ED50 of hydromorphone suppressing body movement in artificial abortion: A dose-finding study.

Abstract

The present study attempted to investigate the median effective dose (ED₅₀) of hydromorphone on suppressing of body movement in artificial abortion. A total of 23 female patients were assigned into the study using the up-and-down method. The usage amount of hydromorphone for each patient was decreased or increased by a gradient, depending on whether the anterior patient's body movement during the abortion procedure is positive or not. By using probit regression analysis, the ED₅₀ of hydromorphone was 19.637 μg/kg for the suppression body movement in abortion. This result may provide a reference for the safety and rational use of the drug in clinic.