Pakistan journal of pharmaceutical sciences最新文献_第10页

Comparative study of the efficacy of glucosamine sulfate capsules and Huoxue Xiaozhong prescription in the treatment of knee osteoarthritis and the recovery of knee joint function. 硫酸氨基葡萄糖胶囊与活血消肿方治疗膝关节骨性关节炎及膝关节功能恢复的疗效比较研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Zhifei Peng, Liang Ou, Jianjun Kuang

{"title":"Comparative study of the efficacy of glucosamine sulfate capsules and Huoxue Xiaozhong prescription in the treatment of knee osteoarthritis and the recovery of knee joint function.","authors":"Zhifei Peng, Liang Ou, Jianjun Kuang","doi":"","DOIUrl":"","url":null,"abstract":"This study focused on the difference in efficacy between glucosamine sulfate capsules and Huoxue Xiaozhong recipe in the treatment of knee osteoarthritis, as well as their effects on knee joint function recovery. A total of 128 patients with knee osteoarthritis who met the criteria were prospectively enrolled and randomly divided into a glucosamine sulfate group (n = 64) and a traditional Chinese medicine group (n = 64). The total effective rate, visual analogue score (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), degree of joint swelling, range of motion (ROM), serum inflammatory factor levels, degree of articular cartilage wear, knee joint function recovery and adverse reactions were observed from multiple dimensions. In this study, independent sample t-test and repeated measures analysis of variance were used to statistically evaluate the data. The results showed that the traditional Chinese medicine group had significant advantages in total effective rate, improvement of WOMAC score, relief of joint swelling, improvement of ROM, control of articular cartilage wear and knee joint function recovery; the glucosamine sulfate group performed outstandingly in reducing VAS scores and regulating serum inflammatory factor levels and the incidence of adverse reactions in the traditional Chinese medicine group was lower. In summary, for patients who urgently need to relieve pain, glucosamine sulfate capsules can be used as an initial option; while for patients who hope to comprehensively improve joint function, the blood circulation and swelling reduction formula is more valuable.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"325-332"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of compound glycyrrhizin combined with fractional CO2 laser on the improvement of skin lesions and skin barrier function in rosacea. 复方甘草酸联合CO2激光对酒渣鼻皮损及皮肤屏障功能改善的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Si-Cheng Zhao, Dan Wang, Ting-Yan Wu, Ming-Jing Fu, Xiao-Ming Lu

引用次数: 0

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Xuran Pan

{"title":"Analysis of related factors of malnutrition in patients with chronic obstructive pulmonary disease and changes in blood routine parameters with Ajuga ciliata Bunge.","authors":"Xuran Pan","doi":"","DOIUrl":"","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD), currently one of the most common chronic lung diseases in clinical practice, is the third leading cause of death globally, after ischemic heart disease and stroke. In this study, we analyzed the factors related to malnutrition in chronic obstructive pulmonary disease and found that long-term smoking, body mass index, fasting plasma glucose and total cholesterol were all independent risk factors. This suggests that in future clinical treatment of chronic obstructive pulmonary disease, attention should be paid to these indicators to prevent malnutrition (P<0.05). Ajuga ciliata Bunge is one of the drugs commonly used in traditional Chinese medicine for the adjuvant treatment of lung inflammation and sore throat. We found that the addition of Ajuga ciliata Bunge to the treatment of COPD can effectively improve the inflammatory response of patients. Meanwhile, the improvement of inflammatory response was more significant in COPD patients who were malnourished among them (P<0.05). In addition, the incidence of adverse reactions with Ajuga ciliata Bunge was low and improved the patients' treatment satisfaction. These results suggest that Ajuga ciliata Bunge has an important application in the treatment of COPD in the future.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"387-394"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of 25(OH)D supplementation on adipokines and advanced glycation end products in experimental type 2 diabetic and obesity rat model. 补充25(OH)D对实验性2型糖尿病和肥胖大鼠模型中脂肪因子和晚期糖基化终产物的影响

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Cigdem Toprak, Semra Yigitaslan, Ezgi Bektur Aykanat, Basar Sirmagul, Varol Sahinturk

{"title":"Effect of 25(OH)D supplementation on adipokines and advanced glycation end products in experimental type 2 diabetic and obesity rat model.","authors":"Cigdem Toprak, Semra Yigitaslan, Ezgi Bektur Aykanat, Basar Sirmagul, Varol Sahinturk","doi":"","DOIUrl":"","url":null,"abstract":"Diabetes mellitus is a global health problem and vitamin D deficiency is thougt to be a reasonal factor for development of diabetes. Our aim is to investigate among vitamin D levels and blood glucose, insulin resistance, adiponectin, apelin, tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), oxidative stress index (OSI) levels and advanced glycation end products (AGEs) formation in modeled obesity and type 2 diabetes mellitus (T2DM) rats. During the 14-week experiment; Control group was fed standart diet-(12 % of calories of fat), Diabetes group was fed high fat diet (HFD)-at the 4th week Streptozotocin (STZ) (35 mg/kg) was injected, Diabetes/vitamin D group was fed HFD-at the 4th week STZ was injected-between 4th- 14th week vitamin D supplement was administered, Obesity group was fed HFD-(40% of calories as fat), Obesity/vitamin D group was fed HFD-between 4th-14th week vitamin D supplement was administered. At 14th week, biochemical parameters, adipokine concentrations, kidney tissue cytokine levels, liver tissue oxidative stress index parameters were measured by using ELISA method and Hematoxylinamp;Eosin staining of kidney, heart, liver, coronary/renal artery tissues and immunohistochemical staining of kidney tissues were performed. Vitamin D can alleviate glucose and lipid parameters and we think vitamin D may be useful adjuvant agent in obesity and T2DM treatment.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"463-472"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network analysis for the discovery of key biomarkers and potential therapeutic targets in hypertrophic cardiomyopathy. 发现肥厚性心肌病关键生物标志物和潜在治疗靶点的网络分析。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Bin Xie, Zhao Chen, Jian Liu, Jimei Chen, Jian Zhuang, Huimin Guo, Jiyan Chen

{"title":"Network analysis for the discovery of key biomarkers and potential therapeutic targets in hypertrophic cardiomyopathy.","authors":"Bin Xie, Zhao Chen, Jian Liu, Jimei Chen, Jian Zhuang, Huimin Guo, Jiyan Chen","doi":"","DOIUrl":"","url":null,"abstract":"Hypertrophic cardiomyopathy (HCM) is a genetic heart disorder that can lead to sudden cardiac death. Current treatment strategies, such as implantable cardioverter-defibrillators, exhibit limitations in impeding disease progression. Despite the identification of several pathogenic genes, the complex mechanisms underlying HCM remain unclear. This study aims to identify novel pathogenic genes and critical biomarkers for HCM using network-based bioinformatics analysis, with the potential to discover therapeutic targets for pharmaceutical interventions. Gene expression data from 119 HCM patients and 55 healthy donors were analyzed using differential gene expression (DEG) analysis, followed by gene ontology (GO), KEGG and Reactome pathway enrichment studies. A protein-protein interaction (PPI) network was constructed to identify hub genes and their interactions, with a focus on potential drug targets. We identified a key gene module, with TNNT1 emerging as a critical hub gene. TNNT1 was found to significantly influence cardiac development and contribute to HCM pathogenesis. Our findings suggest that TNNT1's role in regulating cardiac contractility could provide a foundation for developing new therapeutic agents targeting this pathway. This study provides novel insights into the molecular mechanisms of HCM and identifies TNNT1 as a potential biomarker for early screening and a promising target for pharmaceutical therapies. The identification of TNNT1 offers opportunities for personalized medicine approaches, which could facilitate the development of drugs aimed at modulating its expression and mitigating disease progression in HCM patients.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"493-510"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aromatic turmerone regulates the migration and autophagy of cutaneous squamous cell carcinoma cells through the Igf-1/Pi3k/Akt pathway. 芳香姜黄酮通过Igf-1/Pi3k/Akt通路调控皮肤鳞状细胞癌细胞的迁移和自噬。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Zheng Zhang, Enze Jiang, Xiaobo Zhou, Guanglei Hu, Xiaoqing Wang

{"title":"Aromatic turmerone regulates the migration and autophagy of cutaneous squamous cell carcinoma cells through the Igf-1/Pi3k/Akt pathway.","authors":"Zheng Zhang, Enze Jiang, Xiaobo Zhou, Guanglei Hu, Xiaoqing Wang","doi":"","DOIUrl":"","url":null,"abstract":"In recent years, the incidence of cutaneous squamous cell carcinoma (CSCC) has been increasing year by year. Due to its characteristics of high recurrence and high invasion, CSCC poses a great potential threat to the prognosis of patients. Aromatic turmerone, an active component of Curcuma longa, has been shown to have anti-tumor, anti-inflammatory and anti-oxidation effects in modern pharmacological research, but its influence on CSCC remains unclear. In this study, we used AT to intervene in human CSCC A431 cell line. The results showed that the growth ability of A431 was significantly inhibited by the intervention of AT. Also, we found that compared to normal A431, the cell invasion number and migration rate of A431 were reduced to (116.00±8.00) and (39.87±4.20) %, respectively, after the intervention of AT. And detecting the inflammatory response in the cells, we found that AT reduced the inflammatory factors and oxidative stress in A431. Meanwhile, aromatic turmerone suppressed the autophagy of A431 and silenced the IGF-1/PI3K/AKT pathway expression, which further reveals the mechanism and pathway of action of aromatic turmerone on CSCC, laying a reliable foundation for the clinical application of aromatic turmerone.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"381-386"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical, physicochemical and preliminary phytochemical analysis of siddha poly herbal drugs used for treating diabetes mellitus in Northern province, Sri Lanka. 斯里兰卡北部省治疗糖尿病的西陀多药理化及植物化学初步分析。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Merin Dinushiya J, Nilanusha S, Sugansika M, Sivasinthujah S, Sivarangini S, Ravimannan N

{"title":"Physical, physicochemical and preliminary phytochemical analysis of siddha poly herbal drugs used for treating diabetes mellitus in Northern province, Sri Lanka.","authors":"Merin Dinushiya J, Nilanusha S, Sugansika M, Sivasinthujah S, Sivarangini S, Ravimannan N","doi":"","DOIUrl":"","url":null,"abstract":"The Siddha system of medicine uses natural herbal products for the treatment of Diabetes Mellitus (DM). In Northern Province, Sri Lanka Madhumeha chooranam, Neerizhivu chooranam 1 and Neerizhivu chooranam 2 are famously used ones among the most prioritized drugs for DM. Therefore, this study aimed to formulate the crude drug, evaluate the physical properties, physiochemical properties and phytochemical screening of crude drugs as it is necessary to standardize this formulation for the safety of the stakeholders. Plant materials were collected in Jaffna and powdered. Madhumeha chooranam, Neerizhivu chooranam 1 and Neerizhivu chooranam 2 were prepared using siddha literature. Organoleptic properties, physical and physiochemical parameters were evaluated for the crude drug. The crude drug was macerated with methanol separately for 48 hours at room temperature and phytochemical were analysed for each crude extracts. The results of physical and physiochemical were analysed with one-way ANOVA using SPSS 23. All three drugs showed the presence of alkaloids, flavonoids, carbohydrates, reducing sugars, tannins, steroids, proteins, amino acids, glycosides, phenol, terpenoids and anthraquinones. The results of physical and physiochemical parameters were confirned and can be used for setting standards for the selected drugs Madhumeha chooranam, Neerizhivu chooranam 1, and Neerizhivu chooranam 2.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"571-578"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of anti-inflammatory drugs in pain management and osseointegration after orthodontic micro implant brace surgery. 消炎药在正畸微种植支具术后疼痛控制和骨整合中的作用。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Qing Li

{"title":"The role of anti-inflammatory drugs in pain management and osseointegration after orthodontic micro implant brace surgery.","authors":"Qing Li","doi":"","DOIUrl":"","url":null,"abstract":"This study systematically compared the efficacy of four nonsteroidal anti-inflammatory drugs (NSAIDs) including a placebo, ibuprofen, diclofenac potassium, and rofecoxib-in managing postoperative pain and their impact on osseointegration following orthodontic micro implant surgery. Pain was quantified using the visual analog score (VAS) method, while osseointegration was assessed through laboratory examinations, bone morphogenetic protein-2 (BMP-2) secretion and cell proliferation rates. We collected and analyzed data on patients' pain scores, medication usage, and bone healing indicators to inform clinical decisions and enhance treatment outcomes. The ibuprofen group showed consistent and significant pain reduction in both non-occlusal and occlusal states, with a pain index decrease to 3.1±0.9 in the non-occlusal state and 3.8±1.3 in the occlusal state by the fifth postoperative day. The ibuprofen group also exhibited peak cell proliferation (246% at 48 hours post-implantation), surpassing the diclofenac potassium (180%) and rofecoxib (158%) groups, indicating its pronounced effect on osteoblast proliferation. Additionally, ibuprofen led to higher BMP-2 secretion (2.71μg/L at 24 hours) compared to diclofenac potassium (2.25μg/L) and rofecoxib (1.62μg/L), underscoring its role in BMP-2 secretion by osteoblasts. The ibuprofen group achieved the highest scores in occlusal function, aesthetics, masticatory function and satisfaction with orthodontic treatment. The study establishes a rationale for drug selection in pain management and osseointegration post-orthodontic micro implant surgery, affirming the short-term safety and efficacy of NSAIDs in orthodontic procedures.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"511-520"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observation of the efficacy of hemocoagulase atrox combined with Mayinglong hemorrhoid Cream on postoperative treatment of perianal abscess. 凝血酶atrox联合马应龙痔膏治疗肛周脓肿术后疗效观察。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Zhi Li Yang, Liang Zhou

{"title":"Observation of the efficacy of hemocoagulase atrox combined with Mayinglong hemorrhoid Cream on postoperative treatment of perianal abscess.","authors":"Zhi Li Yang, Liang Zhou","doi":"","DOIUrl":"","url":null,"abstract":"To observe and study the efficacy of combined therapy of Hemocoagulase Atrox for Injection and Mayinglong Hemorrhoid cream on wound healing and complications after perianal abscess resection. The data of 162 patients who underwent perianal abscess resection were retrospectively analyzed. The data were divided into an observation group and a control group. The control group applied Mayinglong hemorrhoid cream on the wound surface on the basis of normal saline flushing and the observation group injected atrocoagulase on this basis. The medication cycle was 4 weeks and the clinical effect, wound healing and complication rate after treatment were compared. After treatment, the total efficacy of the observation group was higher than that of the control group (P<0.05); the clinical index scores and Wexner scores of the two groups were lower than before treatment and even lower in the observation group (P<0.05); the anal function and The incidence rate of complications was better than that of the control group (P<0.05). The combined therapy of Hemocoagulase Atrox for Injection and Mayinglong Hemorrhoid cream can effectively reduce the pain symptoms of patients after perianal abscess resection, promote the recovery of anal function and has a short wound healing time, low complication rate and significant effect.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"579-585"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial resistance and virulence profiling of Klebsiella pneumoniae isolated from urinary tract infections in community and hospital settings in Pakistan. 巴基斯坦社区和医院尿路感染分离肺炎克雷伯菌的抗微生物药物耐药性和毒力分析

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Zia Ashraf, Muhammad Hidayat Rasool, Mohsin Khurshid, Bilal Aslam

{"title":"Antimicrobial resistance and virulence profiling of Klebsiella pneumoniae isolated from urinary tract infections in community and hospital settings in Pakistan.","authors":"Zia Ashraf, Muhammad Hidayat Rasool, Mohsin Khurshid, Bilal Aslam","doi":"","DOIUrl":"","url":null,"abstract":"Urinary tract infections (UTIs) caused by multidrug-resistant (MDR) bacteria pose escalating challenges in resource-limited settings. This cross-sectional study addresses critical gaps in molecular surveillance by directly comparing antimicrobial resistance (AMR) genotypes, virulence factors, and resistance phenotypes of K. pneumoniae isolates from community (CA-UTI) and hospital-acquired (HA) UTI. in Pakistan. Bacterial identification was performed using standard microbiological techniques and MALDI-TOF MS. Antimicrobial susceptibility was assessed via the Kirby-Bauer disk diffusion and broth microdilution methods, following CLSI guidelines. PCR was employed to detect AMR genes and virulence factors. Of 2,700 urine samples analyzed, 721 (26.7%) tested positive for uropathogens, with K. pneumoniae accounting for 128 isolates (17.8%). HA-UTI isolates exhibited significantly higher resistance to amoxicillin-clavulanic acid (p = 0.0117) as well as cefotaxime and ceftriaxone (p = 0.0002). All isolates remained fully susceptible to colistin and tigecycline. Genotypic analysis revealed HA-UTI isolates carried higher frequencies of ESBL (blaCTXM-15: 23.1% vs. 13.5%) and carbapenemase genes (blaNDM: 9.9% vs. 2.7%), alongside tetracycline (tetB: 64.8% vs. 54.1%) and fluoroquinolone resistance determinants (qnrA: 37.4% vs. 29.7%). Virulence factors fimH (32.0%) and mrkD (26.6%) were common overall with no statistical difference between CA and HA UTI cases. The burden of AMR particularly in HA-UTI isolates coupled with carbapenemase production underscore the urgent need for hospital-specific infection control and stewardship programs prioritizing carbapenem-sparing regimens in Pakistan.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"395-405"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0