Patient preference and adherence最新文献

{"title":"Retrospective Patient Perspectives on Symptom Burden, Emotional Experiences, and Unmet Needs in Nasopharyngeal Carcinoma: A Qualitative Study.","authors":"Weiwei Zuo, Yuanyuan Wang, Li Wang, Chongjie Guo, Yanrong Lei, Zhang Lei, Yonghong Han","doi":"10.2147/PPA.S637783","DOIUrl":"10.2147/PPA.S637783","url":null,"abstract":"<p><strong>Objective: </strong>To explore how adults with nasopharyngeal carcinoma (NPC) retrospectively described physical symptoms, emotional experiences, and unmet supportive care needs across diagnosis, active treatment, and home recovery in a Chinese tertiary-care setting.</p><p><strong>Methods: </strong>This retrospective, cross-sectional qualitative descriptive study followed the Consolidated Criteria for Reporting Qualitative Research. A purposive sample of 13 patients with pathologically confirmed NPC (7 men and 6 women; aged 28-64 years) was recruited from a tertiary hospital in central China between April and May 2026. Each participant completed one semi-structured, face-to-face interview lasting 30-45 minutes and recalled experiences across diagnosis, active treatment, and home recovery. Recruitment continued until three consecutive interviews yielded no new codes, subthemes, or contextual information. Data were analyzed using Colaizzi's seven-step procedure with NVivo 15.0. The themes were organized in a Patient Journey Map informed by Corbin and Strauss's Chronic Illness Trajectory Framework.</p><p><strong>Results: </strong>Three themes and nine subthemes described distinct phase-specific experiences. At diagnosis, participants reported misattribution of early symptoms, diagnostic shock, role disruption, and unmet information needs. During active treatment, co-occurring oral mucositis, xerostomia, dysphagia, fatigue, body-image concerns, and reduced access to support at night contributed to substantial distress. During home recovery, persistent symptoms, uncertainty about rehabilitation, difficulty resuming daily roles, and fear of cancer recurrence remained prominent, although some participants also described renewed engagement in valued activities.</p><p><strong>Conclusion: </strong>Participants' retrospective accounts identified phase-specific supportive-care gaps at diagnosis, during active treatment, and after discharge. The findings support structured diagnostic communication, coordinated management of co-occurring symptoms with accessible out-of-hours support, and transitional follow-up that includes rehabilitation guidance and psychological screening. Because the study used one retrospective interview per participant at a single center, the findings should be interpreted as a qualitative synthesis rather than evidence of a longitudinal or quantitative pattern.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"637783"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Management of Patients' Own Medications in Hospitalized Older Adults: A Multidisciplinary Before-And-After Intervention Study.","authors":"Xiaoyan Chen, Lin Liu, Jie Zhang, Linghua Zheng, Xiaona Chen, Mingxia Zhang","doi":"10.2147/PPA.S642041","DOIUrl":"10.2147/PPA.S642041","url":null,"abstract":"<p><strong>Purpose: </strong>Patients' own medications (POMs) may pose safety risks when their use is not integrated into hospital medication-management processes. This study evaluated a multidisciplinary intervention for POM management in hospitalized older adults.</p><p><strong>Patients and methods: </strong>This single-center before-and-after intervention study was conducted from March 2024 to February 2025. The intervention comprised five coordinated components: physician-led assessment, authorization, order entry, guidance, and monitoring; pharmacist-led verification, order review, and record maintenance; nurse-led verification, supervision, and education using color-coded labels (green, approved for use; red, not to be used; yellow, awaiting confirmation); IT-led integration of POM information into the electronic medication administration record; and procurement-led upgrades to storage equipment. The primary outcome was the incidence rate of POM-related medication errors per 1000 patient-days. Secondary outcomes were correct POM documentation within 24 hours of admission and correct POM storage at the pre-discharge assessment.</p><p><strong>Results: </strong>The study included 162 patients, with 81 in each period. Before the intervention, 174 POM-related medication errors occurred over 1628 patient-days (106.9 per 1000 patient-days), compared with 29 errors over 1581 patient-days after the intervention (18.3 per 1000 patient-days). The incidence rate ratio was 0.172 (95% CI, 0.116-0.254; P<0.001), representing an 82.8% reduction. Correct POM documentation within 24 hours increased from 53.1% (43/81) to 92.6% (75/81; <i>χ</i> ²=31.951, P<0.001; OR=11.047, 95% CI, 4.319-28.253; RR=1.744, 95% CI, 1.408-2.160). Correct POM storage at the pre-discharge assessment increased from 32.1% (26/81) to 84.0% (68/81; <i>χ</i> ²=44.707, P<0.001).</p><p><strong>Conclusion: </strong>The intervention was associated with improvements in all three measured POM outcomes at this center. Multicenter studies with longer follow-up are needed to assess generalizability and sustainability.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"642041"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.","authors":"Wei Wang, Dan Zhou, Haoping Zhao, Liling Yang, Jiwei Wang","doi":"10.2147/PPA.S643084","DOIUrl":"10.2147/PPA.S643084","url":null,"abstract":"<p><strong>Purpose: </strong>Inflammatory bowel disease (IBD) requires long-term self-management, yet evidence on patients' knowledge, attitude, and practice (KAP) remains limited. This study assessed KAP levels in patients with IBD, identified factors associated with overall KAP levels and explored whether attitude mediates the relationship between knowledge and practice.</p><p><strong>Patients and methods: </strong>A cross-sectional survey was conducted among patients with IBD attending the Second Affiliated Hospital of Nanchang University from June to December 2025. Data were collected using a study-specific questionnaire covering sociodemographic characteristics and KAP dimensions. Spearman correlation analysis, multivariable linear regression, and structural equation modeling with bootstrap resampling were performed.</p><p><strong>Results: </strong>A total of 520 patients were included. The mean knowledge, attitude, and practice scores were 3.97 ± 1.98 (range: 0-10), 24.43 ± 3.58 (range: 8-40), and 28.82 ± 4.41 (range: 8-40), respectively. Knowledge item correct response rates ranged from 29.4% to 48.3%, indicating limited disease-related knowledge. Knowledge was positively correlated with attitude (<i>r</i> = 0.190, P < 0.01) and practice (<i>r</i> = 0.223, P < 0.001), while attitude was positively correlated with practice (<i>r</i> = 0.346, P < 0.001). In multivariable analysis, female sex was associated with lower total KAP scores, whereas higher monthly family income was associated with higher scores. Former and current smoking and drinking were associated with lower total KAP scores, while having 2-3 comorbidities was associated with higher scores. Attitude did not significantly mediate the knowledge-practice relationship.</p><p><strong>Conclusions: </strong>Patients with IBD showed limited knowledge, relatively unfavorable attitude, and moderately proactive practice. Knowledge and attitude were both positively associated with practice, but attitude did not significantly mediate the association between knowledge and practice. The potential benefits of educational, behavioral, and psychosocial interventions require evaluation in prospective or interventional studies.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"643084"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profiles of Early Personal Mastery and Their Association with Out-of-Hospital Rehabilitation Exercise Adherence One Month After Hip Arthroplasty: A Single-Centre Prospective Observational Study.","authors":"Jiaxue Li, Shan Li, Jiaju Zhao, Guoliang Hou, Lingyun Shi, Yanping Guo","doi":"10.2147/PPA.S639782","DOIUrl":"10.2147/PPA.S639782","url":null,"abstract":"<p><strong>Purpose: </strong>In this single-centre prospective observational study, we aimed to identify latent profiles of early personal mastery in patients after hip arthroplasty, examine factors associated with profile membership, and explore differences in out-of-hospital rehabilitation exercise adherence across profiles.</p><p><strong>Patients and methods: </strong>A total of 350 patients who underwent primary hip arthroplasty at a tertiary hospital in Urumqi, Xinjiang, from August to December 2024, were recruited by convenience sampling; 17 were lost to follow-up, and 333 completed the 1-month assessment and were included in the analysis. Personal mastery was assessed on postoperative day 1-2 with the Personal Mastery Scale, together with a general information questionnaire; adherence to out-of-hospital rehabilitation exercise was assessed at 1 month postoperatively with the Functional Exercise Adherence Scale for Orthopedic Patients. Latent profile analysis (LPA) was used to identify profiles of personal mastery, and multinomial logistic regression to examine factors associated with profile membership. Differences in adherence across profiles were analysed using the Bolck-Croon-Hagenaars (BCH) approach to account for classification uncertainty, and were additionally examined in linear models adjusted for demographic and clinical covariates.</p><p><strong>Results: </strong>Of the 350 patients recruited, 17 were lost to follow-up, giving a 1-month follow-up retention rate of 95.14%. LPA identified three profiles of early personal mastery: low (31.53%), intermediate (32.13%) and high (36.34%) personal mastery. In the multinomial logistic regression, age, gender, education level, employment status and chronic comorbidities were independently associated with profile membership (<i>p</i> < 0.05), whereas place of residence was not. Adherence at 1 month differed significantly across profiles (<i>χ</i> ² = 81.398, <i>p</i> < 0.001), and profile membership remained independently associated with adherence after adjustment for demographic and clinical covariates (total adherence score F(2, 307) = 23.23, <i>p</i> < 0.001). The intermediate and high personal mastery profiles did not differ significantly from each other on the learning dimension, the physical dimension or the total adherence score.</p><p><strong>Conclusion: </strong>Early personal mastery in hip arthroplasty patients is heterogeneous and is associated with out-of-hospital rehabilitation exercise adherence at 1 month. These findings suggest that interventions tailored to patients' mastery profiles warrant investigation, although causal relationships remain to be established.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"639782"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profiles of Fear of Complications and Associated Factors Among Older Inpatients with Type 2 Diabetes: A Cross-Sectional Study.","authors":"Jinxian Xu, Juan Gao, Qin Wu, Yuhan Duan, Shuqin Zeng, Jiaqi Liao","doi":"10.2147/PPA.S643946","DOIUrl":"10.2147/PPA.S643946","url":null,"abstract":"<p><strong>Aim: </strong>In the context of diabetes, fear of complications (FoC) refers to a psychological response to the anticipated onset or progression of diabetes-related chronic complications. However, analyses based solely on total scores may conceal the heterogeneity among patients. This study aimed to identify latent FoC profiles among older inpatients with type 2 diabetes mellitus (T2DM) and examine the demographic and clinical characteristics, hope, and self-management factors associated with these profile.</p><p><strong>Methods: </strong>In this cross-sectional study, 310 older inpatients with T2DM were recruited from the endocrinology department of a tertiary hospital between January and October 2024, and 299 valid questionnaires were analyzed. Data were collected through face-to-face interviews using a general information questionnaire, the Fear of Complications Questionnaire (FCQ), the Adult Dispositional Hope Scale (ADHS), and the Summary of Diabetes Self-Care Activities (SDSCA). Latent profile analysis was conducted in Mplus 8.3, group comparisons and hierarchical multinomial logistic regression were performed using SPSS 26.0.</p><p><strong>Results: </strong>Three profiles were identified: low FoC (36.8%), moderate FoC (43.8%), and high FoC (19.4%). Compared with the low FoC profile, higher hope scores, higher self-management scores, and absence of complications, were associated with lower odds of membership in both moderate FoC profile (ORs = 0.867, 0.955, and 0.390 respectively; all P < 0.01) and high FoC profile (ORs = 0.694, 0.811, and 0.194 respectively; all P < 0.05).</p><p><strong>Conclusion: </strong>A person-centered analysis identified three profiles characterized by increasing levels of FoC among older inpatients with T2DM. Higher-FoC profiles were associated with greater complication burden, lower hope, and lower self-management capacity, suggesting that FoC assessment may benefit from integrating clinical characteristics with psychological and behavioral factors. External replication and prospective validation are needed before these profiles can be applied to bedside classification or profile-matched interventions.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"643946"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing Trends of Osteoporosis Medications, Adherence and Persistence with Denosumab versus Alendronate: A Real-World Retrospective Study in China.","authors":"Jun Chen, Yuliang Huang, Puqing Liu, Lei Fan","doi":"10.2147/PPA.S642741","DOIUrl":"10.2147/PPA.S642741","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis, a common metabolic bone disease with high fracture risk and heavy global burden, requires long-term medication adherence and persistence for fracture prevention, yet both remain suboptimal. Prescribing trends, adherence, and persistence data for denosumab and alendronate remain limited, especially in Chinese populations.</p><p><strong>Methods: </strong>This retrospective cohort study used hospital data. Patients aged ≥50 who newly initiated denosumab or alendronate in 2023-2025 were screened; 2025 initiators were excluded for insufficient 1-year follow-up. New users had no prior prescription of either drug since 2009. The proportion of days covered (PDC) was assessed, with good adherence defined as ≥80%. Persistence was time from initiation to discontinuation, with >60-day gap after coverage end defining discontinuation for both drugs. Propensity score matching (PSM) balanced baseline characteristics. Multivariable logistic regression and Kaplan-Meier survival analysis compared adherence and persistence.</p><p><strong>Results: </strong>A shift in prescribing from oral to injectable formulations, with alendronate decreasing by 44% and denosumab increasing by 94% in 2023-2025. Denosumab demonstrated greater persistence and adherence than alendronate. The 1-year persistence rate was 46.28% (95% CI: 41.88%-50.80%) for denosumab vs 2.89% (95% CI: 1.60%-4.79%) for alendronate, with a 90.80% lower risk [HR: 0.092 (95% CI: 0.077-0.110), p < 0.001]. PDC was 0.530 (IQR: 0.493-0.975), adherence rate 46.90% (227/484) for denosumab vs 0.077 (IQR: 0.077-0.153), 2.48% (12/484) for alendronate; adherence was 41.29-fold higher with denosumab (95% CI: 22.41-76.07, p < 0.001). Multivariate analysis showed hypertension and fracture history with better adherence and persistence; inpatient status was associated with poorer persistence and adherence; and female sex with poorer persistence (all p < 0.05).</p><p><strong>Conclusions: </strong>A shift from oral to injectable formulations was observed. Denosumab was associated with higher persistence and adherence than alendronate. Hypertension and fracture history were associated with better persistence and adherence, whereas inpatient status was associated with poorer persistence and adherence. Female sex was associated with poorer persistence without affecting adherence.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"642741"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholder Perspectives on Needs, Preferences, and Perceived Barriers for a Smart Integrated Care Platform for Older Adults with Cardiometabolic Multimorbidity: A Qualitative Study.","authors":"Xing Wu, Shanshan Dou, Xu Yao, Tian Qiu, Jiahui Lv, Yajuan Feng","doi":"10.2147/PPA.S630325","DOIUrl":"10.2147/PPA.S630325","url":null,"abstract":"<p><strong>Purpose: </strong>Guided by stakeholder theory, this study explored the functional needs, usage preferences, and anticipated challenges in use of older adults with cardiometabolic multimorbidity (CMM) regarding the smart integrated care platform from the perspectives of four key groups-patients, family caregivers, physicians, and nurses-so as to provide a basis for platform development and optimization.</p><p><strong>Patients and methods: </strong>A qualitative descriptive design was employed. A total of 24 participants-including older adults with CMM, family caregivers, physicians, and nurses-were recruited via maximum-variation purposive sampling and underwent semi-structured interviews. Data were analyzed using Braun and Clarke's thematic analysis framework, supported by NVivo 15.0 software.</p><p><strong>Results: </strong>Three main themes and twelve subthemes were identified: (1) health needs, (2) technical needs, and (3) anticipated challenges in use.</p><p><strong>Conclusion: </strong>From multiple stakeholder perspectives, the perceived needs of older adults with CMM for smart integrated care platforms are diverse. Perceived barriers to use include technical complexity, poor health, privacy concerns, and economic burden, while age-appropriate design and technical training serve as potential facilitators. This study provides insights into the design of smart integrated care platforms for this population. Future research is needed to examine the long-term adoption and adherence of such platforms.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"630325"},"PeriodicalIF":2.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Survival: Psychological Burden Impairs Medication Adherence in Chinese Patients with Chronic Myeloid Leukemia on TKI Therapy.","authors":"Fang Cheng, Zheng Cui, Qiang Li, Wei Chang, Weiming Li","doi":"10.2147/PPA.S631481","DOIUrl":"10.2147/PPA.S631481","url":null,"abstract":"<p><strong>Background: </strong>Increasing research has linked mental health to reduced adherence in chronic diseases, yet this interplay remains insufficiently explored in chronic myeloid leukemia (CML).</p><p><strong>Methods: </strong>We conducted a cross-sectional online survey to analyze the critical role of non-treatment factors among Chinese CML patients receiving tyrosine kinase inhibitor (TKI) therapy. Anxiety and depression were assessed with the GAD-7/PHQ-9, quality of life (QoL) with the SF-12. Medication adherence was assessed using the Medication Possession Ratio (MPR), calculated as the percentage of actual medication possession days relative to the theoretical medication possession days. Binary logistic regression was used to identify factors associated with psychological burden and adherence.</p><p><strong>Results: </strong>Of 486 patients included, 52.5% reported anxiety (mild: 45.3%; moderate-severe: 7.2%) and 40.5% reported depression (mild: 29.8%; moderate-severe: 10.7%). QoL was impaired in both physical and mental domains (mean SF-12 PCS 46.22; MCS 45.62). Employment status and higher SF-12 PCS scores were significantly associated with lower psychological burden. Compared with patients reporting medium or high adherence, those with low adherence had higher rates of anxiety (20.2% vs 3.5% and 3.3%, P < 0.001) and depression (17.4% vs 8.8% and 8.7%, P=0.007) and lower MCS scores (43.72 vs 46.45 and 45.75, P=0.021). Binary logistic regression analysis showed that therapy duration, line of treatment, and psychological burden were significantly associated with adherence, patients with elevated psychological burden had 76.0% lower adherence odds (OR=0.24; 95% CI: 0.13-0.44; P<0.001), the strongest influencing factor.</p><p><strong>Conclusion: </strong>Psychological burden is the strongest determinant of impaired medication adherence in Chinese patients with CML on TKI therapy. Interventions that reduce psychological burden, particularly by promoting social-role participation and improving perceptions of physical health, may offer a new dimension for optimizing long-term outcomes in CML.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"631481"},"PeriodicalIF":2.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gynecologist and Menopausal Patient Perspectives on Vaginal Hormone Therapy for the Management of the Genitourinary Syndrome of Menopause in Canada: A Real-World Survey.","authors":"Alison K Shea, Negar Nassiri, Luc Tremblay, Jessé Moisan, Céline Bouchard","doi":"10.2147/PPA.S636147","DOIUrl":"10.2147/PPA.S636147","url":null,"abstract":"<p><strong>Purpose: </strong>The genitourinary syndrome of menopause (GSM) is common during menopause and can have a profound negative impact on quality of life. Vaginal hormone therapy (HT) is a guideline-recommended second-line treatment for GSM but its real-world utilization in Canada is poorly described in the literature. The objectives of this real-world study were to examine current patterns of practice and potential gaps in the management of GSM in Canada and to evaluate factors affecting patient satisfaction with vaginal hormone therapy for GSM.</p><p><strong>Patients and methods: </strong>Real-world study that surveyed 13 Canadian gynecologists and 119 patients diagnosed with GSM who were eligible for vaginal HT but had not been prescribed this treatment (naïve cohort) or were currently being treated with vaginal HT (on-treatment cohort). Data were analyzed using descriptive statistics.</p><p><strong>Results: </strong>The main therapies prescribed by gynecologists for GSM were vaginal moisturizers or lubricants (49%), vaginal estrone/conjugated estrogen creams (35%), vaginal estradiol inserts (26%) or tablets (20%), and vaginal dehydroepiandrosterone (DHEA) ovules (12%). Among vaginal HT-naïve patients, the most important factors impacting treatment selection were ease of use, onset of action, and low risk of systemic hormone absorption. Most patients in the on-treatment cohort (77%) were satisfied with their current vaginal HT yet 77% would consider switching treatment most commonly due to convenience factors. After consultation with their gynecologist, 43% of patients on vaginal HT switched treatment, mainly to estradiol inserts (43%) or DHEA ovules (36%). Even patients who had no change to their GSM treatment had experienced issues with their current vaginal HT, suggesting an opportunity to discuss alternative treatment options with their gynecologist.</p><p><strong>Conclusion: </strong>Gaps and opportunities to improve the current management of GSM in Canada were identified. Discussions about GSM and available treatment options could be strengthened to support shared decision-making.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"636147"},"PeriodicalIF":2.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriately Designed and Adequately Powered Studies are Required to Evaluate the Experiences of GBS Patients Undergoing Plasma Exchange [Letter].","authors":"Josef Finsterer","doi":"10.2147/PPA.S660247","DOIUrl":"10.2147/PPA.S660247","url":null,"abstract":"","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"660247"},"PeriodicalIF":2.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}