Medication Adherence to Semaglutide Once-Weekly Injection Among Type-2 Diabetes Patients in Tabuk, Saudi Arabia - A Cross-Sectional Study.

IF 2 3区医学 Q2 MEDICINE, GENERAL & INTERNAL

Patient preference and adherence Pub Date : 2025-08-20 eCollection Date: 2025-01-01 DOI:10.2147/PPA.S534534

Palanisamy Amirthalingam, Olayan Salamah Alatawi, Ahmed Mohsen Elsaid Hamdan, Ahmed Aljabri, Saleh Alqifari, Hanan Alshareef, Faris Ahmed M Hakami, Nader Salem Albalawi, Hazem Moufeed A Albrahimi, Sultan Mohammed Mubark Alanazi, Ahmed Mutair Alatawi, Abdullah Abdalziz S Albalwi, Mostafa A Sayed Ali

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引用次数: 0

Abstract

Background: Semaglutide, a once-weekly injection (SOWI), is a glucagon-like peptide-1 receptor agonist for managing type-2 diabetes (T2D). However, it has a high discontinuation rate among users in the first year after treatment initiation. This study investigated the medication adherence level among T2D patients managed with SOWI.

Methods: This cross-sectional study was conducted among T2D patients aged 18 years or above who visited the outpatient pharmacy to refill their prescriptions for SOWI. The patients responded to their sociodemographic characteristics and the Adherence to Refills and Medications Scale (ARMS). The patient's electronic health record obtained details of the proportion of days covered (PDC), glycosylated hemoglobin (HbA1C), and body mass index (BMI). The association of medication adherence and sociodemographic characteristics, as well as the clinical outcomes between patients with different levels of adherence, were analyzed.

Results: A total of 434 patients were included in this study. According to the ARMS score, only 32.48% (141) of the patients adhered to SOWI. Sociodemographic characteristics had lower odds association for medication non-adherence. However, non-adherent patients had a significant association with BMI (overweight and obese) and HbA1C (>7). The adherence level of PDC for SOWI was significantly associated with the ARMS medication adherence level. The mean HbA1C and BMI between adherents and non-adherents were statistically significant (p<0.001). The patients who adhered to both ARMS and PDC (n = 126) experienced a significant decline in mean BMI (p < 0.001) and HbA1C (p < 0.001) compared to patients who adhered to PDC but not ARMS and those who did not adhere to either ARMS or PDC.

Conclusion: Medication adherence to the SOWI is subjective to T2D patients and not influenced by sociodemographic characteristics. T2D patients need more motivation to refill and administer the SOWI according to the schedule since medication adherence directly impacts HbA1C and BMI.

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沙特阿拉伯Tabuk地区2型糖尿病患者每周注射一次西马鲁肽的依从性-一项横断面研究

背景：Semaglutide，每周一次注射（SOWI），是一种治疗2型糖尿病（T2D）的胰高血糖素样肽-1受体激动剂。然而，在开始治疗后的第一年，它在使用者中有很高的停药率。本研究调查了SOWI治疗的T2D患者的药物依从性水平。方法：横断面研究对象为18岁及以上到门诊药房补药的t2dm患者。患者对他们的社会人口学特征和对补药和药物的依从性量表（ARMS）有反应。患者的电子健康记录获得了覆盖天数比例（PDC）、糖化血红蛋白（HbA1C）和体重指数（BMI）的详细信息。分析药物依从性与社会人口学特征的关系，以及不同程度依从性患者的临床结果。结果：本研究共纳入434例患者。根据ARMS评分，只有32.48%（141例）的患者坚持了SOWI。社会人口学特征与药物依从性的相关性较低。然而，非依从性患者与BMI（超重和肥胖）和HbA1C （bb0.7）有显著相关性。SOWI患者的PDC依从性水平与ARMS药物依从性水平显著相关。坚持治疗组和非坚持治疗组的平均HbA1C和BMI差异有统计学意义(p)。结论：t2dm患者对SOWI的药物依从性是主观的，不受社会人口学特征的影响。由于服药依从性直接影响HbA1C和BMI， t2dm患者需要更多的动力来根据计划补充和管理SOWI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Patient preference and adherence MEDICINE, GENERAL & INTERNAL-

CiteScore

3.60

自引率

4.50%

发文量

354

审稿时长

6-12 weeks

期刊介绍： Patient Preference and Adherence is an international, peer reviewed, open access journal that focuses on the growing importance of patient preference and adherence throughout the therapeutic continuum. The journal is characterized by the rapid reporting of reviews, original research, modeling and clinical studies across all therapeutic areas. Patient satisfaction, acceptability, quality of life, compliance, persistence and their role in developing new therapeutic modalities and compounds to optimize clinical outcomes for existing disease states are major areas of interest for the journal. As of 1st April 2019, Patient Preference and Adherence will no longer consider meta-analyses for publication.