Pakistan journal of pharmaceutical sciences最新文献

Efficacy and safety of eltrombopag in combination with rituximab in the treatment of immune thrombocytopenic purpura: A multicentre, randomised, open-label, prospective study. eltrombopag联合利妥昔单抗治疗免疫性血小板减少性紫癜的疗效和安全性：一项多中心、随机、开放标签、前瞻性研究

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14225.1

Yurong Zhang, Haiyan Zhang, Huirong Shan, Yuyang Qi, Yanyan Feng, Sumei Wang, Li Xu, Wei Wei, Shoudong Zhang, Sha Chen, Xiaohui Dai

{"title":"Efficacy and safety of eltrombopag in combination with rituximab in the treatment of immune thrombocytopenic purpura: A multicentre, randomised, open-label, prospective study.","authors":"Yurong Zhang, Haiyan Zhang, Huirong Shan, Yuyang Qi, Yanyan Feng, Sumei Wang, Li Xu, Wei Wei, Shoudong Zhang, Sha Chen, Xiaohui Dai","doi":"10.36721/PJPS.2025.38.5.REG.14225.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14225.1","url":null,"abstract":"This study aimed to evaluate the efficacy and safety of eltrombopag plus rituximab in the treatment of patients with immune thrombocytopenic purpura (ITP). Sixty ITP patients treated from September 2022 to September 2023 were recruited for this study, and were randomly divided into a control group and a treatment group. The former was given eltrombopag, and the later was given eltrombopag plus rituximab. The treatment efficacy, platelet levels, coagulation function, sustained effective SR, progression-free-survival, and incidence of adverse reactions and adverse events were compared in both groups using SPSS 22.0 statistical software. After nine months of treatment, the platelet level of the treatment group was significantly better than that of the control group (P<0.05). The platelet levels of the treatment group were better than those of the control group at discharge and 6 months after discharge (P<0.05). After treatment, the levels of PT and APPT in the treatment group were lower than those in the control group (P>0.05). There was no difference in the incidence of adverse reactions and adverse events between 2 groups after treatment (P<0.05). In conclusion, eltrombopag combined with rituximab can effectively improve the efficacy of treatment in ITP patients, with high safety.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1656-1663"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and clinical significance of glutamic acid decarboxylase antibodies among young diabetic patients in Faisalabad, Punjab. 旁遮普费萨拉巴德地区年轻糖尿病患者谷氨酸脱羧酶抗体的流行及临床意义

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14746.1

Mazhar Iqbal, Shazia Anwer Bukhari, Muhammad Arif Nadeem Saqib

{"title":"Prevalence and clinical significance of glutamic acid decarboxylase antibodies among young diabetic patients in Faisalabad, Punjab.","authors":"Mazhar Iqbal, Shazia Anwer Bukhari, Muhammad Arif Nadeem Saqib","doi":"10.36721/PJPS.2025.38.5.REG.14746.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14746.1","url":null,"abstract":"Glutamic acid decarboxylase (GAD) antibodies are markers of pancreatic beta-cell autoimmunity and play a critical role in understanding the autoimmune component of diabetes mellitus. Despite its importance for distinguishing autoimmune diabetes, limited data exists on GAD antibody among young patients. This study determined the prevalence and clinical significance of GAD antibodies among young diabetic patients in Faisalabad, Punjab, Pakistan. This cross-sectional study recruited diabetic patients aged ≤40 years from tertiary care hospitals of Faisalabad. Data were collected using a validated questionnaire, and GAD antibodies were measured using the chemiluminescence immunoassay. Among 506 patients (253 T1DM, 253 T2DM), GAD prevalence was 18.2%, significantly higher in T1DM (28.9%) versus T2DM (7.5%; p<0.001). Age at onset demonstrated good predictive value (AUC=0.714) with an optimal cutoff at 20 years (sensitivity=69.6%, specificity=69.3%). BMI showed predictive utility (AUC=0.702) with a cutoff at <23kg/m². Multivariate analysis also revealed younger age at onset (OR=3.2, 95% CI: 1.8-5.6) and lower BMI (OR=2.8, 95% CI: 1.6-4.9) significantly associated with GAD positivity. GAD antibodies are prevalent among young diabetic patients in Faisalabad, with significantly higher prevalence in T1DM. Younger onset age and lower BMI were significant predictors of GAD positivity but should be interpreted along with other clinical and biochemical factors.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1932-1939"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of enteral nutrition guidance on immune function in CRRT-treated renal failure patients: A comparative study of furosemide versus sodium bicarbonate. 肠内营养指导对crrt治疗肾衰竭患者免疫功能的影响：速尿与碳酸氢钠的比较研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14097.1

Jianhua Lin, Jinyou Zhu

{"title":"Impact of enteral nutrition guidance on immune function in CRRT-treated renal failure patients: A comparative study of furosemide versus sodium bicarbonate.","authors":"Jianhua Lin, Jinyou Zhu","doi":"10.36721/PJPS.2025.38.5.REG.14097.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14097.1","url":null,"abstract":"This quantitative research assesses the effectiveness of enteral nutrition guidance on the immune function of subjects with acute renal failure undergoing continuous renal replacement therapy, with either furosemide or sodium bicarbonate interventions. The findings revealed that both interventions indeed enhanced the renal, metabolic, nutritional and immune profiles of the patients over 14 days, which were not different from each other. Sodium bicarbonate had a numerically superior effect in correcting acidosis, which was marginally superior to placebo, whereas furosemide significantly improved the fluid clearance. Regression analysis on the chosen variables showed that serum creatinine, BUN, pH, BMI and NLR were significant for outcomes. Most prominently, changes in the nitrogen balance and oxidative stress indicators were differentiated and significantly better in both groups due to the structured EN approach. These outcomes underscore more importance of providing personalized medical care in the care of critical illness and interactively integrating EN with pharmacologic approaches to promote the recovery as well as the immune status of the patients.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1961-1973"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auxiliary effect of clopidogrel on neurological rehabilitation in patients with post-stroke motor disorders. 氯吡格雷对脑卒中后运动障碍患者神经康复的辅助作用。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13260.1

Lan Chen, Jianqiu Gong

引用次数: 0

Cytotoxicity of bovine serum albumin nanoparticles loaded with vincristine sulfate for intravenous drug delivery: In vitro and in vivo studies. 载硫酸长春新碱用于静脉给药的牛血清白蛋白纳米颗粒的细胞毒性：体外和体内研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13432.1

Hamid Jabbar Hasan, Mowafaq M Ghareeb

{"title":"Cytotoxicity of bovine serum albumin nanoparticles loaded with vincristine sulfate for intravenous drug delivery: In vitro and in vivo studies.","authors":"Hamid Jabbar Hasan, Mowafaq M Ghareeb","doi":"10.36721/PJPS.2025.38.5.REG.13432.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.13432.1","url":null,"abstract":"One common approach for treating cancer is chemotherapy. The extremely low distribution efficiency and lack of specificity of anticancer medications might occasionally limit systemic chemotherapy due to the lack of targeting and the existence of severe toxic side effects. Bioengineered from bovine serum albumin, the protein's viability was assessed by loading it into nanoparticles intended for intravenous delivery of vincristine sulfate for cancer treatment. Utilizing the desolvation process, cross-linked nanoparticles containing vincristine sulfate and made of albumin were created. This work examined the produced nanoparticles' in vitro and in vivo properties. After effective preparation, the bovine serum albumin nanoparticles loaded with vincristine sulfate had a spherical shape and a small particle size of 162.70 nm, as confirmed by a transmission electron microscope. In comparison to the standard vincristine solution, the nanoparticles showed sustained cytotoxicity on the MCF-7 breast cancer cell line and primary dermal fibroblast normal cell line (HDFn) cells. The nanoparticle-treated group did not exhibit appreciable histological alterations compared to the control group. In conclusion, albumin nanoparticles can enhance the distribution of vincristine sulfate to cancer cells, thereby increasing the drug's lethal effect. One promising therapeutic strategy for cancer treatment involves the development of injectable nano-based medications.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1793-1803"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tea polysaccharide ameliorates glucolipotoxicity-induced oxidative damage and apoptosis of RIN-m5F cells through Nrf2/HO-1 pathway. 茶多糖通过Nrf2/HO-1通路改善糖脂中毒诱导的RIN-m5F细胞的氧化损伤和凋亡。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14206.1

Haiyan Liu, Jianwei Zhang, Liangrong Zhu

{"title":"Tea polysaccharide ameliorates glucolipotoxicity-induced oxidative damage and apoptosis of RIN-m5F cells through Nrf2/HO-1 pathway.","authors":"Haiyan Liu, Jianwei Zhang, Liangrong Zhu","doi":"10.36721/PJPS.2025.38.5.REG.14206.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14206.1","url":null,"abstract":"Glucolipotoxicity (GLTy) could cause the islet β cell dysfunction in metabolic diseases such as diabetes. Tea polysaccharide (TPS) has the potential to ameliorate islet damage, but its protective effects on GLTY-induced islet β cell damages and its mechanism remain unclear. The RIN-m5F cell damage model was constructed by GLTy induction. The effects of TPS on cell damage were investigated from apoptosis, oxidative stress, inflammatory response, cell senescence and cell function. MTT, ELISA, immunofluorescence, flow cytometry, WB and kits were used to detect cell viability, insulin secretion level, inflammatory factors, antioxidant enzyme activity, cell apoptosis rate and related protein expression. Si-Nrf2 was used to verify whether TPS can activate Nrf2/HO-1 signaling to play a protective role. TPS can increase the cell viability, the positive rate of EdU, insulin secretion, anti-inflammatory factor level, and the activities of SOD and CAT, reduce apoptosis, proinflammatory factor levels and the expression of p21, p53 and p16 proteins. By activating Nrf2/HO-1 pathway, TPS alleviated oxidative stress damage, thus playing a protective role against GLTY-induced cell damage. TPS effectively reduced GLTY-induced RIN-m5F cells damage through activating Nrf2/HO-1 pathway, providing a new idea and potential drug selection for the treatment of diabetes.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1700-1713"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro microbiological evaluation of gemifloxacin derivatives: Synthesis, vibrational spectroscopy, molecular docking and DFT studies. 吉氟沙星衍生物的体外微生物学评价：合成、振动光谱、分子对接和DFT研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13901.1

Sana Shamim, Rabya Munawar, Majid Ali, Nasir Shahzad, Sonia Khan, Irshad Begum, Safia Khan

{"title":"In-vitro microbiological evaluation of gemifloxacin derivatives: Synthesis, vibrational spectroscopy, molecular docking and DFT studies.","authors":"Sana Shamim, Rabya Munawar, Majid Ali, Nasir Shahzad, Sonia Khan, Irshad Begum, Safia Khan","doi":"10.36721/PJPS.2025.38.5.REG.13901.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.13901.1","url":null,"abstract":"Herein, to address the challenges associated with microbial resistance against antibiotics, three new gemifloxacin derivatives (G-D08, G-D09 and G-D10), have been synthesized using conventional esterification (Fischer) and amide approach (C-3 and C-7 modified) in efficient yields. UV-Vis, FT-IR, 1HNMR, and Mass spectroscopy for characterization while DFT studies for computational conformational stability. In-silico pharmacokinetics (Swiss ADME, Bio transformers) and toxicological properties (T.E.S.T software) evaluated that all derivatives followed Lipinski's criterion and exhibits no vital organ toxicity. Microbiological evaluation in reciprocation towards designated strains of Gram +ve and Gram -ve bacteria, and fungi demonstrated potent actuation towards K. pneumonia, Candida albicans and Citrobacter freundii in comparison to gemifloxacin, surpassing antibacterial and antifungal responsiveness, reinforced by B3LYP/6-311 G level of theory. Energy gaps (HOMO-LUMO) of derivative G-D09 and G-D10 is 1.72 eV determinant as cognizant. Molecular docking approach was also applied through MOE software against K. pneumonia (PDB ID: 6k63), C. freundii (PDB ID: 3JWB) and C. albicans (PDB ID: 1AI9) ranging between -6.05 and -7.79 kcal/ mol, authenticating their higher antibacterial response towards Klebsiella pneumoniae among all compounds and G-D10 as potent antifungal agent.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1750-1764"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the role of immune checkpoint inhibitors in combination with conventional DMARDS for treating rheumatoid arthritis. 探索免疫检查点抑制剂联合常规DMARDS治疗类风湿关节炎的作用。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14343.1

Qing Lu, Yunyun Lin

{"title":"Exploring the role of immune checkpoint inhibitors in combination with conventional DMARDS for treating rheumatoid arthritis.","authors":"Qing Lu, Yunyun Lin","doi":"10.36721/PJPS.2025.38.5.REG.14343.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14343.1","url":null,"abstract":"Rheumatoid arthritis (RA) is chronic autoimmune disorder leading to joint damage and systemic complications. This study aimed to explore the clinical effectiveness of combining immune checkpoint inhibitors (ICIs) with conventional disease-modifying antirheumatic drugs (DMARDs) in patients diagnosed with RA. A total of 50 patients undergoing cancer treatment with ICIs were enrolled in this observational study. Demographic and clinical data were collected. Patients receiving ICI therapy were concomitantly managed with conventional DMARDs, with treatment initiation and duration recorded. Response to therapy was assessed over a follow-up period of 60 days using clinical improvement scores. The mean age of the patients was 59.5 years, with males comprising 56% and smoking history comprising 62% of patients. Melanoma (36%) and renal carcinoma (30%) were the most common malignancies. Most patients were in stage III cancer, with 16% showing brain metastases. Grade 3 arthritis was present in 42% of the cohort. Kaplan-Meier survival estimates showed time to arthritis control within 60 days of DMARD initiation. Clinical improvement was observed in 62% of patients. RA patients treated with ICIs appears immune-related adverse events. Conventional DMARDs may contribute to manage inflammatory arthritis without significantly compromising cancer control. Further studies are needed to establish optimal treatment protocols.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1605-1613"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC-MS/MS analysis, antimicrobial and antioxidant potential of phenolic extracts derived from Urtica dioica leaves and roots. 枸杞叶和根酚类提取物的LC-MS/MS分析及抗氧化活性研究。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.13072.1

Keddar Fayza, Boualem Malika, Fizir Meriem, Brada Moussa, Benabdelmoumene Djilali, Belhadji Amel

{"title":"LC-MS/MS analysis, antimicrobial and antioxidant potential of phenolic extracts derived from Urtica dioica leaves and roots.","authors":"Keddar Fayza, Boualem Malika, Fizir Meriem, Brada Moussa, Benabdelmoumene Djilali, Belhadji Amel","doi":"10.36721/PJPS.2025.38.5.REG.13072.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.13072.1","url":null,"abstract":"This research examined the antimicrobial and antioxidant properties of phenolic compounds from Urtica dioïca, a plant widely used in traditional medicine. The total polyphenol content in the leaves and roots were 5.37mg EAG/g and 1.21 mg EAG/g, respectively, while the flavonoid content was 0.40 mg QAE/g (leaves) and 0.19 mg QAE/g (roots). Using LC-MS/MS, 22 compounds were identified in the roots and 27 in the leaves, with gallic acid and 4-methylguaiacol found predominantly in both extracts. Unique to the leaf extract were Phenylethyl Ester and 3,5-Dimethoxyphenol. The extracts were tested against bacterial strains including Escherichia coli, Klebsiella, Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, and Proteus mirabilis, all showing sensitivity. MIC values ranged from 0.07 to 0.15mg/ml and MBC values ranged from 0.7 to 0.30mg/ml, indicating primarily bactericidal activity. Additionally, anti-free radical tests using DPPH showed 80.54% inhibition for the leaf extract and 49.23% for the root extract. This study highlights the significant antimicrobial and antioxidant properties of Urtica dioica, supporting its traditional medicinal use and suggesting its potential in developing novel therapies.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1528-1538"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the synergistic effects of poly-l-lactic acid (Sculptra®) and retinoic acid (tretinoin) in facial rejuvenation treatment for age-related skin laxity. 探索聚乳酸（Sculptra®）和维甲酸（维甲酸）在面部年轻化治疗中与年龄相关的皮肤松弛的协同作用。

IF 0.7 4区医学

Pakistan journal of pharmaceutical sciences Pub Date : 2025-09-01 DOI: 10.36721/PJPS.2025.38.5.REG.14005.1

Kuo-Liang Liao, Kuo-Hsiang Liao

{"title":"Exploring the synergistic effects of poly-l-lactic acid (Sculptra®) and retinoic acid (tretinoin) in facial rejuvenation treatment for age-related skin laxity.","authors":"Kuo-Liang Liao, Kuo-Hsiang Liao","doi":"10.36721/PJPS.2025.38.5.REG.14005.1","DOIUrl":"https://doi.org/10.36721/PJPS.2025.38.5.REG.14005.1","url":null,"abstract":"To investigate the synergistic effects of Poly-L-Lactic Acid (PLLA) and Retinoic Acid (RA) on age-related skin relaxation in the treatment of facial rejuvenation. 120 patients received facial rejuvenation treatment at Sin-An Cosmetic Clinic Hospital from April 2022 to August 2023 were divided into control group (n=42) and observation group (n=78). Both groups were treated with RA and observation group was added with PLLA. The outer corner wrinkles and lower eyelid wrinkles, nasolabial wrinkles, self-perception ratings of skin effects and adverse reactions incidence were compared between both groups. After treatment, the total improvement rates of outer eye corners, lower eyelid wrinkles and nasolabial folds, the improvement rate of the overall aesthetics of the mid-face, the scores of skin elasticity, water content, skin colour, pores and other skin conditions of the observation group were significantly higher than the control group and the scores of oil secretion and dark spots were significantly lower than the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than the control group, but the difference was not significant (P>0.05). Combined treatment can improve patients' skin condition and promote facial rejuvenation, which has high clinical application value.","PeriodicalId":19971,"journal":{"name":"Pakistan journal of pharmaceutical sciences","volume":"38 5","pages":"1867-1874"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0