Patient preference and adherence最新文献

{"title":"A Qualitative Investigation into the Determinants of Unfulfilled Needs in Caregivers of Patients with Phenylketonuria.","authors":"Yu-Juan Zheng, Yong-Chao Hou, Hua Zhao, Xiao-Yun Wang, Yu-Dan Liu, Li Li, Liang Yu, Ming-Mei Guo","doi":"10.2147/PPA.S481857","DOIUrl":"https://doi.org/10.2147/PPA.S481857","url":null,"abstract":"<p><strong>Objective: </strong>To conduct an in-depth exploration of the factors influencing unfulfilled needs in caregivers of patients with phenylketonuria.</p><p><strong>Methods: </strong>A rapid qualitative analysis approach was used to conduct semi-structured interviews with 16 caregivers of patients with phenylketonuria undergoing specialized dietary interventions, along with 5 medical professionals, within a designated phenylketonuria diagnosis and treatment center in Shanxi Province. Interview data were systematically organized, analyzed, and thematically extracted.</p><p><strong>Results: </strong>Four primary themes were extracted: self-imposed constraints (including insufficient caregiver engagement, economic limitations, and stigma); interpersonal constraints (encompassing social isolation, inadequate social support networks, and lack of doctor-patient interactions); structural limitation factors (inadequate provision of specialized professional support systems, lack of medical dietary supplements, and deficiencies in national policies); and experiential limitation factors (encompassing sensory perceptions of medical dietary supplements and insufficient continuity in psycho-emotional care).</p><p><strong>Conclusion: </strong>The unfulfilled needs of caregivers of patients with phenylketonuria primarily manifest across four dimensions. Greater emphasis on addressing these needs is warranted, necessitating increased attention to patients with phenylketonuria and their caregivers. Specifically, the focus should be directed toward addressing their emotional requirements, along with proactive development of the medical service infrastructure. Such measures are imperative for reducing unfulfilled needs among caregivers of patients and enhancing their prognosis.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2249-2259"},"PeriodicalIF":2.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and Validating an Epilepsy Awareness and Education Program: Bridging Gaps in Knowledge and Support for People Living with Epilepsy and Their Families.","authors":"Ofhani Prudance Musekwa, Lufuno Makhado, Angelina Maphula","doi":"10.2147/PPA.S463151","DOIUrl":"https://doi.org/10.2147/PPA.S463151","url":null,"abstract":"<p><p>Various epilepsy studies on epilepsy awareness and knowledge highlight underlying myths, misconceptions, stigma, and discrimination associated with epilepsy, People Living with Epilepsy (PLWE), and their families. This study aimed to develop an epilepsy awareness and education programme to enhance epilepsy awareness and support among individuals living with epilepsy and their families. Participatory Action Research (PAR) laid the ground for the programme's investigation, development, and implementation. The study stakeholders (co-researchers) included PLWE, family members and caregivers (FMCs), community members, and health care providers (HCPs) who participated in the inception of the study, data collection, programme development, and validation. The study included four phases: phase one was a systematic review, phase two was an empirical phase that included an explanatory sequential mixed method, phase three was meta-inferences and conceptualization, and the last phase was the development and validation of the programme. All phases of the study informed the development of the programme (using a step-step guide to programme development). From these, the gaps and potential education needs were identified. Gaps such as insufficient knowledge about epilepsy in rural communities, negative attitudes and satisfactory awareness, and a need for support and care for PLWE and FMCs. Implementation of this programme will improve epilepsy knowledge, care, and support in marginalised communities, establishing a more conducive environment and ultimately improving the quality of life for patients and their families.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2235-2248"},"PeriodicalIF":2.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intake Patterns and Experiences of Patients Using Direct Oral Anticoagulants Measured by Electronic Monitoring in Community Pharmacies.","authors":"Sara Desmaele, Andreas Capiau, Maxim Grymonprez, Antoine Pironet, Stephane Steurbaut, Silas Rydant","doi":"10.2147/PPA.S469910","DOIUrl":"https://doi.org/10.2147/PPA.S469910","url":null,"abstract":"<p><strong>Purpose: </strong>Several international organizations advocate for monitoring of adherence to direct oral anticoagulants (DOACs), given the prevalent issue of suboptimal adherence to DOACs. The aim was to investigate intake patterns in patients on DOAC therapy by electronic monitoring of medication adherence in community pharmacies (using a Medication Event Monitoring System^® (MEMS^®)-device), and to assess patients' experiences with this device.</p><p><strong>Patients and methods: </strong>Patients using apixaban, rivaroxaban or edoxaban and visiting a community pharmacy, were included. Adherence was electronically monitored over a twelve-week period. Pharmacists conducted data readings from the electronic device at six and twelve weeks, and discussed these data with the patients. At the beginning and end of the study, patients completed a questionnaire about their expectations and experiences respectively.</p><p><strong>Results: </strong>Eighty-nine patients were included and high taking adherence rates were observed (median adherence of 100% for once-daily dosed patients and 96.7% for twice-daily dosed patients), but more than half of the patients took at least one dose too late or skipped at least one dose, possibly resulting in temporarily reduced protection against thromboembolic events. Most patients who felt that their adherence had improved, believed this was due to the combination of the electronic device and the personal follow-up by the pharmacist. Although most patients stated that medication adherence is their own responsibility, they were grateful for the support they received from their community pharmacist.</p><p><strong>Conclusion: </strong>High adherence rates were observed, but there was still room for improvement regarding intake moments. Positive experiences with an electronic device for medication adherence monitoring were reported.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2225-2234"},"PeriodicalIF":2.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Effect of Perceived Health Competence on the Association Between Mindfulness and Adherence to Health Behaviors in Patients with Acute Coronary Syndrome: A Cross-Sectional Study.","authors":"Anan Li, Yangfan Nie, Meixuan Chi, Naijuan Wang, Siying Ji, Zhaoying Zhu, Shan Li, Yunying Hou","doi":"10.2147/PPA.S487100","DOIUrl":"https://doi.org/10.2147/PPA.S487100","url":null,"abstract":"<p><strong>Purpose: </strong>Given the importance of adherence to health behaviors in patients with acute coronary syndrome (ACS) and the potential influence of mindfulness, it is important to determine the association between mindfulness and adherence to health behaviors and its potential mechanisms in this population. Perceived health competence is a person's confidence in his/her ability to achieve health goals successfully and may explain how mindfulness influences adherence to health behaviors. This study aimed to examine the association between mindfulness and adherence to health behaviors and whether this association was mediated by perceived health competence.</p><p><strong>Methods: </strong>A cross-sectional study (N = 555) was conducted at the First Affiliated Hospital of Soochow University from September 2022 to January 2024. Patients' sociodemographic and clinical data, mindfulness (Mindful Attention Awareness Scale [MAAS]), and perceived health competence (Perceived Health Competence Scale [PHCS]) were assessed one-two days before discharge, and adherence to health behaviors (Medical Outcomes Study Specific Adherence Scale [MOSSAS]) was assessed one month after discharge. Good adherence to health behaviors was defined as achieving a cumulative score of ≥ 80%. A mediating effect model was used to analyze data.</p><p><strong>Results: </strong>The mean score of adherence to health behaviors was 42.58 ± 7.13 and only 27.39% (152/555) of the patients had good adherence. Mindfulness positively predicted adherence to health behaviors (β = 0.13, <i>P</i> < 0.01). Perceived health competence partially mediated the association between mindfulness and adherence to health behaviors, with the mediating effect accounting for 7.00% of the total effect (<i>P</i> = 0.03).</p><p><strong>Conclusion: </strong>The adherence to health behaviors in patients with ACS was very low. Mindfulness positively predicted adherence to health behaviors, and perceived health competence partially mediated the association between mindfulness and adherence to health behaviors. Healthcare providers could intervene patients' mindfulness or perceived health competence to improve adherence to health behaviors.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2203-2215"},"PeriodicalIF":2.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omidubicel for Hematopoietic Cell Transplants: Considerations for Patients and Treatment Outcomes.","authors":"Allison L Morse, Hana Kurz, Donald C Moore","doi":"10.2147/PPA.S419253","DOIUrl":"https://doi.org/10.2147/PPA.S419253","url":null,"abstract":"<p><p>For patients with hematologic malignancies requiring allogeneic stem cell transplantation, alternative donor sources are needed when lacking access to a matched related or unrelated donor. Umbilical cord blood (UCB) has been an important alternative allograft donor source for these patients; however, several limitations exist. Omidubicel is a nicotinamide modified allogeneic hematopoietic progenitor cell therapy derived from UCB. Omidubicel was approved in May 2023 by the United States Food and Drug Administration based on the results of a Phase III trial comparing it to UCB transplantation in patients with high-risk hematologic malignancies. Median time to neutrophil engraftment was faster with omidubicel compared to UCB transplantation (12 days vs 22 days; p<0.001). There was also a lower incidence of grade 2/3 bacterial or invasive fungal infections with omidubicel compared to UCB transplantation (37% vs 57%; p=0.027). From a safety perspective, omidubicel has a boxed warning due to the risk of life-threatening infusion reactions, graft-versus-host disease, graft failure, and engraftment syndrome. Omidubicel represents an important advancement in developing novel alternative allograft donor sources. This also has important implications in ensuring access to alternative donor sources for ethnic and minority populations.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2217-2223"},"PeriodicalIF":2.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Perspectives on and Preferences for an Enhanced Neonatal Jaundice Education Program: An Evaluation Using the Consolidated Framework for Implementation Research.","authors":"Businge Alinaitwe, Faith Sharon Kisakye, Charles Kato, Francis Nkunzimaana, Elizabeth Ayebare, Jameel J Winter, Tom Denis Ngabirano","doi":"10.2147/PPA.S486921","DOIUrl":"10.2147/PPA.S486921","url":null,"abstract":"<p><strong>Introduction: </strong>Neonatal mortality is a major contributor to under-five deaths yet the main causes of these deaths are preventable. Postnatal health education programs can improve timely detection and care seeking for newborn morbidities such as neonatal jaundice (NNJ). Being a common occurrence in low-income countries, it is surprising that women do not have sufficient knowledge about NNJ. Although the knowledge can be improved through routine education programs, healthcare providers rarely engage women in evaluating such programs, which limits their uptake and sustainability.</p><p><strong>Methods: </strong>This was a qualitative study evaluating a postnatal neonatal jaundice health education program conducted at Jinja Regional Referral Hospital (JRRH). Narrative data on the structure, design, and delivery of the program was recorded from 12 postnatal women through unstructured interviews. The participants were those who had taken part in an enhanced NNJ education program. Qualitative content analysis, guided by the Consolidated Framework for Implementation Research (CFIR) was performed.</p><p><strong>Results: </strong>Using the CFIR, two themes were identified; the intervention characteristics domain and the individual domains. The constructs under these domains were intervention design quality and packaging, relative advantage, and maternal knowledge needs. The augmented nature of the intervention, sorting individual needs, ability to promote continuity of care, and care-seeking were identified as key facilitators. Lack of group interaction was identified by some women as a possible barrier.</p><p><strong>Conclusion: </strong>Overall, the education program was positively perceived by women and preferred compared to the conventional method of health education. In low-resource settings where maternal health education can contribute to a reduction in newborn mortality, the design, implementation, and evaluation of maternal education programs should be informed by women's preferences. Healthcare providers should utilize multiple sources of information and routinely practice patient-centered evaluation to meet the changing knowledge demands of postnatal women.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2187-2202"},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient Satisfaction on Non-Pharmacological Interventions for Acute Settings: A Systematic Review.","authors":"Shaherah Yousef Andargeery, Abdullah Ahmed Almalki, Nada Aljohani, Hanan Alyami, Abdulrhman Alhagbani","doi":"10.2147/PPA.S485369","DOIUrl":"10.2147/PPA.S485369","url":null,"abstract":"<p><strong>Background: </strong>Many patients experience stress and dissatisfaction when they are admitted to acute settings, where they receive short-term and active care for severe injuries, illnesses, or surgeries. Patient satisfaction is a key indicator of healthcare quality that affects patient outcomes, service delivery, and safety.</p><p><strong>Objective: </strong>This review aimed at systematically mapping and summarizing the evidence on non-pharmacological interventions that targeted patient satisfaction in inpatient acute settings.</p><p><strong>Methods: </strong>Three electronic databases were searched, including PubMed, EBSCO, and ScienceDirect. The inclusion criteria were: (1) studies of non-pharmacological interventions to improve patients' satisfaction and targeting inpatients between the ages of 19 and 65 years old; (2) studies written in English and published in the last 10 years, starting from 2017. The search results were imported and screened for eligibility on Covidence. The data was then extracted, using a tool entered in Covidence's Extraction 2.0. The extraction tool included domains on both intervention impact and delivery processes.</p><p><strong>Results: </strong>A total of 11 articles met the inclusion criteria. Randomized control trials represented the most among the group; seven studies were included given that the others were quasi-experimental studies. Those studies were conducted on the different types of services offered in acute care departments. These studies did not use a standardized questionnaire to evaluate their respective trial outcomes or to implement various adapted or adopted modules of intervention. Of note, the intervention was effective in enhancing patient satisfaction in only some of the studies.</p><p><strong>Conclusion: </strong>Different types of intervention modules have been effective in improving acute care patient satisfaction. However, further studies are needed to evaluate the effectiveness of an intervention among all patients in different acute care departments at the same time.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2169-2185"},"PeriodicalIF":2.0,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Bispecific T-Cell Engagers for the Treatment of Relapsed B Cell Non-Hodgkin Lymphomas: Current Knowledge and Treatment Considerations.","authors":"Ben Varon, Netanel A Horowitz, Hazim Khatib","doi":"10.2147/PPA.S485838","DOIUrl":"10.2147/PPA.S485838","url":null,"abstract":"<p><p>This article provides an overview of the novel treatments focusing on the class of bispecific T cell engagers (BiTEs) for the treatment of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), the two most prevalent subtypes of B cell non-Hodgkin lymphomas (B-NHL). After a brief outline of these diseases, the difficulties in the management of relapsed or refractory (R/R) disease are highlighted. There are currently 4 main BiTEs showing promise in treating R/R B-NHL-glofitamab, epcoritamab, mosunetuzumab, and odronextamab. Although the rational of their mechanism of action is similar, there are significant differences in their respective clinical trial design, reported outcomes, and the final FDA approvals. Considerations for selecting a specific BiTE therapy, including treatment duration, cost, administration route, adverse effects, and impact on quality of life, are also discussed. Patient preferences and shared decision making should be acknowledged by healthcare providers. Finally, the importance of personalized treatment strategies and ongoing research to optimize outcomes in the evolving landscape of R/R B-NHL therapy cannot be overstated.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2159-2167"},"PeriodicalIF":2.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient, Care Partner, and Physician Voices in Treatment Decision-Making for Multiple Myeloma.","authors":"Lisa Dwyer Orr, Dee Lin, Bingcao Wu, Thomas W LeBlanc, Beth Faiman, Jenny Ahlstrom, Margaret Yung, Kathleen L Deering, Victoria Kulbokas, Joshua L Feldman, Erika Kline, Noa Biran","doi":"10.2147/PPA.S474722","DOIUrl":"https://doi.org/10.2147/PPA.S474722","url":null,"abstract":"<p><strong>Introduction: </strong>Treatment decision-making for multiple myeloma (MM) is complex. Individuals involved in decision-making may value treatment attributes differently based on their role as a patient, care partner, or physician. This study describes those attributes, and what is most important by role.</p><p><strong>Methods: </strong>We conducted a cross-sectional online survey with consenting adult patients with MM, MM care partners, and physicians treating MM. Respondents were recruited from US panels (Inspire and M3 Global Research) between September and December 2022. Survey items were informed by a targeted literature review, qualitative interviews, and a steering committee comprising clinical experts, a patient advocate, patient, and care partner. Descriptive statistics were generated and reported in aggregate.</p><p><strong>Results: </strong>Email invitations were sent to 8071 Inspire members interested in or posting about MM. Of these, 4427 viewed the invitation, 941 responded, and 156 patients and care partners completed the survey (17% of respondents). For physicians, 5588 were invited via Email by M3 Global Research, with 761 viewing the invitation, 214 accessing the survey link, and 137 completing the survey (64% of respondents). Duration of response, side effects, and patients' quality-of-life (QoL) were the top three treatment attributes selected across the three cohorts; alignment of these attributes was consistent among patients regardless of disease severity. Separately, patients rated QoL and the amount of caregiving needed during/after treatment as the most important factors for future treatment decisions. If more effective MM treatments were offered, care partners were more willing to assume greater family burden (77%) compared to patients (49%), and patients were more accepting of potential serious side effects (50%) than were care partners (34%).</p><p><strong>Conclusion: </strong>Patients with MM, care partners, and physicians consider and value various treatment decision-making factors. Recognizing and addressing these differences is critical to meeting patients' preferences, needs, and optimizing patient outcomes.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2147-2158"},"PeriodicalIF":2.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11498144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information-Seeking and Risk Perception to Explain Infection-Prevention Behaviors: Conditional Analysis on Trust in Media and Government as Moderator.","authors":"Myonghwa Park, Keunyeob Oh, Hyungjun Kim, Jongkun Jun, Jooyoung Kim, Thi-Thanh-Tinh Giap, Rhayun Song","doi":"10.2147/PPA.S484216","DOIUrl":"10.2147/PPA.S484216","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore how the relationship between information-seeking and infection-prevention behaviors through risk perception changes according to the level of trust in the media and government.</p><p><strong>Methods: </strong>The study is a secondary data analysis of data from a cross-sectional national survey of 700 adults living in the community, representing different age groups, genders, and geographic regions. A validated questionnaire was used to assess information-seeking behaviors, trust in media and government, and risk perception to explain infection-prevention behaviors in response to the COVID-19 pandemic. A conditional analysis was conducted using SPSS and PROCESS macro (Model 7) to identify the effect of moderated mediation.</p><p><strong>Results: </strong>The participants were fairly balanced by gender and age group. Most participants learned about COVID-19 through major broadcasts and television (56.7%) followed by internet media (21.7%). Information-seeking and risk perception together explained 17% of the variance in infection-prevention behaviors (F=63.95, p<0.01). The standardized indirect effect (β=0.04, BootCI 0.02, 0.06) was significant at 95% CI. The moderated mediation index (M=-0.04, CI -0.05, -0.01) indicates that trust in media and government influences the effect of information-seeking on risk perception and infection-prevention behavior even after controlling for age and gender.</p><p><strong>Conclusion: </strong>Information-seeking behaviors affect infection-prevention behaviors directly and indirectly through risk perception. Trust in media and government modulates this relationship, emphasizing the importance of establishing trust to promote effective risk communication and long-term public compliance with infection-prevention practices. Health authorities should focus on building trust through transparent risk communication and integrating diverse media perspectives. Further research is needed to explore the psychological and social mechanisms underlying trust in media and government through qualitative, cross-cultural comparisons.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2135-2145"},"PeriodicalIF":2.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}