Pakistan journal of pharmaceutical sciences最新文献_第10页

In vivo evaluation of the traditional uses of Salvia veneris Hedge and development of a topical formulation for localized pain and inflammation. 鼠尾草的传统用途的体内评价和局部疼痛和炎症的局部配方的发展。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Goksu Oduncuoglu, Emmanuel Mshelia Halilu

{"title":"In vivo evaluation of the traditional uses of Salvia veneris Hedge and development of a topical formulation for localized pain and inflammation.","authors":"Goksu Oduncuoglu, Emmanuel Mshelia Halilu","doi":"","DOIUrl":"","url":null,"abstract":"Salvia veneris is endemic to Cyprus and used for pain relief and infectious diseases by local people. This study aimed to evaluate folkloric uses of Salvia veneris and develop a topical formulation for analgesic and anti-inflammatory effects as an alternative to NSAIDs. The analgesic activity of Salvia veneris ethanol extract was studied using an acetic acid-induced writhing test in mice and formalin-induced paw licking in rats. For anti-inflammatory activity, the formalin-induced paw edema model was used. Five topical formulations were prepared by varying the concentrations of ingredients and evaluated. One-way analysis of variance was used at the P<0.05 confidence level for data analysis. The oral LD50 of Salvia veneris in rats was greater than 5000mg/kg. The extract showed significant (P=0.008) analgesic activity in the acetic acid-induced writhing test and significant (P<0.01) dose-dependent analgesic activity in both phases of the formalin test. In the formalin-induced paw edema test, 50 and 200mg/kg of extract significantly (P<0.05) suppressed inflammation. The extract showed dose-dependent antioxidant activity with 0.04559mg/mL IC50. This study confirms the folkloric use of Salvia veneris and shows that a topical formulation of Salvia veneris can be used as an alternative to topical NSAIDs.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatodamianol as hepatoprotective constituent of Turnera diffusa. 山莨菪碱是白花蛇舌草的保肝成分。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Cecilia Delgado-Montemayor, Jonathan Perez-Meseguer, Ricardo Salazar-Aranda, Paula Cordero-Perez, Noemí Waksman

引用次数: 0

Chemical characterization, nematicidal and antioxidant activities of Thymus linearis Benth. 线性百里香的化学特性、杀线虫活性和抗氧化活性。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Rubeena Saleem, Aisha Sana, Yusra Ghani, Faiza Mushtaq, Rubina Abid, Jan Alam, Marium Tariq, Shahnaz Dawar, Razia Sultana, Shaheen Faizi

{"title":"Chemical characterization, nematicidal and antioxidant activities of Thymus linearis Benth.","authors":"Rubeena Saleem, Aisha Sana, Yusra Ghani, Faiza Mushtaq, Rubina Abid, Jan Alam, Marium Tariq, Shahnaz Dawar, Razia Sultana, Shaheen Faizi","doi":"","DOIUrl":"","url":null,"abstract":"Thymus linearis and its essential oil (EO) are used to cure a range of diseases in traditional medicine. GC-MS analysis of Thymus linearis EO revealed the presence of sixty-four components. Thymol (50.62%), carvacrol (13.23 %), carvacrol acetate (7.72%), -bisabolene (5.47%) and o-cymene (5.47%) are the only five basic constituents in the oil which accounts for 82.07% of oil. When compared to other compounds, the EO and its primary components thymol and carvacrol had the largest proportion of mortality in Meloidogyne javanica. Carvacrol has also been proven to be helpful in suppressing the hatching of M. javanica eggs. This is the first time T. linearis EO and its constituents, such as borneol and caryophyllene, have been studied for nematicidal action. The antioxidant activity of EO components and active compounds was assessed using the ABTS radical scavenging method. Thymol and carvacrol were found to exhibit high antioxidant activity. The IC50 of thymol and carvacrol are found to be 38.18 g/ml and 49.65 g/ml, respectively and are comparable to the positive control trolox (47.12 g/ml). Results clearly showed high potency for EO and its constituents, thymol and carvacrol as nematicidal and antioxidant agents.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the effect of addition of Momordica charantia to glibenclamide on amelioration of endothelial dysfunction in diabetic rats by activating Takeda G protein-coupled receptor 5. 在格列本脲中添加苦瓜通过激活武田G蛋白偶联受体5改善糖尿病大鼠内皮功能障碍的作用研究。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Muhammad Idrees, Inayat U Rahman, Hamza A Khan, Yasar M Yousufzai, Ejaz H Khan, Mohammad I Khan, Saima Gul

{"title":"Investigation of the effect of addition of Momordica charantia to glibenclamide on amelioration of endothelial dysfunction in diabetic rats by activating Takeda G protein-coupled receptor 5.","authors":"Muhammad Idrees, Inayat U Rahman, Hamza A Khan, Yasar M Yousufzai, Ejaz H Khan, Mohammad I Khan, Saima Gul","doi":"","DOIUrl":"","url":null,"abstract":"Endothelial dysfunction (ED) is a significant risk factor of blood vessel related diseases of diabetes and this study evaluate the effect of adding Momordica charantia (Mc) to glibenclamide (GLB) on ED markers in diabetic rats. Streptozotocin (STZ-40mg/kg b. w.) induced diabetic rats were randomly put into 3 groups with 10 rats/group; diabetic control [DC] group, glibenclamide treated group (GLB -2.5mg/kg) and GLB-Mc treated group (2.5mg/kg + 400mg/kg). Serum glucose was measured weekly for eight weeks whereas insulin, sVCAM-1, vWF-Ag and interleukin-6 [IL-6] were measured at week 0 and week 8. Luciferase assay was performed to determine luminescence. At week 8, GLB and GLB-Mc groups revealed improvements in blood glucose and insulin concentrations (P≤0.05) when compared to corresponding baseline values with GLB-Mc group showing slightly greater improvements. GLB-M c group also revealed improvement (P≤0.05) in vWF-Ag, sVCAM-1 and IL-6 concentrations but was non-significant in GLB group when compared to corresponding baseline values. Comparison between GLB and GLB-Mc group showed significantly high concentration of sVCAM-1 in GLB group (P≤0.05) due to its minimal effect on TGR5 activation. We conclude that adding M. charantia to GLB may be a useful choice for modulating diabetes induced ED due to its stimulatory effect on TGR5 receptors.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents. 两种新型喹唑啉PI3K/mTOR双抑制剂的药代动力学和组织分布研究。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Jiangang Chen, Xiaoli Bian, Sanqi Zhang, Guangde Yang

{"title":"Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents.","authors":"Jiangang Chen, Xiaoli Bian, Sanqi Zhang, Guangde Yang","doi":"","DOIUrl":"","url":null,"abstract":"S1 and S2, two structurally similar quinazoline derivatives, are novel anticancer drugs targeting the PI3K/AKT/mTOR signaling pathway channel. However, their pharmacokinetic and tissue distribution characteristics are unknown, which has hindered further development and in-depth studies. In this study, a simple, rapid and sensitive method using high performance liquid chromatography was established and validated to quantitatively study the pharmacokinetics and tissue distribution profiles of S1 and S2 in rats following intravenous injection. The results indicated that after intravenous injection, the elimination of S1 and S2 fit the two-compartment model and linear pharmacokinetics characteristics were observed. Furthermore, S1 and S2 were widely distributed and found in high concentrations in liver and kidney tissues and a small proportion of S1 and S2 could cross the blood-brain barrier and be distributed in the brain. The current findings will contribute to interpretation and understanding the relationship between dosage and pharmacodynamic effects of S1 and S2.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evaluation of curcumin effects on some acute phase proteins in aflatoxin B1 applied rats. 姜黄素对黄曲霉毒素B1应用大鼠急性期某些蛋白质影响的评价。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Deniz Uluisik, Ercan Keskin, Durmus Hatipoglu

{"title":"The evaluation of curcumin effects on some acute phase proteins in aflatoxin B1 applied rats.","authors":"Deniz Uluisik, Ercan Keskin, Durmus Hatipoglu","doi":"","DOIUrl":"","url":null,"abstract":"This study was designed to determine the effects of curcumin on some acute phase proteins in rats treated with aflatoxin B1. In this study, healthy 38 male Wistar Albino rats were used. The animals in control group were given food and distilled water. The animals in DMSO group were orally given 1 ml 10% DMSO daily for 60 days, animals in Cur group was orally given 300mg/kg curcumin dissolved in 10% DMSO daily for 60 days. Animals in AFB1 group were orally given 250µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days. Animals in AFB1+Cur group was orally given 250µg/kg aflatoxin B1 dissolved in 10% DMSO and 300mg/kg curcumin dissolved in 10% DMSO daily for 60 days. In blood samples taken from all animals, fibrinogen, prothrombin, albumin and CRP levels were determined. In this study, fibrinogen, prothrombin and CRP levels with AFB1 group were found to be significantly higher than the control group (p<0.05). In the AFB1+Cur group, fibrinogen and CRP levels were lower than in the aflatoxin group (p<0.05). In the study, it was observed that albumin level in rats in AFB1 group significantly decreased compared to the control group (p<0.05) and this difference was found to be eliminated depend on the application of curcumin together with aflatoxin B1 (p<0.05). In conclusion, our findings regarding the ameliorating effects of curcumin on acute phase protein abnormalities caused by aflatoxicosis will contribute to future research.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urgent first-step screening method for ketamine, phenobarbital, zopiclone, zolpidem, phenytoin and thiopental in adulterated soft drink. 掺假软饮料中氯胺酮、苯巴比妥、佐匹克隆、唑吡坦、苯妥英钠和硫喷妥钠的紧急一步筛查方法。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Beril Anilanmert, Sena Caglar-Andac, Ibrahim Narin

{"title":"Urgent first-step screening method for ketamine, phenobarbital, zopiclone, zolpidem, phenytoin and thiopental in adulterated soft drink.","authors":"Beril Anilanmert, Sena Caglar-Andac, Ibrahim Narin","doi":"","DOIUrl":"","url":null,"abstract":"Date-rape drugs given to victims through drinks without their knowledge in drug-facilitated sexual assaults and thefts (money, property and body organs), are important threats for the public. Detection in beverage residues gains importance, since some of them can be quickly eliminated from the body, till the victim understands what he/she has experienced, goes to the hospital and gives a urine sample for analysis. Here, date-rape drugs; ketamine, thiopental, phenobarbital, zolpidem, phenytoin and zopiclone were analyzed simultaneously in 1.00mL caffeine-based carbonated beverage residue, through direct injection, using a modified, economical emergency first-step screening method with high performance liquid chromatography-diode array detector (elution time: 11 minutes). Screening power of the method was qualitatively observed in sour cherry juice, sweet soda and beer with some additional experiments. Caffeine in caffeine-based carbonated beverage could also be detected simultaneously. LODs and LOQs were between 0.02-1.79 and 0.08-5.60µgmL-1. Repeatability and reproducibility values were <9.91%. HorRat values were between 0.184-0.500. As the first screening and quantitative study on the simultaneous analysis of these drugs in a beverage, it's important for solving the crimes committed using drugs in caffeine-based carbonated beverage residues found at the crime scene, when the use of these drugs is suspected after anamnesis and inspection.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of hypoglycemic and antioxidant effects of Brickellia eupatorioides, Citrus limettioides and Gochnatia hypoleuca. 白石柳、柑桔、枸杞子降血糖和抗氧化作用的评价。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Silvia Guadalupe Trevino-Moreno, Diana Patricia Moreno-Peña, Ezequiel Viveros-Valdez, María Julia Verde-Star, Catalina Rivas-Morales, Paula Cordero-Perez

{"title":"Evaluation of hypoglycemic and antioxidant effects of Brickellia eupatorioides, Citrus limettioides and Gochnatia hypoleuca.","authors":"Silvia Guadalupe Trevino-Moreno, Diana Patricia Moreno-Peña, Ezequiel Viveros-Valdez, María Julia Verde-Star, Catalina Rivas-Morales, Paula Cordero-Perez","doi":"","DOIUrl":"","url":null,"abstract":"Diabetes is a chronic metabolic condition with a rapidly increasing prevalence. It comes with a rise in the generation of free radicals, potentially leading to additional health issues. Further studies and creative approaches are required to address this. Natural products are potential new antidiabetic drugs that are worth exploring. The aim of the present study is to assess the antihyperglycemic and antioxidant effects of ethanolic extracts of Brickellia eupatorioides, Citrus limettioides and Gochnatia hypoleuca. The antihyperglycemic activity of the extracts was tested on Wistar rats (diabetes induced by alloxan, 150mg/kg), as well as the inhibitory effect on a-glucosidase and a-amylase (in vitro assay). The antioxidant potential was evaluated using DPPH and ABTS assays. The total phenolic and flavonoid contents were also determined. The results indicated that ethanolic extracts of B. eupatorioides induced a powerful hypoglycemic in vivo effect with a significant decrease at 6h after administration, similar to that produced by glibenclamide; the decrease could be related to a-glucosidase inhibition. Moreover, the extract exhibited a potent scavenging activity (IC50 values 33±6mg/mL and 15±2mg/mL in the DPPH and ABTS methods, respectively). The results demonstrated antihyperglycemic and antioxidant activity of ethanolic extracts of B. eupatorioides.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial activity of phenolic compounds of Teucrium polium L. 紫锥藻酚类化合物的抗菌活性。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Mohammed Arafat Mohammed, Younis Saadi Saeed, Jassim Fatehi Ali

{"title":"Antibacterial activity of phenolic compounds of Teucrium polium L.","authors":"Mohammed Arafat Mohammed, Younis Saadi Saeed, Jassim Fatehi Ali","doi":"","DOIUrl":"","url":null,"abstract":"Teucrium polium L., a member of the Lamiaceae family. The plant's leaf ingredients were extracted with hexane, ethyl acetate and ethanol, in that order. Column chromatography (CC), thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) were used to figure out what phenolic components were in different extracts. Through these methods, three distinct fractions were isolated, originating from ethyl acetate and ethanolic extractions. Further examination of these fractions led to the discovery of 4-Hydroxybenzoic acid, catechol and coumaric acid. The antibacterial activity of isolated components was examined through rigorous testing. To evaluate the efficacy against different types of bacteria, the disc-diffusion assay was employed. This involved testing each fraction against Staphylococcus aureus, a Gram-positive bacterium, as well as four Gram-negative bacteria, including Staphylococcus aureus and Salmonella typhi, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli. Fraction (F1) was able to stop the growth of K. pneumoniae, P. aeruginosa, and S. aureus well with an inhibition zone of 19-21 mm. Fraction (F2) showed high activity against all types of bacteria used in this study, with an inhibition zone of 19-23 mm. This study's findings suggest that Teucrium polium holds potential as a valuable source of natural antibacterial phenolic compounds.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of vitamin B12 levels and cardiovascular risk factors in metformin- and non-metformin-treated type 2 diabetic patients. 二甲双胍和非二甲双胍治疗的2型糖尿病患者维生素B12水平和心血管危险因素的评估。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Kinga Ilona Nyulas, Mariana Cornelia Tilinca, Sándor Pál, Erzsébet Májai Fogarasi, Mircea Dumitru Croitoru, Robert Gabriel Tripon, Zoltán Preg, Márta Germán-Salló, Zsuzsánna Simon-Szabó, Enikő Nemes-Nagy

{"title":"Assessment of vitamin B12 levels and cardiovascular risk factors in metformin- and non-metformin-treated type 2 diabetic patients.","authors":"Kinga Ilona Nyulas, Mariana Cornelia Tilinca, Sándor Pál, Erzsébet Májai Fogarasi, Mircea Dumitru Croitoru, Robert Gabriel Tripon, Zoltán Preg, Márta Germán-Salló, Zsuzsánna Simon-Szabó, Enikő Nemes-Nagy","doi":"","DOIUrl":"","url":null,"abstract":"Oxidative stress enhances cardiovascular risk. Metformin decreases intestinal absorption of vitamin B12. Our objective was the evaluation of type 2 diabetics focusing on differences due to their treatment. A prospective study on 224 type 2 diabetics was realized between 2015-2018 in Targu Mures, Romania, divided into 2 subgroups (metformin vs. other therapy - 2nd/3rd generation sulfonylureas, insulin, dietary regimen -, followed for at least one year) and non-diabetic controls (n=25) for oxidative stress level comparison. Serum homocysteine (HC), vitamin B12 were determined by chemiluminescence (Immulite One). Lipid peroxidation was assessed by serum malondialdehyde (MDA) measurement (HPLC). Biochemical tests, minerals, cystatin C, high-sensitivity C reactive protein (hs-CRP) were measured on Konelab20Xti, glycated hemoglobin on Nycocard Reader. GraphPad InStat-3 was used for statistics. Negative correlation occured between serum vitamin B12 and HC, this vitamin's level was significantly lower and serum zinc was significantly higher in patients on metformin. Hyperhomocysteinemia was present in 87% of the subjects, 46% had zinc deficiency and 41% elevated hs-CRP. Serum cystatin C showed positive correlation with creatinine. Serum MDA was significantly higher in diabetics compared to control patients. Elevated hs-CRP and homocysteine represent raised cardiovascular risk. Intense oxidative stress, vitamin, mineral deficiencies are frequent in diabetic subjects.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0