Patient preference and adherence最新文献

{"title":"Exploring the Impact of Schizophrenia and Its Pharmacological Treatment on Health-Related Quality of Life and Treatment Preferences.","authors":"Celso Arango, Inmaculada Baeza, Clemente García-Rizo, Benedicto Crespo-Facorro, Guillermo Lahera, Eduard Vieta, Frauke Becker, Georges Dwyer, Siobhan Bourke, Adam E J Gibson, Irene Gabarda-Inat, Elena Alvarez-Baron","doi":"10.2147/PPA.S494721","DOIUrl":"10.2147/PPA.S494721","url":null,"abstract":"<p><strong>Purpose: </strong>Pharmacological treatments play an important role in managing symptoms of schizophrenia but can also be associated with side effects. The aim of this study was to understand the impact of schizophrenia and its pharmacological treatment on patients' health-related quality of life (HRQoL) and to explore patient preferences around treatment benefits and side effects.</p><p><strong>Patients and methods: </strong>This study employed a mixed methods approach with two stages of recruitment of adult patients in Spain. Stage 1 included qualitative and quantitative elements (including included two validated patient-reported outcome measures: PETiT and EQ-5D-5L) administered in telephone interviews with people with schizophrenia. Stage 2 consisted of a quantitative online survey completed by people with schizophrenia attending outpatient clinics. Responses to quantitative items across both stages were combined for analysis.</p><p><strong>Results: </strong>Twenty respondents completed the mixed methods interviews (stage 1), and 25 participants completed the online survey (stage 2). Results from stages 1 and 2, showed that participants perceived treatments to have a beneficial impact on controlling their symptoms. However, cognitive side effects were reported to have a detrimental impact on respondents' daily life and were considered a primary reason for treatment cessation in the past. Qualitative findings further showed that most participants hoped future treatments would minimise the impact of cognitive symptoms of schizophrenia.</p><p><strong>Conclusion: </strong>The findings suggest that patients' expectation around treatment efficacy and their acceptability of treatment side effects may indicate their capacity to maintain long-term treatment adherence. Trade-offs that patients may be willing to make between these components may prove useful to consider in clinical practice to improve treatment adherence and hence treatment effectiveness in people with schizophrenia.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2647-2661"},"PeriodicalIF":2.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profile Analysis for Patient Activation in Patients with Essential Hypertension.","authors":"Qingqing Wang, Xiao Xin, Xianhua Li","doi":"10.2147/PPA.S524968","DOIUrl":"10.2147/PPA.S524968","url":null,"abstract":"<p><strong>Purpose: </strong>Hypertension constitutes a significant global health issue, requiring active patient participation in self-management and health-related behaviors. Patient activation is defined as the knowledge, skills, and confidence in the management of their health. Prior studies have primarily employed total-score methods, potentially overlooking the variability in patient engagement. This study employs Latent Profile Analysis (LPA) to identify distinct patient activation profiles and investigate key predictors influencing activation levels in individuals with hypertension.</p><p><strong>Patients and methods: </strong>A convenience sampling method was employed to select 301 patients with essential hypertension from an outpatient clinic in a tertiary care hospital located in Shanghai for a cross-sectional study. A general demographic questionnaire, the Patient Activation Measure (PAM), the General Self-Efficacy Scale (GSES), the Health Literacy Scale for patients with chronic diseases (HLSCP), and the Hypertension Adherence Scale (TASHP) were utilized. Latent profile analysis was employed to investigate the latent profiles of patient activation, while univariate analysis and binomial logistic regression were used to identify significant predictors of patient activation types, based on factors found significant in univariate analysis.</p><p><strong>Results: </strong>The research revealed two distinct latent profiles of patient activation in individuals with essential hypertension: High Cognition-Proactive Action Type (33.9%) and Passive Cognition-Low Skills Type (66.1%). The logistic regression analysis indicated that monthly income (<i>OR</i>=1.725, <i>p</i><0.05), self-efficacy (<i>OR</i>=1.162, <i>p</i><0.01), and health literacy (<i>OR</i>=1.027, <i>p</i><0.05) are significant predictors of patient activation.</p><p><strong>Conclusion: </strong>Patients with essential hypertension exhibit diverse activation levels, with a majority (66.1%) demonstrating low skills and passive cognition, indicating the need for targeted interventions. Increased income, health literacy and self-efficacy facilitate activation. Interventions must improve self-efficacy and refine health education to enhance patient engagement and self-management.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2635-2645"},"PeriodicalIF":2.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Related Factors of Chinese Herbal Medicine Use in Middle-Aged and Older Patients with Cardiovascular Disease in China: A Cross-Sectional Study.","authors":"Long Chen, Yu-Li Huang, Fang Liu, Nan Huang, Ding-Cheng Zeng, Yan-Biao Zhong, Jing-Hai Liao, Mao-Yuan Wang","doi":"10.2147/PPA.S538773","DOIUrl":"10.2147/PPA.S538773","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) poses a significant health burden in middle-aged and older Chinese populations, with Chinese herbal medicine (CHM) often used as a complementary therapy. This study aimed to analyze the characteristics of CHM use and its influencing factors in middle-aged and older Chinese patients with CVD.</p><p><strong>Methods: </strong>This was a cross-sectional study based on data from the 2018 China Health and Aging Longitudinal Study (CHARLS). We surveyed 4511 patients with CVD, aged 45 years or older, who reported using CHM to analyze their demographic characteristics, healthcare utilization, and health status.</p><p><strong>Results: </strong>Approximately 24.05% (1085/4511) of the participants reported managing CVD with CHM. Compared with non-users, CHM users were older (OR=1.21; 95% CI=1.04-1.40), more educated (OR=1.30; 95% CI=1.08-1.57), more likely to reside in a city (OR=1.19; 95% CI=1.01-1.41), and were associated with visiting a Chinese medicine hospital (OR=1.17; 95% CI=1.01-1.37), self-medication (OR=1.48; 95% CI=1.24-1.77), poor health (OR=1.52; 95% CI=1.17-1.98), comorbidities such as kidney disease (OR=1.34; 95% CI=1.02-1.75), asthma (OR=1.67; 95% CI=1.21-2.32), and emotional problems (OR=1.98; 95% CI=1.28-3.07). In an additional interaction analysis, patients with urban residence and mood problems were most likely to use CHM (OR=6.93, 95% CI: 1.77-27.19).</p><p><strong>Conclusion: </strong>Factors contributing to CHM use in middle-aged and older patients with CVD are multifaceted, encompassing demographic characteristics, health service, and health status.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2623-2633"},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Decision-Making Experience of Patients with Lumbar Disc Herniation: A Qualitative Study.","authors":"Mingyang Qian, Wei Jiang, Qingsong Zou, Wenlin Cheng, Mengyi Xu, Li Hua, Jiangming Yu","doi":"10.2147/PPA.S539717","DOIUrl":"10.2147/PPA.S539717","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the experiences and pivotal influencing factors of patients with Lumbar disc herniation (LDH) during the surgical decision-making phase to provide a basis for optimizing the shared decision-making between medical professionals and patients and for the implementation of personalized nursing care.</p><p><strong>Patients and methods: </strong>This phenomenological study employed face-to-face semi-structured interviews, conducted between January and February 2025. Purposive sampling method was used to select 20 patients with lumbar disc herniation from the orthopedic ward of a tertiary hospital. The interview data were analyzed by Colaizzi's seven-step phenomenological analysis method.</p><p><strong>Results: </strong>The findings of this study revealed that the surgical decision-making experiences of patients with LDH can be delineated into four themes: (1) Motivations underlying the surgical Decision; (2) Decision-making dilemmas arising from insufficient patient information; (3) The multi-dimensional factors influencing decision-making, and (4) Patients express unmet peri-operative needs.</p><p><strong>Conclusion: </strong>This study reveals that surgical decision-making in patients with lumbar disc herniation is a complex process involving the interaction of biological, psychological, and social factors. It is essential to establish a patient-centered decision-support system, integrating structured information tools, psychological interventions, and hierarchical educational strategies. Future research endeavors should concentrate on the potential value of digital health technologies in enhancing the decision-making experience and seek to augment the effectiveness of decision-making aids through cultural adaptation.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2609-2621"},"PeriodicalIF":2.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking Changes in Oral Health-Related Quality of Life Before, During, and After Radiotherapy in Tongue Squamous Cell Carcinoma: A Case Series.","authors":"Irna Sufiawati, Novi Indriyani, Imme Kris Wicaksono, Emailsa Denta","doi":"10.2147/PPA.S539093","DOIUrl":"10.2147/PPA.S539093","url":null,"abstract":"<p><strong>Background: </strong>Tongue squamous cell carcinoma (TSCC) is the most common type of oral cancer. Effective and patient-centered management is essential to reduce mortality, improve survival, and enhance oral health-related quality of life (OHRQoL).</p><p><strong>Purpose: </strong>To assess OHRQoL and pain levels in TSCC patients across radiotherapy phases and the impact of supportive care on treatment adherence and patient well-being.</p><p><strong>Case report: </strong>Four patients presented with painful, non-healing tongue ulcers of 4-8 months' duration and were referred to the Oral Medicine Clinic. All were diagnosed with TSCC and underwent radiotherapy. OHRQoL and pain levels were assessed using the oral health impact profile-14 (OHIP-14) and visual analogue scale (VAS), before, during, after radiotherapy. Common intraoral side effects included oral candidiasis, mucositis, and xerostomia, all of which impacted patients' comfort and adherence to ongoing treatment.</p><p><strong>Case management: </strong>Management of radiotherapy-induced side effects included nystatin oral suspension, 0.025% hyaluronic acid mouthwash, diphenhydramine HCl, and artificial saliva gel. Individualized care plans were developed based on patient feedback and treatment tolerance. All patients demonstrated clinical improvement in oral lesions within 1-7 weeks. OHIP-14 and VAS scores improved before treatment (OHIP-14: 30-44; VAS: 9), during treatment (OHIP-14: 27-36; VAS: 8), and one month afterward (OHIP-14: 10-15; VAS: 1-5).</p><p><strong>Conclusion: </strong>The integration of proactive and personalized supportive oral care during radiotherapy can significantly improve OHRQoL and reduce pain levels, facilitating better treatment adherence and patient satisfaction. These findings support the importance of multidisciplinary collaboration and proactive symptom management in TSCC care.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2525-2534"},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Experience of Fear of Complications Among Patients with Type 2 Diabetes Mellitus: A Qualitative Study.","authors":"Yuping Xiao, Zihao Song, Ziyi Wei, Nina Xie, Zhenzhen Wang","doi":"10.2147/PPA.S536379","DOIUrl":"10.2147/PPA.S536379","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes (T2DM) is a globally concerning chronic disease. Fear of complications (FoC) refers to a unique diabetes-related emotion among diabetic patients, arising from worries that complications may cause physical harm, which can affect blood glucose control. Therefore, it is crucial to comprehensively understand the factors influencing FoC and implement effective intervention plans.</p><p><strong>Purpose: </strong>To understand the real experiences of patients with T2DM when facing the FoC, so as to provide a reference for implementing targeted nursing intervention measures to alleviate the patients' psychological FoC.</p><p><strong>Methods: </strong>Using the purposive sampling method, 16 patients with T2DM were selected as the research subjects from the Department of Endocrinology of a Class III Grade A hospital in Shaanxi Province from March to April 2025. A phenomenological research method was adopted to conduct semi-structured interviews with them. The Colaizzi's seven-step analysis method was used to analyze the data and extract themes.</p><p><strong>Results: </strong>A total of 3 themes and 9 sub-themes were extracted, including disease uncertainty (uncertainty in symptoms, uncertainty in management, uncertainty caused by medical staff sources, uncertainty caused by personal sources), social support (peer support, medical support, family support), and coping styles (acceptance and facing, evasion and submission).</p><p><strong>Conclusion: </strong>The experience of FoC among patients with T2DM is complex and diverse. Medical staff should attach great importance to providing psychological counseling for these patients, eliminating their sense of uncertainty about the disease, offering professional guidance, and assisting in achieving multi-faceted support. This can help alleviate their experience of FoC and thus promote their physical and mental health.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2553-2563"},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"User Experience and Acceptability of a Digital Educational Game for Self-Management Health Education Among People Living with HIV.","authors":"Min Tian, Longsheng Xie, Wei Wei, Yanhua Chen, Jian Tang","doi":"10.2147/PPA.S538527","DOIUrl":"10.2147/PPA.S538527","url":null,"abstract":"<p><strong>Background: </strong>The self-management of people living with HIV plays a pivotal role in enhancing their health quality of life. However, the self-management practices within this population are suboptimal. Therefore, it is imperative to reinforce HIV self-management education interventions to improve self-management ability among people living with HIV. The advent of digital educational games presents an unparalleled opportunity for innovative educational methods.</p><p><strong>Objective: </strong>This study aimed to evaluate the user experience and acceptability of a digital educational game as a novel health education intervention to support self-management for people living with HIV.</p><p><strong>Methods: </strong>A mixed-method study with explanatory sequential design was conducted to evaluate the user experience and acceptability of a digital educational game for self-management health education among people living with HIV. Fifty people living with HIV participated in this study and completed a questionnaire to investigate their user experience after playing the game. Nine participants were interviewed face-to-face to evaluate the acceptability of the game. Categorical data are presented as percentages. Qualitative data were analyzed via thematic analysis.</p><p><strong>Results: </strong>The overall user evaluation of the \"Cute Pet Butler\" by the 50 participants (28 males and 22females with an average age of 33.64 years) was excellent or good at 90.91%, medium at 8.64%, and poor at 0.45%. The interviewees included 5 males and 4 females, with ages ranging from 23--51 years. After analyzing the interview data, the acceptability evaluation of the \"Cute Pet Butler\" with five themes were extracted, that are: perceived usefulness, perceived ease of use, positive user attitudes, the intention of game playing, and modification suggestions.</p><p><strong>Conclusion: </strong>Cute Pet Butler had a good user experience and acceptance among people living with HIV. These results support further evaluation of its effectiveness as a new method to improve self-management health education interventions for people living with HIV.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2593-2608"},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing the Choice Between Surgical Intervention and Physiotherapy for Individuals Experiencing Lumbar Spine Issues: A Qualitative Study in Iran.","authors":"Bahram Amirshakeri, Leila Doshmangir, Hamideh Keyvani","doi":"10.2147/PPA.S542535","DOIUrl":"10.2147/PPA.S542535","url":null,"abstract":"<p><strong>Background: </strong>Lumbar spine disorders are a prevalent global health issue, with surgery and physiotherapy being the most common treatment options. Although many studies have explored the clinical outcomes of these treatments, little is known about the decision-making process from the perspective of both patients and healthcare providers in Iran. This process is shaped by a range of medical, social, psychological, and systemic factors. Accurately identifying these determinants and understanding their influence is essential for guiding patients toward informed and effective treatment decisions.</p><p><strong>Objective: </strong>The aim of this study was to explore the factors affecting the decision to choose between surgery and physiotherapy as treatment options by Iranian patients with lumbar spine disorders using the views of the patients, health care providers and decision-makers.</p><p><strong>Methods: </strong>The study utilized semi-structured interviews to collect data from 27 stakeholders, comprising 12 patients, 9 healthcare professionals (surgeons and physiotherapists), and 6 policymakers/administrators from Tehran, East Azarbaijan, and Yazd provinces. Participants were selected through purposeful sampling with maximum variation to ensure diverse representation across age, gender, condition type, and treatment preference. Data were analyzed using thematic analysis, with research rigor maintained through member checking, peer review, and inter-coder reliability assessments.</p><p><strong>Results: </strong>Four themes were identified; service provider factors (eg provider knowledge/expertise, provider preference), service recipient factors (eg trust, financial worries), health system/insurance-related issues (eg cost coverage, treatment facility distance), and societal/family influences (eg media depictions, traditional beliefs). For example, the decision for surgery of some patients was due to other health professionals promoting quicker results, whereas some opposed surgical advice because of past experiences.</p><p><strong>Conclusion: </strong>The decision to use surgery or physiotherapy for lumbar spine problems in Iran is multivariate. Interventions to facilitate shared decision-making and patient education can improve concordance between clinical recommendations and patient preferences. There is a need for culturally sensitive decision aids and policy changes.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2577-2591"},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Adherence to Semaglutide Once-Weekly Injection Among Type-2 Diabetes Patients in Tabuk, Saudi Arabia - A Cross-Sectional Study.","authors":"Palanisamy Amirthalingam, Olayan Salamah Alatawi, Ahmed Mohsen Elsaid Hamdan, Ahmed Aljabri, Saleh Alqifari, Hanan Alshareef, Faris Ahmed M Hakami, Nader Salem Albalawi, Hazem Moufeed A Albrahimi, Sultan Mohammed Mubark Alanazi, Ahmed Mutair Alatawi, Abdullah Abdalziz S Albalwi, Mostafa A Sayed Ali","doi":"10.2147/PPA.S534534","DOIUrl":"10.2147/PPA.S534534","url":null,"abstract":"<p><strong>Background: </strong>Semaglutide, a once-weekly injection (SOWI), is a glucagon-like peptide-1 receptor agonist for managing type-2 diabetes (T2D). However, it has a high discontinuation rate among users in the first year after treatment initiation. This study investigated the medication adherence level among T2D patients managed with SOWI.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among T2D patients aged 18 years or above who visited the outpatient pharmacy to refill their prescriptions for SOWI. The patients responded to their sociodemographic characteristics and the Adherence to Refills and Medications Scale (ARMS). The patient's electronic health record obtained details of the proportion of days covered (PDC), glycosylated hemoglobin (HbA1C), and body mass index (BMI). The association of medication adherence and sociodemographic characteristics, as well as the clinical outcomes between patients with different levels of adherence, were analyzed.</p><p><strong>Results: </strong>A total of 434 patients were included in this study. According to the ARMS score, only 32.48% (141) of the patients adhered to SOWI. Sociodemographic characteristics had lower odds association for medication non-adherence. However, non-adherent patients had a significant association with BMI (overweight and obese) and HbA1C (>7). The adherence level of PDC for SOWI was significantly associated with the ARMS medication adherence level. The mean HbA1C and BMI between adherents and non-adherents were statistically significant (p<0.001). The patients who adhered to both ARMS and PDC (n = 126) experienced a significant decline in mean BMI (p < 0.001) and HbA1C (p < 0.001) compared to patients who adhered to PDC but not ARMS and those who did not adhere to either ARMS or PDC.</p><p><strong>Conclusion: </strong>Medication adherence to the SOWI is subjective to T2D patients and not influenced by sociodemographic characteristics. T2D patients need more motivation to refill and administer the SOWI according to the schedule since medication adherence directly impacts HbA1C and BMI.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2535-2551"},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Factors Related to Medication Adherence in Patients with Rheumatoid Arthritis Based on Social Cognitive Theory: A Path Analysis.","authors":"Liqing Liang, Xiaomin Zhang, Yinghua Pan, Lei Huang, Lei Jia, Peijun Xu, Kun Li","doi":"10.2147/PPA.S529952","DOIUrl":"10.2147/PPA.S529952","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that poor medication adherence is common in patients with rheumatoid arthritis (RA). However, the related factors and underlying mechanisms remain unclear. Through theory-based research, the mechanism of medication adherence in RA patients can be better explored and clarified, providing reference for clinical intervention.</p><p><strong>Aim: </strong>To explore the mediating role of medication self-efficacy between perceived barriers, pharmacologic treatment expectations, social support and medication adherence in patients with RA based on the social cognitive theory.</p><p><strong>Methods: </strong>A total of 232 participants diagnosed with RA were recruited from three general hospitals in Guangzhou, China. Participants' sociodemographic, disease-, and medication-related information as well as data on their perceived barriers, pharmacologic treatment expectations, social support, medication self-efficacy, and adherence were collected. SPSS 25.0 software was used for univariate analysis of medication adherence and to explore the correlation between variables. Mplus 8.0 was used to build a parallel mediation model and perform path analysis.</p><p><strong>Results: </strong>In addition to pharmacologic treatment expectations, perceived barriers, family support, and medication self-efficacy were associated with medication adherence. A mediating model with three independent variables showed that medication self-efficacy fully mediated the negative impact of perceived barriers on medication adherence. Family support had a positive effect on both medication adherence and self-efficacy, but it did not affect medication adherence through medication self-efficacy.</p><p><strong>Conclusion: </strong>Medication self-efficacy, as a mediating factor, plays a key role in improving medication adherence of RA patients. In nursing practice, timely assessment of the actual or potential barriers on medication adherence of patients and implementation of targeted intervention measures such as health education, as well as giving full play to the positive role of the family support system to improve patients' medication self-efficacy, will effectively enhance the medication adherence of patients with RA.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2565-2575"},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}