Pakistan journal of pharmaceutical sciences最新文献

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Therapeutic evaluation of herbal foot bath for tinea pedis: Impact on fungal clearance, adverse reactions and patient well-being. 草药足浴对足癣的治疗评价:对真菌清除、不良反应和患者健康的影响。
IF 0.7 4区 医学
Haixia Li, Jinchai Lin, Peihua Chen, Youfa Wang, Wanling Chen, Jianping Huang
{"title":"Therapeutic evaluation of herbal foot bath for tinea pedis: Impact on fungal clearance, adverse reactions and patient well-being.","authors":"Haixia Li, Jinchai Lin, Peihua Chen, Youfa Wang, Wanling Chen, Jianping Huang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We aimed to analyze the curative effect of herbal foot bath on tinea pedis patients, and observe its effect on fungal clearance rate, adverse reactions and patients' quality of life. One hundred patients with tinea pedis admitted to an outpatient clinic of Shunde Hospital of Guangzhou University of Chinese Medicine from July 2022 to December 2023 were selected and 50 cases each for the treatment group and 50 cases each for the control group were chosen at random. The control group was treated with Dakening Cream, while the treatment group was treated with the Chinese herbal foot - soaking liquid. The TCM syndrome score and quality of life score were compared before and after therapy, and the curative impact, fungus clearance rate, and safety of the two groups were examined. The treatment group's overall effective rate was greater than the control group's (P<0.05). Following therapy, both groups' primary and secondary symptom scores were lower than they were before to treatment, and the treatment group's scores were lower than the control group. And it is even lower in the treatment group. (P<0.05). When compared to the control group, the treatment group's fungal clearance rate was greater and their recurrence rate was lower (P<0.05). Adverse reaction rates were comparable across the two groups (P>0.05). Following therapy, both groups' SF-36 ratings were higher than their pre-treatment levels, with the treatment group outperforming the control group and it is higher in the treatment group (P< 0.05). Patients' quality of life can be improved by using a herbal foot bath to treat tinea pedis, which can successfully relieve symptoms and has a high fungus clearance rate, few side effects and a low recurrence rate.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"615-622"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An auxiliary role of deep neural network ophthalmic disease identification models in choosing medication treatment strategy. 深度神经网络眼科疾病识别模型在药物治疗策略选择中的辅助作用。
IF 0.7 4区 医学
Wang Xi, Hongxu Sun, Huan Liu, Shouxi Lan, Xiaofei Dong
{"title":"An auxiliary role of deep neural network ophthalmic disease identification models in choosing medication treatment strategy.","authors":"Wang Xi, Hongxu Sun, Huan Liu, Shouxi Lan, Xiaofei Dong","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To evaluated a Deep Neural Network (DNN)-based ophthalmic disease diagnosis framework in facilitating personalized medication treatment plans using a prospective, single-center, randomized controlled clinical trial design. 500 patients were randomly assigned to either a DNN-aided experimental group or a control group receiving standard physician-based treatment plans. The primary outcomes were medication selection accuracy, clinical efficacy (assessed by BCVA and CMT), patient compliance, and adverse reaction management. Results showed that DNN-aided treatment plans significantly improved medication selection accuracy and treatment quality, with higher BCVA and CMT scores in the experimental group. Patients in the experimental group also demonstrated higher compliance and a trend towards lower adverse reaction rates. The study highlights the potential of DNN models to enhance ophthalmic disease management, offering precise and personalized treatment strategies with potential benefits for patient outcomes and safety as AI technology advances.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"531-537"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic evaluation of the effectiveness of Xuesaitong combined with nutraceutical drugs in the treatment of diabetic peripheral neuropathy. 血塞通联合营养药物治疗糖尿病周围神经病变疗效的系统评价。
IF 0.7 4区 医学
Jie Li, Zehui Deng, Ronghai Cui, Jian Zhang
{"title":"Systematic evaluation of the effectiveness of Xuesaitong combined with nutraceutical drugs in the treatment of diabetic peripheral neuropathy.","authors":"Jie Li, Zehui Deng, Ronghai Cui, Jian Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study aims to evaluate the effectiveness of combining Xuesaitong with nutraceutical drugs, including alpha-lipoic acid, B vitamins, and coenzyme Q10, in the treatment of diabetic peripheral neuropathy (DPN). A 12-week randomized controlled trial was conducted with 140 clinically diagnosed DPN patients, who were randomly assigned into two groups. The intervention group received Xuesaitong along with nutraceuticals, while the control group was treated with nutraceuticals alone. Primary outcomes included changes in nerve conduction velocities (NCVs) and pain intensity using the Visual Analog Scale (VAS). Secondary outcomes assessed neuropathic symptoms (NSS), glycemic control (HbA1c), oxidative stress markers, inflammatory biomarkers and quality of life (SF-36). The intervention group showed significantly greater improvements in NCVs of the peroneal, tibial, and sural nerves compared to the control group (p<0.01). Pain intensity (VAS) and neuropathy symptoms (NSS) significantly decreased, with VAS scores reduced from 7.3±1.2 to 1.5±0.6 (p<0.001) and NSS from 7.2±1.5 to 2.0±0.9 (p<0.001). The combination therapy of Xuesaitong and nutraceuticals demonstrated superior efficacy and safety in improving nerve function, reducing symptoms, managing inflammation and oxidative stress, and enhancing quality of life in DPN patients.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"631-640"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of phenolic yield of Carthamus oxyacantha Bieb. leaves and flowers extracts pertaining to the antioxidant and antidiabetic effect by response surface methodology. 红花酚类物质产率的优化。用响应面法研究叶和花提取物的抗氧化和抗糖尿病作用。
IF 0.7 4区 医学
Hosh Muhammad Lashari, A H Memon, Muhammad Akram, Geeta Kumari, Qurat Ul Ain, Madan Lal Maheshwari, Sana Javaid Awan, Darakhshan Masroor
{"title":"Optimization of phenolic yield of Carthamus oxyacantha Bieb. leaves and flowers extracts pertaining to the antioxidant and antidiabetic effect by response surface methodology.","authors":"Hosh Muhammad Lashari, A H Memon, Muhammad Akram, Geeta Kumari, Qurat Ul Ain, Madan Lal Maheshwari, Sana Javaid Awan, Darakhshan Masroor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study was designed to establish the pharmacognostic and pharmacological validation of Carthamus oxyacantha (C. oxyacantha) leaves and flowers crude extracts, the optimization of crude extracts as per Box-Behnken's experimental design, indicated that ethanolic leaves and flowers extracts of C. oxyacantha prepared at extraction conditions of run # 3 and 8 (ELE-3 and EFE-8) respectively, presented the highest level of dependent variables, while, the alpha-amylase IC<sub>50</sub> value (5.976 µg/mL) of ELE-3 was relatively closer to that of standard acarbose (3.524 µg/mL). Chromatographic fingerprinting of ELE-3 resulted in the identification of bioactive phenolic compounds (quantitatively; 11.47 µg/mL of gallic acid and 8.27 µg/mL of quercetin). Furthermore, acute oral toxicity of ELE-3 suggested the LD<sub>50</sub> > 2000 mg/kg. The findings of an in vivo antidiabetic study indicated that ELE-3 (100 and 500 mg/kg) produced a significant reduction in alloxan induced hyperglycemia of diabetic rats. Thus, the present study demonstrated the pharmacognostic and pharmacological implications of C. oxyacantha leaves and flowers crude extracts and revealed the remedial role of optimized extract (ELE-3) for the management of diabetes mellitus owing to its oxidative stress-lowering tendency and presence of bioactive phenolic compounds.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"423-437"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The protective role of Calotropis procera Linn against cisplatin-induced oxidative stress, insight into antioxidant effects. 原花椒对顺铂诱导的氧化应激的保护作用,洞察抗氧化作用。
IF 0.7 4区 医学
Sardar Ali, Saima Nawaz, Shakir Ullah, Zainab Irshad, Niaz Ali, Ahad Nawaz, Muhammad Riaz, Najm Ur Rahman
{"title":"The protective role of Calotropis procera Linn against cisplatin-induced oxidative stress, insight into antioxidant effects.","authors":"Sardar Ali, Saima Nawaz, Shakir Ullah, Zainab Irshad, Niaz Ali, Ahad Nawaz, Muhammad Riaz, Najm Ur Rahman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has been hypothesized that inflammation and oxidative stress have a potential role in neurodegeneration. Cisplatin is a commonly used in different types of cancers but it is notorious for oxidative stress which leads to neurodegeneration. Therefore, the current study focused on the antioxidant effect of Calotropis procera during cisplatin treatment. The methanolic extract of C. procera was extracted using rotary evaporator. Memory impairment was evaluated by using Y-Maze and Morris water model. The antioxidant effect of C. procera extract was measured by assessing oxidative stress markers such as lipid peroxidation (LPO), reactive oxygen species (ROS), glutathione (GSH), and catalase (CAT) in the experimental groups. It has been found that C. procera extract showed a significant (p<0.05) effect on preventing memory dysfunction compared to a positive control (cisplatin). The effect of C. procera extract was observed in a dose-dependent manner. Similarly, the increase (p<0.05) in the level of oxidative stress marker was high compared to the positive control group in a dose-dependent manner. While the decrease in the level of malondialdehyde (MDA) was found in the C. procera extract treated groups dose-dependently. C. procera significantly reduces cisplatin-induced oxidative stress by restoring the level of antioxidant enzymes and reducing MDA levels. The therapeutic benefits are significant at a dose of 400 mg/kg.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"605-613"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study of the efficacy of glucosamine sulfate capsules and Huoxue Xiaozhong prescription in the treatment of knee osteoarthritis and the recovery of knee joint function. 硫酸氨基葡萄糖胶囊与活血消肿方治疗膝关节骨性关节炎及膝关节功能恢复的疗效比较研究。
IF 0.7 4区 医学
Zhifei Peng, Liang Ou, Jianjun Kuang
{"title":"Comparative study of the efficacy of glucosamine sulfate capsules and Huoxue Xiaozhong prescription in the treatment of knee osteoarthritis and the recovery of knee joint function.","authors":"Zhifei Peng, Liang Ou, Jianjun Kuang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study focused on the difference in efficacy between glucosamine sulfate capsules and Huoxue Xiaozhong recipe in the treatment of knee osteoarthritis, as well as their effects on knee joint function recovery. A total of 128 patients with knee osteoarthritis who met the criteria were prospectively enrolled and randomly divided into a glucosamine sulfate group (n = 64) and a traditional Chinese medicine group (n = 64). The total effective rate, visual analogue score (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), degree of joint swelling, range of motion (ROM), serum inflammatory factor levels, degree of articular cartilage wear, knee joint function recovery and adverse reactions were observed from multiple dimensions. In this study, independent sample t-test and repeated measures analysis of variance were used to statistically evaluate the data. The results showed that the traditional Chinese medicine group had significant advantages in total effective rate, improvement of WOMAC score, relief of joint swelling, improvement of ROM, control of articular cartilage wear and knee joint function recovery; the glucosamine sulfate group performed outstandingly in reducing VAS scores and regulating serum inflammatory factor levels and the incidence of adverse reactions in the traditional Chinese medicine group was lower. In summary, for patients who urgently need to relieve pain, glucosamine sulfate capsules can be used as an initial option; while for patients who hope to comprehensively improve joint function, the blood circulation and swelling reduction formula is more valuable.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"325-332"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of compound glycyrrhizin combined with fractional CO2 laser on the improvement of skin lesions and skin barrier function in rosacea. 复方甘草酸联合CO2激光对酒渣鼻皮损及皮肤屏障功能改善的影响。
IF 0.7 4区 医学
Si-Cheng Zhao, Dan Wang, Ting-Yan Wu, Ming-Jing Fu, Xiao-Ming Lu
{"title":"Effect of compound glycyrrhizin combined with fractional CO2 laser on the improvement of skin lesions and skin barrier function in rosacea.","authors":"Si-Cheng Zhao, Dan Wang, Ting-Yan Wu, Ming-Jing Fu, Xiao-Ming Lu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rosacea is a chronic facial inflammatory disease affecting quality of life, with complex causes including psychological, lifestyle and immune factors. This study examines the use of compound glycyrrhizin with fractional CO2 laser treatment for rosacea patients. From January 2018 to January 2022, 108 patients with rosacea lesions were randomly assigned to a control group (conventional treatment) and an observation group (glycyrrhizin plus laser treatment). Both groups received 12 weeks of therapy. Analysis using SPSS26.0 and GraphPad Prism 8.0 showed improvement in skin lesions and barrier function post-treatment. The observation group had fewer lesions and better skin hydration compared to the control group (P<0.05). Adverse reactions were higher in the observation group but not significantly different (P>0.05). The combination treatment enhances therapeutic effects, improves skin lesions, and strengthens the skin barrier, warranting promotion.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"407-411"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of related factors of malnutrition in patients with chronic obstructive pulmonary disease and changes in blood routine parameters with Ajuga ciliata Bunge. 慢性阻塞性肺疾病患者营养不良相关因素及纤毛草血常规参数变化分析。
IF 0.7 4区 医学
Xuran Pan
{"title":"Analysis of related factors of malnutrition in patients with chronic obstructive pulmonary disease and changes in blood routine parameters with Ajuga ciliata Bunge.","authors":"Xuran Pan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD), currently one of the most common chronic lung diseases in clinical practice, is the third leading cause of death globally, after ischemic heart disease and stroke. In this study, we analyzed the factors related to malnutrition in chronic obstructive pulmonary disease and found that long-term smoking, body mass index, fasting plasma glucose and total cholesterol were all independent risk factors. This suggests that in future clinical treatment of chronic obstructive pulmonary disease, attention should be paid to these indicators to prevent malnutrition (P<0.05). Ajuga ciliata Bunge is one of the drugs commonly used in traditional Chinese medicine for the adjuvant treatment of lung inflammation and sore throat. We found that the addition of Ajuga ciliata Bunge to the treatment of COPD can effectively improve the inflammatory response of patients. Meanwhile, the improvement of inflammatory response was more significant in COPD patients who were malnourished among them (P<0.05). In addition, the incidence of adverse reactions with Ajuga ciliata Bunge was low and improved the patients' treatment satisfaction. These results suggest that Ajuga ciliata Bunge has an important application in the treatment of COPD in the future.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"387-394"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of 25(OH)D supplementation on adipokines and advanced glycation end products in experimental type 2 diabetic and obesity rat model. 补充25(OH)D对实验性2型糖尿病和肥胖大鼠模型中脂肪因子和晚期糖基化终产物的影响
IF 0.7 4区 医学
Cigdem Toprak, Semra Yigitaslan, Ezgi Bektur Aykanat, Basar Sirmagul, Varol Sahinturk
{"title":"Effect of 25(OH)D supplementation on adipokines and advanced glycation end products in experimental type 2 diabetic and obesity rat model.","authors":"Cigdem Toprak, Semra Yigitaslan, Ezgi Bektur Aykanat, Basar Sirmagul, Varol Sahinturk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diabetes mellitus is a global health problem and vitamin D deficiency is thougt to be a reasonal factor for development of diabetes. Our aim is to investigate among vitamin D levels and blood glucose, insulin resistance, adiponectin, apelin, tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), oxidative stress index (OSI) levels and advanced glycation end products (AGEs) formation in modeled obesity and type 2 diabetes mellitus (T2DM) rats. During the 14-week experiment; Control group was fed standart diet-(12 % of calories of fat), Diabetes group was fed high fat diet (HFD)-at the 4<sup>th</sup> week Streptozotocin (STZ) (35 mg/kg) was injected, Diabetes/vitamin D group was fed HFD-at the 4<sup>th</sup> week STZ was injected-between 4<sup>th-</sup> 14<sup>th</sup> week vitamin D supplement was administered, Obesity group was fed HFD-(40% of calories as fat), Obesity/vitamin D group was fed HFD-between 4<sup>th-</sup>14<sup>th</sup> week vitamin D supplement was administered. At 14<sup>th</sup> week, biochemical parameters, adipokine concentrations, kidney tissue cytokine levels, liver tissue oxidative stress index parameters were measured by using ELISA method and Hematoxylinamp;Eosin staining of kidney, heart, liver, coronary/renal artery tissues and immunohistochemical staining of kidney tissues were performed. Vitamin D can alleviate glucose and lipid parameters and we think vitamin D may be useful adjuvant agent in obesity and T2DM treatment.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"463-472"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network analysis for the discovery of key biomarkers and potential therapeutic targets in hypertrophic cardiomyopathy. 发现肥厚性心肌病关键生物标志物和潜在治疗靶点的网络分析。
IF 0.7 4区 医学
Bin Xie, Zhao Chen, Jian Liu, Jimei Chen, Jian Zhuang, Huimin Guo, Jiyan Chen
{"title":"Network analysis for the discovery of key biomarkers and potential therapeutic targets in hypertrophic cardiomyopathy.","authors":"Bin Xie, Zhao Chen, Jian Liu, Jimei Chen, Jian Zhuang, Huimin Guo, Jiyan Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypertrophic cardiomyopathy (HCM) is a genetic heart disorder that can lead to sudden cardiac death. Current treatment strategies, such as implantable cardioverter-defibrillators, exhibit limitations in impeding disease progression. Despite the identification of several pathogenic genes, the complex mechanisms underlying HCM remain unclear. This study aims to identify novel pathogenic genes and critical biomarkers for HCM using network-based bioinformatics analysis, with the potential to discover therapeutic targets for pharmaceutical interventions. Gene expression data from 119 HCM patients and 55 healthy donors were analyzed using differential gene expression (DEG) analysis, followed by gene ontology (GO), KEGG and Reactome pathway enrichment studies. A protein-protein interaction (PPI) network was constructed to identify hub genes and their interactions, with a focus on potential drug targets. We identified a key gene module, with TNNT1 emerging as a critical hub gene. TNNT1 was found to significantly influence cardiac development and contribute to HCM pathogenesis. Our findings suggest that TNNT1's role in regulating cardiac contractility could provide a foundation for developing new therapeutic agents targeting this pathway. This study provides novel insights into the molecular mechanisms of HCM and identifies TNNT1 as a potential biomarker for early screening and a promising target for pharmaceutical therapies. The identification of TNNT1 offers opportunities for personalized medicine approaches, which could facilitate the development of drugs aimed at modulating its expression and mitigating disease progression in HCM patients.</p>","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 2","pages":"493-510"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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