food plant, in lipid and glucose metabolism","authors":"Mariana Buranelo Egea ,&nbsp;Ailton Cesar Lemes","doi":"10.1016/j.phanu.2025.100455","DOIUrl":"10.1016/j.phanu.2025.100455","url":null,"abstract":"<div><div>Brazil has one of the world's richest plant biodiversity, with approximately 46,000 species, including approximately 3000 non-conventional food plants (NCFPs). However, the nutritional, bioactive, and technological potentials of these plants remain underutilized and often overlooked. <em>Tropaeolum majus</em> (<em>T. majus</em>), an underexplored NCFPs, has shown promise in modulating lipid and glucose metabolism, which are key factors in metabolic health. Metabolic potential is closely linked to diverse bioactive compounds, including flavonoids, glucosinolates, and antioxidants, which contribute to its health-promoting properties. Moreover, it is a edible plant with a complete nutritional composition, characterized by high levels of protein and fiber along with low lipid content, making it an appealing option for both dietary inclusion and as a raw material for extracting and isolating valuable components. This review aimed to present information about the production processes, physicochemical characteristics, and bioactive potential of <em>T. majus</em>, emphasizing its role as a regulator of lipid and glucose metabolism, as supported by current scientific evidence.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100455"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145418242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peiminine as an anti-inflammatory agent: Mechanisms and therapeutic applications across diseases","authors":"Amin Azizan ,&nbsp;Mohamadali Abyazi ,&nbsp;Seyed Kiarash Aghayan ,&nbsp;Majid Mirzaei Nodooshan ,&nbsp;Akbar Ghorbani Alvanegh ,&nbsp;Hadi Esmaeili Gouvarchin Ghaleh","doi":"10.1016/j.phanu.2025.100460","DOIUrl":"10.1016/j.phanu.2025.100460","url":null,"abstract":"<div><div>Inflammatory diseases, including cancers and autoimmune disorders, demand therapeutic strategies that are both effective and associated with fewer side effects. Current treatment modalities, particularly immunosuppressive agents, often exhibit limited efficacy and undesirable outcomes, necessitating exploration into alternative solutions. Natural compounds have emerged as promising candidates for addressing this gap. This review focuses on peiminine, a bioactive alkaloid derived from the Fritillaria species, investigating its potential as a natural therapeutic agent. A comprehensive search was conducted across multiple databases, including MEDLINE, EMBASE, and Scopus, to collate evidence from preclinical studies assessing the anti-inflammatory and disease-modulating properties of peiminine. The findings reveal that peiminine exhibits significant potential in ameliorating a range of conditions, such as cancers, autoimmune diseases, and other inflammation-driven disorders like endometriosis and Parkinson's disease in preclinical stages. Mechanistically, peiminine exerts its effects by inhibiting critical signaling pathways, including NF-κB and ERK, and by regulating cell cycle progression and apoptosis. The preclinical literature highlights its promise as a natural therapeutic agent for future studies such as clinical trials. Harnessing the therapeutic potential of peiminine could pave the way for more effective and safer treatment strategies for inflammatory diseases.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100460"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential strategies of natural products in the treatment of atherosclerosis: Focusing on modulating macrophage polarization","authors":"Wenjie Zhao ,&nbsp;Peng Sun ,&nbsp;Jiaming Huan ,&nbsp;Lei Zhang ,&nbsp;Shijing Peng ,&nbsp;Tong Jiang ,&nbsp;Linghui Kong ,&nbsp;Xinghao Zhu ,&nbsp;Wenqing Yang ,&nbsp;Dongmei Qi ,&nbsp;Yunlun Li","doi":"10.1016/j.phanu.2025.100461","DOIUrl":"10.1016/j.phanu.2025.100461","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerosis is the primary contributor to coronary artery disease, peripheral artery disease, and cerebrovascular disease, making it one of the most prevalent causes of mortality worldwide. Macrophages play crucial roles in all stages of atherosclerosis development, providing new avenues for therapeutic interventions due to their inherent plasticity. Consequently, therapies aimed at macrophages may be advantageous for both the prevention and treatment of atherosclerosis. Accumulating evidence strongly indicates that traditional Chinese medicine (TCM) and its derived natural products have remarkable efficacy in modulating macrophage polarization. In this work, we comprehensively summarize the therapeutic potential of diverse natural products, aiming to provide a comprehensive overview.</div></div><div><h3>Methods</h3><div>A literature search was performed with the keywords “atherosclerosis” or “macrophage polarization” or “herbal medicine” or “natural extracts” or “natural compounds” or “traditional Chinese medicine” or “natural products”. Classic book-based herbal and scientific databases include PubMed, CNKI, SciFinder, Scopus, Web of Science, and Google Scholar.</div></div><div><h3>Results</h3><div>This review highlights the relationship between macrophage polarization and the progression of atherosclerotic disease and discusses the limitations and future prospects of the current clinical applications of TCM and natural products, as well as the potential for therapeutic strategies targeting macrophages.</div></div><div><h3>Conclusion</h3><div>A range of natural products, such as ginsenosides, alkaloids, polysaccharides, terpenoids, flavones and quinones, have been shown to affect the treatment of atherosclerosis by modulating macrophage polarization. This study meticulously summarizes their effective dosages both <em>in vitro</em> and <em>in vivo</em>, with the intention of providing valuable insights for further drug development.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100461"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the anticancer potential of milk thistle in hepatocellular carcinoma: A network pharmacology perspective","authors":"Tushar Mishra,&nbsp;Ravinder K. Kaundal","doi":"10.1016/j.phanu.2025.100458","DOIUrl":"10.1016/j.phanu.2025.100458","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, characterized by limited therapeutic options and poor prognosis. The multifaceted nature of HCC pathogenesis, encompassing oxidative stress, immune dysregulation, angiogenesis, and metabolic reprogramming, underscores the need for multi-targeted treatment strategies. In this study, we employed an integrative network pharmacology approach to elucidate the molecular mechanisms through which Silybum marianum (Milk Thistle) constituents, particularly silymarin, exert anti-HCC effects. A total of 208 overlapping targets between Milk Thistle phytoconstituents and HCC-related genes were identified, with silymarin emerging as the most connected compound. Topological and co-expression analyses revealed 20 hub genes, including TP53, STAT3, MYC, AKT1, ESR1, and BCL2, which regulate apoptosis, proliferation, angiogenesis, and metabolism. Functional classification of these targets showed silymarin's potential to restore apoptosis via BCL2 and Caspase-3 interaction, inhibit hypoxia-induced angiogenesis through HIF-1α disruption, suppress cell cycle progression via CCND1, and impair glycolytic metabolism by targeting AKT1. Molecular docking confirmed strong interactions of silymarin with key oncogenic proteins, suggesting plausible in vivo target engagement. GO and KEGG enrichment analyses highlighted involvement in apoptosis, cytokine signaling, oxidative stress, and immune regulation. Nonetheless, this study provides a systems-level perspective of silymarin’s polypharmacological potential, positioning it as a promising multi-targeted candidate for HCC therapy, especially in overcoming resistance associated with monotherapies.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"34 ","pages":"Article 100458"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The regulation of gut microbiota and urate lowering: A study on the mechanisms of action of probiotics and plant components","authors":"Zhihua Xing ,&nbsp;Yue Xu ,&nbsp;Wen Jiang ,&nbsp;Mingyu Gao ,&nbsp;Guanghuan Shen ,&nbsp;Yingjie Liu ,&nbsp;Na Ling ,&nbsp;Linlin Cui","doi":"10.1016/j.phanu.2025.100450","DOIUrl":"10.1016/j.phanu.2025.100450","url":null,"abstract":"<div><div>The gut microbiota system serves as a \"barometer\" of human health, with significant differences observed in the intestinal microbiome between individuals with hyperuricemia (HUA) and gout compared to those in the general population. This article comprehensively reviews the correlation between gut microbiota and HUA and uric acid-lowering substances that regulate the gut microbiota. It elucidates the mechanisms underlying the occurrence and progression of HUA associated with the gut microbiota. It summarizes the effects and mechanisms through which probiotics, plant polysaccharides, and plant small molecular compounds reduce serum uric acid by modulating the gut microbiota. It is hoped that this review will provide a theoretical basis for the development of strategies for uric acid-lowering drugs targeting the gut microbiota, serving as a reference for subsequent in-depth research.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"33 ","pages":"Article 100450"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hesperetin as a potential therapeutic agent for colorectal cancer: Targeting PI3K/AKT and EMT in cell lines through network pharmacology-guided strategies","authors":"Junyi Xue ,&nbsp;Jianmin Liao ,&nbsp;Haixing Ju ,&nbsp;Yuanyuan Lu","doi":"10.1016/j.phanu.2025.100447","DOIUrl":"10.1016/j.phanu.2025.100447","url":null,"abstract":"<div><div>Hesperetin is a naturally occurring flavonoid compound abundantly present in citrus fruit peels and Traditional Chinese Medicinal (TCM). It exhibits diverse pharmacological properties and represents a promising multi-target candidate for anticancer therapy. This study systematically investigated the molecular mechanisms underlying the anti-colorectal cancer (CRC) effects of hesperetin by integrating network pharmacology, molecular docking, and experimental validation. Network pharmacology analysis identified 42 core targets of hesperetin in CRC, with molecular docking confirming strong binding affinities (binding energy &lt; −7 kcal/mol) between hesperetin and key proteins, including Epidermal Growth Factor Receptor (EGFR), Threonine Kinase 1 (AKT1), Proto-oncogene Tyrosine-protein Kinase Src (SRC), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA), and Matrix Metalloproteinase-9 (MMP9). In vitro experiments demonstrated that hesperetin dose-dependently inhibited the proliferation, migration, and invasion of HCT116 and Lovo cells. Mechanistically, hesperetin reversed epithelial-mesenchymal transition (EMT) by upregulating E-cadherin and downregulating N-cadherin, Vimentin, and Snail at both protein and mRNA levels. Western blot analysis revealed that hesperetin suppressed PI3K/AKT pathway activation by reducing phosphorylation of PI3K (Tyr458) and AKT (Ser473). Clinical data further validated the therapeutic relevance of these targets, showing that high expression of EGFR, AKT1, PIK3CA, and MMP9 correlated with poor prognosis in CRC patients. Collectively, these findings establish hesperetin as a promising multi-target nutritional supplement agent against CRC, demonstrating dual modulation of both PI3K/AKT signaling and EMT progression.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"33 ","pages":"Article 100447"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids and macrophage polarization: Key players in the immunomodulation of cardiometabolic syndrome and related therapies","authors":"Parisa Ahmadi ,&nbsp;Soroush Taherkhani ,&nbsp;Maryam Honardoost ,&nbsp;Atousa Janzadeh","doi":"10.1016/j.phanu.2025.100449","DOIUrl":"10.1016/j.phanu.2025.100449","url":null,"abstract":"<div><div>Cardiometabolic syndrome (CMS) is a major public health challenge characterized by obesity, insulin resistance, hypertension, and chronic inflammation, which increase the risk of type 2 diabetes (T2D) and cardiovascular disease. In this context, inflammatory M1 macrophages are pivotal, as they produce proinflammatory cytokines and contribute to oxidative stress, insulin resistance, and lipid accumulation in adipose tissue. Polyphenols with anti-inflammatory, antioxidant, and antiobesity properties alleviate CMS by promoting M2 macrophage differentiation and reprogramming M1 macrophages toward the M2 phenotype. Flavonoids inhibit inflammatory pathways such as NF-kB and activator protein-1 (AP-1); reduce the expression of proinflammatory markers such as TLR4, NOD-like receptor family pyrin domain-containing 3 (NLRP-3), and inducible nitric oxide synthase (iNOS); and enhance anti-inflammatory responses, including IL-10, Nrf-1, and peroxisome proliferator-activated receptor (PPAR) expression. They prevent foam cell formation by decreasing LPX-1, CD36, scavenger receptor-A, B1, and LOX-1 expression while increasing ABCA1 and ABCG1 levels. Flavonoids are antiobesity agents that decrease the infiltration of macrophages in adipose tissue and suppress the M1 phenotype in adipose tissue macrophages, lowering inflammation and leading to the suppression of lipogenesis and stimulation of lipolysis in adipocytes. This review highlights the importance of macrophage activation in metabolic imbalance and the potential of flavonoids in treating CMS through the induction of M2 macrophages.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"33 ","pages":"Article 100449"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective potential of saffron metabolites in Parkinson's disease","authors":"Mohamed Ben El Caid ,&nbsp;Mohamed Ait Haddou ,&nbsp;Ouahid El Asri ,&nbsp;Laila Aboudlou ,&nbsp;Lalla Hadda Atyane ,&nbsp;Vikas Ramteke ,&nbsp;Rachid Ait Hammou","doi":"10.1016/j.phanu.2025.100448","DOIUrl":"10.1016/j.phanu.2025.100448","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons. Although current pharmaceutical treatments mitigate symptoms, these frequently induce adverse effects and may not prevent disease progression, highlighting the need for safer neuroprotective alternatives. Natural products like saffron (<em>Crocus sativus</em> L.) have emerged as promising candidates due to their pharmacological and nutritional properties. While prior studies have investigated saffron and its extracts in the context of PD, no review has comprehensively analyzed the specific roles of its major secondary metabolites. Saffron’s bioactive compounds, particularly crocetin, crocins, and safranal, have demonstrated significant therapeutic potential across <em>in vitro</em>, <em>in vivo</em>, and clinical studies. Crocetin has been shown to inhibit α-synuclein aggregation and preserve mitochondrial integrity. Crocins exhibit neuroprotective effects, including inhibition of amyloid fibril formation, protection of dopaminergic neurons, and enhancement of synaptic plasticity through pathways such as PI3K/Akt/mTOR. Notably, picrocrocin remains unstudied mainly, representing a significant research gap. Safranal has shown efficacy in preclinical PD models, with promising effects on dopaminergic neuron preservation, motor function improvement, and apoptosis regulation. However, clinical trials are warranted to validate its therapeutic potential further. This review highlights existing findings, critically examines the literature, and identifies underexplored mechanisms, including neurotrophic and mitochondrial pathways, as promising targets for future research, ultimately paving the way for innovative therapeutic strategies in PD management.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"33 ","pages":"Article 100448"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional food prevents diabetic nephropathy in a rat model through inhibition of aldose reductase and accumulation of advanced glycation end-products","authors":"Krishna Kalyan Kalahasti,&nbsp;Marka Nagaraju,&nbsp;Sneha Jakhotia,&nbsp;S.Sreenivasa Reddy,&nbsp;G.Bhanuprakash Reddy","doi":"10.1016/j.phanu.2025.100446","DOIUrl":"10.1016/j.phanu.2025.100446","url":null,"abstract":"<div><div>Diabetic nephropathy (DN) is a chronic microvascular complication of diabetes mellitus, characterized by glomerulomegaly, podocytopathy, and proteinuria. Among the many molecular mechanisms, accumulation of advanced glycation end-products (AGEs) due to non-enzymatic glycation and sorbitol accumulation due to increased aldose reductase (AR) activity are implicated in DN. We previously identified some functional foods and their bioactive molecules for inhibitory potential against AGE formation and, AR activity. Based on those studies, in this study, we formulated a functional food (FF) mix- composed of amla, turmeric, cinnamon, ginger, and black pepper in a specific proportion and tested its efficacy against DN in a rat model. Two-month-old Sprague Dawley rats were grouped into control (C), streptozotocin-induced diabetes (D), and diabetes treated with FF at two doses (FF1–0.85 g and FF2–4.25 g/ 100 g diet). The animals were maintained for 20 weeks on respective diets after the induction of diabetes. Elevated serum albumin, creatinine, and urea were observed in the untreated diabetic group compared to the control. These changes were significantly ameliorated by FF supplementation. FF2 showed better efficacy than FF1 in preventing proteinuria, as reflected in the albumin and creatinine ratio. Further, FF prevented diabetes induced AGE accumulation, inflammation, and activation of the polyol pathway in the kidney. The FF decreased the expression of TGF-β in the diabetic kidney and prevented fibrotic changes. Most importantly, FF prevented the depletion of podocyte slit diaphragm proteins and histological changes. These results provide a mechanistic basis of FF and its potential against progression of DN in a rat model.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"33 ","pages":"Article 100446"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced therapeutic efficacy of nanocurcumin over free curcumin in the management of diabetes mellitus","authors":"Pratibha Chauhan ,&nbsp;GBKS Prasad","doi":"10.1016/j.phanu.2025.100445","DOIUrl":"10.1016/j.phanu.2025.100445","url":null,"abstract":"<div><h3>Objectives</h3><div>Numerous scientific studies have revealed that curcumin is a pleiotropic molecule and influences multiple signaling pathways but is rapidly eliminated from the body due to its poor bioavailability. In the present study, nanocurcumin was synthesized and evaluated the therapeutic efficacy of nanocurcuminin comparison to those of free curcumin in human subjects with type II diabetes mellitus.</div></div><div><h3>Design</h3><div>Curcumin nanoparticles (NPs) have been synthesized then analyzed employing particle size analyzer and X-ray diffraction, while therapeutic efficacy of nanocurcumin has been assessed by evaluating blood glucose level (BGL), lipid profiles, as well as oxidative stress markers. This randomized trial included subjects (n = 60) with criteria of type II diabetes mellitus(T2DM). Subjects had been allocated randomly for receiving either curcumin or nanocurcumin capsules (1000 mg/day and 600 mg/day, accordingly) for 12 weeks. Nanocurcumin capsules' therapeutic function has been investigated by monitoring blood glucose, lipid profile, oxidative stress biomarkers, and glycosylated hemoglobin, along with DNA damage, prior to and after therapy.</div></div><div><h3>Results</h3><div>Particle size analysis indicated an average particle size of 78 nm of nanocurcumin. 'Nanocurcumin capsules' daily administration for 12 weeks drastically reduced BGLs. Compared to free curcumin, nanocurcumin exhibited a markedly enhanced antihyperglycemic effect. It could additionally preserve lipid homeostasis. Subject demonstrated improvements in enzymatic as well as non-enzymatic biochemical indicators of oxidative stress. When compared directly with free curcumin, nanocurcumin proved to be a more effective antioxidant, indicating enhanced bioavailability and efficacy in mitigating oxidative damage.</div></div><div><h3>Conclusion</h3><div>Current research results demonstrated ‘Nanocurcumin capsules’ anti-hyperglycemic, anti-hyperlipidemic and anti-oxidative potential in subjects with diabetes mellitus (DM). Nanocurcumin therapeutic potential had been prominent than curcumin.</div></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"33 ","pages":"Article 100445"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}