Pakistan journal of pharmaceutical sciences最新文献_第7页

Unearthing novel PPAR-γ activators: In silico design of eucalyptol analogues for ulcerative colitis. 挖掘新的PPAR-γ活化剂：对溃疡性结肠炎的桉树醇类似物的计算机设计。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.13103.1

Ozair Khurram Hashmi, Muhammad Hanzla, Calvin R Wei, Muhammad Aashir Khan, Muhammad Wassam Bin Wasim, Muhammad Abdullah, Syed Hafiz Ahmed, Muhammad Osama

{"title":"Unearthing novel PPAR-γ activators: In silico design of eucalyptol analogues for ulcerative colitis.","authors":"Ozair Khurram Hashmi, Muhammad Hanzla, Calvin R Wei, Muhammad Aashir Khan, Muhammad Wassam Bin Wasim, Muhammad Abdullah, Syed Hafiz Ahmed, Muhammad Osama","doi":"10.36721/PJPS.2025.38.4.REG.13103.1","DOIUrl":"10.36721/PJPS.2025.38.4.REG.13103.1","url":null,"abstract":"Ulcerative colitis (UC) is a chronic inflammatory bowel disease with rising prevalence, necessitating novel therapeutics. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a promising target for UC management. This study aimed to identify potent, selective PPAR-γ agonists derived from the natural product eucalyptol (1,8-cineole), with reported anti-inflammatory and PPAR-γ activating properties but limited clinical utility. A computational workflow encompassing molecular docking of 342 eucalyptol analogues against PPAR-γ, pharmacokinetic prediction, and molecular dynamics simulations was employed. Docking revealed five top-scoring hits with higher predicted PPAR-γ binding affinities than eucalyptol. AA051 emerged as the most promising candidate, exhibiting the lowest binding free energies (-31.16 kcal/mol MMGBSA, -16.53 kcal/mol MMPBSA), favorable ADMET profiles including oral bioavailability, solubility, blood-brain barrier permeability, and conformational stability. AA055 also showed a promising binding profile albeit with initial instability. This study highlights computational approaches in drug discovery, identifying AA051 as a compelling PPAR-γ agonist lead for UC therapy, paving the way for experimental validation and optimization of this novel scaffold.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1415-1425"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of ticagrelor with clopidogrel in patients after interventional therapy for acutely coronary syndrome and effect on serum specificity indices. 替格瑞洛与氯吡格雷在急性冠脉综合征介入治疗后的应用及对血清特异性指标的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.14377.1

Yangzhi Chen, Limei Lei, Qing Ji

{"title":"The use of ticagrelor with clopidogrel in patients after interventional therapy for acutely coronary syndrome and effect on serum specificity indices.","authors":"Yangzhi Chen, Limei Lei, Qing Ji","doi":"10.36721/PJPS.2025.38.4.REG.14377.1","DOIUrl":"10.36721/PJPS.2025.38.4.REG.14377.1","url":null,"abstract":"Acute coronary syndrome (ACS) is a severe form of coronary artery disease that poses a major challenge to clinical management. This study evaluated the effects of ticagrelor and clopidogrel on serum biomarkers and clinical outcomes after intervention in patients with ACS. 112 ACS patients (June 2023 to June 2024) were enrolled and randomized into two groups: control group (n=56) and study group (n=56). Both groups received clopidogrel treatment, while the study group was additionally treated with ticagrelor. Platelet aggregation rate, serum inflammatory markers, cardiac function indices (LVEF, LVEDD, LVESD), immune function, microcirculatory function (CFR, IMR), clinical efficacy, and adverse events were assessed at various time points. Postoperative indicators improved in both groups (P<0.05). Platelet aggregation rate, inflammatory index level, LVEDD and LVESD, percentage of CD8+ T cellls, IMR level and incidence of adverse reactions were lower in Study group patients than in Control group (P<0.05). Study group patients had higher LVEF, percentage of CD3+ T cellls, CD4+ T cellls, CFR level and clinical efficacy than Control group (P<0.05). The efficacy of ticagrelor and clopidogrel in the post-interventional period in patients with ACS is definite and of high clinical value.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1203-1212"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding prescriptions: A closer look at common errors in clinical practice across community pharmacies of Northern Cyprus. 解码处方：仔细观察北塞浦路斯社区药房临床实践中的常见错误。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.14103.1

Syed Sikandar Shah, Aftab Alam, Ashfaq Ahmad Shah Bukhari, Jamil Ahmed, Johana Haindongo

{"title":"Decoding prescriptions: A closer look at common errors in clinical practice across community pharmacies of Northern Cyprus.","authors":"Syed Sikandar Shah, Aftab Alam, Ashfaq Ahmad Shah Bukhari, Jamil Ahmed, Johana Haindongo","doi":"10.36721/PJPS.2025.38.4.REG.14103.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.4.REG.14103.1","url":null,"abstract":"Prescription documentation is essential for patient safety and medication efficacy. However, incomplete or illegible prescriptions can lead to errors, including drug-drug interactions (DDIs). This study evaluated the completeness, clarity and quality of handwritten and electronic prescriptions from community pharmacies in Northern Cyprus, assessing compliance with WHO guidelines. A total of 5,246 prescriptions from 23 pharmacies were analyzed over nine months, with 4,856 meeting inclusion criteria. Of these, 77% were handwritten and 23% electronic. Illegibility was an issue in 23.1% of handwritten prescriptions, increasing the risk of errors. Generic drug names were included in only 11.42% of handwritten and 26.95% of electronic prescriptions, reducing clarity. Potential DDIs were identified in 52.2% of cases, particularly involving anticoagulants and NSAIDs. Additionally, 3.9% of prescriptions showed evidence of DDIs. Antibiotics (28.03%) and analgesics (22.66%) were the most prescribed medications. While electronic prescriptions improved legibility, both formats lacked essential details. The study highlights the need for improved prescription practices, advocating for mandatory electronic prescribing, enhanced prescriber education and clinical decision support systems to reduce errors, improve patient safety and enhance prescription quality in community pharmacies.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1195-1202"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: HPLC-DAD phytochemical revelation, antimicrobial simulation and in-vitro bioactivity of endemic herb extracts. 地方药提取物的HPLC-DAD植物化学揭示、抗菌模拟和体外生物活性的勘误。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.13233-ERRATUM.1

Sarah Alharthi, Rokayya Sami, Mohamed Sabri Bensaad, Necer Abdeldjabar, Mohamed Amine Kahoul, Roqayah Kadi, Ruqaiah Bedaiwi, Abeer ALmasoudi, Manal Almalki, Abdullah Izmirly

引用次数: 0

Effectiveness of combination therapy versus monotherapy in multiple sclerosis: A systematic review and meta-analysis. 联合治疗与单一治疗在多发性硬化症中的有效性：一项系统回顾和荟萃分析。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.14387.1

Xiang Wang, Mingli Zhao, Ping Liu, Xiaoling Shang

{"title":"Effectiveness of combination therapy versus monotherapy in multiple sclerosis: A systematic review and meta-analysis.","authors":"Xiang Wang, Mingli Zhao, Ping Liu, Xiaoling Shang","doi":"10.36721/PJPS.2025.38.4.REG.14387.1","DOIUrl":"10.36721/PJPS.2025.38.4.REG.14387.1","url":null,"abstract":"Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS) and the leading cause of non-traumatic neurological disability in young adults. Although current disease-modifying therapies (DMTs), such as interferon beta (IFNβ) and glatiramer acetate, can reduce inflammation and delay disease progression, many patients continue to experience relapses. Given the complexity and variability of MS, combination therapy targeting multiple disease mechanisms is being explored as a more effective treatment approach. A comprehensive search of Medline and EMBASE databases was conducted using keywords related to MS, immunomodulatory agents, and combination therapy. Additional clinical trials were identified through the National MS Society database. A limited number of studies have investigated the use of IFNβ with or without immunosuppressive agents. Preliminary findings suggest potential benefits of combination therapy, though evidence is constrained by small sample sizes, lack of randomization, and limited follow-up periods. Combination therapies may offer enhanced therapeutic effects in MS management. However, more rigorous and large-scale clinical trials are required to confirm their safety and efficacy.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1334-1346"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Eichhornia crassipes pharmacological potential: Muscle relaxant and sedative activities, molecular docking and molecular dynamics simulations. 探索棘草的药理潜力：肌肉松弛和镇静活性，分子对接和分子动力学模拟。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.14078.1

Fayaz Asad, Mamoona Bibi, Vasila Sharipova, Nodira Rakhimova, Sarir Ahmad, Imtiaz Ahamd, Sajid Ali

{"title":"Exploring Eichhornia crassipes pharmacological potential: Muscle relaxant and sedative activities, molecular docking and molecular dynamics simulations.","authors":"Fayaz Asad, Mamoona Bibi, Vasila Sharipova, Nodira Rakhimova, Sarir Ahmad, Imtiaz Ahamd, Sajid Ali","doi":"10.36721/PJPS.2025.38.4.REG.14078.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.4.REG.14078.1","url":null,"abstract":"This study aims to investigate the therapeutic properties of Eichhornia crassipes (Mart.) Solms, demonstrating its sedative and muscle relaxant capabilities. It examines molecular dynamics simulations, docking investigations, in silico screening and molecular interactions. The study revealed that there are differences in the responses of muscle relaxant activity to several extracts, highlighting the intricate connection between dose and effects. The E. crassipes did not exhibit considerable muscle relaxant action. Additionally, the study showed that E. crassipes had dose-dependent sedative effects, underscoring the plant's potential for targeted sedative uses and the management of stress-induced sleep disturbances. According computational studies, E. crassipes interacts with the COX-1 and COX-2 proteins. Orientin is a promising chemical since it has strong docking scores against both proteins. The possible sedative properties of E. crassipes compounds are further explained by intricate amino acid interactions. The constant B-factor and RMS scores, together with the examination of eigenvalues and covariance matrices, validate the simulations' dependability in confirming the binding stability found in docking experiments. Further research is needed to explore the potential muscle relaxant properties and this could lead to new opportunities for investigating herbal medicine in the future.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1184-1194"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periplocin has anti-tumor actions in prostate cancer through modulating the miR-3614-5p/SLC4A4 axis. Periplocin通过调节miR-3614-5p/SLC4A4轴在前列腺癌中具有抗肿瘤作用。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.13101.1

Jinjun Tian, Dingguo Zhang

{"title":"Periplocin has anti-tumor actions in prostate cancer through modulating the miR-3614-5p/SLC4A4 axis.","authors":"Jinjun Tian, Dingguo Zhang","doi":"10.36721/PJPS.2025.38.4.REG.13101.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.4.REG.13101.1","url":null,"abstract":"Periplocin (PPLN) can inhibit malignant tumors including prostate cancer (PC), but its impact on prostate cancer is unknown. Prostate cancer cells were treated with various doses of periplocin (PPLN), and the optimal treatment concentration of PPLN was determined using a CCK-8 assay. Bioinformatics analysis was performed to examine the link between miR-3614-5p and SLC4A4. The influences of miR-3614-5p and SLC4A4 levels on prostate cancer cells were analyzed using CCK-8, EdU, cell-scratch, Transwell, and flow cytometry analyses. A nude-mouse tumor model was created by injecting mice with PC3 cells subcutaneously. MiR-3614-5p and SLC4A4 levels in cancer cells and tumor tissues were measured using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and western blot analyses. 100 nM PPLN dramatically decreased the proliferation, migration, and invasion of prostate cancer cells and promoted apoptosis. MiR-3614-5p reduced SLC4A4 levels, and both the reduction of miR-3614-5p and increase of SLC4A4 expression greatly promoted the malignancy behavior of cells. Low miR-3614-5p expression decreased PPLN's inhibitory effect on malignant behavior, which was reversed by down-regulation of SLC4A4. PPLN reduced tumor growth in mice, increased miR-3614-5p levels, and decreased SLC4A4 levels. In conclusion, PPLN exerted anti-prostate-cancer effects by modulating the miR-3614-5p/SLC4A4 axis.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1309-1320"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of radical surgery, chemotherapy combined with PD-1 inhibitor camrelizumab on prognosis of hilar cholangiocarcinoma patients and its clinical significance. 根治性手术、化疗联合PD-1抑制剂camrelizumab对肝门部胆管癌患者预后的影响及临床意义

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.13496.1

Yuchen Liu, Jianjiao Zhu, Fanning Xie, Jilin Tao, Jingdong Li

{"title":"Effects of radical surgery, chemotherapy combined with PD-1 inhibitor camrelizumab on prognosis of hilar cholangiocarcinoma patients and its clinical significance.","authors":"Yuchen Liu, Jianjiao Zhu, Fanning Xie, Jilin Tao, Jingdong Li","doi":"10.36721/PJPS.2025.38.4.REG.13496.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.4.REG.13496.1","url":null,"abstract":"Hilar cholangiocarcinoma (HCCA), a malignant bile duct tumor, has an obscure pathogenesis. We aimed to assess the therapeutic effects of surgery and chemotherapy combined with the PD-1 inhibitor camrelizumab on HCCA patients' prognosis. This study included 26 HCCA patients. Post-surgery, patients received camrelizumab (3mg/kg IV) every 3 weeks, oxaliplatin (100 mg/m2) weekly and gemcitabine (1000 mg/m2) biweekly. Computed tomography assessed treatment response after 6 weeks and survival was evaluated through quarterly follow-ups. Among the 26 patients, 2 achieved complete response, 9 partial response, and 5 stable disease, while 10 progressed. The objective response rate (ORR) and disease control rate (DCR) were 42.3% and 61.5%, respectively. Successful down staging was observed in 16 patients. Post-treatment, AST and ALT levels significantly increased. The overall survival (OS) and disease-free survival (DFS) rates were 76.9% and 69.2%, respectively. Sensitive patients (with down staging) had significantly better survival than non-sensitive patients. Radical surgery and chemotherapy combined with camrelizumab may be effective and safe for HCCA management. Statistical analyses were performed using GraphPad Prism version 7.0, employing Student's t-tests for comparisons between groups.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1110-1116"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Danning tablet alleviates cholecystitis caused by gallstone through enhancing bile secretion and rinsing. 丹宁片通过促进胆汁分泌和冲洗，减轻胆结石引起的胆囊炎。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.13874.1

Weiyi Shen, Fan Ding, Hongchao Zhang, Yixing Wang, Run Guo, Qihan Wang, Zhengyu Cui, Yan Shen, Lang Liu, Gang Zhao

{"title":"Danning tablet alleviates cholecystitis caused by gallstone through enhancing bile secretion and rinsing.","authors":"Weiyi Shen, Fan Ding, Hongchao Zhang, Yixing Wang, Run Guo, Qihan Wang, Zhengyu Cui, Yan Shen, Lang Liu, Gang Zhao","doi":"10.36721/PJPS.2025.38.4.REG.13874.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.4.REG.13874.1","url":null,"abstract":"Danning tablets are widely used as a conservative treatment for gallstones in China. However, the underlying pharmacological mechanisms remain to be elucidated. We performed network pharmacology analyses. The intersection between the therapeutic target of Danning tablet and the gallstone target was taken. Adult male C57BL/6J mice were fed with the lithogenic diet only or LD supplemented with Danning tablet for 8 weeks. The gallbladder was stained with HE to assess inflammation, the liver was tested at RNA and protein levels, and bile duct cannulation was used to assess bile secretion function. All these experiments revealed that Danning tablets improved gallbladder inflammation in both humans and mice. Active ingredients such as luteolin in Danning tablet can upregulate the expression of AQP7 by binding to transcription factors such as ESR1, promote the liver to secrete more bile for gallbladder rinsing and relieving cholecystitis. Therefore, we believe that the use of Danning tablets is beneficial for patients with gallstone disease accompanied by inflammation.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1146-1155"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To observe the effect of acetylcysteine combined with diphylline on pulmonary function and inflammatory response in children with bronchopneumonia. 目的观察乙酰半胱氨酸联合苯酞对支气管肺炎患儿肺功能及炎症反应的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-07-01 DOI: 10.36721/PJPS.2025.38.4.REG.13415.1

Lian Zhang

{"title":"To observe the effect of acetylcysteine combined with diphylline on pulmonary function and inflammatory response in children with bronchopneumonia.","authors":"Lian Zhang","doi":"10.36721/PJPS.2025.38.4.REG.13415.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.4.REG.13415.1","url":null,"abstract":"Bronchopneumonia is an extremely common respiratory disease in children, which may cause bronchiectasis, respiratory failure, and other complications. In this study, we observed the effect of acetylcysteine combined with diphylline in the treatment of bronchopneumonia. This includes the session time of the child's cough and wheezing symptoms, lung function, and the inflammatory response before and after treatment. In addition, we also counted the adverse reactions during the treatment of the children. The results of the study showed that children in the research group treated with acetylcysteine combined with diphylline had a shorter time to symptomatic relief compared to the control group using bronchopneumonia (P<0.05). Also, the lung function after treatment was better in the research group than in the control group, and the levels of inflammatory factors were lower in the research group than in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). These results suggest that acetylcysteine combined with diphylline has excellent potential for the treatment of bronchopneumonia.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 4","pages":"1117-1124"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0