Patient preference and adherence最新文献

{"title":"Medication Adherence and Perceptions According to the Presence or Absence of a Migration Background in a Dialysis Unit (DIANA Qualitative Study).","authors":"Jennifer Dotta-Celio, Mélanie Lelubre, Sabrina Bolzon, Georges Halabi, Michel Burnier, Patrick Bodenmann, Menno Pruijm, Marie P Schneider","doi":"10.2147/PPA.S503025","DOIUrl":"10.2147/PPA.S503025","url":null,"abstract":"<p><strong>Purpose: </strong>Migration status has received little attention in the context of medication adherence. This qualitative study aims to consolidate the findings of the quantitative DIANA study by: 1) exploring medication management, medication knowledge and perceptions and 2) identifying whether there are differences in medication management, knowledge and perceptions between patients according to the patients' migration status.</p><p><strong>Patients and methods: </strong>This monocentric qualitative study was part of the research protocol DIANA (<i>Dialyse chronique et adhésion thérapeutique</i>). Patients were recruited at the chronic dialysis unit of the Lausanne University Hospital. In-depth, face-to-face interviews were conducted; for allophone patients, an interpreter was present. Each interview was recorded and transcribed verbatim. A content analysis was performed.</p><p><strong>Results: </strong>Eighteen interviews were performed. Nine patients were Swiss, 3 had a residence/settlement permit, 6 were provisionally admitted/asylum seekers. Six interviews were performed with an interpreter. Core themes were: (1) treatment management (medication intake had become a habit, forgetting was rare), (2) heterogeneous treatment knowledge but highly perceived necessity, (3) reported medication disadvantages were pill burden and side effects, (4) role of the patient in the medical environment (trust in physicians but patients making decisions regarding their treatment on their own, without consulting healthcare professionals). Swiss patients engaged more in shared decision-making and were more likely to talk about side effects than migrant patients. Provisionally admitted foreign nationals/asylum seekers talked more about their gratitude to the healthcare system.</p><p><strong>Conclusion: </strong>More studies are needed to understand how shared decision-making can be established between health professionals and patients, taking into account their migration status. To provide tailored education, it is essential to evaluate patients' health literacy and to use the teach-back method to find the best way to convey health messages. The acquisition of transcultural clinical skills by health professionals is necessary to support medication adherence.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2107-2118"},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study of Virtual Reality in Hemodialysis for Mitigating Pain and Anxiety: User Experiences and Perceptions.","authors":"Solmar Rodríguez de Galvis, Elena Guerrero Rodríguez, Julia Audije-Gil, Sandra Hernández Hernández, Marta Argilés-Huguet, Ana Botella, Marina Burgos Villulas, Ana Casaux-Huertas, Isabel González Sánchez, María Teresa Marín López, Paula Manso, David Hernán, Fabiola Dapena, María Dolores Arenas Jiménez","doi":"10.2147/PPA.S517622","DOIUrl":"10.2147/PPA.S517622","url":null,"abstract":"<p><strong>Background: </strong>Virtual reality (VR) helps control symptoms during procedures in chronic patients. This study analyzes VR's effect on pain and anxiety in hemodialysis (HD) patients at two points: the vascular access puncture and disconnection.</p><p><strong>Methods: </strong>A prospective, non-randomized, crossover, multicenter pilot study assessing pre- and post-intervention outcomes with VR headsets. The intervention group used VR for up to 13 sessions, around the puncture, and at the end of the session. Pain was measured with the Faces Pain Scale - Revised (FPS-R) and anxiety with the Visual Analogue Scale for Anxiety (VAS-A). Usability and patient satisfaction with VR were also evaluated.</p><p><strong>Results: </strong>A total of 73 patients (66.2 ± 13.3 years, 67% men) were included. At the start, 8.2% declined to wear the VR headset. The average number of sessions with the headset was 6.5 ± 4.8, with 23.3% completing all 13 sessions. Pain during punctures significantly improved with VR (1.26 vs 0.97; p = 0.039), while anxiety improved non-significantly. Anxiety during disconnection slightly increased, but also not significantly. Patients with higher initial pain and anxiety levels during puncture and disconnection showed significant improvement, while those with lower initial levels worsened (p < 0.05 in all cases). The HD population showed varying levels of acceptance of VR.</p><p><strong>Conclusion: </strong>VR headsets help reduce pain during punctures, especially in patients with more intense pain. The effect on anxiety reduction during punctures or at the end of the session is inconclusive, with better results in those with higher anxiety levels. VR acceptance in the HD population is variable.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2069-2079"},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences and Needs of Patients with Esophageal Cancer Receiving Esophagectomy: A Qualitative Longitudinal Study.","authors":"Ai-Ying Sun, Xiao-Xia Xu, Yan Zheng, Ying-Ying Wang, Rui-Chen Ma","doi":"10.2147/PPA.S523765","DOIUrl":"10.2147/PPA.S523765","url":null,"abstract":"<p><strong>Purpose: </strong>With the incidence of esophageal cancer increasing year by year, it is very important to understand the disease experience of patients at different stages of the cancer journey. Supportive care is a long-term task for patients with esophageal cancer. This study was designed to explore the disease experiences and needs of esophageal cancer patients receiving esophagectomy at key time points in their cancer journey.</p><p><strong>Patients and methods: </strong>A qualitative longitudinal study based on the Timing It Right framework. A purposive sampling method was used, and a sample of 17 patients completed 79 interviews. One-to-one and semistructured interviews were conducted in a tertiary cancer hospital in China from March to August 2024, and Colaizzi's method was used to analyze data.</p><p><strong>Results: </strong>Twelve subthemes were identified: the diagnosis phase (deep in fear and excessive worry, desire for comprehensive and professional information), the perioperative phase (multiple pressures and looking forward to humanistic care, not adapted to the ward environment and sleep disorders, urgently require for symptom management program), the discharge preparation phase (home-based rehabilitative information and medication guidance, home self-monitoring and continuous care needs), the adjustment phase (loss of normal \"daily life\", avoidant social behavior, social support needs), and the adaptation phase (improved health management behavior, integration into society needs and eager for national policy support).</p><p><strong>Conclusion: </strong>The needs of esophageal cancer patients vary during the diagnosis and treatment process. Continuous and dynamic care should be provided for patients according to their needs in different stages of the disease.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2055-2068"},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Patients' Preference During Their Hospital Experience. A Sentiment and Topic Analysis of Patient-Experience Comments via Natural Language Techniques.","authors":"Jie Yuan, Xiao Chen, Chun Yang, JianYou Chen, PengFei Han, YuHong Zhang, YuXia Zhang","doi":"10.2147/PPA.S526623","DOIUrl":"10.2147/PPA.S526623","url":null,"abstract":"<p><strong>Background: </strong>Open-ended questions in patient experience surveys provide a valuable opportunity for people to express and discuss their authentic opinions. The analysis of free-text comments can add value to quantitative measures by offering information which matters most to patients and by providing detailed descriptions of the service issues that closed-ended items may not cover.</p><p><strong>Objective: </strong>To extract useful information from large amounts of free-text patient experience comments and to explore differences in patient satisfaction and loyalty between patients who provided negative comments and those who did not.</p><p><strong>Methods: </strong>We collected free-text comments on a broad, open-ended question in a cross-sectional patient satisfaction survey. We adopted a mixed-methods approach involving a literature review, human annotation, and natural language processing technique to analyze free-text comments. The associations of patient satisfaction and loyalty scores with the occurrence of certain patient comments were tested via logistic regression analysis.</p><p><strong>Results: </strong>In total, 28054 free-text comments were collected (comment rate: 72.67%). The accuracy of the machine learning approach and the deep learning approach for topic modeling and sentiment analysis was 0.98 and 0.91 respectively, indicating a satisfactory prediction. Participants tended to leave positive comments (69.0%, 19356/28054). There were 22 patient experience themes discussed in the open-ended comments. The regression analysis showed that the occurrence of negative comments about \"humanity of care\", \"information, communication, and education\", \"sense of responsibility of staff\", \"technical competence\", \"responding to requests\", and \"continuity of care\" was significantly associated with a worse patient satisfaction and loyalty, while the occurrence of negative comments about other aspects of healthcare services had no impact on patient satisfaction and loyalty.</p><p><strong>Conclusion: </strong>The results of this study highlight the interpersonal and functional aspects of care, especially the interpersonal aspects, which are often the \"moment of truth\" during a service encounter when patients critically evaluate hospital services.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2027-2037"},"PeriodicalIF":2.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Traditional Chinese Version of the Belief About Medicines Questionnaire-Specific Among Adults with Type 2 Diabetes in Taiwan.","authors":"Yen-Ming Huang, Yu-Meng Yang, Tzu Wang, Yunn-Fang Ho, Hsun-Yu Chan","doi":"10.2147/PPA.S531219","DOIUrl":"10.2147/PPA.S531219","url":null,"abstract":"<p><strong>Background: </strong>Understanding personal beliefs about medications is an effective approach to improving adherence. A validated tool is essential for identifying these beliefs in routine clinical practice.</p><p><strong>Objective: </strong>To validate the factor structure and reliability of the Traditional Chinese version of the Beliefs about Medicines Questionnaire-Specific (BMQ-Specific) among individuals with type 2 diabetes (T2D) in Taiwan.</p><p><strong>Methods: </strong>The original 10-item BMQ-Specific was translated into Traditional Chinese using a forward-backward translation process and reviewed by four experts in pharmacy practice and educational psychology. A cross-sectional study was conducted among adults with T2D who were using diabetes medications. Participants were recruited from five community pharmacies in Taiwan between June 2023 and May 2024. Internal consistency was assessed using McDonald's omega (ω). Construct validity was examined through exploratory factor analysis, and criterion validity was determined by exploring associations between concern beliefs, medication adherence, and glycemic control, as measured by A1C levels.</p><p><strong>Results: </strong>Two hundred and seventy-three patients participated in the study. Exploratory factor analysis confirmed a two-factor structure consistent with the original English version, comprising the Specific-Necessity and Specific-Concerns subscales. All items loaded onto their respective subscales. The internal consistency reliability of the instrument was acceptable, with McDonald's ω values of 0.785 for both the BMQ-Specific Necessity and BMQ-Specific Concerns subscales. These satisfactory properties were further supported by predictive validity data, which demonstrated the impact of treatment beliefs on adherence levels. The BMQ-Specific Concerns subscale showed a positive correlation with higher barriers to medication-taking (r = 0.270, p < 0.001) and poorer glycemic control (r = 0.130, p = 0.032).</p><p><strong>Conclusion: </strong>The Traditional Chinese BMQ-Specific is a reliable and valid tool for assessing medication beliefs among patients with T2D in Taiwan. It can be effectively incorporated into clinical practice to support patient-provider communication and improve medication adherence.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2039-2053"},"PeriodicalIF":2.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Perspectives of Lung Cancer Chemotherapy Patients on Self-Management: A Qualitative Interview Study Using the COM-B Model.","authors":"Ruimei Jia, Nina Xie, Yue Li, Yu Zhang","doi":"10.2147/PPA.S522066","DOIUrl":"10.2147/PPA.S522066","url":null,"abstract":"<p><strong>Purpose: </strong>Lung cancer chemotherapy patients' self-management behaviors were not satisfactory, especially treatment-related management scored low compared to other management. This study used the capability, opportunity, and motivation-behavior (COM-B) model of behavioral change to explore the perspectives when performing self-management.</p><p><strong>Methods: </strong>The study employed semi-structured interviews with 15 patients undergoing chemotherapy for lung cancer. The COM-B model was utilized to guide the development of interview themes and to inform the content analysis methods applied.</p><p><strong>Results: </strong>The study identified three main themes and eight sub-themes. These included: (1) Competency factors, which encompassed poor management of symptoms and chemotherapy side effects, as well as a lack of patient self-management awareness; (2) Motivational factors, which involved the complexity of the chemotherapy regimen reducing patients' confidence in treatment management, insufficient family support, and a lack of patients' sense of meaning in life with low future expectations; and (3) Opportunity factors, which included financial burden preventing patients from practicing self-management of their disease, lack of access to authoritative knowledge, and limited opportunities to practice self-management.</p><p><strong>Conclusion: </strong>This study proposes targeted interventions based on the research findings, including strengthening symptom management for patients, enhancing patients' knowledge of self-management of health through health training, seminars, and peer exchange meetings, and providing further opportunities for patient self-management by establishing family support networks, community peer support groups, and constructing authoritative health information platforms. By linking social resources, the economic pressure on patients is alleviated. Our research results will contribute to comprehensive self-management for lung cancer chemotherapy patients.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"1991-2002"},"PeriodicalIF":2.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Cardiac Rehabilitation Compliance in Elderly Myocardial Infarction Patients and the Development of a Nomogram Prediction Model.","authors":"Baihua Zhou, Jun Yan, Qin Wang, Qiwei He, Wei Ao, Ying Yang, Yanjiao Ren","doi":"10.2147/PPA.S529753","DOIUrl":"10.2147/PPA.S529753","url":null,"abstract":"<p><strong>Objective: </strong>To explore the influencing factors of cardiac rehabilitation compliance in elderly patients with acute myocardial infarction (AMI) and to construct a nomogram prediction model.</p><p><strong>Methods: </strong>A retrospective study was conducted on 239 elderly AMI patients admitted to our hospital from April 2022 to April 2024. The patients were randomly assigned into a modeling group (167 cases) and a validation group (72 cases) in a 7:3 ratio. The modeling group was separated into a good compliance group and a poor compliance group based on their compliance with cardiac rehabilitation.</p><p><strong>Results: </strong>Among the 167 patients in the modeling group, 67 had poor compliance, with an incidence rate of 40.12%. Multivariate logistic regression revealed that age, educational level, perception of disease, anxiety and depression, social support, and medical staff supervision were risk factors for cardiac rehabilitation compliance in elderly AMI patients (P<0.05). The AUC values of the modeling and validation groups were 0.955 and 0.937, respectively. The slope of the calibration curve was close to 1, and the H-L test showed <i>χ</i> ²=7.863 and 7.453, with P=0.789 and 0.775, indicating good consistency. DCA curve showed that when the high-risk threshold probability was between 0.08 and 0.93, the nomogram model had a high clinical value.</p><p><strong>Conclusion: </strong>Age, educational level, perception of the disease, anxiety and depression, social support, and medical staff supervision are the influencing factors of cardiac rehabilitation compliance in elderly AMI patients. The nomogram model constructed based on this has good discrimination and consistency, and can predict cardiac rehabilitation compliance.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2015-2025"},"PeriodicalIF":2.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antirheumatic Medication Calendar Significantly Improves Adherence in First-Time Methotrexate Users: A Prospective, Single-Blind, Randomized Controlled Trial.","authors":"Fangfang Yuan, Qiong Yang, Xin Zhang, Jing Luo, Jixia Lin, Yahui Chen, Haiyan Huang, Junhong He, Luna Cheng","doi":"10.2147/PPA.S527173","DOIUrl":"10.2147/PPA.S527173","url":null,"abstract":"<p><strong>Purpose: </strong>Methotrexate is widely used to treat rheumatoid arthritis; however, the adherence rate greatly varies due to its weekly dosing schedule. Incorrect administration can lead to disease progression and toxicity. To design a graphic-based medication calendar aiming to improve adherence in first-time methotrexate users.</p><p><strong>Patients and methods: </strong>This prospective, single-blind, randomized controlled trial included participants aged 18-75 years who were starting methotrexate for the first time or resuming it after a 3-month break. Seventy-nine participants from October 1, 2023, to January 30, 2024, were randomly assigned in a 1:1 ratio to the calendar (38 participants) or control (41 participants) group for 6 weeks and followed up for 2, 6, and 10 weeks. The primary outcome was methotrexate adherence, assessed by the proportion of patients with a PDC value of 100%.</p><p><strong>Results: </strong>After 6 and 10 weeks, the calendar group had a higher proportion of patients with a PDC value of 100% compared with the control group (97.2% vs 73.2%, P < 0.004; 88.9% vs 68.9%, P < 0.03, respectively) and a higher correct medication adherence rate within 10 weeks (87.81% vs 69%, P = 0.0307). Compared with the control group, the calendar group had a significantly higher rate of on-time return visits during both follow-up visits (97.2% vs 78.0% and 91.7% vs 70.7%, respectively). Additionally, 94.74% of the calendar group patients believed the intervention improved their adherence and wished to continue using it.</p><p><strong>Conclusion: </strong>The antirheumatic medication calendar improved initial methotrexate adherence; however, its effect diminished following its discontinuation.</p><p><strong>Clinical trial registration: </strong>ChiCTR2300076228 (2023-09-27).</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2003-2014"},"PeriodicalIF":2.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Think Before You Take: Understanding Adult Medication Literacy in Saudi Arabia.","authors":"Faten Alhomoud, Walaa Alsaeed, Fatimah Alzainaldain, Kawthar Alelq, Farah Kais Alhomoud, Khalid A Alamer, Mohammed M Alsultan, Yousef Saeed Alqarni, Bashayer Alshehail, Abdullah A Alhifany","doi":"10.2147/PPA.S536578","DOIUrl":"10.2147/PPA.S536578","url":null,"abstract":"<p><strong>Background: </strong>Poor medication literacy may lead to serious health risks. Nevertheless, very little research has examined medication literacy in Saudi Arabia. Thus, this study assessed medication literacy and factors associated with poor medication literacy.</p><p><strong>Methods: </strong>A descriptive, cross-sectional study was conducted, with eligibility criteria including individuals aged ≥ 18 years, speaking Arabic or English, and residing in Saudi Arabia. Eligible participants completed an online, self-administered survey disseminated through social media platforms over a two-month period. Horvat's Medication Literacy Assessment Questionnaire was employed. The analysis used regression in SPSS version 29 to identify predictors of medication literacy.</p><p><strong>Results: </strong>A total of 815 participants were included. Most were female (75.7%), aged 18-24 years (50.1%), and held undergraduate degree (47%). The median (IQR) medication literacy score, assessed using Horvat's Medication Literacy Assessment Questionnaire (score range: 0-29), was 22.0 (18-24). Results showed a relatively poor level of medication literacy, with 50% of participants scoring below the average of correct answers. Most problems were found in items related to dosing, requiring understanding information from longer texts and numerical skills. Other issues included refills, drug use in pregnancy, storage and disposal, expiration date, adverse effects, drug interactions, missed doses, label understanding, tablet splitting, and duration of therapy. Multiple linear regression revealed significant predictors. Lower educational levels were associated with reduced scores (β = -1.765, p = 0.009 for high school or below; β = -5.872, p = 0.016 for diploma). Smaller households were associated with higher scores (β = 1.252, p = 0.031 for 1-4 members; β = 1.255, p = 0.021 for 5-8 members). Prescription medications use (β = 2.375, p < 0.001) and less frequent pharmacists consultation (β = 3.602, p = 0.001) were positively associated with higher scores.</p><p><strong>Conclusion: </strong>Medication literacy among study participants requires improvement, especially in areas involving dosing instructions and numerical understanding. Targeted interventions are necessary for those with inadequate literacy levels.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"1973-1990"},"PeriodicalIF":2.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Affecting Quality of Life in Chronic Limb Threatening Ischemia Patients.","authors":"Rui Wu, Yuan Yu, Julong Guo, Xixiang Gao, Zhu Tong, Jianming Guo, Shijun Cui, Chengchao Zhang, Lianrui Guo","doi":"10.2147/PPA.S532224","DOIUrl":"10.2147/PPA.S532224","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the independent risk factors affecting quality of life (QoL) in chronic limb threatening ischemia (CLTI) patients, with a particular focus on the role of the Wound, Ischemia, and foot Infection (WIfI) classification. Understanding these relationships could provide insights into optimizing patient management and improving their overall QoL.</p><p><strong>Patients and methods: </strong>This study was conducted at our center from January 2021 to January 2024. Hospitalized patients diagnosed with CLTI (Rutherford categories 4-6) were enrolled for QoL assessment using the Vascular Quality of Life Questionnaire (VascuQoL). We analyzed the differences in the scores of vascuQoL and its five dimensions among patients grouped by different WIfI stages. A linear regression model was used to identify independent risk factors of overall VascuQoL scores and its different dimensions.</p><p><strong>Results: </strong>This study included 309 patients with an average age of 70.11 years; 30.1% were female. The mean baseline VascuQoL score was 2.02 ± 0.83. According to the WIfI classification, patients were distributed as follows: 15.53% stage 4, 39.16% stage 3, 27.83% stage 2, and 17.48% stage 1. WIfI classification emerged as a key independent predictor, significantly affecting overall VascuQoL scores (β=-0.15, 95% CI -0.24 to -0.06, P=0.002) and four out of five QoL dimensions (activity, symptoms, emotional well-being, and social interactions). Female sex, smoking history, cerebral infarction history, and previous limb revascularization also affect the quality of life from different dimensions or as a whole.</p><p><strong>Conclusion: </strong>CLTI markedly worsens patients' QoL, with WIfI stage playing a crucial role in determining outcomes.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"1965-1972"},"PeriodicalIF":2.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}