Patient preference and adherence最新文献

{"title":"A Systematic Review of Patient Preferences, Expectations, and Values for the Management and Treatment of Graves Disease.","authors":"Yingjie Chen, Zonghao Ren, Xiujuan Zhou, Peiyang Gao","doi":"10.2147/PPA.S540261","DOIUrl":"10.2147/PPA.S540261","url":null,"abstract":"<p><strong>Objective: </strong>To systematically synthesize evidence on treatment preferences, values, and expectations among patients with Graves' disease (GD), in order to understand the disease's impact on quality of life and inform clinical decision-making..</p><p><strong>Methods: </strong>PubMed, Embase, Web of Science, and Cochrane Library were searched for articles about GD, patient preferences, and expectations from database inception to December 2024. Studies included in the review must report raw data on patient-reported outcomes, preferences or experiences relating to GD, and must undergo quality assessment according to the Agency for Healthcare Research and Quality (AHRQ).</p><p><strong>Results: </strong>Twenty-one studies involving patients with GD were included. Although preferences varied, several trends emerged: 1) Most patients reported that GD significantly disrupted their quality of life and social functioning, with 60% experiencing severe discomfort. 2) Antithyroid drugs (ATD) was the most preferred initial treatment (64%), followed by surgery (25%) and radioactive iodine therapy (RAI) (11%), with concerns about radioactivity and surgical complications influencing decisions. 3) Key factors affecting treatment choices included remission rates, recovery time, impact on daily life, and physician recommendations. 4) Graves' ophthalmopathy (GO) patients faced additional challenges, including social withdrawal and appearance-related distress, with female patients expressing greater concern about disfigurement.</p><p><strong>Conclusion: </strong>This systematic review indicates that GD, particularly GO, significantly impairs patients' self-confidence, quality of life, and social functioning. Treatment choices are influenced by expected outcomes, personal circumstances, psychological concerns, and economic factors. ATD remains the preferred first-line treatment, though individual preferences vary significantly, emphasizing the importance of personalized approaches and decision aids.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2949-2957"},"PeriodicalIF":2.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Importance vs Performance in Dental Care: Exploring Patient Satisfaction Across Age, Gender, and Purchasing Power.","authors":"Reyner Pérez-Campdesuñer, Alexander Sánchez-Rodríguez, Gelmar García-Vidal, Rodobaldo Martínez-Vivar, Margarita De Miguel-Guzmán","doi":"10.2147/PPA.S546628","DOIUrl":"10.2147/PPA.S546628","url":null,"abstract":"<p><strong>Introduction: </strong>Patient satisfaction is a key indicator of healthcare quality, particularly in dental services, where both clinical and non-clinical factors shape perceptions of care. This study aims to investigate the impact of demographic variables-specifically age, gender, and purchasing power-on patient satisfaction with dental services in Quito, Ecuador.</p><p><strong>Methods: </strong>A sample of 485 patients was surveyed using a modified SERVPERF model combined with an attribute matrix. The instrument captured the perceived importance and satisfaction associated with 14 service attributes. Stratified random sampling was applied based on age, gender, and purchasing power. Satisfaction indices were calculated, and differences among groups were analyzed using the chi-square test.</p><p><strong>Results: </strong>Age was the only variable with a statistically significant impact on patient satisfaction (p < 0.05), whereas gender and purchasing power showed no significant differences. Professionalism, quality, and empathy were rated as the most essential attributes across all groups. Interestingly, attributes considered less important-such as waiting time and payment methods-received higher satisfaction scores. The attribute matrix revealed that critical attributes (important but underperforming) differed mainly by age group. The highest satisfaction scores were observed among patients under 25, while the lowest were reported among those aged 40 to 60 and in lower-income groups.</p><p><strong>Discussion: </strong>Findings highlight the relevance of age-sensitive strategies in dental care and underscore a potential misalignment between what patients value most and what they rate most positively. The combined SERVPERF and attribute matrix approach proved effective for generating actionable insights. Further research in diverse contexts is needed to validate these findings.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2933-2947"},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, Validation and Exploration of the Chinese Version of the Health Care Climate Questionnaire Among Hypertensive Patients in Healthcare Settings.","authors":"Wenjing Peng, Ciyu Chen, Juan Wang","doi":"10.2147/PPA.S533784","DOIUrl":"10.2147/PPA.S533784","url":null,"abstract":"<p><strong>Background: </strong>Healthcare providers' autonomy support influences patients' health behaviors. The Health Care Climate Questionnaire (HCCQ) effectively measures perceived autonomy support in healthcare settings, but its Chinese version lacks proper reliability and validity testing, hindering objective evaluations in China.</p><p><strong>Purpose: </strong>This study aimed to cross-culturally adapt and validate the HCCQ for assessing perceived autonomy support among Chinese hypertensive patients.</p><p><strong>Methods: </strong>Following the Brislin translation model, the Chinese version of the HCCQ was adapted. From September 2023 to January 2024, 375 hospitalized hypertensive patients from a Guangzhou tertiary hospital completed the adapted questionnaire. Exploratory (EFA) and confirmatory factor analysis (CFA) were used to test the structural validity; internal consistency and item-total correlations were used to assess reliability.</p><p><strong>Results: </strong>After excluding invalid questionnaires, this study finally analyzed data from 357 patients (with 105 cases used for EFA in the first stage and 252 cases used for CFA in the second stage). Consistent with the original questionnaire, the Chinese version of the HCCQ contains a total of 15 items and extracts one common factor, which explains 66.019% of the variance. According to the CFA results, the fitted model meets each goodness-of-fit index. The Cronbach's α coefficient of the Chinese version of the HCCQ is 0.961.</p><p><strong>Conclusion: </strong>Within the scope of this study, the Chinese version of the HCCQ demonstrates good validity and reliability in measuring the perceived autonomy support of hypertensive patients in healthcare settings, which can provide some reference for related research. To a certain extent, the Chinese version of the HCCQ can assist health professionals in assessing and guiding patients' perceived autonomy support.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2919-2932"},"PeriodicalIF":2.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity Medication Treatment Perspectives Among People with Overweight or Obesity.","authors":"John W Ostrominski, Anindit Chhibber, Effie L Kuti, Brendan Clark, Bonnie M K Donato","doi":"10.2147/PPA.S555622","DOIUrl":"10.2147/PPA.S555622","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Obesity is a complex, chronic condition associated with multiple health complications. While obesity medications (OMs), particularly GLP-1 receptor agonists (GLP-1RAs), have demonstrated significant clinical benefits, real-world insights into patient experiences with these therapies remain limited. This study evaluated patients' behaviors and experiences with OMs, including their financial impact; and aimed to identify key decision points for seeking and receiving treatment with OMs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Individuals were recruited from a national database to complete a 20-minute online survey between July 8 and July 18, 2024. Eligible participants were adults aged 21 years or older with a body mass index (BMI) of ≥30 kg/m&lt;sup&gt;2&lt;/sup&gt;, or ≥27 kg/m&lt;sup&gt;2&lt;/sup&gt; with at least one obesity-related complication (ORC) and were currently using an OM. Participants reported their experiences with OMs, motivations and barriers for treatment, challenges, interactions with HCPs and financial challenges with OMs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;100 people with obesity (PwO) participated in the survey. The median age of the respondents was 46 years. Most PwO (94%) had at least one comorbidity in addition to overweight/obesity, and 58% were more concerned about obesity compared with other health conditions. Most PwO (91%) were currently using GLP-1RAs and had previously attempted a median of 3 unique weight management strategies prior to OM initiation. Primary drivers for OM initiation were long-term health improvement (58%) and functional enhancement (53%). Major barriers included insurance restrictions (38%), concerns about side effects (37%), and cost (31%). While on OMs, most (88%) PwO reported a positive experience, citing significant benefits on body weight and appetite reduction; 9% were neutral and 3% reported a negative experience. Participants with longer durations of reported treatment more often reported positive experiences (79% among those with ≥6 months of therapy; 51% among those with &lt;6 months of therapy). The study also found that 56% of PwO expected to be on their current OM for a limited period, with 20% anticipating less than a year and 28% anticipating less than two years. The anticipated treatment duration among PwO varied with reported out-of-pocket (OOP) costs. Communication with HCPs frequently addressed side effects and administration, but discussions about treatment duration and lifestyle integration were less consistent.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study highlights the multifaceted experiences of PwO in managing obesity, particularly regarding OM use. The findings underscore the importance of early intervention, robust patient-provider communication, equitable access, and financial support to optimize treatment outcomes. Addressing systemic barriers, stigma, education, and access challenges will be essential to maximize the utility of obesity pharmacotherapy in clinical practice.&lt;","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2887-2899"},"PeriodicalIF":2.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticipations and Requirements of Individuals with Long-Term Health Conditions Regarding Self-Management and Digital Health Support Tools.","authors":"Tourkiah Alessa","doi":"10.2147/PPA.S545496","DOIUrl":"10.2147/PPA.S545496","url":null,"abstract":"<p><strong>Background and objectives: </strong>This research examines the individuals with chronic health conditions who desire self-management support, exploring their views towards digital health for self-management purposes.</p><p><strong>Materials and methods: </strong>The researchers conducted an exploratory qualitative investigation through eight focus groups, allocating two groups to each condition: diabetes (groups of seven and six participants), hypertension (groups of six and six), chronic obstructive pulmonary disease (COPD) (groups of six and five), and cardiovascular conditions (groups of five and five). The discussion focused on three areas: 1) how chronic illness affects everyday living; 2) viewpoints and requirements regarding self-management; and 3) expectations, needs, and readiness to use digital health (eHealth) for self-management. The research employed a content-based analytical approach.</p><p><strong>Results: </strong>The patient groups showed different expectations and needs regarding eHealth and self-management. The diabetes and hypertension groups reported the most needs and perceived benefits, while COPD came next in terms of willingness to use eHealth for self-management. In contrast, cardiovascular patients indicated fewer requirements for self-management support as their condition had a minimal effect on their daily activities. Across all groups, patients favored having the choice to utilize eHealth tools rather than healthcare professionals mandating their use despite the Saudi healthcare system's directive nature. Some participants also saw potential for AI to support self-management, particularly through features like early warnings. Participants believed that eHealth should be enhanced rather than substituted for personal health care, with numerous individuals expressing anxiety about conducting self-measurements and uncertainty regarding appropriate responses to abnormal readings.</p><p><strong>Conclusion: </strong>This study revealed differences in requirements and expectations among patient groups regarding self-management and indicates that aspects of eHealth and its implementation should be tailored to individual patients. The anticipated benefits of eHealth to support self-management and perceived disease controllability appeared to significantly influence patients' willingness to adopt eHealth for self-management purposes.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2901-2918"},"PeriodicalIF":2.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Health Education Checklist for Healthcare Professionals to Ensure Treatment Adherence of Newly Diagnosed Young People Living with HIV: A Delphi Study.","authors":"Meishan Chen, Yi Wang, Liwen Jiang, Tingting Chen, Xiaoyu Song, Min Tian, Yanhua Chen, Jian Tang","doi":"10.2147/PPA.S543312","DOIUrl":"10.2147/PPA.S543312","url":null,"abstract":"<p><strong>Background: </strong>Young people living with HIV (YLWH) are a key population in global HIV prevention and control. YLWH often shows poor adherence to antiretroviral therapy (ART), with poor medication adherence, delayed initiation and frequent treatment interruption. This study aimed to develop a theory-based health education checklist to support ART adherence among newly diagnosed YLWH.</p><p><strong>Methods: </strong>An initial pool of 41 items was generated through a literature review and the Protection Motivation Theory (PMT) framework, covering ART knowledge, coping strategies, psychosocial support, and behavioral skills. A structured health education checklist was then designed and refined through expert panel discussions and the Delphi method. Between November 2024 and January 2025, 17 experts from seven provinces in China participated in a two-round Delphi consultation. Experts assessed and revised the scientific rigor, importance, and feasibility of the proposed checklist. The expert authority coefficient and Kendall's coefficient of concordance were calculated to evaluate the consistency of expert opinions, leading to the development of a standardized checklist.</p><p><strong>Results: </strong>The final checklist comprises 5 primary indicators, 10 secondary indicators, and 32 tertiary indicators. The expert authority coefficients for the two Delphi rounds were 0.867 and 0.905, respectively, the Kendall's coefficients of concordance were 0.621 and 0.716 (<i>P</i> < 0.001). The expert participation rates were 100% in the first round and 94.12% in the second round.</p><p><strong>Conclusion: </strong>The health education checklist developed in this study demonstrates high scientific rigor and feasibility. It provides healthcare professionals with a structured tool to guide health education, which may support both short-term and long-term ART adherence among YLWH.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2873-2885"},"PeriodicalIF":2.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Heart Disease Patients' Knowledge, Attitudes, and Practices Regarding Coronary Artery Bypass Grafting.","authors":"Wentong Dong, Bin Yang, Xianjie Li, Runsheng Zhang, Qiankun Chen, Wenhao Peng, Zhengyu Li, Feilong Zeng, Tinghua Li, Siming Zhu","doi":"10.2147/PPA.S548589","DOIUrl":"10.2147/PPA.S548589","url":null,"abstract":"<p><strong>Background: </strong>Coronary heart disease (CHD) is a leading cause of mortality worldwide. Coronary artery bypass grafting (CABG) is a recognized effective treatment, particularly for patients with complex multivessel disease. However, there is limited research on the knowledge, attitudes, and practices (KAP) of CHD patients toward this surgery.</p><p><strong>Aim: </strong>This study aimed to investigate the KAP of CHD patients regarding CABG.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from September 13, 2023 to January 25, 2024 at the Cardiology and Cardiothoracic Surgery Departments of Zhengzhou Seventh People's Hospital through the dissemination of a self-designed KAP questionnaire, which demonstrated good internal consistency with a Cronbach's α coefficient of 0.921 in the pilot test.</p><p><strong>Results: </strong>A total of 427 participants (mean age 58.05 ± 13.2 years; 62.53% male) were enrolled. Among them, 151 (35.36%) had undergone or are scheduled for CABG. The mean knowledge, attitude, and practice scores were 6.03±2.16, 43.03±6.61, and 37.7±5.51, respectively. Participants with CABG experience or plans exhibited significantly higher attitude and knowledge scores compared to those without. Correlation analyses showed that there were significant positive correlations between knowledge and attitude (r = 0.128, P = 0.008) as well as practice (r = 0.202, P < 0.001). Also, there was a correlation between attitude and practice (r = 0.654, P < 0.001). Multivariate analyses showed that attitude score (OR = 1.294, 95% CI: [1.226-1.367], P < 0.001), marital status other than married (OR = 2.32, 95% CI: [1.048-5.136], P = 0.038) were independently associated with proactive practice.</p><p><strong>Conclusion: </strong>CHD patients exhibited insufficient knowledge, positive attitudes and proactive practices regarding CABG. Healthcare professionals should prioritize patient education initiatives aimed at enhancing knowledge regarding CABG, while also reinforcing and leveraging positive attitudes and proactive behaviors to optimize patient outcomes and treatment adherence.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2861-2871"},"PeriodicalIF":2.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constrained by Instruments: How Quantitative Screening May Limit Exploration of Diabetic Patients' Lived Fear Experiences of Complications [Letter].","authors":"Fei-Yi Zhao, Qiang-Qiang Fu, Chin Moi Chow","doi":"10.2147/PPA.S563702","DOIUrl":"10.2147/PPA.S563702","url":null,"abstract":"","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2817-2820"},"PeriodicalIF":2.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation Of The Asthma Self-Management Questionnaire For The Brazilian Population.","authors":"Lenice Daiane da Costa Lopes, Maria Luíza de Araújo Teixeira, Layane Priscila Costa da Silva, Jose Alexandre Barbosa Almeida, Lucien Peroni Gualdi","doi":"10.2147/PPA.S502613","DOIUrl":"10.2147/PPA.S502613","url":null,"abstract":"<p><strong>Introduction: </strong>The lack of instruments to assess asthma self-management in Brazil highlights the need to develop specific tools to help patients manage their own health condition.</p><p><strong>Objective: </strong>The study aimed to translate, cross-culturally adapt, and evaluate the psychometric properties of the Asthma Self-Management Questionnaire (ASMQ) for the Brazilian adult population diagnosed with asthma.</p><p><strong>Materials and methods: </strong>This is a methodological, exploratory, and descriptive study approved by the Research Ethics Committee (CEP) of the Federal University of Rio Grande do Norte (UFRN) under opinion number 6.062.022. The study followed international guidelines to design and execute six stages: translation, synthesis of translations, back-translation, synthesis of back-translations, Multidisciplinary Committee of Experts, and pre-testing. For the translation phase, five judges participated using the Delphi Technique through the Multidisciplinary Committee of Experts. For the cross-cultural adaptation, a pre-test phase was conducted using a questionnaire applied to individuals who met the eligibility criteria. Data analysis was performed using SPSS statistical software, version 22.0, with a significance level of 5%.</p><p><strong>Results: </strong>The translation and cross-cultural adaptation of the ASMQ-Brazil to Brazilian Portuguese were completed. The results of this study demonstrated a Content Validity Index (CVI) greater than 0.80 for all items in the instrument. The ASMQ-Brazil is presented as a valid and reliable health measurement instrument for assessing asthma self-management in the Brazilian adult population.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2847-2859"},"PeriodicalIF":2.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Adherence in Parkinson's Disease: Longitudinal Changes and the Influence of Depressive Symptoms.","authors":"Konstantin G Heimrich, Aline Schönenberg, Gabriele Helga Franke, Tino Prell","doi":"10.2147/PPA.S529538","DOIUrl":"10.2147/PPA.S529538","url":null,"abstract":"<p><strong>Purpose: </strong>Parkinson's disease (PD) is a progressive neurodegenerative disease. As the disease progresses, medication regimens become increasingly complex. The long-term success of PD pharmacotherapy is highly dependent on patient adherence to the prescribed medication regimen. The aim of this study is to investigate how intentional and unintentional non-adherence evolves over time and to identify PD-related factors that influence these longitudinal changes. These findings may be crucial in developing targeted interventions to improve adherence, particularly in patients who have difficulties with intentional or unintentional non-adherence.</p><p><strong>Patients and methods: </strong>The sample consisted of 91 people with PD who were initially treated as part of the PD multimodal complex treatment at the Department of Neurology, Jena University Hospital, Germany. They were followed up three and six months after discharge. Medication adherence was assessed using the Stendal Adherence to Medication Score (SAMS) and its three subscores for forgetfulness, knowledge, and modification. Statistical analyses included Wilcoxon signed rank test, Friedman test, and generalized estimating equations to determine longitudinal changes in non-adherence and the influence of PD-related variables.</p><p><strong>Results: </strong>Analysis of SAMS subscores showed improvement over time in modification and knowledge, whereas forgetfulness did not show significant change. Modification was significantly associated with depressive symptoms.</p><p><strong>Conclusion: </strong>Medication adherence in PD is a dynamic process and changes over time. The findings suggest that while educational interventions are effective in improving knowledge and reducing intentional non-adherence, addressing depressive symptoms and cognitive impairment is critical to improving overall adherence. Future research should continue to explore the factors that influence adherence behaviors and develop targeted strategies to help people with PD maintain adherence throughout the course of their disease.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2835-2845"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}