Pakistan journal of pharmaceutical sciences最新文献_第8页

Exploring the antidepressant and anxiolytic effects of Desmostachya bipinnata: Evidence from animal models and in-silico studies. 探讨石竹的抗抑郁和抗焦虑作用：来自动物模型和计算机研究的证据。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Muhammad Muzammil Nazir, Muhammad Arif, Mahnoor Arif, Iqra Farzeen, Anjum Khursheed, Asma Ashraf, Hareem Noor, Muhammad Haneef, Abdulhakeem S Alamri, Majid Alhomrani, Walaa F Alsanie, Hammad Saleem

{"title":"Exploring the antidepressant and anxiolytic effects of Desmostachya bipinnata: Evidence from animal models and in-silico studies.","authors":"Muhammad Muzammil Nazir, Muhammad Arif, Mahnoor Arif, Iqra Farzeen, Anjum Khursheed, Asma Ashraf, Hareem Noor, Muhammad Haneef, Abdulhakeem S Alamri, Majid Alhomrani, Walaa F Alsanie, Hammad Saleem","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study was to assess the ethanolic extract of Desmostachya bipinnata (EEDBR)'s sedative and antidepressant properties in Swiss albino mice. The extract was given to Swiss albino mice in single doses of 100, 200 and 400mg/kg of body weight for different biological tests. In the open field test, the diazepam group and the 400mg/kg dosage group spent more time in the centre zone than the control group. The 400mg/kg dosage and diazepam group had no discernible effect on centre time response. Additionally, a dosage of 100mg/kg exhibits a significant impact of 44±3.60. Compared to treated with EEDBR, those given with standard control Diazepam (1mg/kg) had higher head dips. At all dosages, there was a substantial decrease in locomotor activity in HCT as compared to the control group at all time intervals (between 30 and 120 minutes). Diazepam, the positive control, significantly lowers locomotor activity. EEDBR reduced sadness and anxiety in a dose-dependent way. Higher dosages of EEDBR result in noticeably stronger antidepressant effects, indicating a dose-dependent connection. For the molecules isopulegone, geranyl isovalerate and eucalyptol, the in-silico docking scores for Cyclooxygenase-1 and Cyclooxygenase-2 are -8.2, -6.2, -8.4 and -8.9, -7.2, -7.6 respectively.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"279-289"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of saponin extract from Panax notoginseng on hyperlipidemic mice. 三七皂苷提取物对高脂血症小鼠的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Zheng-Yong Yu, Ya-Juan Luo, Tai-Hui Yang, Wen-Bo Zeng, Heng Liu, Wen-Feng Xin, Guang-Quan Feng

{"title":"Effects of saponin extract from Panax notoginseng on hyperlipidemic mice.","authors":"Zheng-Yong Yu, Ya-Juan Luo, Tai-Hui Yang, Wen-Bo Zeng, Heng Liu, Wen-Feng Xin, Guang-Quan Feng","doi":"","DOIUrl":"","url":null,"abstract":"To investigate the impact of the Panax notoginseng saponin extract on hyperlipidaemic mice. We developed a hyperlipidemia model in mouse through the administration of a high-fat diet. We conducted weekly measurements of body weight, serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and highdensity lipoprotein cholesterol (HDL-C). Additionally, serum levels of Apolipoprotein A (APOA) and Apolipoprotein B (APOB) were determined post-feeding. We assessed pathological liver tissue damage in mice, as well as examined malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity in liver tissue. Immunohistochemical analysis was conducted to detect the expression levels of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) proteins within liver tissues. Administration of Panax notoginseng saponin extract led to a reduction in body weight, liver index, and histopathological scores among mice. Additionally, there was a significant reduction in TC, TG and LDL-C levels, accompanied by an increase in HDL-C levels. Additionally, an increase in hepatic SOD activity and a decrease in MDA content were observed in the liver homogenates of mice. Furthermore, the expression levels of HO-1 and Nrf2 proteins were upregulated in liver tissue. These findings suggest that Panax notoginseng saponin extracts may ameliorate high-fat diet-induced hyperlipidemia.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"207-217"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the active components and mechanisms of chang-yan-ning granule in inflammation relief: Insights from serum pharmacochemistry and network pharmacology. 从血清药物化学和网络药理学角度探讨肠炎宁颗粒的消炎活性成分及其作用机制。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Ziqi Sun, Mingyuan Yuan, Xiaoli Wang, Minjie Li, Xueying Wang, Yaqing Li, Tiejun Zhang, Quanguo Liu, Xiaoshu Zhang

{"title":"Exploring the active components and mechanisms of chang-yan-ning granule in inflammation relief: Insights from serum pharmacochemistry and network pharmacology.","authors":"Ziqi Sun, Mingyuan Yuan, Xiaoli Wang, Minjie Li, Xueying Wang, Yaqing Li, Tiejun Zhang, Quanguo Liu, Xiaoshu Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Chang-Yan-Ning granule (CYNG) is a traditional Chinese patent medicine used to treat ulcerative colitis (UC). In this study, we investigated the effect of CYNG on UC and its mechanism. In this study, the active components in CYNG drug serum were characterized by serum pharmacochemistry and network pharmacology was used to predict key targets. To elucidate the potential anti-inflammatory mechanism of CYNG in UC patients, in vitro experiments were performed to evaluate the effect of different concentrations of CYNG on lipopolysaccharide (LPS) -induced RAW 264.7. The results showed that the serum pharmacochemical study revealed 15 compounds, which were subjected to network pharmacology analysis. Integrating these results identified the key signaling pathway (MAPK signaling pathway). Western blot and ELISA further demonstrated that CYNG might also regulate p38/MAPK pathway through down-regulating the expression of p-p38 and p-JNK proteins and exerting anti-inflammatory effects. This study explains the anti-inflammatory mechanism of CYNG and provides beneficial support for the treatment of UC with CYNG.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"269-278"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the comparative efficacy of multimodal treatment strategies for hyperkalemia management in a tertiary care hospital setting: A prospective cohort study. 评价三级医院高钾血症管理多模式治疗策略的比较疗效：一项前瞻性队列研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Bushra Muzamil Patel, Humera Ishaq, Muzamil Patel, Adnan Iqbal, Shoaib Alam, Khalid Orayj, Asif Ansari Shaik Mohammad, Azfar Athar Ishaqui

{"title":"Evaluating the comparative efficacy of multimodal treatment strategies for hyperkalemia management in a tertiary care hospital setting: A prospective cohort study.","authors":"Bushra Muzamil Patel, Humera Ishaq, Muzamil Patel, Adnan Iqbal, Shoaib Alam, Khalid Orayj, Asif Ansari Shaik Mohammad, Azfar Athar Ishaqui","doi":"","DOIUrl":"","url":null,"abstract":"Hyperkalemia poses significant risks to patients due to its potential to cause life-threatening cardiac and neuromuscular complications. This study aimed to evaluate the effectiveness of different treatment protocols for hyperkalemia in hospitalized patients. This prospective observational study, conducted at Sindh Government Hospital Korangi, Karachi, included adult patients (>18 years) with potassium levels ≥5.5 mEq/L. The study evaluated the effectiveness of different treatments in normalizing potassium levels, with treatment choices made at the discretion of the treating physicians. Among the 341 patients, treatment effectiveness varied by hyperkalemia severity. For mild hyperkalemia, D50W with insulin and sodium bicarbonate achieved normokalemia in 83.3% of cases, compared to 55% with Sodium-Polysorbate alone. In moderate hyperkalemia (189 patients), the combination of D50W, insulin, sodium bicarbonate, calcium gluconate and Sodium-Polysorbate reduced potassium levels from 6.52 to 6.01 mmol/L (p<0.001), with 27.2% achieving normokalemia. In severe hyperkalemia (104 patients), this regimen led to significant reductions (0.88-1.18 mmol/L, p<0.001), with 17.6% reaching normokalemia. Multi-drug approaches are advocated for effective hyperkalemia management, particularly for moderate to severe cases. Future research should focus on refining treatment protocols and improving adherence to guidelines to ensure consistent management outcomes.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"55-60"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of scenario simulation combined Mini-CEX teaching model in gynecology and obstetrics resident teaching: A case study of paclitaxel and cisplatin use. 情景模拟结合Mini-CEX教学模式在妇产科住院医师教学中的应用——以紫杉醇与顺铂应用为例

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Xiaoxin Sui, Zhi Cui, Qingxian Li

{"title":"Application of scenario simulation combined Mini-CEX teaching model in gynecology and obstetrics resident teaching: A case study of paclitaxel and cisplatin use.","authors":"Xiaoxin Sui, Zhi Cui, Qingxian Li","doi":"","DOIUrl":"","url":null,"abstract":"This study aims to investigate the application of scenario simulation combined with the Mini-CEX teaching model on the instruction of paclitaxel and cisplatin use in gynecology and obstetrics residents. A retrospective analysis was conducted, selecting 32 gynecology and obstetrics residents who received traditional teaching from July 2019 to June 2021 as the control group and another 27 gynecology and obstetrics residents who received scenario simulation combined with Mini-CEX teaching from July 2021 to June 2023 as the observation group. In comparison to controls, participants from our observational cohort demonstrated superior performance across both theoretical examinations and case analyses (P<0.05). Furthermore, within our observational cohort we observed heightened proficiency across all seven dimensions assessed by Mini-CEX compared to controls (P<0.05). Additionally, the total score of teaching satisfaction in observation group was significantly higher than that in control group (P<0.05). Notably, the satisfaction score of the observation group was significantly higher than that of the control group (P<0.05). The application of scenario simulation combined with Mini-CEX teaching mode has a positive impact on the instruction of paclitaxel and cisplatin use in gynecology and obstetrics residents. It improved clinical competence and satisfaction and is worth promoting.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"157-164"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors. 替卡格雷和氯吡格雷治疗不稳定型心绞痛的疗效及其对血清炎症因子的影响

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Donghui Qin, Yuanyuan Ren, Na Zhang, Xue Yang, Zhuo Chen, Changliang Zhao

{"title":"Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors.","authors":"Donghui Qin, Yuanyuan Ren, Na Zhang, Xue Yang, Zhuo Chen, Changliang Zhao","doi":"","DOIUrl":"","url":null,"abstract":"To evaluate the comparative efficacy of Ticagrelor and Clopidogrel in treating patients with coronary heart disease and unstable angina, as well as their effects on serum inflammatory factors, thereby providing a solid foundation for future clinical diagnosis and treatment. The frequency of angina attacks in the Ticagrelor group was lower than in the Clopidogrel group (P<0.05). The duration of angina and shortness of breath were also shorter in the Ticagrelor group (P<0.05). The levels of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), lipoprotein-associated phospholipase A2 (Lp-PLA2), myeloperoxidase (MPO), type 1 tissue plasminogen activator inhibitor (tPAI-1), homocysteine (Hcy), endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-α), platelet-derived growth factor (PDGF), brain natriuretic peptide (BNP), soluble CD40 ligand (sCD40L), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule (sLCAM-1), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG), as well as the incidence of MACCE events, were all lower in the Ticagrelor group compared to the Clopidogrel group (P<0.05), while high-density lipoprotein cholesterol (HDL-C) levels and overall efficacy were higher in the Ticagrelor group (P<0.05). Ticagrelor demonstrates superior therapeutic efficacy compared to Clopidogrel in patients with coronary heart disease and unstable angina, effectively reducing serum inflammatory factor levels.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"77-82"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tretinoin loaded NLCs-based sunscreen cream; preparation and characterization. 含维生素a的nlcs防晒霜；制备和表征。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Rabbia Saleem, Mubashar Rehman, Tanveer Ahmed Khan, Qandeel Khalid, Aousaf Ahmad, Muhammad Awais, Ayesha Ahmad, Shakeel Ijaz

{"title":"Tretinoin loaded NLCs-based sunscreen cream; preparation and characterization.","authors":"Rabbia Saleem, Mubashar Rehman, Tanveer Ahmed Khan, Qandeel Khalid, Aousaf Ahmad, Muhammad Awais, Ayesha Ahmad, Shakeel Ijaz","doi":"","DOIUrl":"","url":null,"abstract":"FDA has recognized tretinoin as the gold standard for skin anti-aging products but it has the disadvantage of being a strong irritant and unstable in light. Nanostructured lipid carriers (NLCs) are advanced, second-generation solid lipid nanoparticles with the intriguing feature of acquiring the properties of physical sunscreens in terms of UV ray scattering. Thus, this study was designed to formulate a tretinoin-loaded NLCs-based sunscreen cream to potentiate the photo-stability of tretinoin. Tretinoin-loaded NLCs were prepared using micro-emulsion method and the Box-Benkhen design was utilized to optimize the formulations. The optimized tretinoin-loaded formulations were characterized based on particle size, PDI, zeta potential and entrapment efficiency. Moreover, the physicochemical parameters of optimized tretinoin-loaded NLCs, including morphology, FTIR studies, DSC analysis and stability studies and release profile were also examined. The results revealed that tretinoin-loaded NLCs-based sunscreen formulation was stable in all aspects and showed better photo-stability and sun protection with prolonged release profile. In conclusion, the present study affirms the NLCs formulation as a viable carrier for topically administering tretinoin, reducing its photosensitivity and suggesting that incorporated sunscreens may provide prolonged protective effects against harmful UV radiations.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"315-323"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing oral bioavailability of escitalopram by self-nanoemulsifying drug delivery systems (SNEDDS): An in-vivo, in-vitro and in-silico study. 通过自纳米乳化给药系统（SNEDDS）提高艾司西酞普兰的口服生物利用度：一项体内、体外和计算机研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Muhammad Junaid Asaad, Abdul Majeed, Syed Nisar Hussain Shah, Ghulam Abbas, Farhan Siddique, Muhammad Hanif, Furqan Muhammad Iqbal, Maryam Bashir

{"title":"Enhancing oral bioavailability of escitalopram by self-nanoemulsifying drug delivery systems (SNEDDS): An in-vivo, in-vitro and in-silico study.","authors":"Muhammad Junaid Asaad, Abdul Majeed, Syed Nisar Hussain Shah, Ghulam Abbas, Farhan Siddique, Muhammad Hanif, Furqan Muhammad Iqbal, Maryam Bashir","doi":"","DOIUrl":"","url":null,"abstract":"This study aimed to develop SNEDDS to address the issue of low water solubility of escitalopram (ETP), which consequently leads to inadequate oral bioavailability. The formulation consisted of Tween 80, geranium oil, and polyethylene glycol 400. An evaluation was conducted to determine the surface charge and particle size of ETP-SNEDDS. The stability and compatibility of excipients were evaluated by TGA, DSC and FTIR. Studies were carried out to examine the dissolution, digestion, permeability, in in-vitro, in-vivo, and ex-vivo settings. ETP-SNEDDS bioavailability was assessed in a group of six albino rats under normal conditions. The synthesized SNEDDS exhibited thermodynamic stability, characterized by a 145nm droplet size with a polydispersity index of 0.120 and a minute emulsification duration. Developed SNEDDS containing ETP in FSSIF had a dissolution rate of 96%. Based on the permeation results, the SNEDDS demonstrated a 4.2-fold and 3.1-fold increase in drug penetration relative to standard powder-ETP drug and a reference tablet, correspondingly. Statistically significant improvements (p<0.05) were reported in in-vitro digestion, dissolution and ex-vivo permeability. SNEDDS exhibited a 5.34-fold increase in Cmax and a 4.71-fold rise in AUC compared to the reference. Based on findings, the formulated SNEDDS have a valuable method for enhancing ETP oral bioavailability.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"299-313"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effect of levodopa-carbidopa-entacapone combined with rTMS in Parkinson's disease. 左旋多巴-卡比多巴-恩他卡朋联合rTMS治疗帕金森病的疗效。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Ke-Fei Zhang, Bing Wang, Qing-Yun Yu, Guo-Bang Wei, Xiao-Rui Cui, Li-Ying Zhang

{"title":"Therapeutic effect of levodopa-carbidopa-entacapone combined with rTMS in Parkinson's disease.","authors":"Ke-Fei Zhang, Bing Wang, Qing-Yun Yu, Guo-Bang Wei, Xiao-Rui Cui, Li-Ying Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive tissue deterioration. This study evaluated the effects of levodopa-carbidopa-entacapone (LCE) combined with high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in elderly PD patients. Participants were divided into an observation group (HF-rTMS + LCE) and a control group (HF-rTMS alone). Motor and cognitive function, quality of life, and adverse effects were assessed before treatment and at 8 weeks, 16 weeks and 6 months post-treatment. Both groups showed no significant differences in baseline data. However, post-treatment, the observation group demonstrated superior clinical improvements. The Unified Parkinson's Disease Rating Scale-III (UPDRS-III) score significantly decreased from 43.40±3.94 to 34.73±5.05 at 6 months (P<0.01), while the Berg Balance Scale (BBS) score increased from 30.97±5.17 to 46.35±5.75 (P<0.01). The Timed Up and Go test (TUGT) time reduced from 13.12±2.23 seconds to 8.62±2.50 seconds (P<0.01) and the Parkinson's Disease Questionnaire (PDQ-39) score decreased from 37.32±3.69 to 25.75±4.59 (P<0.01). Additionally, the Montreal Cognitive Assessment (MoCA) score increased from 22.05±2.24 to 28.15±1.99 (P<0.001). Adverse effects were similar between groups (16.7% vs. 15%, P>0.05). These results suggest HF-rTMS combined with LCE enhances motor function, balance, cognition, and quality of life in elderly PD patients without increasing adverse effects.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"241-247"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro urease inhibition screening of some edible and medicinal herbs to combat Helicobacter pylori related gastric diseases. 部分食、药材抗幽门螺杆菌相关胃病脲酶体外抑制筛选

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-01-01

Hina Zahid, Bushra Hina, Khizar Abbas

{"title":"In vitro urease inhibition screening of some edible and medicinal herbs to combat Helicobacter pylori related gastric diseases.","authors":"Hina Zahid, Bushra Hina, Khizar Abbas","doi":"","DOIUrl":"","url":null,"abstract":"Prevalence of gastric diseases caused by Helicobacter Pylori bacteria is very common especially in developing countries. H. pylori is not only responsible for initiating gastric complaints like gastritis and peptic ulcer but may also lead to gastric cancer. The aim of this research study is to explore natural flora that exhibit anti urease potential. For this purpose, fifteen edible and medicinal herbs (Silybium marianum, Fagonia arabica, Nigella sativa, Curcuma longa, Ocimum sanctum, Salvia rosmainus, Hyssopus officinalis, Antrirrhinum majus, Salvia splendens, Tropaeolum majus, Dalbergia sisso, Aloe barbadensis, Abelmoschus esculentus, Cuscuta reflexa, Hibiscus schizopetalus) were screened for anti-urease activity at three different concentration i.e, 25μg/ml, 50μg/ml and 75μg/ml. The results indicated significant outcomes for urease inhibitory activity for all tested medicinal plants. However, F. arabica (87.2±1.47), N. sativa (90.4±0.09), O. sanctum (75.6±0.95), H. officinalis (78.9±0.69), T. maju (87.3±0.14), A. esculentus (90.3±0.86), C. reflexa (94.1±0.92) showed significant results at 75μg/ml when compared to Thiourea. Moreover IC50 values were also calculated for urease inhibitory activity. It can be concluded that utilization of these valuable medicinal plants can not only decrease the prevalence of gastric diseases caused by H. pylori bacteria but a good candidate for therapeutic purposes.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 1","pages":"7-14"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0