{"title":"N-乙酰半胱氨酸改善肝功能的疗效：对照临床试验的系统综述和荟萃分析","authors":"Mahlagha Nikbaf-Shandiz , Shaghayegh Adeli , Amir Hossein Faghfouri , Fateme Khademi , Parsa Jamilian , Meysam Zarezadeh , Mehrangiz Ebrahimi-Mamaghani","doi":"10.1016/j.phanu.2023.100343","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>N-acetylcysteine (NAC) could improve liver function through its antioxidant and anti-inflammatory activities. We conducted a systematic review<span> and meta-analysis of randomized clinical trials to examine whether NAC administration could lead to changes in liver function.</span></p></div><div><h3>Methods</h3><p>The search was done using appropriate keywords in PubMed-Medline, SCOPUS, Embase databases and Google Scholar up to July 2022. Random-effects model was employed to obtain the pooled estimate. Additional analyses including subgroup and sensitivity analyses were carried out.</p></div><div><h3>Results</h3><p><span><span>Eight eligible studies were identified. The results indicated no significant effect of NAC on aspartate aminotransferase (AST), alanine aminotransferase (ALT), </span>alkaline phosphatase (ALP), [(SMD= −0.03 pg/ml; 95% CI: −0.53, 0.47; P = 0.917, I</span><sup>2</sup> = 71.3%, P = 0.004), (SMD= −0.22 pg/ml; 95% CI: −0.63, 0.19; P = 0.288, I<sup>2</sup> = 56.9%, P = 0.040), (SMD= −0.22 pg/ml; 95% CI: −0.67, 0.23; P = 0.343, I<sup>2</sup><span> = 52.6%, P = 0.097), respectively], however, it significantly increased albumin (ALB) and decreased bilirubin levels [(SMD= 1.05 pg/ml; 95% CI: 0.41, 1.69; P < 0.001, I</span><sup>2</sup> = 87.3%, P < 0.001) and (SMD= −0.34 pg/ml; 95% CI: −0.53, −0.14; P < 0.001, I<sup>2</sup> = 0.0%, P = 0.447) respectively].</p></div><div><h3>Conclusion</h3><p>Although NAC might have favorable effect on ALB and bilirubin levels, larger trials assessing liver function as primary outcome are required.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The efficacy of N-acetylcysteine in improving liver function: A systematic review and meta-analysis of controlled clinical trials\",\"authors\":\"Mahlagha Nikbaf-Shandiz , Shaghayegh Adeli , Amir Hossein Faghfouri , Fateme Khademi , Parsa Jamilian , Meysam Zarezadeh , Mehrangiz Ebrahimi-Mamaghani\",\"doi\":\"10.1016/j.phanu.2023.100343\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>N-acetylcysteine (NAC) could improve liver function through its antioxidant and anti-inflammatory activities. We conducted a systematic review<span> and meta-analysis of randomized clinical trials to examine whether NAC administration could lead to changes in liver function.</span></p></div><div><h3>Methods</h3><p>The search was done using appropriate keywords in PubMed-Medline, SCOPUS, Embase databases and Google Scholar up to July 2022. Random-effects model was employed to obtain the pooled estimate. Additional analyses including subgroup and sensitivity analyses were carried out.</p></div><div><h3>Results</h3><p><span><span>Eight eligible studies were identified. The results indicated no significant effect of NAC on aspartate aminotransferase (AST), alanine aminotransferase (ALT), </span>alkaline phosphatase (ALP), [(SMD= −0.03 pg/ml; 95% CI: −0.53, 0.47; P = 0.917, I</span><sup>2</sup> = 71.3%, P = 0.004), (SMD= −0.22 pg/ml; 95% CI: −0.63, 0.19; P = 0.288, I<sup>2</sup> = 56.9%, P = 0.040), (SMD= −0.22 pg/ml; 95% CI: −0.67, 0.23; P = 0.343, I<sup>2</sup><span> = 52.6%, P = 0.097), respectively], however, it significantly increased albumin (ALB) and decreased bilirubin levels [(SMD= 1.05 pg/ml; 95% CI: 0.41, 1.69; P < 0.001, I</span><sup>2</sup> = 87.3%, P < 0.001) and (SMD= −0.34 pg/ml; 95% CI: −0.53, −0.14; P < 0.001, I<sup>2</sup> = 0.0%, P = 0.447) respectively].</p></div><div><h3>Conclusion</h3><p>Although NAC might have favorable effect on ALB and bilirubin levels, larger trials assessing liver function as primary outcome are required.</p></div>\",\"PeriodicalId\":20049,\"journal\":{\"name\":\"PharmaNutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PharmaNutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213434423000154\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213434423000154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
The efficacy of N-acetylcysteine in improving liver function: A systematic review and meta-analysis of controlled clinical trials
Background
N-acetylcysteine (NAC) could improve liver function through its antioxidant and anti-inflammatory activities. We conducted a systematic review and meta-analysis of randomized clinical trials to examine whether NAC administration could lead to changes in liver function.
Methods
The search was done using appropriate keywords in PubMed-Medline, SCOPUS, Embase databases and Google Scholar up to July 2022. Random-effects model was employed to obtain the pooled estimate. Additional analyses including subgroup and sensitivity analyses were carried out.
Results
Eight eligible studies were identified. The results indicated no significant effect of NAC on aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), [(SMD= −0.03 pg/ml; 95% CI: −0.53, 0.47; P = 0.917, I2 = 71.3%, P = 0.004), (SMD= −0.22 pg/ml; 95% CI: −0.63, 0.19; P = 0.288, I2 = 56.9%, P = 0.040), (SMD= −0.22 pg/ml; 95% CI: −0.67, 0.23; P = 0.343, I2 = 52.6%, P = 0.097), respectively], however, it significantly increased albumin (ALB) and decreased bilirubin levels [(SMD= 1.05 pg/ml; 95% CI: 0.41, 1.69; P < 0.001, I2 = 87.3%, P < 0.001) and (SMD= −0.34 pg/ml; 95% CI: −0.53, −0.14; P < 0.001, I2 = 0.0%, P = 0.447) respectively].
Conclusion
Although NAC might have favorable effect on ALB and bilirubin levels, larger trials assessing liver function as primary outcome are required.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
