Pakistan journal of pharmaceutical sciences最新文献

Research on the combined impact of high-flux dialysis and levocarnitine on the functionality of arteriovenous fistulas in patients undergoing maintenance hemodialysis. 高通量透析联合左卡尼汀对维持性血液透析患者动静脉瘘功能影响的研究

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Lei Pang, Shanshan Sun, Ying Shi, Xiaoyan Yu, Na Luo, Shuangyu Li

{"title":"Research on the combined impact of high-flux dialysis and levocarnitine on the functionality of arteriovenous fistulas in patients undergoing maintenance hemodialysis.","authors":"Lei Pang, Shanshan Sun, Ying Shi, Xiaoyan Yu, Na Luo, Shuangyu Li","doi":"","DOIUrl":"","url":null,"abstract":"To explore the influence of levocarnitine on arteriovenous fistula (AVF) function in patients undergoing high-flux dialysis and delve into its potential mechanisms. Complication Reduction: The treatment group had markedly lower incidences of vascular stenosis (4.69% vs. 20%), thrombosis (3.13% vs. 15%), poor venous return (6.25% vs. 18.33%), and pre-dialysis hypotension (7.81% vs. 23.33%) (all P < 0.05). Hematological Benefits: Significant improvements in hemoglobin (11.57 ± 1.63 vs. 10.38 ± 1.49g/dL) and red blood cell count (3.89 ± 0.51 vs. 3.53 ± 0.46 ×10¹²/L) were observed in the treatment group (P < 0.001), alongside reduced white blood cell counts (6.05 ± 1.49 vs. 6.23 ± 1.60 ×109/L, P = 0.006). Quality of Life: Karnofsky Performance Scale (KPS) scores were significantly higher in the treatment group at both 1-month (P < 0.01) and 3-month follow-ups (P < 0.01). In the context of high-flux hemodialysis, supplementing with levocarnitine can appreciably improve AVF function in ESRD patients, mitigate the occurrence of complications, and potentially enhance the quality of life by alleviating dialysis-related issues. Levocarnitine emerges as a promising adjunctive therapy for patients with compromised AVF function.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 3","pages":"781-788"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the effect of phentolamine combined with vitamins A/D on inflammatory responses and humoral immunity in children with severe pneumonia. 酚妥拉明联合维生素A/D对重症肺炎患儿炎症反应及体液免疫影响的研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Yinfang Li, Dan Xu, Peiling Yin

{"title":"Study on the effect of phentolamine combined with vitamins A/D on inflammatory responses and humoral immunity in children with severe pneumonia.","authors":"Yinfang Li, Dan Xu, Peiling Yin","doi":"","DOIUrl":"","url":null,"abstract":"Pneumonia is a common childhood illness that can become life-threatening if it progresses to severe pneumonia. Currently, there are considerable limitations in the diagnosis and treatment of severe pneumonia in clinical practice, which also leads to a persistently high mortality rate of severe pneumonia. In this study, we first analyzed the related factors for the progression of pneumonia to severe pneumonia and discovered that age, disease duration, infection type, C reactive protein, anemia, malnutrition and underlying diseases were relevant. This suggests that when admitting children with pneumonia in future clinical settings, attention should be paid to these indicators to prevent the progression to severe pneumonia. Subsequently, we explored the therapeutic effect of phentolamine combined with vitamins A/D on severe pneumonia and confirmed the significant clinical efficacy of their combination, which effectively alleviated inflammation in children with severe pneumonia, enhanced immunity and reduced the risk of recurrence of pneumonia, suggesting the extremely high clinical application value of this treatment regimen. These results will provide reliable reference and guidance for the diagnosis and treatment of severe pneumonia in the future, thereby ensuring the prognostic health of children with severe pneumonia.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 3","pages":"771-779"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of levocarnitine plus iron sucrose on nutritional status and life cycle in uremic patients with renal anemia. 左卡尼汀加蔗糖铁对尿毒症合并肾性贫血患者营养状况及生命周期的影响。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Li Ren, Jun Wu, Yanqin Shi, Dong Li, Gelu Huang, Nana Meng

{"title":"Effect of levocarnitine plus iron sucrose on nutritional status and life cycle in uremic patients with renal anemia.","authors":"Li Ren, Jun Wu, Yanqin Shi, Dong Li, Gelu Huang, Nana Meng","doi":"","DOIUrl":"","url":null,"abstract":"Research team believes that Levocarnitine (L-carnitine) combined with Iron sucrose (IS) has a more significant positive effect on the nutritional status and lifespan of uremic patients with renal anemia and has carried out research and demonstration based on this. First, research team selected 90 uremic patients with renal anemia admitted to our hospital from February 2019 to February 2022 and randomized them to an experimental group (n=45) and a control group (n=45) that were given L-carnitine+IS and L-carnitine, respectively. The clinical efficacy and adverse reactions of the two groups of patients were counted and fasting venous blood was collected before and after treatment to test nutrient proteins, calcium and phosphorus metabolism and renal function. In addition, 1-year prognostic follow-up was performed to count the prognostic survival of the patients. The results of the study showed that the clinical efficacy of the experimental group was better than that of the control group and the nutritional protein, calcium and phosphorus metabolism and renal function were better after treatment (P<0.05), but there was no difference in the incidence of adverse reactions between the two groups (P>0.05). Prognostic follow-up showed that there was no difference in the prognostic overall survival rate between the two groups (P>0.05), but the median survival of the experimental group was prolonged compared with the control group (P<0.05). In conclusion, L-carnitine combined with IS effectively ameliorated the anemia status of patients, improved their nutritional status and prolonged their median survival.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 3","pages":"745-750"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the therapeutic efficacy of tinidazole combined with compound chlorhexidine gargle in the treatment of oral infections caused by Candida albicans following orthodontics. 替硝唑联合复方氯己定含漱液治疗正畸术后口腔白色念珠菌感染的疗效分析。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Haibao Sun, Wei Feng, Xiaoling Wang, Peng Wang, Dan Zheng

{"title":"Analysis of the therapeutic efficacy of tinidazole combined with compound chlorhexidine gargle in the treatment of oral infections caused by Candida albicans following orthodontics.","authors":"Haibao Sun, Wei Feng, Xiaoling Wang, Peng Wang, Dan Zheng","doi":"","DOIUrl":"","url":null,"abstract":"This study evaluated the efficacy of tinidazole combined with compound chlorhexidine gargle in treating oral Candida albicans infections after orthodontic procedures. Sixty patients (July 2021-December 2023) were divided into an observation group (tinidazole + chlorhexidine, n=30) and a control group (chlorhexidine alone, n=30). After 7 days, the observation group showed significantly lower oral Candida albicans colony counts (t=6.536, P<0.05), a higher total clinical efficacy rate (96.67% vs. 80.00%, χ²=4.043, P<0.05), reduced oral pain scores (t=12.420, P<0.05), lower periodontal indices (PLI and GI, t=18.884, 18.689, P<0.05), decreased levels of inflammatory markers (IL-1β, IL-6, TNF-α, and hs-CRP, t=5.859, 5.868, 3.436, 16.303, P<0.05), and improved oral health-related quality of life scores (t=8.693, 11.198, 5.086, 5.549, P<0.05). The incidence of adverse reactions was lower in the observation group (χ²=0.577, P>0.05), with no recurrence observed. The combination therapy demonstrated superior clinical efficacy and safety compared to monotherapy. The combined application can effectively reduce the number of Candida albicans colonies in the oral cavity, alleviate oral pain, decrease the levels of inflammatory markers, improve periodontal health and oral health-related quality of life and exhibit good safety.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 3","pages":"901-910"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and characterization of thiolated chitosan coated TPGSylated nanodiamonds for oral delivery of curcumin. 巯基壳聚糖包覆TPGSylated纳米金刚石的构建与表征。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Dandan Liu, Zhiyuan Yang, Yue Lu, Weiwei Yang

{"title":"Construction and characterization of thiolated chitosan coated TPGSylated nanodiamonds for oral delivery of curcumin.","authors":"Dandan Liu, Zhiyuan Yang, Yue Lu, Weiwei Yang","doi":"","DOIUrl":"","url":null,"abstract":"Low water solubility and poor intestinal permeability hinder the oral absorption of curcumin (CUR). To address this, we designed a core-shell structured nanoparticle based on nanodiamonds (NDs) and thiolated chitosan (TCS). First, D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) covalently modified NDs were prepared and loaded with CUR (CUR@NDs-TPGS). N-acetylcysteine (NAC) was then coupled to chitosan (CS) to obtain positively charged CS-NAC, which electrostatically coated the negatively charged NDs-TPGS/CUR. Particle size (PS), zeta potential (ZP) and drug loading efficiency (DLE) were selected as screening indices to optimize the formulation and preparation process of CUR@NDs-TPGS/CS-NAC via single-factor experiments. The results showed that after coating with CS-NAC, the PS of optimized CUR@NDs-TPGS/CS-NAC increased from 183.63±5.24 nm to 245.24±3.95 nm, the ZP value flipped from -25.47±1.36 to +25.81±1.06 and the DLE value decreased slightly. Moreover, the nanoparticles adopted a spherical morphology and the cumulative release percentage of the nanocomplexes within 24 h decreased from 35.69% to 25.54% after coating. CUR@NDs-TPGS/CS-NAC remained stable within 48 h in simulated intestinal fluid. Mucin adsorption, GI retention and oral absorption of CUR@NDs-TPGS/CS-NAC were further enhanced compared to CUR@NDs-TPGS. These findings suggest that CUR@NDs-TPGS/CS-NAC is a promising carrier for oral delivery of CUR.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 3","pages":"1095-1105"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug efficacy and safety of azithromycin combined with pulmonary physical therapy for bacterial pneumonia in children. 阿奇霉素联合肺部物理治疗儿童细菌性肺炎的疗效和安全性。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Lingxiao Shi, Yangjin Chen, Huidan Yang, Shuai Wei

引用次数: 0

Erratum to: Lycorine attenuates lipopolysaccharide-induced inflammation and intestinal epithelial barrier dysfunction in Caco-2 cells through inhibiting the STING/NF-κB pathway. 石蒜碱通过抑制STING/NF-κB通路，减轻脂多糖诱导的Caco-2细胞炎症和肠上皮屏障功能障碍。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Weiwei Gao, Peng Guan, Wanpeng Gao, Xiaodan Li

引用次数: 0

Clinical study on preventive treatment of postpartum hemorrhage with carboprost tromethamine combined with oxytocin and misoprostol. 卡前列素联合催产素、米索前列醇预防产后出血的临床研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Jie Jiao, Lei Li, LiYang Liu, ChunYan Huang

{"title":"Clinical study on preventive treatment of postpartum hemorrhage with carboprost tromethamine combined with oxytocin and misoprostol.","authors":"Jie Jiao, Lei Li, LiYang Liu, ChunYan Huang","doi":"","DOIUrl":"","url":null,"abstract":"To study the clinical effect of carboprost tromethamine combined with oxytocin and misoprostol in the preventive treatment of postpartum hemorrhage. 94 cases of postpartum hemorrhage patients from October, 2022 to October, 2023 were divided into the reference group (treated with oxytocin and misoprostol) and the observation group (treated with carboprost tromethamine, oxytocin and misoprostol) and the treatment situation was analyzed. Compared with the reference group, the stress and serum indexes in the observation group were significantly decreased. Except oxygen saturation, the postpartum hemorrhage and hemostasis time in the observation group were significantly lower than those in the reference group and the hemoglobin content was relatively high. After treatment, the improvement of coagulation function in the observation group was better than that in the reference group. The incidence of complications was 21.28% in the reference group and 4.26% in the observation group, the difference was statistically significant (P < 0.05). In the preventive treatment of postpartum hemorrhage, triple medication is more effective, which can improve patients' stress response and serum indexes, reduce the amount of bleeding and improve patients' coagulation function. At the same time, it is also very beneficial to control complications and has high safety.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 3","pages":"1023-1027"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of cyclosporine eye drops in managing post-cataract surgery dry eye symptoms: A randomized controlled trial. 环孢素滴眼液治疗白内障术后干眼症状的疗效：一项随机对照试验

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Zhaolian Xie, Shuxiang Tan, Linlin Liu, Yue Xu

{"title":"Efficacy of cyclosporine eye drops in managing post-cataract surgery dry eye symptoms: A randomized controlled trial.","authors":"Zhaolian Xie, Shuxiang Tan, Linlin Liu, Yue Xu","doi":"","DOIUrl":"","url":null,"abstract":"Many patients develop dry eye symptoms or further exacerbation post-cataract surgery. The aim is to analyse the efficacy of cyclosporine A (CsA) eye drops on the dry eye symptoms post-cataract surgery (DEPC). 100 DEPC patients admitted to First Affiliated Hospital of Gannan Medical University from August 2022 to August 2024 were randomly divided into control group (n=50) and study group (n=50): The control group was treated with sodium vitrate eye drops, the study group was treated with CsA eye drops. The primary assessments were the ocular surface disease index questionnaire (OSDI): tear break-up time (TBUT) and schirmer I test (SIT). Secondary outcomes included visual acuity, tear inflammatory factors, clinical efficacy and adverse reaction incidence. Before medication, no remarkable difference of the both groups. TBUT, SIT and visual acuity were obviously improved, and the OSDI score and inflammatory factors were markedly decreased in the both groups after medication 1 week, 2 weeks and 1 month (P<0.05). The study group were superior to the control group (P<0.05). The study group's clinical efficacy was above the control group, the adverse reaction incidence was below the control group (P<0.05). This treatment is accurate in its efficacy and has high clinical value.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 3","pages":"921-930"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of the impact of traditional Chinese medicine treatment on the quality of life of patients with chronic obstructive pulmonary disease-CM improves quality of COPD patients. 中医药治疗对慢性阻塞性肺疾病（COPD）患者生活质量影响的meta分析- cm改善COPD患者生活质量。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-05-01

Zhiyong Zhang

引用次数: 0