Pakistan journal of pharmaceutical sciences最新文献_第10页

A comparative study of sequential and simultaneous enzymatic and ultrasound-assisted aqueous two-phase extraction for anticholesterol compounds from Strobilanthes crispus leaves. 脆石斛叶中抗胆固醇化合物的酶法和超声波辅助水溶液两相萃取顺序和同步比较研究

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Rita Arbianti, Harti Ningsih, Najah Fadilah Putri, Tania Surya Utami, Yuswan Muharam, - Slamet

{"title":"A comparative study of sequential and simultaneous enzymatic and ultrasound-assisted aqueous two-phase extraction for anticholesterol compounds from Strobilanthes crispus leaves.","authors":"Rita Arbianti, Harti Ningsih, Najah Fadilah Putri, Tania Surya Utami, Yuswan Muharam, - Slamet","doi":"","DOIUrl":"","url":null,"abstract":"An innovative ultrasonic-assisted enzymatic aqueous two-phase extraction (UAE-ATPE) method was applied to enhance the yield from Strobilanthes crispus leaves, exploring both sequential and simultaneous approaches. Comparative analysis included assessing total phenolic content (TPC), total flavonoid content (TFC), partition coefficient (k) and recovery (R). Liquid chromatography-mass spectrometry and scanning electron microscopy evaluated extracts from both techniques. Simultaneous UAE-ATPE demonstrated significantly higher TPC (5.7±0.1 mg GAE/g dry leaves) and TFC (3.3±0.1 mg QE/g dry leaves) compared to sequential extraction, where TPC and TFC measured 4.5±0.3 mg GAE/g dry leaves and 1.7±0.1 mg QE/g dry leaves. Additionally, simultaneous UAE-ATPE yielded higher k and R values for phenolic and flavonoid compounds. Notably, it identified 32.4% of the area corresponding to 6 compounds, surpassing the 25.3% area identified sequentially with 13 compounds. A collaborative effect of enzymatic hydrolysis and ultrasonic extraction was observed in simultaneous UAE-ATPE. In the inhibition test on the HMG-CoA reductase enzyme, simultaneous UAE-ATPE extract (200 µg/mL) exhibited exceptional results, achieving superior inhibition of 66.1% compared to the sequential method's inhibition of 39.4%. This underscores the efficacy of simultaneous UAE-ATPE in producing concentrated anti-cholesterol compounds. The study strongly emphasizes the superiority of simultaneous UAE-ATPE over the sequential approach.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and in vitro/in vivo evaluation of famotidine hydrochloride bioadhesive sustained release suspension. 盐酸法莫替丁生物黏附性缓释混悬液的开发和体内外评估。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Hongfei Liu, Jintong Dai, Jiangming He, Yang Xu, Caleb Kesse Firempong, Yingshu Feng, Haibing He

{"title":"Development and in vitro/in vivo evaluation of famotidine hydrochloride bioadhesive sustained release suspension.","authors":"Hongfei Liu, Jintong Dai, Jiangming He, Yang Xu, Caleb Kesse Firempong, Yingshu Feng, Haibing He","doi":"","DOIUrl":"","url":null,"abstract":"To develop a new kind of famotidine-resin microcapsule for gastric adhesion sustained release by screening out suitable excipients and designing reasonable prescriptions to improve patient drug activities to achieve the expected therapeutic effect. The famotidine drug resin was prepared using the water bath method with carbomer 934 used as coating material. Microcapsules were prepared using the emulsified solvent coating method and appropriate excipients were used to prepare famotidine sustained release suspension. Pharmacokinetics of the developed microcapsules were studied in the gastrointestinal tract of rats. The self-made sustained-release suspension of famotidine hydrochloride effectively reduced the blood concentration and prolonged the action time. The relative bioavailability of the self-made suspension of the famotidine hydrochloride to the commercially available famotidine hydrochloride was 146.44%, with an average retention time of about 5h longer, which indicated that the new suspension had acceptable adhesion properties. The findings showed that the newly developed famotidine-resin microcapsule increased the bioavailability of the drug with a significant sustained-release property.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic and antiulcer activity of methanolic extract of Tradescantia spathacea in rats. 大鼠体内 Tradescantia spathacea 甲醇提取物的抗糖尿病和抗溃疡活性。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Syeda Shaheen Sultana, S Tasqeeruddin, Yahya I Asiri, Ns Murali Krishna, Syeda Nishath Sultana

引用次数: 0

Effects of dapagliflozin against streptozotocin and isoproterenol-induced heart failure via investigating NLRP3 and PPAR-γ signaling. 达帕格列净通过研究NLRP3和PPAR-γ信号传导对链脲佐菌素和异丙肾上腺素诱导的心力衰竭的影响

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Khadija Ijaz, Arif-Ullah Khan, Yousaf Kamal, Nadeem Irshad

{"title":"Effects of dapagliflozin against streptozotocin and isoproterenol-induced heart failure via investigating NLRP3 and PPAR-γ signaling.","authors":"Khadija Ijaz, Arif-Ullah Khan, Yousaf Kamal, Nadeem Irshad","doi":"","DOIUrl":"","url":null,"abstract":"Heart failure is a condition in which the heart's one or both ventricles are unable to either receive an adequate amount of blood or eject an adequate amount of blood. Diabetes is considered one of the major risk factors for cardiovascular diseases. The current research is designed to evaluate the cardioprotective effects of dapagliflozin in streptozotocin and isoproterenol-induced comorbid rats. The COX-2, TNF-α, NF-КB, NLRP3, PPAR-γ, CKMB, TROP-I, AR, GP and SGLT were docked against dapagliflozin, propranolol and metformin. Dapagliflozin restored adequate blood flow and halted myofibril damage. Moreover, it's evident from this study that dapagliflozin significantly decreased serum concentration of various blood markers, decreased relative growth rate and QT interval prolongation, as compared to the negative control group. However, it improved the ventricular ejection fraction in rats of the treatment group. The GST, GSH and CAT levels were increased, as compared to normal. On the contrary, a decrease in LPO concentrations was observed. Evaluation of the coronal section of heart tissues showed the anti-inflammatory expressions evaluated through H & E staining and immunohistochemical techniques and with ELISA and PCR. In a nutshell, dapagliflozin reverses myocardial necrosis and apoptosis.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of efficacy of neoadjuvant chemotherapy with gemcitabine plus cisplatin versus docetaxil, cisplatin, plus fluorouracil in locally advanced nasopharyngeal carcinoma. 吉西他滨加顺铂与多西他赛、顺铂加氟尿嘧啶新辅助化疗对局部晚期鼻咽癌疗效的比较。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Abdul Rehman, Ghulam Haider, Akash Ramchand, - Anaum, Shumaila Nawaz Khan, Faiza Mahar, Raheela Mahmood, Sana Saher, Yasir Rehman Khattak, Muhammad Arsalan Aqeel

{"title":"Comparison of efficacy of neoadjuvant chemotherapy with gemcitabine plus cisplatin versus docetaxil, cisplatin, plus fluorouracil in locally advanced nasopharyngeal carcinoma.","authors":"Abdul Rehman, Ghulam Haider, Akash Ramchand, - Anaum, Shumaila Nawaz Khan, Faiza Mahar, Raheela Mahmood, Sana Saher, Yasir Rehman Khattak, Muhammad Arsalan Aqeel","doi":"","DOIUrl":"","url":null,"abstract":"Induction followed by concurrent chemoradiation (CCRT) is the standard of care for locally advanced nasopharyngeal carcinoma (LANPC). This study evaluated and compared the efficacy of two regimens of neoadjuvant chemotherapy along with CCRT in LANPC. Patients with LANPC were randomly divided in Group I (receiving neoadjuvant gemcitabine and cisplatin) and Group II (receiving neoadjuvant docetaxil, cisplatin and fluorouracil). Both groups also received concurrent single agent (i.e., cisplatin) chemotherapy and radiotherapy (70Gy). Treatment response was assessed at 8 weeks after the completion of CCRT using RECIST criteria. A total of 68 LANPC patients were enrolled. Group I comprised of 32 patients, with male to female ratio of 2.2, a mean (range, median) age of 38.6±11.3 (19-58, 36) years. Group II comprised of 36 patients, with male to female ratio of 3.5, mean (range, median) age of 40.9 ±11.6 (17-63, 40) years. The complete response was higher whereas the partial response was lower in Group I as compared to Group II (23/32 versus 16/36 and 06/32 versus 18/36, respectively). LANPC patients receiving gemcitabine plus cisplatin based neoadjuvant chemotherapy showed higher response, as compared with docetaxil, cisplatin and fluorouracil based neoadjuvant chemotherapy.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of GRK5 variant rs10886471 with the therapeutic effect of repaglinide in patients of type 2 diabetes mellitus in Peshawar, Pakistan. 巴基斯坦白沙瓦2型糖尿病患者GRK5变异体rs10886471与瑞格列奈治疗效果的关系

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Kiran Ijaz, - Zakiullah, Haseenullah Shah, Sajid Ali, Mohsin Raziq, Haji Bahadar

{"title":"Association of GRK5 variant rs10886471 with the therapeutic effect of repaglinide in patients of type 2 diabetes mellitus in Peshawar, Pakistan.","authors":"Kiran Ijaz, - Zakiullah, Haseenullah Shah, Sajid Ali, Mohsin Raziq, Haji Bahadar","doi":"","DOIUrl":"","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with a rising global prevalence. The primary objective of this study was to explore the relationship between the GRK5 variant (rs10886471) and the therapeutic effect of repaglinide in patients of T2DM in Peshawar, Pakistan. A quasi-experimental study was designed. The study group consisted of patients with Type 2 Diabetes Mellitus (T2DM) categorized into responders and non-responders based on their HbA1c level reduction in response to repaglinide treatment. After ethical approval, and consent from the participants, sociodemographic and clinical data was collected from 60 T2DM patients. Blood samples were collected followed by DNA extraction and quantification with UV-Vis Spectroscopy. Genotyping for the GRK5 variant rs10886471 was done using the PCR-based method. Among socio-demographic factors family history and BMI showed significant association (P<0.05) with the therapeutic response to repaglinide. The Statistical analyses, including chi-square tests and logistic regression of GRK5 variant rs10886471 exhibited a significant association with the therapeutic response. Variant allele exhibited significant association (OR: 1.2, p=0.049) with the therapeutic response to repaglinide. The study demonstrated a significant relationship between the GRK5 variant (rs10886471) and the therapeutic response to repaglinide in patients of T2DM of Peshawar, Pakistan.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dexmedetomidine alleviates acute postoperative anxiety in rats by suppressing the NF-ĸB pathway. 右美托咪定通过抑制 NF-ĸB 通路缓解大鼠术后急性焦虑症

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Si-Wei Wei, Lei Wu, Zhen Xiang, Er-You Yu, Zhen Du

{"title":"Dexmedetomidine alleviates acute postoperative anxiety in rats by suppressing the NF-ĸB pathway.","authors":"Si-Wei Wei, Lei Wu, Zhen Xiang, Er-You Yu, Zhen Du","doi":"","DOIUrl":"","url":null,"abstract":"Evidence suggests that surgical procedures can effect the central nervous system and lead to changes in mood and behavior, rarely understood about the role of acute inflammation in promoting acute anxiety postoperatively. This study was designed to explore the possible mechanism of dexmedetomidine (DEX, a2-adrenergic receptor agonist) for reducing acute postoperative anxiety, which may be related to the activation of nuclear factor kappa B (NF-κB) and downstream signal pathway in the hippocampus. Experiments were conducted with rat, the elevated plus-maze and open field test were performed to evaluate anxiety-like behavior. Inhibit DEX with Atipamezole (AT, α2-adrenergic receptor antagonist) and inhibit NF-κB with Pyrrolidinedithiocarbamate (PDTC, inhibit phosphorylation of IκB, prevent the activation of NF-κB), the level of interleukin-6 (IL-6), IL-1β, IL-10 and Tumor necrosis factor-α (TNF-α); the nuclear translocation of NF-κB in the hippocampus and anxiety-like behavior were measured. Rats exhibited anxiety-like behavior at 6h and 12h after surgery. Preoperative administration of DEX significantly alleviated postoperative anxiety-like behavior. DEX premedication inhibited the nuclear translocation of NF-κB alleviate acute postoperative anxiety. These findings are the first to show that acute postoperative anxiety may be related to NF-κB nuclear translocation in the hippocampus in rats, which can be alleviated by DEX premedication.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium valproate inhibited apoptosis in lethally scalded rat cardiomyocytes by regulating hypoxia-inducible factor-1α expression. 丙戊酸钠通过调节缺氧诱导因子-1α的表达抑制致死性烫伤大鼠心肌细胞的凋亡

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Xiangxi Meng, Hailing Wen, Sen Hu, Jinguang Zheng

{"title":"Sodium valproate inhibited apoptosis in lethally scalded rat cardiomyocytes by regulating hypoxia-inducible factor-1α expression.","authors":"Xiangxi Meng, Hailing Wen, Sen Hu, Jinguang Zheng","doi":"","DOIUrl":"","url":null,"abstract":"This study assessed the inhibitory effect of sodium valproate (VPA) on apoptosis of cardiomyocytes in lethally scalded rats. The model of a 50% total body surface area (TBSA) third-degree full-thickness scald was produced, 48 male SD rats were randomly divided into three groups (n = 16), the sham group and the scald group were given an intraperitoneal injection of 0.25ml of saline, the scald +VPA group was given an intraperitoneal injection of VPA (300 mg/kg) after scalded, Each group was subdivided into two subgroups (n=8) according to the two observation time points of 3h and 6h after scald. Apoptotic cardiomyocytes were observed, and myocardial tissue levels of nitric oxide (NO), cysteine protease-3 (caspase-3) activity, hypoxia-inducible factor-1α (HIF-1α), inducible nitric oxide synthase (iNOS), BCL2/adenovirus E1B interacting protein 3 (BNIP3) and caspase-3 protein were measured. Compared with sham scald group, severe scald elevated CK-MB, cardiomyocyte apoptosis rate, caspase-3 activity and protein levels, NO content, and HIF-1α signalling pathway proteins; whereas VPA decreased CK-MB, cardiomyocyte apoptosis rate and inhibited HIF-1α signalling pathway protein expression. In conclusion, these results suggested that VPA inhibited early cardiomyocyte apoptosis and attenuated myocardial injury in lethally scalded rats, which may be related to the regulation of the HIF-1α signalling pathway.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice. 羟基红花黄色素 A 可改善帕金森病小鼠的抑郁样行为。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Huilin Zhang, Xiaohan Zhang, Xue Jia, Wei Zheng, Jie He, Zhenhua Wang, Tian Wang, Bing Han

{"title":"Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice.","authors":"Huilin Zhang, Xiaohan Zhang, Xue Jia, Wei Zheng, Jie He, Zhenhua Wang, Tian Wang, Bing Han","doi":"","DOIUrl":"","url":null,"abstract":"Depression is a common non-motor symptom of Parkinson's disease. Previous studies demonstrated that hydroxysafflor yellow A had properties of improving motor symptoms of Parkinson's disease. The effect of hydroxysafflor yellow A on depression in Parkinson's disease mice is investigated in this study. To induce Parkinson's disease model, male Swiss mice were exposed to rotenone (30 mg/kg) for 6 weeks. The chronic unpredictable mild stress was employed to induce depression from week 3 to week 6. Sucrose preference, tail suspension, and forced swimming tests were conducted. Golgi and Nissl staining of hippocampus were carried out. The levels of dopamine, 5-hydroxytryptamine and the expression of postsynaptic density protein 95, brain-derived neurotrophic factor in hippocampus were assayed. It showed that HSYA improved the depression-like behaviors of Parkinson's disease mice. Hydroxysafflor yellow A attenuated the injury of nerve and elevated contents of dopamine, 5-hydroxytryptamine in hippocampus. Treatment with hydroxysafflor yellow A also augmented the expression of postsynaptic density protein 95 and brain-derived neurotrophic factor. These findings suggest that hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice through regulating the contents of postsynaptic density protein 95 and brain-derived neurotrophic factor, therefore protecting neurons and neuronal dendrites of the hippocampus.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ciprofol suppresses proliferation, invasion and migration of human pancreatic cancer cells. 环丙酚可抑制人类胰腺癌细胞的增殖、侵袭和迁移。

IF 0.8 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2024-03-01

Fangfang Han, Shi Dong, Zhou Chen, Chunlu Dong, Huaqing Shi, Yan Du, Wence Zhou

{"title":"Ciprofol suppresses proliferation, invasion and migration of human pancreatic cancer cells.","authors":"Fangfang Han, Shi Dong, Zhou Chen, Chunlu Dong, Huaqing Shi, Yan Du, Wence Zhou","doi":"","DOIUrl":"","url":null,"abstract":"Pancreatic cancer (PC) is heterogeneous cancer having a high death rate and poor prognosis. The perioperative variables, such as anesthetics, may affect the cancer progression. Ciprofol is an intravenous anesthetic widely used recently. We aimed to explore the influence of ciprofol on PC and investigate its possible pathway. The proliferation, migration and invasion roles and apoptosis of ciprofol in human PC cells were examined using methylthiazolyldiphenyl-tetrazolium bromide, trans well and flow cytometery analysis. Then the putative targeted genes were examined using RNA-sequencing (RNA-seq) analysis. When differentially expressed genes (DEGs) were found, a protein-protein interaction network and pathway analyses were made. Moreover, MMP1 gene expression was confirmed in PC cells using quantitative real-time PCR. PANC-1 cells of PC were significantly suppressed with ciprofol in a dose-dependent and time-dependent way, and 20µg/mL ciprofol significantly suppressed tumor cell aggressiveness. Additionally, the RNA-seq analysis demonstrated that ciprofol controls the expression of 929 DEGs. 5 of 20 hub genes with increased connection were selected. Survival analysis demonstrated that MMP1 may be involved in the carcinogenesis and establishment of PC, reflecting the possible roles associated with ciprofol. Moreover, one target miRNA (hsa-miR-330-5p) of MMP1 was identified.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0