Liqing Liang, Xiaomin Zhang, Yinghua Pan, Lei Huang, Lei Jia, Peijun Xu, Kun Li
{"title":"基于社会认知理论的类风湿关节炎患者药物依从性影响因素的通径分析","authors":"Liqing Liang, Xiaomin Zhang, Yinghua Pan, Lei Huang, Lei Jia, Peijun Xu, Kun Li","doi":"10.2147/PPA.S529952","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that poor medication adherence is common in patients with rheumatoid arthritis (RA). However, the related factors and underlying mechanisms remain unclear. Through theory-based research, the mechanism of medication adherence in RA patients can be better explored and clarified, providing reference for clinical intervention.</p><p><strong>Aim: </strong>To explore the mediating role of medication self-efficacy between perceived barriers, pharmacologic treatment expectations, social support and medication adherence in patients with RA based on the social cognitive theory.</p><p><strong>Methods: </strong>A total of 232 participants diagnosed with RA were recruited from three general hospitals in Guangzhou, China. Participants' sociodemographic, disease-, and medication-related information as well as data on their perceived barriers, pharmacologic treatment expectations, social support, medication self-efficacy, and adherence were collected. SPSS 25.0 software was used for univariate analysis of medication adherence and to explore the correlation between variables. Mplus 8.0 was used to build a parallel mediation model and perform path analysis.</p><p><strong>Results: </strong>In addition to pharmacologic treatment expectations, perceived barriers, family support, and medication self-efficacy were associated with medication adherence. A mediating model with three independent variables showed that medication self-efficacy fully mediated the negative impact of perceived barriers on medication adherence. Family support had a positive effect on both medication adherence and self-efficacy, but it did not affect medication adherence through medication self-efficacy.</p><p><strong>Conclusion: </strong>Medication self-efficacy, as a mediating factor, plays a key role in improving medication adherence of RA patients. In nursing practice, timely assessment of the actual or potential barriers on medication adherence of patients and implementation of targeted intervention measures such as health education, as well as giving full play to the positive role of the family support system to improve patients' medication self-efficacy, will effectively enhance the medication adherence of patients with RA.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"19 ","pages":"2565-2575"},"PeriodicalIF":2.0000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375331/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exploring the Factors Related to Medication Adherence in Patients with Rheumatoid Arthritis Based on Social Cognitive Theory: A Path Analysis.\",\"authors\":\"Liqing Liang, Xiaomin Zhang, Yinghua Pan, Lei Huang, Lei Jia, Peijun Xu, Kun Li\",\"doi\":\"10.2147/PPA.S529952\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Studies have shown that poor medication adherence is common in patients with rheumatoid arthritis (RA). However, the related factors and underlying mechanisms remain unclear. Through theory-based research, the mechanism of medication adherence in RA patients can be better explored and clarified, providing reference for clinical intervention.</p><p><strong>Aim: </strong>To explore the mediating role of medication self-efficacy between perceived barriers, pharmacologic treatment expectations, social support and medication adherence in patients with RA based on the social cognitive theory.</p><p><strong>Methods: </strong>A total of 232 participants diagnosed with RA were recruited from three general hospitals in Guangzhou, China. Participants' sociodemographic, disease-, and medication-related information as well as data on their perceived barriers, pharmacologic treatment expectations, social support, medication self-efficacy, and adherence were collected. SPSS 25.0 software was used for univariate analysis of medication adherence and to explore the correlation between variables. Mplus 8.0 was used to build a parallel mediation model and perform path analysis.</p><p><strong>Results: </strong>In addition to pharmacologic treatment expectations, perceived barriers, family support, and medication self-efficacy were associated with medication adherence. A mediating model with three independent variables showed that medication self-efficacy fully mediated the negative impact of perceived barriers on medication adherence. Family support had a positive effect on both medication adherence and self-efficacy, but it did not affect medication adherence through medication self-efficacy.</p><p><strong>Conclusion: </strong>Medication self-efficacy, as a mediating factor, plays a key role in improving medication adherence of RA patients. In nursing practice, timely assessment of the actual or potential barriers on medication adherence of patients and implementation of targeted intervention measures such as health education, as well as giving full play to the positive role of the family support system to improve patients' medication self-efficacy, will effectively enhance the medication adherence of patients with RA.</p>\",\"PeriodicalId\":19972,\"journal\":{\"name\":\"Patient preference and adherence\",\"volume\":\"19 \",\"pages\":\"2565-2575\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375331/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Patient preference and adherence\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/PPA.S529952\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Patient preference and adherence","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/PPA.S529952","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Exploring the Factors Related to Medication Adherence in Patients with Rheumatoid Arthritis Based on Social Cognitive Theory: A Path Analysis.
Background: Studies have shown that poor medication adherence is common in patients with rheumatoid arthritis (RA). However, the related factors and underlying mechanisms remain unclear. Through theory-based research, the mechanism of medication adherence in RA patients can be better explored and clarified, providing reference for clinical intervention.
Aim: To explore the mediating role of medication self-efficacy between perceived barriers, pharmacologic treatment expectations, social support and medication adherence in patients with RA based on the social cognitive theory.
Methods: A total of 232 participants diagnosed with RA were recruited from three general hospitals in Guangzhou, China. Participants' sociodemographic, disease-, and medication-related information as well as data on their perceived barriers, pharmacologic treatment expectations, social support, medication self-efficacy, and adherence were collected. SPSS 25.0 software was used for univariate analysis of medication adherence and to explore the correlation between variables. Mplus 8.0 was used to build a parallel mediation model and perform path analysis.
Results: In addition to pharmacologic treatment expectations, perceived barriers, family support, and medication self-efficacy were associated with medication adherence. A mediating model with three independent variables showed that medication self-efficacy fully mediated the negative impact of perceived barriers on medication adherence. Family support had a positive effect on both medication adherence and self-efficacy, but it did not affect medication adherence through medication self-efficacy.
Conclusion: Medication self-efficacy, as a mediating factor, plays a key role in improving medication adherence of RA patients. In nursing practice, timely assessment of the actual or potential barriers on medication adherence of patients and implementation of targeted intervention measures such as health education, as well as giving full play to the positive role of the family support system to improve patients' medication self-efficacy, will effectively enhance the medication adherence of patients with RA.
期刊介绍：
Patient Preference and Adherence is an international, peer reviewed, open access journal that focuses on the growing importance of patient preference and adherence throughout the therapeutic continuum. The journal is characterized by the rapid reporting of reviews, original research, modeling and clinical studies across all therapeutic areas. Patient satisfaction, acceptability, quality of life, compliance, persistence and their role in developing new therapeutic modalities and compounds to optimize clinical outcomes for existing disease states are major areas of interest for the journal.
As of 1st April 2019, Patient Preference and Adherence will no longer consider meta-analyses for publication.
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