Pakistan journal of pharmaceutical sciences最新文献_第6页

The composition of chemicals and anti-osteogenic properties in the volatile extracts from Homalomena gigantea rhizome. 千层塔根茎挥发性提取物中的化学成分和抗骨质生成特性。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-01-01

Pham Thanh, Viet Ty Pham, Thi Quynh Trang Nguyen, Van Giang Tran, Ty Nguyen, Thi Quynh Nguyen

{"title":"The composition of chemicals and anti-osteogenic properties in the volatile extracts from Homalomena gigantea rhizome.","authors":"Pham Thanh, Viet Ty Pham, Thi Quynh Trang Nguyen, Van Giang Tran, Ty Nguyen, Thi Quynh Nguyen","doi":"","DOIUrl":"","url":null,"abstract":"In this study, the anti-osteogenic properties of the volatile oil extracted from Homalomena gigantea rhizome using ethyl acetate (EtOAc) and methanol (MeOH) were examined. Gas chromatography-mass spectrometry (GC-MS) was employed for the identification of volatile components. Following this, bioassays were performed to evaluate their effects on osteogenesis, encompassing parameters like cell viability, osteoblast differentiation, collagen synthesis and mineralization. The GC-MS analysis revealed 19 compounds in the EtOAc extract and 36 compounds in the MeOH extract. In the MeOH extract, major constituents included bis(2-ethylhexyl) terephthalate (13.83%), linalool (9.58%), palmitic acid (6.55%) and stearic acid (4.29%). The EtOAc extract contained bis(2-ethylhexyl) terephthalate (16.64%), palmitic acid (5.60%) and stearic acid (3.11%) as the predominant components. Both the EtOAc and MeOH extracts of H. gigantea exhibited promising potential for further investigation in anti-osteoporosis research. These findings contribute to the exploration of natural compounds with potential anti-osteoporotic properties, expanding our understanding of their therapeutic potential.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioural impacts of following administration of Ficus carica leaves extract in animal model of acute and chronic unpredictable mild stressed exposed rats. 在急性和慢性不可预知的轻度应激暴露大鼠动物模型中服用薜荔叶提取物后对行为的影响。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-01-01

Saima Khaliq, Maria Arshad, Tabinda Ruby, Muhammad Farhan, Wajahat Nadeem

{"title":"Behavioural impacts of following administration of Ficus carica leaves extract in animal model of acute and chronic unpredictable mild stressed exposed rats.","authors":"Saima Khaliq, Maria Arshad, Tabinda Ruby, Muhammad Farhan, Wajahat Nadeem","doi":"","DOIUrl":"","url":null,"abstract":"Stress is described as a noxious stimulus that affects the health of an individual and alters body homeostasis resulting in changes the individual behavioural and metabolic condition. Synthesis of drug from plants has main interest due the significant medicinal values. The recent investigation was designed to examine the pharmacological impacts of Ficus carica leaves extract on stress. In this experiment, the rodents were randomly distributed as (n=6) control rats were kept at standard condition, second group of rats were exposed with different stressors and Third group of rodents was exposed to stress and treated with extract of ficus carica leaves at the dose of 100 mg/kg. Acute behavioural alteration was observed after 7 days and prolonged impact was monitored after the 28 days. The current finding showed that administration of Ficus carica leaves extract produced anxiolytic behaviours and decreased depression like symptoms in CUMS treated rats. It also increased stimulatory, ambulatory, locomotor activity and enhanced spatial working memory and recognition memory in CUMS exposed rats. So, it can be concluded from recent study that leaves of Ficus carica can be utilized as secure drug for curing physiological stress with less side effect profile.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binary and ternary complex formation and characterization of artemisinin with sulfobutyl ether β-cyclodextrin and oleic acid. 青蒿素与磺丁基醚 β-环糊精和油酸形成的二元和三元复合物及其特征。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-01-01

Muhammad Yousaf Shahzad, Muhammad Abbas, Muhammad Tayyab Ansari, Mudassar Abbas

{"title":"Binary and ternary complex formation and characterization of artemisinin with sulfobutyl ether β-cyclodextrin and oleic acid.","authors":"Muhammad Yousaf Shahzad, Muhammad Abbas, Muhammad Tayyab Ansari, Mudassar Abbas","doi":"","DOIUrl":"","url":null,"abstract":"Drug-resistant malaria is a global risk to the modern world. Artremisinin (ART) is one of the drugs of choice against drug-resistant (malaria) which is practically insoluble in water. The objective of our study was to improve the solubility of artemisinin (ART) via development of binary complexes of ART with sulfobutylether β-cyclodextrins (SBE7 β-CD), sulfobutylether β-cyclodextrins (SBE7 β-CD) and oleic acid (ternary complexes). These are prepared in various drugs to excipients ratios by physical mixing (PM) and solvent evaporation (SE) methods. Characterizations were achieved by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and attenuated total reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy. The aqueous-solubility in binary complexes was 12-folds enhanced than ternary complexes. Dissolution of binary and ternary complexes of artemisinin in simulated gastric fluid (pH 1.6) was found highest and 35 times higher for ternary SECx. The crystallinity of artemisinin was decreased in physical mixtures (PMs) while SECx exhibited displaced angles. The attenuated-intensity of SECx showed least peak numbers with more displaced-angles. SEM images of PMs and SECx showed reduced particle size in binary and ternary systems as compared to pure drug-particles. ATR-FTIR spectra of binary and ternary complexes revealed bonding interactions among artemisinin, SBE7 β-CD and oleic acid.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation of sumatriptan succinate orodispersible tablets using chitosan and sodium starch glycolate for immediate migraine relief. 使用壳聚糖和淀粉乙醇酸钠配制琥珀酸舒马曲坦口崩片剂，用于立即缓解偏头痛。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-01-01

Tuba Sahar, Syed Muhammad Farid Hasan, Salman Ashfaq Ahmad, Rabia Bushra, Abdur Rehman, Rabia Noor, Shahnaz Usman, Nighat Razvi, Fouzia Hassan

{"title":"Formulation of sumatriptan succinate orodispersible tablets using chitosan and sodium starch glycolate for immediate migraine relief.","authors":"Tuba Sahar, Syed Muhammad Farid Hasan, Salman Ashfaq Ahmad, Rabia Bushra, Abdur Rehman, Rabia Noor, Shahnaz Usman, Nighat Razvi, Fouzia Hassan","doi":"","DOIUrl":"","url":null,"abstract":"Migraine is one of the common neurological disease affecting around 23% of the Pakistani population. Prompt treatment is required to regain the functional ability of patients. The present study was designed to develop sumatriptan succinate orodispersible tablets that would quickly overcome acute migraine episodes using 22 full-factorial design. The chitosan and sodium starch glycolate were taken as independent variables; friability, disintegration, dispersion time and water absorption ratio as response variables. Eight trial formulations were generated by Design Expert® software. The main effect plots were used to check the interaction of formulations with response variables. All trial formulations showed good micromeritic properties in terms of angle of repose (19.59o-24.57°), Carr's index (17.08-24.90%) and Hausner's ratio (1.20-1.33). The tablets wetted quickly (17.1- 39 sec) in dispersion medium, showed higher water absorption ratio (188-341 sec) and disintegrated quickly (13-20 sec) with an excellent dissolution rate (94-99%). The main effect plots show interactions between the independent variables against most of the study responses. A 22 full-factorial model was found to be effective in studying the influence of formulation variables on response parameters. Both chitosan and sodium starch glycolate can be used in combination to fabricate an effective orodispersible formulation of sumatriptan succinate.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Cucumis melo and Citrullus lanatus extracts on glucose level, lipid profile and hepato-renal performance of streptozotocin-induced diabetic albino rats. 甜瓜和南瓜提取物对链脲佐菌素诱导的糖尿病白化大鼠血糖水平、血脂状况和肝肾功能的影响

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-01-01

Arifa Mehreen, Muhammad Anwar Iqbal, Zunaira Ashfaq, Rida Anwar, Mahwish Mahmood, Faisal Jameel, Muhammad Awais Khan

{"title":"Effects of Cucumis melo and Citrullus lanatus extracts on glucose level, lipid profile and hepato-renal performance of streptozotocin-induced diabetic albino rats.","authors":"Arifa Mehreen, Muhammad Anwar Iqbal, Zunaira Ashfaq, Rida Anwar, Mahwish Mahmood, Faisal Jameel, Muhammad Awais Khan","doi":"","DOIUrl":"","url":null,"abstract":"Diabetes mellitus, recognized by elevated glucose level in the body fluids is commonly caused by less insulin production or its action. To overcome the complications of diabetes, chemical drugs are never preferred over herbal medicines. Present study was designed to find out the anti-diabetic and health-promoting effects of ethanolic leaf extracts of Cucumis melo and Citrullus lanatus in induced-diabetic albino rats. Thirty male albino rats were bought from the animal house of the university and divided randomly into five feeding groups (n=6). Diabetes was induced in rats of groups A, B, C & D by a single dose of intra-peritoneal injection of streptozotocin (55 mg/Kg), whereas, the rats of group E were considered as control. The rats of groups A, B & C were fed basal diet supplemented with plant extracts (150mg/Kg body weight), whereas; only basal diet was offered to rats of groups D & E. After 28 days of the experiment, blood was collected for biochemical analysis. Results revealed that body weight, glucose, AST, ALB, GGT, HDL, cholesterol, triglyceride, urea and creatinine level differed significantly among treatment groups. It was therefore concluded that ethanolic leaf extracts of Cucumis melo and Citrullus lanatus can be used separately or in combination for the management of diabetes.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antileishmaniasis effects of monoherbal skin ointment made from bark and leaf of Holoptelea integrifolia (Roxb.) Planch. in patients of cutaneous leishmaniasis. 用Holoptelea integrifolia (Roxb.) Planch.的树皮和叶子制成的单草本皮肤软膏对皮肤利什曼病患者的抗利什曼病效果。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-11-01

Darshna Kumari, Ghazala H Rizwani, Bushra Hina, Ishrat Younus, Maryam Ahmed, Huma Shareef

{"title":"Antileishmaniasis effects of monoherbal skin ointment made from bark and leaf of Holoptelea integrifolia (Roxb.) Planch. in patients of cutaneous leishmaniasis.","authors":"Darshna Kumari, Ghazala H Rizwani, Bushra Hina, Ishrat Younus, Maryam Ahmed, Huma Shareef","doi":"","DOIUrl":"","url":null,"abstract":"Prevalence of parasitic skin diseases, cutaneous leishmaniasis is very frequent in Pakistan, especially in Baluchistan where occurrence of phelbotomine sand flies (vector of protozoan parasite of genus Leishmania) is very common. This study was conducted to assess the antileishmaniasis activity of Intericutol plus ointment (2% and 3%) made with ethanolic extract of bark and leaves of Holoptelea integrifolia (Roxb.)Planch. The antileishmaniasis effect was observed by applying the ointments on the lesions of leishmaniasis patients. 150 patients were included in the study that had single and multiple painful wet and dry ulcerative lesions on the exposed area of the body. The patients were divided into two groups of 75 patients each, applying 2% and 3% ointment respectively for 28 days. Dose of 10gm/week was applied topically on wounds. Excellent antileishmaniasis effect was observed with significant quick healing properties in the patients receiving 3% Intericutol plus ointment as compare to 2% showing 89% and 81% cure (p=0.02) respectively. It can be concluded that ointment made from medicinal plant proved to be very effective in treating cutaneous Leishmaniasis.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of plasmid-mediated quinolone resistance and 16S rRNA methylase genes among Escherichia coli clinical isolates in a hospital in Saudi Arabia. 沙特阿拉伯一家医院临床分离的大肠埃希菌中质粒介导的喹诺酮耐药性和 16S rRNA 甲基化酶基因的流行情况。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-11-01

Mutasim E Ibrahim

{"title":"Prevalence of plasmid-mediated quinolone resistance and 16S rRNA methylase genes among Escherichia coli clinical isolates in a hospital in Saudi Arabia.","authors":"Mutasim E Ibrahim","doi":"","DOIUrl":"","url":null,"abstract":"The plasmid-mediated quinolone resistance (PMQR) and 16S ribosomal RNA (rRNA) methylase genes can lead to high-level bacterial resistance to various antibiotics, including quinolones and aminoglycosides. This study determined the prevalence of PMQR and 16S rRNA methylase determinants in clinical Escherichia coli. Non-duplicate E. coli resistant to quinolones (nalidixic acid, ciprofloxacin, or norfloxacin) and/or aminoglycosides (amikacin or gentamicin) were collected from patients at King Abdullah Hospital, Bisha, Saudi Arabia. A multiplex PCR was performed to identify the targeted genes. Out of 107 screened isolates, 44 (41%) were found to carry resistance genes, individually or in combination, including 41 PMQR and 14 16S rRNA methylase. The qnrS gene had the highest prevalence (23.4%) among PMQR, followed by aac(6')-Ib (16.8%). Of the 14 identified 16S rRNA methylase, 8 were rmtB and 6 were armA. Out of 44 positive isolates, 72.7% carried only one resistance gene, 25% had co-existing resistance genes, with qnrS and rmtB or aac(6)-Ib and armA being the most common pairs. A single isolate was carried three genes (qnrS, aac(6')-Ib and rmtB). As antibiotic resistance continues to become more prevalent, there is a need for extensive research to identify the genetic determinants of resistance and to develop new antibiotic therapies.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical analysis and antihyperglycemic activity of Carissa grandiflora leaves extract on streptozotocin-induced diabetic mice. 对链脲佐菌素诱导的糖尿病小鼠进行的植物化学分析和大叶鸢尾叶提取物的降血糖活性。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-11-01

Imran Waheed, Sayyeda Saba, Khurram Aamir, - Maria, Madiha Javaid, Hira Ijaz, Farooq Saleem, Sulaman Yaqub

{"title":"Phytochemical analysis and antihyperglycemic activity of Carissa grandiflora leaves extract on streptozotocin-induced diabetic mice.","authors":"Imran Waheed, Sayyeda Saba, Khurram Aamir, - Maria, Madiha Javaid, Hira Ijaz, Farooq Saleem, Sulaman Yaqub","doi":"","DOIUrl":"","url":null,"abstract":"Diabetes mellitus (DM), a prevalent metabolic condition that impairs glucose metabolism, causes morbidity and hospitalization. Thus, there is need to establish novel therapeutics against DM. The current study examined the phytochemical analysis and antidiabetic effects of Carissa grandiflora leave extracts (CGLE) on streptozotocin (STZ)-induced DM in mice. CGLE (n-hexane, chloroform, ethanol) was extracted and phytochemically examined for primary and secondary metabolites. Fourier transformed infrared spectroscopy (FTIR) detected functional groups, while 2,2-diphenyl-1-picrylhydrazyl (DPPH) test assessed antioxidant capacity. Later, antidiabetic potential of CGLE extract was investigated in vivo in STZ induced diabetic mice. Phytochemical investigation revealed sugars, ketones, alkaloids, triterpenoids, and glycosides. FTIR indicated phenol, aldehyde, ketone, alkene, alkyne, alcohol, benzene ring and amines, while DPPH assay demonstrated antioxidant potential of extract. Oral CGLE treatment significantly improved body weight (P<0.05), polyphagia and polydipsia (P<0.05) and FBG (P<0.001). Moreover, CGLE extract reversed histopathological alterations in the pancreas, liver, and kidney of diabetic mice. These outcomes highlighted that C. grandiflora extract could be effective therapeutic approach against DM.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of ritonavir on the pharmacokinetics of clonidine in vivo and in vitro. 利托那韦对体内和体外氯尼定药代动力学的影响。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-11-01

Peng Wang, Xiaoxia Hu

{"title":"The effect of ritonavir on the pharmacokinetics of clonidine in vivo and in vitro.","authors":"Peng Wang, Xiaoxia Hu","doi":"","DOIUrl":"","url":null,"abstract":"This project aims to explore the repercussions of ritonavir on both the drug kinetics of clonidine in rats and clonidine metabolism in liver micro somes. Eighteen healthy male laboratory rats were haphazardly placed into groups: Group A, the control, Group B, got 20mg/kg ritonavir and Group C, got 180 mg/kg ritonavir. Ritonavir was administered to the rats by oral gavage and 30 minutes later, clonidine at 0.25mg/kg was administered for once. Moreover, rat and human liver micro somes, along with recombinant human CYP2D6*1, were used to study the inhibition effect of ritonavir on clonidine in vitro. The concentrations of clonidine and its metabolite were determined by the UPLC-MS/MS. The area under the curve (AUC) of clonidine increased (P<0.01) and clearance (CL) decreased significantly (P<0.01), after co-administration with 180mg/kg ritonavir. The half-maximal inhibitory concentration (IC50) of ritonavir was 11.48μmol/L in rat liver micro somes, 3.52μmol/L in human liver micro somes and 18.04μmol/L in CYP2D6*1. Our findings demonstrate that ritonavir exhibited an inhibitory effect on clonidine metabolism in vitro and in vivo. It suggests that concurrent use of clonidine with ritonavir required close monitoring of the clonidine plasma concentration to alert drug adverse reactions.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiolytic interventions of extracts and pure compounds from Adenanthera pavonina and Peltophorum pterocarpum leaves to treat acute anxiety and depression symptoms in mice. 从 Adenanthera pavonina 和 Peltophorum pterocarpum 叶子中提取的提取物和纯化合物对治疗小鼠急性焦虑和抑郁症状的抗焦虑干预。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-11-01

Farhana Tasleem, Syed Sabir Hassan, Safia Abidi, Saima Zahid, Zafar Alam Mahmood

{"title":"Anxiolytic interventions of extracts and pure compounds from Adenanthera pavonina and Peltophorum pterocarpum leaves to treat acute anxiety and depression symptoms in mice.","authors":"Farhana Tasleem, Syed Sabir Hassan, Safia Abidi, Saima Zahid, Zafar Alam Mahmood","doi":"","DOIUrl":"","url":null,"abstract":"Anxiolytic effect of ethanol, hexane extracts and pure compounds β- sito sterol glucoside and bergenin isolated from Adenanthera pavonina AP (Fabaceae) and Peltophorum pterocarpum PP (Fabaceae) leaves were monitored in this study. Mice were treated with dose of 125mg/kg body weight of ethanol and hexane leaves extracts of both tested plants while, 5mg/kg body weight of β-sito sterol glucoside and 25mg/kg body weight of bergenin. The effect was monitored by hole board test, forced swimming test, open field apparatus and stationary rod test. Results from neuropharmacological effects revealed that ethanol extract of AP leaves and hexane extract of PP leaves had significant anxiolytic (forced swimming test) exploratory (head dip and open field test) and neuro activator activity (stationary rod test) at tested dose. The greatest anti-depressant and anxiolytic effect was found in ethanol extract of AP leaves when compared to all treated drugs. A part from memory enhancing effects, diazepam treated mice also exhibited anxiolytic and antidepressant effects and found comparable with ethanol extract of AP. These findings may clarify the impact of ethanol, hexane extracts and pure substances β-sitosterol glucoside and bergenin at tested concentrations, as well as their potential to treat the Parkinson's and related disorders as an alternative therapy.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0