Pakistan journal of pharmaceutical sciences最新文献_第9页

Exploring the therapeutic potential of (+)-catechin gallate: An in vivo approach to combat liver fibrosis. 探索(+)-儿茶素没食子酸酯的治疗潜力：对抗肝纤维化的体内方法。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Rizwan Mehmood, Ghulam Mustafa, Muhammad Ali

{"title":"Exploring the therapeutic potential of (+)-catechin gallate: An in vivo approach to combat liver fibrosis.","authors":"Rizwan Mehmood, Ghulam Mustafa, Muhammad Ali","doi":"","DOIUrl":"","url":null,"abstract":"Liver fibrosis occurs as a result of the progression of chronic liver diseases, regardless of underlying causes such as hepatitis virus infection, alcohol intake, and metabolic fatty liver disorder. It is often associated with liver damage, inflammation, and cell death. In the current study, the potential of (+)-catechin gallate was checked against liver fibrosis in rat models. Carbon tetrachloride (CCl4) was administrated to induce liver fibrosis, and 0.7 mL/kg of CCl4 with olive oil was injected into rats for six weeks twice a week. The analysis of liver markers (i.e., alkaline phosphatase (ALP), aspartate transaminase (AST), and alanine transaminase (ALT)) was found to be increased in rats treated with CCl4, confirming the induction of liver fibrosis. After induction, the rats were divided into four groups (i.e., G2 to G5) with 6 rats in each group. Group 3 was treated with silymarin standard drug, and groups 4 and 5 were treated with (+)-catechin gallate low dose (50 mg/kg) and high dose (100 mg/kg), respectively for four weeks. After treatment, the levels of ALP, AST, and ALT revealed highly significant results compared to the standard drug. Histopathological study after treatment with (+)-catechin gallate revealed reduced inflammation, nuclear damage, necrosis, and hemorrhage. The study clearly shows the anti-liver fibrosis potential of (+)-catechin gallate, which could be used as a potential drug candidate in the treatment of liver fibrosis in the future.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"587-592"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal fumigation combined with vessels acupoint improves the prognosis and reduces inflammation in patients with dry eye disease: A retrospective study. 中药熏洗联合血管穴位可改善干眼病患者的预后，减少炎症反应：一项回顾性研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Yuan Liao, Caidong Guo

{"title":"Herbal fumigation combined with vessels acupoint improves the prognosis and reduces inflammation in patients with dry eye disease: A retrospective study.","authors":"Yuan Liao, Caidong Guo","doi":"","DOIUrl":"","url":null,"abstract":"Dry eye disease (DED) is a prevalent condition often associated with inflammation and tear film dysfunction. Complementary treatments such as herbal fumigation and acupoint applications have shown promise in handling EDE. This study evaluates the combined efficacy of herbal fumigation and vessels acupoint in treating DED. A total of 123 DED patients were randomly assigned to three groups: Fumigation group, Acupoint group, and combined group. Treatment outcomes were assessed using the Schirmer I test (SIT) for tear production, the Ocular surface disease index (OSDI) for symptom evaluation, corneal sensitivity measurements, and inflammatory cytokine levels. All groups showed significant improvements post-treatment, with the combined therapy yielding the greatest effects. SIT scores increased by an average of 4.5 mm in Fumigation group, 5.0 mm in Acupoint group and 6.6 mm in combined group. OSDI scores improved by 31.0%, 34.5%, and 40.8% for each group, respectively. Corneal sensitivity and cytokine levels also showed the highest improvement in combined group, indicating enhanced tear production and anti-inflammatory effects. The combination of herbal fumigation and acupoint application provides superior benefits for DED patients, enhancing tear production, symptom relief, and inflammatory reduction. This integrative approach could be a valuable complementary treatment for managing DED symptoms.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"343-349"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing atopic dermatitis treatment: The efficacy of modified Qingxin decoction. 革命性的特应性皮炎治疗：加味清心汤的疗效。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-03-01

Ying Guo, Jianzhou Ye, Guoying Miao

{"title":"Revolutionizing atopic dermatitis treatment: The efficacy of modified Qingxin decoction.","authors":"Ying Guo, Jianzhou Ye, Guoying Miao","doi":"","DOIUrl":"","url":null,"abstract":"We aimed to explore the Modified Qingxin Decoction for Invigorating the Spleen (MQDIS) in the treatment of atopic dermatitis (AD) the efficacy and safety. We selected AD192 patients treated from June 2018 to June 2023 as a retrospective case-control study, and divided the patients into the observation group and the comparison group with 96 cases. Patients in the control group received conventional treatment. Observation group was treated with MQDIS on the basis of comparison group. Symptoms and signs, Scoring Atopic Dermatitis Index (SCORAD) score, itch score, dryness score and quality of life index were analyzed in the two groups. The improvement of skin area, severity, pruritus and sleep in the comparison group was better than that in the observation group, especially in the severity and sleep, and the statistical difference was very significant.(P-value<0.05).SCORAD score and itch degree of both groups decreased, the difference was statistically significant.(P-value<0.05).MQDIS for treating AD had a good effect on improving various points of skin lesion, dry points and quality of life, and the recurrence rate was lower, it was safe and effective.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"593-603"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of ginkgolides on neurological function and nutritional status of patients with cerebral hemorrhage. 银杏内酯对脑出血患者神经功能和营养状况的疗效。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Sisi Chen, Xiaoli Feng

{"title":"Effectiveness of ginkgolides on neurological function and nutritional status of patients with cerebral hemorrhage.","authors":"Sisi Chen, Xiaoli Feng","doi":"","DOIUrl":"","url":null,"abstract":"Cerebral hemorrhage (CH) is characterized by acute onset, rapid progression and poor prognosis, posing a great potential threat to the health of patients. Ginkgolides, an excellent natural perpend, have the functions of vasodilation, anti-inflammation, anti-oxidation and memory and cognitive enhancement and the rich trace elements help improve the nutritional status of the human body, which is an important guarantee for the prognosis and health of CH patients. In this study, we observed the therapeutic efficacy of Ginkgolides combined with all-in-one nursing care for CH, thus providing a new reference for the future treatment of CH. We divided 100 patients with CH into a study group receiving Ginkgolides combined with all-in-one nursing care and a control group receiving all-in-one nursing care and compared their neurological and cognitive function, inflammatory response and nutritional status. The results found that ginkgolides combined with all-in-one nursing care better enhanced the neurological and cognitive functions of CH patients and inhibited inflammatory responses. Besides, ginkgolides significantly promoted the increase of nutritional protein levels in CH patients, better ensuring their health. Therefore, we recommend to popularize the use of ginkgolides combined with all-in-one nursing care in the treatment of CH in the future.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"83-88"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between serum CEACAM1 levels and prognosis and temozolomide chemotherapy sensitivity in patients undergoing neuroendoscopic transsphenoidal pituitary tumor resection. 接受神经内镜经蝶垂体瘤切除术的患者血清CEACAM1水平与预后和替莫唑胺化疗敏感性之间的关系

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Chong Chen Ma, Er Ping He, Yue Qing Zhang, Yong Jing Wang, Chun Ming Zhu, Xuan Yu

{"title":"Relationship between serum CEACAM1 levels and prognosis and temozolomide chemotherapy sensitivity in patients undergoing neuroendoscopic transsphenoidal pituitary tumor resection.","authors":"Chong Chen Ma, Er Ping He, Yue Qing Zhang, Yong Jing Wang, Chun Ming Zhu, Xuan Yu","doi":"","DOIUrl":"","url":null,"abstract":"Pituitary tumors are common intracranial neoplasms with complex pathogenesis. Temozolomide (TMZ) has shown potential in treatment, but its efficacy and related biomarkers require further investigation. This study explores the relationship between serum CEACAM1 levels, prognosis after neuroendoscopic transsphenoidal pituitary tumor resection, and TMZ sensitivity. A retrospective analysis of 70 patients who underwent surgery from 2020 to 2022 was conducted. Patients were classified into high- and low-CEACAM1 groups. Baseline characteristics showed no significant differences (P>0.05). After six months, patients with poor prognosis had significantly higher preoperative CEACAM1 levels (P<0.05). TMZ-resistant patients also had elevated levels (P<0.05). The AUC of preoperative CEACAM1 for predicting prognosis was 0.716 (cutoff: 5857.5 pg/mL) and for TMZ resistance was 0.742 (cutoff: 6431 pg/mL). High preoperative CEACAM1 levels are associated with poor prognosis and TMZ resistance, serving as a potential biomarker to guide clinical evaluation and treatment.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"165-173"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of tislelizumab combined with albumin-bound paclitaxel and carboplatin on intestinal flora and gastrointestinal toxicities in advanced lung cancer. tislelizumab联合白蛋白结合紫杉醇和卡铂对晚期肺癌患者肠道菌群和胃肠道毒性的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Kai Feng, Tianwei Liu, Ruihua Ren, Yanan Zhao, Haiyang Li, Jiyun Wang

引用次数: 0

Pharmacological insights into Azadirachta indica fruit: GC-MS Profiling and evaluation of key bioactivities on experimental animals. 对 Azadirachta indica 果实的药理研究：GC-MS 图谱分析和对实验动物关键生物活性的评估。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Mariam Razzak, Azra Riaz, Muhammad Ali Rajput, Shahana Wahid, Ali Alqahtani, Saira Saeed Khan, Maham Nawaz, Anusha Ahmed

{"title":"Pharmacological insights into Azadirachta indica fruit: GC-MS Profiling and evaluation of key bioactivities on experimental animals.","authors":"Mariam Razzak, Azra Riaz, Muhammad Ali Rajput, Shahana Wahid, Ali Alqahtani, Saira Saeed Khan, Maham Nawaz, Anusha Ahmed","doi":"","DOIUrl":"","url":null,"abstract":"Azadirachta indica, fruit with significant therapeutic potential, was evaluated using a multidimensional approach to systematically evaluate its pharmacological spectrum covering antimicrobial, antifungal, anti-inflammatory, analgesic, muscle-relaxant and sleep-inducing effects using in vitro and in vivo models. The study found that fruit extract, when administered at different doses, showed significant antibacterial effects against Gram-positive and Gram-negative bacteria along with a highly significant antifungal effect against Aspergillus niger that might be due to identified azol compounds.‎ Azadirachta indica extract showed significant anti-inflammatory effects at doses of 200 and 400mg/Kg, reducing paw oedema volume and exhibiting analgesic and muscle relaxant activity. Unique findings included significant muscle relaxation and enhanced locomotor activity observed specifically at 400mg/Kg on the 7th and 14th days. Azadirachta indica showed significantly increased sleep duration and reduced sleep onset time in Na-thiopental-induced sleep tests at doses of 200 and 400mg/Kg. ‎Through GC-MS analysis, bioactive compounds, including 2,3-propanetriol, 7-methoxy-‎‎1,3,4,5-tetrahydrobenzo[b]azepin-2-one, piperazine and 4-amino-4,5-dihydro-1H-1,2,4-‎triazol-5-one, were identified, which likely contribute to the observed pharmacological ‎activities.‎ This study first reports Azadirachta indica's muscle-relaxant and sleep-enhancing effects, expanding its known therapeutic potential.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"139-150"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of dexmedetomidine and remimazolam on spinal anesthesia in patients with anxiety disorder: A retrospective case-control study on intraoperative sedation quality and postoperative cognitive function. 右美托咪定和雷马唑仑对焦虑障碍患者脊髓麻醉的影响：术中镇静质量和术后认知功能的回顾性病例对照研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Xinyu Yuan, Fei Liang

{"title":"The effects of dexmedetomidine and remimazolam on spinal anesthesia in patients with anxiety disorder: A retrospective case-control study on intraoperative sedation quality and postoperative cognitive function.","authors":"Xinyu Yuan, Fei Liang","doi":"","DOIUrl":"","url":null,"abstract":"Anxiety disorder patients are accompanied by significant dysfunction and other problems, clinical treatment faces great challenges. The aim of this study is to investigate the effects of dexmedetomidine and remimazolam on spinal anesthesia in anxiety disorder patients, to provide a clinical reference point. 80 anxiety disorder patients coming to our hospital for intrathecal anaesthesia surgery from June 2022 to June 2024 were divided into control group (n=40) and study group (n=40). Remimazolam was used in both groups and dexmedetomidine was added in study group. The heart rates (HR) and means of arterial pressures (MAP), Ramsay scores, visual analog scale (VAS) and hamilton analysis of metabolic anxiety scale (HAMA) scores, mini-mental state examination (MMSE), montreal cognitive assessment scale (MoCA) scores, serum platelet activating factors (PAF) and interferon gamma (IFN-γ) and adverse reactions were compared among the both groups. Compared to control group, HR and MAP levels, MMSE and MoCA scores, and IFN-γ levels were significantly increased, and Ramsay scores, VAS scores, HAMA scores and PAF levels were significantly decreased in the study group (P<0.05). No significant difference in the adverse reaction incidence of the both groups (P>0.05). Spinal anesthesia with dexmedetomidine and remimazolam provides better anesthesia in anxiety disorders patients.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"175-183"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapy with Baofukang suppositories and promestriene cream for postmenopausal atrophic vaginitis: A randomized controlled trial. 保妇康栓和丙三烯乳膏联合治疗绝经后萎缩性阴道炎：随机对照试验。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Jingjing Wang, Shuya Yang, Shujun Yan

{"title":"Combination therapy with Baofukang suppositories and promestriene cream for postmenopausal atrophic vaginitis: A randomized controlled trial.","authors":"Jingjing Wang, Shuya Yang, Shujun Yan","doi":"","DOIUrl":"","url":null,"abstract":"Postmenopausal atrophic vaginitis is a prevalent condition that significantly impacts the quality of life. This study aimed to evaluate the efficacy and safety of combining Baofukang suppositories with Promestriene cream in treating this condition, with a particular focus on clinical outcomes and endometrial thickness. Sixty-eight patients underwent random allocation into either the control group (Baofukang suppositories) or the observational group (Baofukang suppositories and Promestriene cream). Endometrial thickness was measured using transvaginal ultrasound and clinical indicators, including symptom resolution time, vaginal cleanliness, and adverse reactions, were assessed. The observational group showed a higher effective rate (97.06% vs. 79.41%, P<0.05) and faster symptom relief (P<0.05), with significant improvements in vaginal cleanliness and symptom scores (P<0.05). No significant differences in endometrial thickness or adverse reactions were observed (P<0.05). Combining Baofukang suppositories with Promestriene cream offers an effective and safe therapeutic option for postmenopausal atrophic vaginitis, promoting superior symptom recovery without compromising endometrial safety.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"151-156"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the effect of Western medicine caltrate D combined with traditional Chinese medicine eight section brocade practice therapy on preventing postmenopausal osteoporosis. 西药钙化D联合中药八节锦疗法预防绝经后骨质疏松的疗效研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Xiaoyu Lan, Hongyan Sun, Kun Shi, Xiaohong Sun, Taoran Wang, Hui Wang

{"title":"Study on the effect of Western medicine caltrate D combined with traditional Chinese medicine eight section brocade practice therapy on preventing postmenopausal osteoporosis.","authors":"Xiaoyu Lan, Hongyan Sun, Kun Shi, Xiaohong Sun, Taoran Wang, Hui Wang","doi":"","DOIUrl":"","url":null,"abstract":"Caltrate D is a commonly used drug in the treatment of postmenopausal osteoporosis (PMOP), but the effect of single application is not ideal. Therefore, to investigate the eight section brocade therapy combined with caltrate D effect in preventing and treating PMOP. From January 2021 to June 2022, 110 postmenopausal women with decreased bone mass were selected and randomized into group A (n = 54) and group B (n = 56). The both group receiving caltrate D treatment and group B added receiving Chinese medicine eight section brocade therapy. Bone mineral density (BMD), WHOQOL-BREF score and incidence of PMOP were compared in both groups. The bone metabolism indexes [serum calcium, phosphorus, alkaline phosphatase (ALP)], bone formation indexes [serum Procollagen I N-Terminal Propeptide (PINP), type 1 collagen C-terminal cross-linked telopeptides (β-CTX)] were detected in both groups. After treatment, lumbar BMD, femoral neck BMD, serum calcium level and WHOQOL-BREF score in group B were significantly higher compared to group A, serum phosphorus and ALP levels, PMOP recurrence rate decreased significantly and no significant difference in serum PINP and β-CTX levels in both groups. This combination therapy is significantly effective and provides a new reference for the clinical treatment of PMOP.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"1-6"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0